loperamide has been researched along with Disease Models, Animal in 56 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to explore the improvement of chitosan oligosaccharides (COS) on constipation through regulation of gut microbiota." | 8.02 | Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice. ( Bao, X; Jiang, N; Lin, A; Liu, H; Sun, G; Yang, H; Zhang, X; Zheng, J, 2021) |
| " Constipation was induced in rats with loperamide." | 8.02 | 7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats. ( Han, L; Han, Q; He, B; He, J; Luan, X; Ma, L; Qu, Z; Sun, Y; Wang, B; Xu, L, 2021) |
| "16 rats (study group) were evaluated in 3 phases of 6 days each: A (normal conditions), B (loperamide-induced constipation), and C (colic vein legation) and compared with rats treated in phase C with PEG 4,000 (control group)." | 7.78 | Effect of colic vein ligature in rats with loperamide-induced constipation. ( Aldini, R; Bianchi, E; Cavallari, G; Cevenini, M; Guidetti, E; Nardo, B; Neri, F; Pariali, M; Piras, GL; Tsivian, M, 2012) |
| "The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively." | 7.76 | Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium. ( An, R; Cui, B; Hu, Z; Wang, X; Wu, D; Yuan, J; Zhou, J, 2010) |
| " We chose PYY as an index of the intrinsic factor in diarrhea and examined the influence of changes induced in a diarrhea rat model by administration of 4 types of laxative and loperamide hydrochloride (loperamide) as an agent for the treatment of diarrhea." | 7.74 | Changes of intestinal mucosal and plasma PYY in a diarrhea model rat and influence of loperamide as the treatment agent for diarrhea. ( Hirotani, Y; Ikeda, K; Kurokawa, N; Mikajiri, K; Myotoku, M, 2008) |
| "The aim of this study was to establish a pathophysiologic model of irritable bowel syndrome, and then to evaluate the pharmaceutical efficacy of ramosetron, a potent serotonin 3 (5-HT(3)) receptor antagonist, and other anti-irritable bowel syndrome agents in this model." | 7.74 | Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats. ( Akuzawa, S; Funatsu, T; Hirata, T; Keto, Y; Sasamata, M; Takeuchi, A, 2007) |
| "Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life." | 5.56 | Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats. ( Abdellaoui, A; Hajji, N; Jabri, MA; Rtibi, K; Sebai, H; Tounsi, H; Wannes, D, 2020) |
| "Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life." | 5.48 | The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. ( Jang, SH; Yang, DK, 2018) |
| "The causal link between seizure and constipation is a common belief among patients and physicians, but there are no scientific data to support this association." | 5.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "This study was designed to explore the improvement of chitosan oligosaccharides (COS) on constipation through regulation of gut microbiota." | 4.02 | Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice. ( Bao, X; Jiang, N; Lin, A; Liu, H; Sun, G; Yang, H; Zhang, X; Zheng, J, 2021) |
| "In vivo, the ATE was studied in loperamide-induced constipation of mice." | 4.02 | Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca ( Chen, Y; Huang, B; Jia, Z; Liu, J; Wu, H; Xiao, H; Yu, Y; Zhao, S, 2021) |
| " Constipation was induced in rats with loperamide." | 4.02 | 7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats. ( Han, L; Han, Q; He, B; He, J; Luan, X; Ma, L; Qu, Z; Sun, Y; Wang, B; Xu, L, 2021) |
| "Using the Hargreaves assay for thermal nociception, the von Frey assay for mechanical nociception and the complete Freund's adjuvant-induced model of inflammatory pain, we tested the antinociceptive and antihyperalgesic effect of loperamide, oxymorphindole, or the loperamide-oxymorphindole combination." | 3.91 | Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice. ( Akgün, E; Bruce, DJ; Fairbanks, CA; Kitto, KF; Lazzaroni, S; Peterson, CD; Portoghese, PS; Wilcox, GL, 2019) |
| "To determine the local antinociceptive effect of morphine and loperamide, 2 models of acute muscle pain (trigeminal and spinal) were used." | 3.88 | Mu-Opioid Receptors in Ganglia, But Not in Muscle, Mediate Peripheral Analgesia in Rat Muscle Pain. ( Ambrosio, E; Bagues, A; Esteban-Hernández, J; Higuera-Matas, A; Martín, MI; Sánchez-Robles, EM, 2018) |
| "Fatty acid binding protein 4 inhibitor, BMS309403, was administered acutely or chronically for 6 and 13 consecutive days and its effect on GI transit was assessed in physiological conditions and in loperamide-induced constipation." | 3.88 | FABP4 blocker attenuates colonic hypomotility and modulates white adipose tissue-derived hormone levels in mouse models mimicking constipation-predominant IBS. ( Cygankiewicz, A; Fichna, J; Jacenik, D; Krajewska, WM; Małecka-Panas, E; Mokrowiecka, A; Mosińska, P; Pintelon, I; Sałaga, M; Sibaev, A; Storr, M; Timmermans, JP; Wasilewski, A, 2018) |
| " Oral DRAinh-A250 and tenapanor comparably reduced signs of constipation in loperamide-treated mice, with additive effects found on coadministration." | 3.88 | SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. ( Cil, O; Haggie, PM; Lee, S; Phuan, PW; Rivera, AA; Tan, JA; Verkman, AS, 2018) |
| "The loperamide-induced constipation reduced the absorption of rhein." | 3.80 | Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes. ( Chang, LW; Hou, ML; Lin, CH; Lin, LC; Tsai, TH, 2014) |
| " The aqueous leaf and shoot extract was assayed against castor oil-induced diarrhea, transit time, and enteropooling, in comparison to loperamide, a standard drug." | 3.80 | Safety and antidiarrheal activity of Priva adhaerens aqueous leaf extract in a murine model. ( Abimana, J; Alele, PE; Barasa, A; Kasolo, J; Nansunga, M, 2014) |
| "16 rats (study group) were evaluated in 3 phases of 6 days each: A (normal conditions), B (loperamide-induced constipation), and C (colic vein legation) and compared with rats treated in phase C with PEG 4,000 (control group)." | 3.78 | Effect of colic vein ligature in rats with loperamide-induced constipation. ( Aldini, R; Bianchi, E; Cavallari, G; Cevenini, M; Guidetti, E; Nardo, B; Neri, F; Pariali, M; Piras, GL; Tsivian, M, 2012) |
| " The present study evaluated the toxicological effect of aqueous leaf extract of the herb at 50, 100 and 200 mg/kg body weight for 7 days on the haematological parameters as well as liver and kidney function indices in loperamide-induced constipated rats." | 3.77 | Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats. ( Afolayan, AJ; Sunmonu, TO; Wintola, OA, 2011) |
| "The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively." | 3.76 | Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium. ( An, R; Cui, B; Hu, Z; Wang, X; Wu, D; Yuan, J; Zhou, J, 2010) |
| " The effect of GBFY on colonic epithelial proliferation was investigated through loperamide (LPM)-induced constipation in rats." | 3.76 | Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. ( Choi, JH; Jeon, JR, 2010) |
| "Although it is known that both clonidine and loperamide cause delayed colonic transit in mice, these models of drug-induced experimental constipation have not yet been fully characterized." | 3.75 | Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models. ( Doihara, H; Ito, H; Kawabata-Shoda, E; Kojima, R; Nozawa, K; Yokoyama, T, 2009) |
| " We chose PYY as an index of the intrinsic factor in diarrhea and examined the influence of changes induced in a diarrhea rat model by administration of 4 types of laxative and loperamide hydrochloride (loperamide) as an agent for the treatment of diarrhea." | 3.74 | Changes of intestinal mucosal and plasma PYY in a diarrhea model rat and influence of loperamide as the treatment agent for diarrhea. ( Hirotani, Y; Ikeda, K; Kurokawa, N; Mikajiri, K; Myotoku, M, 2008) |
| "The aim of this study was to establish a pathophysiologic model of irritable bowel syndrome, and then to evaluate the pharmaceutical efficacy of ramosetron, a potent serotonin 3 (5-HT(3)) receptor antagonist, and other anti-irritable bowel syndrome agents in this model." | 3.74 | Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats. ( Akuzawa, S; Funatsu, T; Hirata, T; Keto, Y; Sasamata, M; Takeuchi, A, 2007) |
| " Nicotine, however, dose dependently induced vomiting in the Suncus with an ED50 of 8." | 3.69 | Absence of emetic effects of morphine and loperamide in Suncus murinus. ( Friderichs, E; Reimann, W; Reinartz, S; Selve, N, 1994) |
| "Constipation is a condition with a high prevalence rate worldwide and may occur in men and women of any age." | 1.62 | Different ( Chai, M; Chen, W; Li, X; Wang, G; Wang, L; Zhang, H; Zhao, J, 2021) |
| "Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life." | 1.56 | Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats. ( Abdellaoui, A; Hajji, N; Jabri, MA; Rtibi, K; Sebai, H; Tounsi, H; Wannes, D, 2020) |
| "Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life." | 1.48 | The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. ( Jang, SH; Yang, DK, 2018) |
| "0mg/ml) on jejunal contraction were investigated and a dose-response curve constructed using the experimental data after which The ED50 dose was determined." | 1.43 | Freeze dried extracts of Bidens biternata (Lour.) Merr. and Sheriff. show significant antidiarrheal activity in in-vivo models of diarrhea. ( Kinuthia, DG; Muriithi, AW; Mwangi, PW, 2016) |
| "The causal link between seizure and constipation is a common belief among patients and physicians, but there are no scientific data to support this association." | 1.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life." | 1.39 | Laxative effects of Salecan on normal and two models of experimental constipated mice. ( Chen, J; Chen, P; Jia, P; Xiu, A; Zhan, Y; Zhang, J; Zhao, Y; Zhou, M, 2013) |
| "Loperamide was used as a model drug since it normally does not cross the blood-brain barrier (BBB) and was bound to the nanoparticles by adsorption." | 1.35 | Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). ( Hekmatara, T; Herbert, E; Kreuter, J; Ulbrich, K, 2009) |
| "The present results suggest that thermal hyperalgesia in experimental neuropathic pain can be reduced through activation of peripheral delta-opioid receptors." | 1.34 | Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. ( Hruby, VJ; Porreca, F; Shinoda, K, 2007) |
| "Loperamide has antidiarrhoeal activities against secretagogues with different mechanisms of action." | 1.31 | Effect of loperamide on mucosal guanylyl cyclase activity in rat jejunum following Escherichia coli heat-stable toxin-induced fluid accumulation. ( Asher, A; Elsenhans, B; Farack, UM; Gerzer, R; Schütte-Lückenga, B, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.57) | 18.7374 |
| 1990's | 1 (1.79) | 18.2507 |
| 2000's | 14 (25.00) | 29.6817 |
| 2010's | 26 (46.43) | 24.3611 |
| 2020's | 13 (23.21) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 2 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Yan, S | 1 |
| Yue, Y | 1 |
| Sun, M | 1 |
| Chen, Y | 2 |
| Wang, X | 2 |
| Qian, H | 1 |
| Narita, Y | 1 |
| Fukumoto, K | 1 |
| Fukunaga, M | 1 |
| Kondo, Y | 1 |
| Ishitsuka, Y | 1 |
| Jono, H | 1 |
| Irie, T | 1 |
| Saito, H | 1 |
| Kadowaki, D | 1 |
| Hirata, S | 1 |
| Hajji, N | 1 |
| Wannes, D | 1 |
| Jabri, MA | 2 |
| Rtibi, K | 2 |
| Tounsi, H | 1 |
| Abdellaoui, A | 1 |
| Sebai, H | 2 |
| Zhang, X | 1 |
| Yang, H | 1 |
| Zheng, J | 1 |
| Jiang, N | 1 |
| Sun, G | 1 |
| Bao, X | 1 |
| Lin, A | 1 |
| Liu, H | 1 |
| Wu, H | 1 |
| Huang, B | 1 |
| Yu, Y | 1 |
| Zhao, S | 1 |
| Liu, J | 1 |
| Jia, Z | 1 |
| Xiao, H | 1 |
| Ma, L | 1 |
| Qu, Z | 1 |
| Xu, L | 1 |
| Han, L | 1 |
| Han, Q | 1 |
| He, J | 1 |
| Luan, X | 1 |
| Wang, B | 1 |
| Sun, Y | 1 |
| He, B | 1 |
| Zhang, Q | 1 |
| Zhong, D | 1 |
| Ren, YY | 1 |
| Meng, ZK | 1 |
| Pegg, RB | 1 |
| Zhong, G | 1 |
| Makizaki, Y | 1 |
| Uemoto, T | 1 |
| Yokota, H | 1 |
| Yamamoto, M | 1 |
| Tanaka, Y | 1 |
| Ohno, H | 1 |
| Cao, PQ | 1 |
| Li, XP | 1 |
| Ou-Yang, J | 1 |
| Jiang, RG | 1 |
| Huang, FF | 1 |
| Wen, BB | 1 |
| Zhang, XN | 1 |
| Huang, JA | 1 |
| Liu, ZH | 1 |
| Chai, M | 1 |
| Wang, L | 1 |
| Li, X | 1 |
| Zhao, J | 1 |
| Zhang, H | 1 |
| Wang, G | 1 |
| Chen, W | 1 |
| Azad, AK | 1 |
| Doolaanea, AA | 1 |
| Al-Mahmood, SMA | 1 |
| Kennedy, JF | 1 |
| Chatterjee, B | 1 |
| Bera, H | 1 |
| Chen, CM | 1 |
| Wu, CC | 1 |
| Huang, CL | 1 |
| Chang, MY | 1 |
| Cheng, SH | 1 |
| Lin, CT | 1 |
| Tsai, YC | 1 |
| Bagues, A | 1 |
| Martín, MI | 1 |
| Higuera-Matas, A | 1 |
| Esteban-Hernández, J | 1 |
| Ambrosio, E | 1 |
| Sánchez-Robles, EM | 1 |
| Mosińska, P | 1 |
| Jacenik, D | 1 |
| Sałaga, M | 1 |
| Wasilewski, A | 1 |
| Cygankiewicz, A | 1 |
| Sibaev, A | 1 |
| Mokrowiecka, A | 1 |
| Małecka-Panas, E | 1 |
| Pintelon, I | 1 |
| Storr, M | 1 |
| Timmermans, JP | 1 |
| Krajewska, WM | 1 |
| Fichna, J | 1 |
| Jang, SH | 1 |
| Yang, DK | 1 |
| Xu, N | 1 |
| Fan, W | 1 |
| Zhou, X | 1 |
| Liu, Y | 1 |
| Ma, P | 1 |
| Qi, S | 1 |
| Gu, B | 1 |
| Haggie, PM | 1 |
| Cil, O | 1 |
| Lee, S | 1 |
| Tan, JA | 1 |
| Rivera, AA | 1 |
| Phuan, PW | 1 |
| Verkman, AS | 1 |
| Kim, JE | 1 |
| Park, JW | 1 |
| Kang, MJ | 1 |
| Choi, HJ | 1 |
| Bae, SJ | 1 |
| Choi, Y | 1 |
| Lee, YJ | 1 |
| Seo, S | 1 |
| Hong, JT | 1 |
| Hwang, DY | 1 |
| Bruce, DJ | 1 |
| Peterson, CD | 1 |
| Kitto, KF | 1 |
| Akgün, E | 1 |
| Lazzaroni, S | 1 |
| Portoghese, PS | 1 |
| Fairbanks, CA | 1 |
| Wilcox, GL | 1 |
| Zhou, M | 1 |
| Jia, P | 1 |
| Chen, J | 1 |
| Xiu, A | 1 |
| Zhao, Y | 1 |
| Zhan, Y | 1 |
| Chen, P | 1 |
| Zhang, J | 1 |
| Billah, MM | 1 |
| Islam, R | 1 |
| Khatun, H | 1 |
| Parvin, S | 1 |
| Islam, E | 1 |
| Islam, SA | 1 |
| Mia, AA | 1 |
| Souli, A | 1 |
| Selmi, S | 1 |
| Tebourbi, O | 1 |
| El-Benna, J | 1 |
| Sakly, M | 1 |
| Hou, ML | 1 |
| Chang, LW | 1 |
| Lin, CH | 1 |
| Lin, LC | 1 |
| Tsai, TH | 1 |
| Nansunga, M | 1 |
| Barasa, A | 1 |
| Abimana, J | 1 |
| Alele, PE | 1 |
| Kasolo, J | 1 |
| Tadesse, WT | 1 |
| Hailu, AE | 1 |
| Gurmu, AE | 1 |
| Mechesso, AF | 1 |
| Moezi, L | 1 |
| Pirsalami, F | 1 |
| Inaloo, S | 1 |
| Zhang, LP | 1 |
| Kline, RH | 1 |
| Deevska, G | 1 |
| Ma, F | 1 |
| Nikolova-Karakashian, M | 1 |
| Westlund, KN | 1 |
| Dalziel, JE | 1 |
| Young, W | 1 |
| Bercik, P | 1 |
| Spencer, NJ | 1 |
| Ryan, LJ | 1 |
| Dunstan, KE | 1 |
| Lloyd-West, CM | 1 |
| Gopal, PK | 1 |
| Haggarty, NW | 1 |
| Roy, NC | 1 |
| Morgan, B | 1 |
| Bello, FH | 1 |
| Maiha, BB | 1 |
| Anuka, JA | 1 |
| Kinuthia, DG | 1 |
| Muriithi, AW | 1 |
| Mwangi, PW | 1 |
| Liang, L | 1 |
| Zhao, JY | 1 |
| Wu, S | 1 |
| Mo, K | 1 |
| Xiong, M | 1 |
| Marie Lutz, B | 1 |
| Bekker, A | 1 |
| Tao, YX | 1 |
| Hirotani, Y | 1 |
| Mikajiri, K | 1 |
| Ikeda, K | 1 |
| Myotoku, M | 1 |
| Kurokawa, N | 1 |
| Ulbrich, K | 1 |
| Hekmatara, T | 1 |
| Herbert, E | 1 |
| Kreuter, J | 1 |
| Ojewole, JA | 1 |
| Awe, EO | 1 |
| Chiwororo, WD | 1 |
| Kojima, R | 1 |
| Doihara, H | 1 |
| Nozawa, K | 1 |
| Kawabata-Shoda, E | 1 |
| Yokoyama, T | 1 |
| Ito, H | 1 |
| Moriya, R | 1 |
| Shirakura, T | 1 |
| Hirose, H | 1 |
| Kanno, T | 1 |
| Suzuki, J | 1 |
| Kanatani, A | 1 |
| Wu, D | 1 |
| Zhou, J | 1 |
| Yuan, J | 1 |
| Cui, B | 1 |
| An, R | 1 |
| Hu, Z | 1 |
| Wintola, OA | 1 |
| Sunmonu, TO | 1 |
| Afolayan, AJ | 1 |
| Jeon, JR | 1 |
| Choi, JH | 1 |
| Neri, F | 1 |
| Cavallari, G | 1 |
| Tsivian, M | 1 |
| Bianchi, E | 1 |
| Aldini, R | 1 |
| Cevenini, M | 1 |
| Guidetti, E | 1 |
| Piras, GL | 1 |
| Pariali, M | 1 |
| Nardo, B | 1 |
| Besra, SE | 1 |
| Gomes, A | 1 |
| Ganguly, DK | 1 |
| Vedasiromoni, JR | 1 |
| Kimball, ES | 1 |
| Palmer, JM | 1 |
| D'Andrea, MR | 1 |
| Hornby, PJ | 1 |
| Wade, PR | 1 |
| Andersen, YS | 1 |
| Gillin, FD | 1 |
| Eckmann, L | 1 |
| Shinoda, K | 1 |
| Hruby, VJ | 1 |
| Porreca, F | 1 |
| Funatsu, T | 1 |
| Takeuchi, A | 1 |
| Hirata, T | 1 |
| Keto, Y | 1 |
| Akuzawa, S | 1 |
| Sasamata, M | 1 |
| Curto-Reyes, V | 1 |
| Juárez, L | 1 |
| García-Pérez, E | 1 |
| Fresno, MF | 1 |
| Hidalgo, A | 1 |
| Menéndez, L | 1 |
| Baamonde, A | 1 |
| Capasso, R | 1 |
| Borrelli, F | 1 |
| Aviello, G | 1 |
| Romano, B | 1 |
| Scalisi, C | 1 |
| Capasso, F | 1 |
| Izzo, AA | 1 |
| Mir, GN | 1 |
| Alioto, RL | 1 |
| Selve, N | 1 |
| Friderichs, E | 1 |
| Reimann, W | 1 |
| Reinartz, S | 1 |
| Richards, CA | 1 |
| Carr, D | 1 |
| Spitz, L | 1 |
| Milla, PJ | 1 |
| Andrews, PL | 1 |
| Farack, UM | 1 |
| Asher, A | 1 |
| Elsenhans, B | 1 |
| Schütte-Lückenga, B | 1 |
| Gerzer, R | 1 |
| Shimotoyodome, A | 1 |
| Meguro, S | 1 |
| Hase, T | 1 |
| Tokimitsu, I | 1 |
| Sakata, T | 1 |
| Jivegård, L | 1 |
| Svanvik, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Foeniculum Vulgare Ironing on Gastrointestinal Recovery After Colorectal Resection: a Randomized Controlled Trial.[NCT03711487] | Phase 2 | 300 participants (Actual) | Interventional | 2018-10-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
56 other studies available for loperamide and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Comparative Transcriptome Analysis Reveals Relationship among mRNAs, lncRNAs, and circRNAs of Slow Transit Constipation.
Topics: Animals; Cell Differentiation; Constipation; Disease Models, Animal; Gene Expression; Gene Expressio | 2021 |
Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model.
Topics: Animals; Antidiarrheals; Constipation; Defecation; Disease Models, Animal; Humans; Injections, Intra | 2020 |
Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats.
Topics: Animals; Cathartics; Constipation; Disease Models, Animal; Gastrointestinal Tract; Gastrointestinal | 2020 |
Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice.
Topics: Animals; Antidiarrheals; Base Sequence; Bile Acids and Salts; Chitosan; Constipation; Disease Models | 2021 |
Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca
Topics: Animals; Anti-Inflammatory Agents; Aster Plant; Calcium Signaling; Constipation; Defecation; Disease | 2021 |
7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats.
Topics: Animals; Colon; Constipation; Defecation; Disease Models, Animal; Flavones; Gastrointestinal Motilit | 2021 |
Effect of konjac glucomannan on metabolites in the stomach, small intestine and large intestine of constipated mice and prediction of the KEGG pathway.
Topics: Animals; Cathartics; Constipation; Disease Models, Animal; Female; Intestine, Large; Intestine, Smal | 2021 |
Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.
Topics: Animals; Bifidobacterium bifidum; Butyrates; Butyric Acid; Constipation; Disease Models, Animal; Dop | 2021 |
The protective effects of yellow tea extract against loperamide-induced constipation in mice.
Topics: Animals; Aquaporin 3; Aquaporin 4; China; Colon; Constipation; Disease Models, Animal; Gastrointesti | 2021 |
Different
Topics: Animals; Bifidobacterium bifidum; Colon; Constipation; Disease Models, Animal; Feces; Gastrointestin | 2021 |
Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Com | 2021 |
Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice.
Topics: Animals; Disease Models, Animal; Gastrointestinal Motility; Lactobacillus plantarum; Loperamide; Mic | 2022 |
Mu-Opioid Receptors in Ganglia, But Not in Muscle, Mediate Peripheral Analgesia in Rat Muscle Pain.
Topics: Acute Pain; Analgesics; Animals; Disease Models, Animal; Facial Pain; Ganglia, Spinal; Loperamide; M | 2018 |
FABP4 blocker attenuates colonic hypomotility and modulates white adipose tissue-derived hormone levels in mouse models mimicking constipation-predominant IBS.
Topics: Adipose Tissue, White; Animals; Behavior, Animal; Biphenyl Compounds; Colon; Constipation; Disease M | 2018 |
The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats.
Topics: Animals; Cassia; Chronic Disease; Colon; Constipation; Disease Models, Animal; Dose-Response Relatio | 2018 |
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Topics: Animals; Behavior, Animal; Cell Survival; Constipation; Depression; Disease Models, Animal; Hippocam | 2018 |
SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
Topics: Animals; Antiporters; Chloride-Bicarbonate Antiporters; Chlorides; Constipation; Cystic Fibrosis; Di | 2018 |
Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model.
Topics: Animals; Aquaporins; Body Weight; Cholinergic Agents; Constipation; Disease Models, Animal; Eating; | 2019 |
Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.
Topics: Analgesia; Animals; Antidiarrheals; Disease Models, Animal; Drug Therapy, Combination; Loperamide; M | 2019 |
Laxative effects of Salecan on normal and two models of experimental constipated mice.
Topics: Animals; beta-Glucans; Clonidine; Constipation; Defecation; Disease Models, Animal; Dose-Response Re | 2013 |
Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves.
Topics: Animals; Anti-Bacterial Agents; Antidiarrheals; Artemia; Bacteria; Caesalpinia; Defecation; Diarrhea | 2013 |
Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats.
Topics: Administration, Oral; Animals; Antidiarrheals; Antioxidants; Castor Oil; Diarrhea; Disease Models, A | 2014 |
Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes.
Topics: Amino Acid Transport Systems, Basic; Animals; Anthraquinones; Area Under Curve; Biotransformation; C | 2014 |
Safety and antidiarrheal activity of Priva adhaerens aqueous leaf extract in a murine model.
Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Disease Models, Animal; Dose-Response Relationship, D | 2014 |
Experimental assessment of antidiarrheal and antisecretory activity of 80% methanolic leaf extract of Zehneria scabra in mice.
Topics: Animals; Antidiarrheals; Castor Oil; Cucurbitaceae; Diarrhea; Disease Models, Animal; Ethiopia; Gast | 2014 |
Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice.
Topics: Animals; Antidiarrheals; Constipation; Convulsants; Disease Models, Animal; Drug Interactions; Gastr | 2015 |
Alcohol and high fat induced chronic pancreatitis: TRPV4 antagonist reduces hypersensitivity.
Topics: Analgesics; Animals; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Ethanol; | 2015 |
Tracking gastrointestinal transit of solids in aged rats as pharmacological models of chronic dysmotility.
Topics: Animals; Benzofurans; Colon; Digestion; Disease Models, Animal; Gastric Emptying; Gastrointestinal A | 2016 |
Drug development: A healthy pipeline.
Topics: Animals; Benzimidazoles; Benzofurans; Bile Acids and Salts; Carbolines; Colesevelam Hydrochloride; C | 2016 |
The effect of methanol rhizome extract of Nymphaea lotus Linn. (Nymphaeaceae) in animal models of diarrhoea.
Topics: Animals; Antidiarrheals; Castor Oil; Defecation; Diarrhea; Disease Models, Animal; Dose-Response Rel | 2016 |
Freeze dried extracts of Bidens biternata (Lour.) Merr. and Sheriff. show significant antidiarrheal activity in in-vivo models of diarrhea.
Topics: Adrenergic Antagonists; Animals; Antidiarrheals; Bidens; Castor Oil; Defecation; Diarrhea; Dinoprost | 2016 |
G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury.
Topics: Animals; CREB-Binding Protein; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Function | 2016 |
Changes of intestinal mucosal and plasma PYY in a diarrhea model rat and influence of loperamide as the treatment agent for diarrhea.
Topics: Animals; Antidiarrheals; Diarrhea; Disease Models, Animal; Dose-Response Relationship, Drug; Gastroi | 2008 |
Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB).
Topics: Analgesics; Animals; Antibodies, Monoclonal; Biological Transport; Blood-Brain Barrier; Cross-Linkin | 2009 |
Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents.
Topics: Animals; Antidiarrheals; Atropine; Castor Oil; Diarrhea; Disease Models, Animal; Dose-Response Relat | 2008 |
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Topics: Animals; Atropine; Clonidine; Constipation; Disease Models, Animal; Dose-Response Relationship, Drug | 2009 |
NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice.
Topics: Animals; Antidiarrheals; Diarrhea; Disease Models, Animal; Gastrointestinal Transit; Humans; Intesti | 2010 |
Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium.
Topics: Animals; Chlorides; Cholinergic Antagonists; Colon; Constipation; Cyclic AMP; Cyclooxygenase Inhibit | 2010 |
Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats.
Topics: Aloe; Animals; Body Weight; Constipation; Disease Models, Animal; Kidney; Kidney Function Tests; Liv | 2011 |
Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats.
Topics: Animals; Bacteria; Bifidobacterium; Cell Proliferation; Colon; Constipation; Dietary Fiber; Disease | 2010 |
Effect of colic vein ligature in rats with loperamide-induced constipation.
Topics: Animals; Colon; Constipation; Disease Models, Animal; Histocytochemistry; Intestinal Mucosa; Ligatio | 2012 |
Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis).
Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Disease Models, Animal; Dose-Response Relationship, D | 2003 |
Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice.
Topics: Acute Disease; Animals; Antidiarrheals; Colitis; Colon; Diarrhea; Disease Models, Animal; Gastrointe | 2005 |
Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp.
Topics: Animals; Antidiarrheals; Disease Models, Animal; Gastrointestinal Motility; Giardiasis; Immunity, Ac | 2006 |
Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2007 |
Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats.
Topics: Animals; Behavior, Animal; Benzimidazoles; Carbazoles; Carbolines; Colon; Colonic Diseases, Function | 2007 |
Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice.
Topics: Analgesics, Opioid; Animals; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cyclic GMP; Disease M | 2008 |
Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice.
Topics: Acetylcholine; Amidohydrolases; Animals; Cannabidiol; Cannabis; Cholinergic Agents; Croton Oil; Dise | 2008 |
A semichronic diarrheal model.
Topics: Animals; Chronic Disease; Diarrhea; Dietary Carbohydrates; Diphenoxylate; Disease Models, Animal; Fe | 1982 |
Absence of emetic effects of morphine and loperamide in Suncus murinus.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intraperitone | 1994 |
Nissen-type fundoplication and its effects on the emetic reflex and gastric motility in the ferret.
Topics: Animals; Antidiarrheals; Atropine; Behavior, Animal; Disease Models, Animal; Electric Stimulation; F | 2000 |
Effect of loperamide on mucosal guanylyl cyclase activity in rat jejunum following Escherichia coli heat-stable toxin-induced fluid accumulation.
Topics: Animals; Antidiarrheals; Bacterial Toxins; Body Fluids; Disease Models, Animal; Enterotoxins; Escher | 2000 |
Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation.
Topics: Alginates; Animals; Carrageenan; Cellulose; Chondroitin Sulfates; Colon; Constipation; Dietary Fiber | 2001 |
Loperamide inhibits gallbladder inflammatory fluid secretion in experimental cholecystitis.
Topics: Animals; Cats; Cholecystitis; Disease Models, Animal; Female; Gallbladder; Loperamide; Male; Piperid | 1986 |