loperamide has been researched along with Drug Overdose in 29 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the case of a 20-year-old man who presented with severe catatonia following excessive intake of loperamide, fully remitted with lorazepam." | 7.80 | Loperamide overdose-induced catatonia: potential role of brain opioid system and P-glycoprotein. ( Di Rosa, AE; Di Rosa, E, 2014) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 5.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| "Loperamide is a nonprescription opioid widely used for the treatment of diarrhea." | 4.95 | Clinical Review: Loperamide Toxicity. ( Juurlink, DN; Wu, PE, 2017) |
| " Following treatment for hyperkalemia with calcium, insulin, dextrose, and hypertonic sodium bicarbonate a repeat ECG had a ventricular rate of 66/min, QRS 156 ms, and QT 576 ms." | 3.83 | Not your regular high: cardiac dysrhythmias caused by loperamide. ( Biary, R; Hoffman, RS; Howland, MA; Lugassy, D; Rice, B; Wightman, RS, 2016) |
| "Loperamide is an antidiarrheal medication deemed by the U." | 3.81 | Ventricular tachycardia associated with high-dose chronic loperamide use. ( Lonardo, NW; Mulamalla, R; Spinner, HL; Stehlik, J, 2015) |
| "We describe the case of a 20-year-old man who presented with severe catatonia following excessive intake of loperamide, fully remitted with lorazepam." | 3.80 | Loperamide overdose-induced catatonia: potential role of brain opioid system and P-glycoprotein. ( Di Rosa, AE; Di Rosa, E, 2014) |
| "Loperamide overdose is a toxidrome that remains underrecognized, and in patients with unexplained cardiac arrhythmias, loperamide toxicity should be suspected." | 2.61 | Electrocardiographic changes in loperamide toxicity: Case report and review of literature. ( Alimohammad, R; Ellenbogen, KA; Ellenbogen, M; Kalahasty, G; Koneru, JN; Padala, SK; Stahura, H; Teigeler, T, 2019) |
| "Loperamide is an over-the-counter, μ-opioid receptor agonist commonly used as an antidiarrheal agent." | 2.61 | Loperamide as a Potential Drug of Abuse and Misuse: Fatal Overdoses at the Medical University of South Carolina. ( Powell, JW; Presnell, SE, 2019) |
| "Loperamide is an over-the-counter medication which is commonly used to treat diarrhoea." | 1.62 | Loperamide: an emerging drug of abuse and cause of prolonged QTc. ( Newman, J; Whittaker, G, 2021) |
| "Loperamide overdose may cause QT prolongation, life-threatening arrhythmias/cardiogenic shock, or cardiac arrest." | 1.62 | Loperamide-induced cardiotoxicity: a case overlooked? ( Aqeel, M; Fayyaz, SM; Iqbal, S; Saeed, Y, 2021) |
| "Loperamide is an over-the-counter, peripherally acting, μ-opioid receptor agonist used for the treatment of diarrhea." | 1.46 | Loperamide metabolite-induced cardiomyopathy and QTc prolongation. ( Bhatti, Z; Norsworthy, J; Szombathy, T, 2017) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 1.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| "Loperamide is an over-the-counter, inexpensive, antidiarrheal opioid that can produce life-threatening toxicity at high concentrations." | 1.46 | Loperamide-Induced Torsades de Pointes: A Case Series. ( Amaducci, A; Burket, G; Cannon, RD; Cook, MD; Day, R; Enyart, J; Janssen, J; Katz, KD; Porter, L; Roach, T; Williams, KE, 2017) |
| "Loperamide abuse has been increasing in the United States as a potential alternative to manage opioid withdrawal symptoms or to achieve euphoric effects of opioid use." | 1.46 | Epidemiologic Trends in Loperamide Abuse and Misuse. ( Charlton, NP; Holstege, CP; Vakkalanka, JP, 2017) |
| "Loperamide is a synthetic opioid of the phenyl piperidine class used as an over-the-counter antidiarrheal." | 1.33 | Tissue distribution of loperamide and N-desmethylloperamide following a fatal overdose. ( Allan, C; Fowler, D; Levine, B; Moore, KA; Sklerov, J, 2005) |
| "Loperamide was approved for nonprescription use in 1988." | 1.30 | Surveillance of loperamide ingestions: an analysis of 216 poison center reports. ( Clancy, C; Korberly, B; Litovitz, T; Mann, KV; Temple, AR, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 17 (58.62) | 24.3611 |
| 2020's | 7 (24.14) | 2.80 |
| Authors | Studies |
|---|---|
| Font, J | 1 |
| Alexandre, J | 1 |
| Dolladille, C | 1 |
| Milliez, P | 1 |
| Ollitrault, P | 1 |
| Krantz, MJ | 1 |
| Stockbridge, N | 1 |
| Kao, DP | 1 |
| Klein, MG | 1 |
| Haigney, MCP | 1 |
| Reinert, JP | 1 |
| Dunn, RL | 1 |
| Teigeler, T | 1 |
| Stahura, H | 1 |
| Alimohammad, R | 1 |
| Kalahasty, G | 1 |
| Koneru, JN | 1 |
| Ellenbogen, M | 1 |
| Ellenbogen, KA | 1 |
| Padala, SK | 1 |
| Wang, A | 1 |
| Nguyen, M | 1 |
| Diaz, J | 1 |
| Smith, T | 1 |
| Whittaker, G | 1 |
| Newman, J | 1 |
| Levine, M | 1 |
| Lovecchio, F | 1 |
| Iqbal, S | 1 |
| Fayyaz, SM | 1 |
| Saeed, Y | 1 |
| Aqeel, M | 1 |
| Malinky, CA | 1 |
| Lindsley, CW | 1 |
| Han, C | 1 |
| Bhatti, Z | 1 |
| Norsworthy, J | 1 |
| Szombathy, T | 1 |
| Rasla, S | 1 |
| Parikh, P | 1 |
| St Amand, A | 1 |
| Garas, MK | 1 |
| El Meligy, A | 1 |
| Minami, T | 1 |
| Shah, NR | 1 |
| Wu, PE | 1 |
| Juurlink, DN | 1 |
| Katz, KD | 1 |
| Cannon, RD | 1 |
| Cook, MD | 1 |
| Amaducci, A | 1 |
| Day, R | 1 |
| Enyart, J | 1 |
| Burket, G | 1 |
| Porter, L | 1 |
| Roach, T | 1 |
| Janssen, J | 1 |
| Williams, KE | 1 |
| Woronow, D | 1 |
| Swank, KA | 1 |
| Wu, E | 1 |
| Kortepeter, C | 1 |
| Levin, RL | 1 |
| Powell, JW | 1 |
| Presnell, SE | 1 |
| Di Rosa, E | 1 |
| Di Rosa, AE | 1 |
| Spinner, HL | 1 |
| Lonardo, NW | 1 |
| Mulamalla, R | 1 |
| Stehlik, J | 1 |
| Eggleston, W | 1 |
| Nacca, N | 1 |
| Marraffa, JM | 1 |
| Gómez Casal, V | 1 |
| Lage Cendon, L | 1 |
| Lago Preciado, G | 1 |
| Vara Adrio, S | 1 |
| Wightman, RS | 1 |
| Hoffman, RS | 1 |
| Howland, MA | 1 |
| Rice, B | 1 |
| Biary, R | 1 |
| Lugassy, D | 1 |
| Bishop-Freeman, SC | 1 |
| Feaster, MS | 1 |
| Beal, J | 1 |
| Miller, A | 1 |
| Hargrove, RL | 1 |
| Brower, JO | 1 |
| Winecker, RE | 1 |
| Ruan, X | 1 |
| Luo, JJ | 1 |
| Kaye, AD | 1 |
| Vakkalanka, JP | 1 |
| Charlton, NP | 1 |
| Holstege, CP | 1 |
| Lee, HM | 1 |
| Villa, AF | 1 |
| Caudrelier, S | 1 |
| Garnier, R | 1 |
| Sklerov, J | 1 |
| Levine, B | 1 |
| Moore, KA | 1 |
| Allan, C | 1 |
| Fowler, D | 1 |
| Staley, EC | 1 |
| Staley, EE | 1 |
| Epelde, F | 1 |
| Boada, L | 1 |
| Tost, J | 1 |
| Litovitz, T | 1 |
| Clancy, C | 1 |
| Korberly, B | 1 |
| Temple, AR | 1 |
| Mann, KV | 1 |
| Ahmad, SR | 1 |
7 reviews available for loperamide and Drug Overdose
| Article | Year |
|---|---|
Management of overdoses of loperamide, gabapentin, and modafinil: a literature review.
Topics: Drug Overdose; Emergency Treatment; Gabapentin; Humans; Loperamide; Modafinil; Substance-Related Dis | 2019 |
Electrocardiographic changes in loperamide toxicity: Case report and review of literature.
Topics: Adult; Antidiarrheals; Bradycardia; Drug Overdose; Electrocardiography; Female; Humans; Loperamide; | 2019 |
New Designer Drugs.
Topics: Analgesics, Opioid; Buprenorphine; Cannabinoids; Designer Drugs; Drug Overdose; Fentanyl; Humans; Hy | 2021 |
DARK Classics in Chemical Neuroscience: Loperamide.
Topics: Analgesics, Opioid; Antidiarrheals; Drug Overdose; Humans; Loperamide; Substance-Related Disorders | 2021 |
Clinical Review: Loperamide Toxicity.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Diarrhea; Drug Overdose; Humans; Loperamide; Opioid-Relate | 2017 |
Loperamide as a Potential Drug of Abuse and Misuse: Fatal Overdoses at the Medical University of South Carolina.
Topics: Adult; Aged; Antidiarrheals; Drug Misuse; Drug Overdose; Female; Humans; Loperamide; Lung; Male; Mid | 2019 |
Can loperamide cause acute pancreatitis?
Topics: Abdominal Pain; Adolescent; Amylases; Antidiarrheals; Drug Overdose; Female; Humans; Lipase; Loperam | 2011 |
22 other studies available for loperamide and Drug Overdose
| Article | Year |
|---|---|
Loperamide-Associated Ventricular Arrhythmias.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Loperamide | 2023 |
Reply: Loperamide-Associated Ventricular Arrhythmias.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Loperamide | 2023 |
Loperamide toxicity mimicking peripartum cardiomyopathy.
Topics: Adult; Antidiarrheals; Cardiomyopathies; Diagnosis, Differential; Drug Overdose; Electrocardiography | 2020 |
Loperamide: an emerging drug of abuse and cause of prolonged QTc.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Drug Overdose; Female; Humans; Loperamide; Pharmaceutical Prep | 2021 |
Loperamide-induced cardiotoxicity: a case overlooked?
Topics: Drug Overdose; Electric Countershock; Electrocardiography; Humans; Long QT Syndrome; Loperamide; Mal | 2021 |
Loperamide metabolite-induced cardiomyopathy and QTc prolongation.
Topics: Adult; Antidiarrheals; Biotransformation; Cardiomyopathies; Drug Overdose; Electrocardiography; Fema | 2017 |
Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Heart Rate; Humans; | 2017 |
Loperamide-Induced Torsades de Pointes: A Case Series.
Topics: Adult; Antidiarrheals; Drug Overdose; Female; Humans; Loperamide; Male; Torsades de Pointes | 2017 |
Labeling and Drug Safety Communication Approaches to Loperamide Abuse.
Topics: Antidiarrheals; Communication; Drug Overdose; Humans; Loperamide; Nonprescription Drugs | 2017 |
Loperamide overdose-induced catatonia: potential role of brain opioid system and P-glycoprotein.
Topics: Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Catatonia; Drug Over | 2014 |
Ventricular tachycardia associated with high-dose chronic loperamide use.
Topics: Antidiarrheals; Cholecystectomy; Diarrhea; Dose-Response Relationship, Drug; Drug Overdose; Female; | 2015 |
Loperamide toxicokinetics: serum concentrations in the overdose setting.
Topics: Adult; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Half-Life; Heart Rate; Humans; Lope | 2015 |
[Ivabradine poisoning with suicide intention].
Topics: Adult; Antidotes; Benzazepines; Bradycardia; Calcium Gluconate; Combined Modality Therapy; Drug Over | 2015 |
Not your regular high: cardiac dysrhythmias caused by loperamide.
Topics: Alcoholism; Arrhythmias, Cardiac; Benzodiazepines; Blood Pressure; Calcium; Central Nervous System; | 2016 |
Loperamide-Related Deaths in North Carolina.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Overdose; Female; Gas Chromatograp | 2016 |
Loperamide-related deaths in North Carolina.
Topics: Cause of Death; Drug Overdose; Humans; Loperamide; Nonprescription Drugs; North Carolina | 2017 |
Epidemiologic Trends in Loperamide Abuse and Misuse.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Overdose; Female; Humans; Loperamide; Male; Middle | 2017 |
Tissue distribution of loperamide and N-desmethylloperamide following a fatal overdose.
Topics: Adult; Antidiarrheals; Chromatography, High Pressure Liquid; Drug Overdose; Fatal Outcome; Forensic | 2005 |
Loperamide intoxication in a seven-week-old pup.
Topics: Animals; Animals, Newborn; Cerebellum; Cerebral Cortex; Charcoal; Diarrhea; Dog Diseases; Dogs; Dose | 1994 |
Pancreatitis caused by loperamide overdose.
Topics: Adolescent; Antidiarrheals; Drug Overdose; Female; Humans; Loperamide; Pancreatitis; Suicide, Attemp | 1996 |
Surveillance of loperamide ingestions: an analysis of 216 poison center reports.
Topics: Adolescent; Adult; Antidiarrheals; Charcoal; Child; Child, Preschool; Drug Overdose; Female; Humans; | 1997 |
Lomotil overdose.
Topics: Atropine; Child, Preschool; Diphenoxylate; Drug Combinations; Drug Overdose; Gastrointestinal Agents | 1992 |