loperamide has been researched along with Electrocardiogram QT Prolonged in 9 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 5.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide is a nonprescription medication commonly used to treat diarrhea." | 2.82 | Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management. ( Juurlink, DN; Wu, PE, 2022) |
| "Loperamide overdose may cause QT prolongation, life-threatening arrhythmias/cardiogenic shock, or cardiac arrest." | 1.62 | Loperamide-induced cardiotoxicity: a case overlooked? ( Aqeel, M; Fayyaz, SM; Iqbal, S; Saeed, Y, 2021) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 1.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide is a readily accessible nonprescription medication that is increasingly being used surreptitiously as an opioid substitute to alleviate the symptoms of acute opioid withdrawal." | 1.51 | Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk. ( Alexander, A; Brent, J; Calello, DP; Campleman, S; Lee, VR; Nelson, LS; Ruck, B; Vera, A; Wax, P, 2019) |
| "Loperamide is an over-the-counter, peripherally acting, μ-opioid receptor agonist used for the treatment of diarrhea." | 1.46 | Loperamide metabolite-induced cardiomyopathy and QTc prolongation. ( Bhatti, Z; Norsworthy, J; Szombathy, T, 2017) |
| "Loperamide is a μ-opioid receptor agonist commonly used to treat diarrhea and often available as an over-the-counter medication." | 1.43 | Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic. ( Compton, DR; Kang, J; Rampe, D; Vaz, RJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, PE | 1 |
| Juurlink, DN | 1 |
| Myllymäki, L | 1 |
| Westerbergh, J | 1 |
| Carlsson, H | 1 |
| Höjer, J | 1 |
| Simon, M | 1 |
| Rague, J | 1 |
| Iqbal, S | 1 |
| Fayyaz, SM | 1 |
| Saeed, Y | 1 |
| Aqeel, M | 1 |
| Bhatti, Z | 1 |
| Norsworthy, J | 1 |
| Szombathy, T | 1 |
| Nattel, S | 1 |
| Lee, VR | 1 |
| Vera, A | 1 |
| Alexander, A | 1 |
| Ruck, B | 1 |
| Nelson, LS | 1 |
| Wax, P | 1 |
| Campleman, S | 1 |
| Brent, J | 1 |
| Calello, DP | 1 |
| Enakpene, EO | 1 |
| Riaz, IB | 1 |
| Shirazi, FM | 1 |
| Raz, Y | 1 |
| Indik, JH | 1 |
| Kang, J | 1 |
| Compton, DR | 1 |
| Vaz, RJ | 1 |
| Rampe, D | 1 |
1 review available for loperamide and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Opioid-Related Disor | 2022 |
8 other studies available for loperamide and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
[Torsade de pointes following repeated massive loperamide ingestions].
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Heart Diseases; Humans; Long QT Syndrome; | 2020 |
A Case Report of Torsade de Pointes and Brugada Pattern Associated with Loperamide Misuse and Supratherapeutic Loperamide Concentrations.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Male; Torsades de | 2021 |
Loperamide-induced cardiotoxicity: a case overlooked?
Topics: Drug Overdose; Electric Countershock; Electrocardiography; Humans; Long QT Syndrome; Loperamide; Mal | 2021 |
Loperamide metabolite-induced cardiomyopathy and QTc prolongation.
Topics: Adult; Antidiarrheals; Biotransformation; Cardiomyopathies; Drug Overdose; Electrocardiography; Fema | 2017 |
An Emerging Malignant Arrhythmia Epidemic Due to Loperamide Abuse: Underlying Mechanisms and Clinical Relevance.
Topics: Anti-Arrhythmia Agents; Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Epidemics; Humans | 2016 |
Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Arrhythmias, Cardiac; Atrioventricular B | 2019 |
The long QT teaser: loperamide abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Diagnosis, Differential; Electrocardiography; Fatal Out | 2015 |
Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.
Topics: Action Potentials; Antidiarrheals; Cardiotoxicity; Dose-Response Relationship, Drug; ERG1 Potassium | 2016 |