loperamide and Diarrhea studies

Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

Excerpt	Relevance	Reference
" Supportive treatment with loperamide is associated with constipation."	9.69	Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B). ( Doi, M; Iwasa, T; Masuda, H; Matsumoto, K; Miyoshi, Y; Niikura, N; Sagara, Y; Sakai, H; Shimomura, A; Takahashi, M; Takano, T; Tanabe, Y; Tokunaga, S; Tsurutani, J; Yoshimura, K, 2023)
" Primary endpoints included: incidence of investigator assessed severe (≥ Grade 3), prolonged (> 7 days) Grade 2 diarrhea, treatment discontinuation, dose modifications, and loperamide utilization during the first 3 cycles of treatment."	9.51	An open label, randomized phase 2 trial assessing the impact of food on the tolerability of abemaciclib in patients with advanced breast cancer. ( Boyle, F; Chapman, SC; Chen, Y; Ezquerra, MB; Gable, JC; Gainford, MC; Goksu, SS; Hossain, AM; Lim, E; Loi, S; Okera, M; Price, GL; van Hal, G, 2022)
"Recommended treatment for travelers' diarrhea includes the combination of an antibiotic, usually a fluoroquinolone or azithromycin, and loperamide for rapid resolution of symptoms."	9.24	Trial Evaluating Ambulatory Therapy of Travelers' Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide. ( Connor, P; Danboise, B; Fraser, J; Gutierrez, RL; Hulseberg, C; Hutley, EJ; Lalani, T; Porter, CK; Riddle, MS; Simons, MP; Swierczewski, B; Tribble, DR, 2017)
"Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea."	9.14	Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010)
"The recommended treatment for traveler's diarrhea is the combination of an appropriate antibiotic (usually a fluoroquinolone) and loperamide."	9.12	Azithromycin and loperamide are comparable to levofloxacin and loperamide for the treatment of traveler's diarrhea in United States military personnel in Turkey. ( Frenck, RW; Johnston, JR; Monteville, MR; Putnam, SD; Riddle, MS; Rockabrand, DM; Sanders, JW; Tribble, DR; Ulukan, S, 2007)
"Consenting adults with acute diarrhea (> or =3 unformed stools in 24 hours with > or =1 symptom of enteric infection) were randomized to receive rifaximin 200 mg 3 times daily for 3 days; loperamide 4 mg initially followed by 2 mg after each unformed stool; or a combination of both drugs using the same dosing regimen."	9.12	Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone. ( Adachi, JA; Belkind-Gerson, J; De La Cabada, FJ; Dupont, HL; Dupont, MW; Ericsson, CD; Huang, DB; Jaini, S; Jiang, ZD; Ke, S; Martinez Sandoval, F; Okhuysen, PC; Taylor, DN, 2007)
"To compare efficacy and tolerability of a loperamide/simethicone (LOP/SIM) combination product with that of loperamide (LOP) alone, simethicone (SIM) alone, and placebo (PBO) for acute nonspecific diarrhea with gas-related abdominal discomfort."	9.12	Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort. ( Cooper, KM; DuPont, HL; Hanauer, SB; Laudadio, C, 2007)
"Forty-two rectal carcinoma (T(3-4)N(0-2)M(0)) patients with grade 2 or 3 diarrhea refractory to loperamide were enrolled to receive octreotide."	9.12	Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma. ( Karaoglu, A; Topkan, E, 2006)
"The aim of this study was to compare the efficacy and tolerability of wood creosote with those of loperamide hydrochloride in patients with acute, nonspecific diarrhea."	9.11	Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea. ( Kuge, T; Shibata, T; Willett, MS, 2004)
" Loperamide is an effective anti-diarrheal agent, but it usually induces constipation."	9.11	A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005)
"Fourteen patients with CPT-11- and seven patients with 5-FU-induced grade 3-4 (NCI/WHO) diarrhea and loperamide failure were enrolled in this study."	9.09	Substantial activity of budesonide in patients with irinotecan (CPT-11) and 5-fluorouracil induced diarrhea and failure of loperamide treatment. ( Droege, CM; Hausamen, TU; Lenfers, BH; Loeffler, TM, 1999)
"Thirty-seven colorectal cancer patients with grade 1-4 diarrhea (NCICTC) caused by chemotherapy with 5-FU-containing regimens, received oral loperamide at the initial dose of 4 mg followed by 4 mg every 8 h (total dose 16 mg/24 h)."	9.09	High-dose loperamide in the treatment of 5-fluorouracil-induced diarrhea in colorectal cancer patients. ( Agostinelli, R; Amadori, D; Bichisao, E; Cascinu, S; Catalano, G; Catalano, V; Giordani, P; Luppi, G; Sansoni, E; Silingardi, V, 2000)
"Loperamide is a synthetic piperidine derivative used for the treatment of both acute and chronic diarrhea."	9.09	Prospective, controlled, multicentre study of loperamide in pregnancy. ( Addis, A; Arnon, J; Einarson, A; Koren, G; Malm, H; Mastroiacovo, P; Ornoy, A, 2000)
"The objectives of this prospective non-concurrent cohort study were to confirm the efficacy of vaginal misoprostol for early pregnancy termination and to determine whether the incidence of side effects is lower with prophylactic loperamide and acetaminophen."	9.09	Early pregnancy termination with vaginal misoprostol combined with loperamide and acetaminophen prophylaxis. ( Harwood, B; Jain, JK; Meckstroth, KR; Mishell, DR, 2001)
"This study compares maximal daily doses of loperamide to escalating doses of continuous intravenous (CI) octreotide acetate in bone marrow transplant (BMT) and leukemia patients."	9.08	Randomized trial of loperamide versus dose escalation of octreotide acetate for chemotherapy-induced diarrhea in bone marrow transplant and leukemia patients. ( Davidson, TG; Dix, SP; Geller, RB; Gilmore, CE; Holland, HK; Lin, LS; Topping, DL; Wingard, JR, 1995)
"The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride maleate, with that of placebo or loperamide in persons with traveler's diarrhea."	9.08	Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo-controlled trial. ( DuPont, HL; Ericsson, CD; Marani, S; Martinez-Sandoval, FG; Okhuysen, PC; Olesen, MA; Ravelli, GP, 1995)
" The incidence of severe diarrhea is reduced by using a starting dose of irinotecan 125 mg/m2 and by initiating loperamide at the earliest signs of diarrhea."	9.08	Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. ( Burris, HA; Eckardt, JR; Eckhardt, SG; Elfring, GL; Hilsenbeck, SG; Kuhn, JG; Nelson, J; Rinaldi, DA; Rodriguez, GI; Rothenberg, ML; Schaaf, LJ; Smith, LS; Thurman, AM; Von Hoff, DD; Weiss, GR, 1996)
" The first cohort of 14 consecutive patients explored for the mechanism of diarrhea received acetorphan (a new enkephalinase inhibitor) 100 mg three times daily; the second 14-patient cohort received, in addition to acetorphan, loperamide 4 mg three times daily."	9.08	Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. ( Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G, 1998)
"Intensive, high-dose loperamide was used in an attempt to control or downstage CPT-11-induced diarrhea and thus permit the use of higher dose intensities of CPT-11."	9.07	Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. ( Abigerges, D; Armand, JP; Chabot, GG; Cote, C; Da Costa, L; Fadel, E; Gandia, D; Hérait, P, 1994)
"Diarrhea is a prominent feature of fluorouracil (5FU) gastrointestinal toxicity, especially when 5FU is combined with leucovorin (LV) or interferon (IFN)."	9.07	Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial. ( Cascinu, S; Catalano, G; Fedeli, A; Fedeli, SL, 1993)
"The effects of loperamide-N-oxide, a new peripheral opiate agonist precursor, on gastrointestinal function were evaluated in 18 patients with diarrhoea caused by chronic radiation enteritis."	9.07	Gastrointestinal function in chronic radiation enteritis--effects of loperamide-N-oxide. ( Chatterton, BE; Horowitz, M; Muecke, T; Robb, T; Russo, A; Yeoh, EK, 1993)
"To explore the optimal dosing regimen for trimethoprim-sulfamethoxazole (TMP-SMX) when used in combination with loperamide to treat traveler's diarrhea, 190 U."	9.07	Optimal dosing of trimethoprim-sulfamethoxazole when used with loperamide to treat traveler's diarrhea. ( DuPont, HL; Ericsson, CD; Mathewson, JJ; Nicholls-Vasquez, I, 1992)
"To determine the efficacy of loperamide given with long- and short-course quinolone therapy for treating traveler's diarrhea, 142 US military personnel were randomized to receive a single 750-mg dose of ciprofloxacin with placebo, 750 mg of ciprofloxacin with loperamide, or a 3-day course of 500 mg of ciprofloxacin twice daily with loperamide."	9.07	Treatment of traveler's diarrhea with ciprofloxacin and loperamide. ( DeFraites, R; Echeverria, P; Gelnett, J; Haberberger, RL; Murphy, GS; Petruccelli, BP; Sanchez, JL; Taylor, DN; Walz, S, 1992)
"To compare the safety and efficacy of loperamide used in combination with ciprofloxacin or ciprofloxacin alone for the treatment of travelers' diarrhea."	9.07	Treatment of travelers' diarrhea: ciprofloxacin plus loperamide compared with ciprofloxacin alone. A placebo-controlled, randomized trial. ( Candler, W; Echeverria, P; McQueen, C; Sanchez, JL; Taylor, DN; Thornton, S, 1991)
"An open-label, parallel comparison of loperamide hydrochloride (Imodium A-D) and bismuth subsalicylate (Pepto-Bismol) was conducted using nonprescription dosages in adult students with acute diarrhea (three or more unformed stools in the preceding 24 hours plus at least one additional symptom of enteric infection)."	9.06	Comparative efficacy of loperamide hydrochloride and bismuth subsalicylate in the management of acute diarrhea. ( Cruz Luna, A; DuPont, HL; DuPont, MW; Ericsson, CD; Flores Sanchez, J; Mathewson, JJ; Mendiola Gomez, J, 1990)
"The efficacy of nonprescription doses of loperamide hydrochloride (Imodium A-D) was compared with nonfibrous activated attapulgite (Diasorb) in a randomized, parallel, open-label study of adult patients with acute diarrhea."	9.06	A randomized, open-label comparison of nonprescription loperamide and attapulgite in the symptomatic treatment of acute diarrhea. ( Cruz Luna, A; DuPont, HL; DuPont, MW; Ericsson, CD; Mathewson, JJ, 1990)
"In a randomized, double-blind, placebo-controlled trial, 227 US adults with acute diarrhea in Mexico received a single dose of sulfamethoxazole and trimethoprim (1600/320 mg) or 3 days of therapy with loperamide hydrochloride (4-mg loading dose, then 2 mg orally after each loose stool), sulfamethoxazole-trimethoprim (800/160 mg orally twice daily), or the combination of both."	9.06	Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide. ( Bitsura, JA; DuPont, HL; Ericsson, CD; Johnson, PC; Mathewson, JJ; West, MS, 1990)
"Loperamide hydrochloride was compared with bismuth subsalicylate for the treatment of acute nondysenteric travelers' diarrhea in 219 students visiting seven countries in Latin America."	9.06	Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea. ( Bitsura, JA; DuPont, HL; Ericsson, CD; Johnson, PC; Morgan, DR; Wood, LV, 1986)
"The effect of loperamide and diphenoxylate on diarrhoea following jejuno-ileostomy for morbid obesity was investigated in 27 patients by means of a randomized fixed sample size, three-period cross-over trial."	9.05	Diarrhoea following jejuno-ileostomy for morbid obesity. A randomised trial of loperamide and diphenoxylate. ( Andersen, B; Gudmand-Høyer, E; Skovbjerg, H; Wille-Jørgensen, P, 1982)
"We have investigated the effect of loperamide (4 mg tds) on the continence to a standard volume of rectally infused saline and anorectal manometry in 26 patients complaining of chronic diarrhea complicated by fecal incontinence and severe urgency."	9.05	Effects of loperamide on anal sphincter function in patients complaining of chronic diarrhea with fecal incontinence and urgency. ( Barber, DC; Duthie, HL; Read, M; Read, NW, 1982)
"Loperamide is an effective and safe antidiarrheal agent which served as a very useful adjunct in the treatment in 79% of 47 patients with chronic diarrhea."	9.04	Loperamide, a new antidiarrheal agent in the treatment of chronic diarrhea. ( Galambos, JT, 1978)
"Twenty-seven patients with chronic diarrhea due to Crohn's disease, ulcerative colitis, short bowel syndrome, and idiopathic (functional) causes participated in a multiphase study (open, double blind, and long term open) of loperamide HCl, a new single entity, oral antidiarrheal agent."	9.04	Loperamide: a new antidiarrheal agent in the treatment of chronic diarrhea. ( Galambos, JT; Hersh, T; Schroder, S; Wenger, J, 1976)
"Loperamide, a novel antidiarrheal agent, was compared with diphenoxylate in a double blind crossover study of 23 patients with chronic diarrhea of various etiologies."	9.04	A double blind crossover comparison of loperamide with diphenoxylate in the symptomatic treatment of chronic diarrhea. ( Pelemans, W; Vantrappen, F, 1976)
"Fifteen patients (20 to 66 years) with long-standing chronic diarrhea of varying etiology were selected for an open trial of loperamide 2 mg capsules."	9.04	Loperamide in chronic diarrhea and after ileostomy: a placebo-controlled double-blind cross-over study. ( Huibregtse, K; Meuwissen, SG; Tytgat, GN, 1976)
"High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg."	8.98	Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018)
"Loperamide is a popular antidiarrheal medication that has been used for many years."	8.98	Loperamide cardiotoxicity: "A Brief Review". ( Akel, T; Bekheit, S, 2018)
" In children who are older than 3 y with no/minimal dehydration, loperamide may be a useful adjunct to oral rehydration and early refeeding."	8.84	Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. ( Cummings, P; Grossman, DC; Li, ST, 2007)
"Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea."	8.82	Racecadotril versus loperamide: antidiarrheal research revisited. ( Awouters, F; Huighebaert, S; Tytgat, GN, 2003)
"In castor oil challenged rats, low doses of loperamide inhibit diarrhea and normalize intestinal propulsion."	8.78	Loperamide. Survey of studies on mechanism of its antidiarrheal activity. ( Awouters, F; Janssen, PA; Megens, A; Niemegeers, C; Schuurkes, J; Verlinden, M, 1993)
"Loperamide has been a safe and effective treatment for diarrhea for many years."	8.31	The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023)
"Lubeluzole, a neuroprotective anti-ischemic drug, was tested for its ability to act as both antibiotic chemosensitizing and antipropulsive agent for the treatment of infectious diarrhea."	8.02	Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. ( Budriesi, R; Caputo, L; Cavalluzzi, MM; Corazza, I; De Salvia, MA; Franchini, C; Gualdani, R; Lentini, G; Micucci, M; Milani, G; Piarulli, M; Quintieri, L; Rosato, A; Viale, M, 2021)
"The objective of the study was to evaluate the antidiarrheal and antinociceptive activities of ethanol extract and its chloroform and pet ether fraction of Phrynium imbricatum (Roxb."	7.85	Antidiarrheal and antinociceptive activities of ethanol extract and its chloroform and pet ether fraction of Phrynium imbricatum (Roxb.) leaves in mice. ( Arman, MSI; Dash, R; Dinar, MAM; Hosen, SMZ; Hossain, MM; Kabir, MSH; Rahman, MM; Uddin, MMN, 2017)
" All doses of the extract, its anti-motility fractions and loperamide individually stopped diarrhea within 6-24 h of administration, whilst significantly reducing mucus and fecal fluid content, urine production and intestinal bloating."	7.78	Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea. ( Balemba, OB; Boakye, PA; Brierley, SM; Pasilis, SP, 2012)
" EEA-1, EEA-2, the main constituents of EEAs (mangiferin, and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice."	7.76	Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. ( Araki, Y; Hara, H; Iinuma, M; Ito, T; Izuta, H; Kakino, M; Oyama, M; Shimazawa, M; Tsuruma, K, 2010)
" We chose PYY as an index of the intrinsic factor in diarrhea and examined the influence of changes induced in a diarrhea rat model by administration of 4 types of laxative and loperamide hydrochloride (loperamide) as an agent for the treatment of diarrhea."	7.74	Changes of intestinal mucosal and plasma PYY in a diarrhea model rat and influence of loperamide as the treatment agent for diarrhea. ( Hirotani, Y; Ikeda, K; Kurokawa, N; Mikajiri, K; Myotoku, M, 2008)
"A 2-year-old girl was diagnosed as having acute gastroenteritis with severe diarrhoea, for which she was prescribed a loperamide solution."	7.72	[Ileus after the use of loperamide in a child with acute diarrhea]. ( Dudink, J; Mearin, LM; Sukhai, RN, 2003)
"A series of N-(aminoiminomethyl)-1H-pyrrole-1-acetamides, related to guanfacine, were prepared and tested for antidiarrheal activity in castor oil dosed rats."	7.67	Synthesis and antidiarrheal activity of N-(aminoiminomethyl)-1H-pyrrole-1-acetamides related to guanfacine. ( Beattie, DE; Dover, GM; Ward, TJ, 1985)
"To determine whether the antidiarrheal effect of loperamide is due to an effect on intestinal motor function or to an acceleration of the rate of absorption by the intestine (as has been suggested recently), we studied absorption during experimental diarrhea produced by the rapid intragastric infusion of electrolyte solution."	7.67	Mechanism of the antidiarrheal effect of loperamide. ( Fordtran, JS; Morawski, SG; Santa Ana, CA; Schiller, LR, 1984)
"The antidiarrheal action of loperamide hydrochloride was tested against diarrhea experimentally induced in calves by intraduodenal infusion of castor oil or hypertonic solution of mannitol."	7.67	Effects of loperamide hydrochloride on experimental diarrhea and gastrointestinal myoelectrical activity in calves. ( Buéno, L; Fioramonti, J, 1987)
"Effects of loperamide on diarrhea induced by castor oil and prostaglandin E1 were investigated in rats and mice and compared with those of narcotic analgesics, atropine, mecamylamine and local anesthetics."	7.66	[Pharmacological studies of loperamide, an anti-diarrheal agent. I. Effects on diarrhea induced by castor oil and prostaglandin E. (author's transl)]. ( Kawashima, K; Nakamura, H; Shimizu, M; Sohji, Y, 1978)
"45 patients with diarrheas appearing after exposure of the gastro-intestinal region to ionizing radiation were given loperamide in the course of a study."	7.66	[Studies using loperamide in patients with diarrhea following telecobalt irradiation of malignant abdominal tumors (author's transl)]. ( Behdjati, F; Geginat, G; Green, E; Kaeferstein, D, 1978)
" Rates of adverse events were comparable in both groups (37."	6.90	Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study. ( Brenner, DM; Cash, BD; Elmes, SJR; Gutman, CR; Jo, E; Liu, LWC; Sayuk, GS, 2019)
"Loperamide and codeine were more effective in relieving this than was diphenoxylate."	6.65	Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. ( Corbett, CL; Holdsworth, CD; Palmer, KR, 1980)
"Irritable bowel syndrome is categorized into one of three main categories: IBS with diarrhea, IBS with constipation, and IBS with mixed bowel habits."	6.53	Emerging treatments in neurogastroenterology: eluxadoline - a new therapeutic option for diarrhea-predominant IBS. ( Lacy, BE, 2016)
"Diarrhea is a distressing symptom which limits the quality of life in patients receiving palliative care and is associated with high morbidity and mortality."	6.49	[Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. ( Meißner, W; Pastrana, T, 2013)
" Among 6 paired studies comparing antibiotics alone versus antibiotics in combination with loperamide, the odds of clinical cure at 24 h and 48 h favored combination therapy, with summary odds ratios of 2."	6.44	Effect of adjunctive loperamide in combination with antibiotics on treatment outcomes in traveler's diarrhea: a systematic review and meta-analysis. ( Arnold, S; Riddle, MS; Tribble, DR, 2008)
"Loperamide is a safe and effective antidiarrheal for the treatment of acute diarrhea."	6.16	Safety and efficacy of loperamide. ( Ericsson, CD; Johnson, PC, 1990)
"Eighty patients with colorectal cancer were randomized within 2 weeks after surgery to receive either modified BSS or Loperamide combined with the respective dummy."	5.69	Effects of Modified Baizhu Shaoyao San on Postoperative Diarrhea in Colorectal Cancer Patients: A Single-Blind, Randomized Controlled Trial. ( Fei, M; Luo, M; Wu, Y; Zhang, J; Zhang, L; Zhu, C, 2023)
" Supportive treatment with loperamide is associated with constipation."	5.69	Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B). ( Doi, M; Iwasa, T; Masuda, H; Matsumoto, K; Miyoshi, Y; Niikura, N; Sagara, Y; Sakai, H; Shimomura, A; Takahashi, M; Takano, T; Tanabe, Y; Tokunaga, S; Tsurutani, J; Yoshimura, K, 2023)
" Primary endpoints included: incidence of investigator assessed severe (≥ Grade 3), prolonged (> 7 days) Grade 2 diarrhea, treatment discontinuation, dose modifications, and loperamide utilization during the first 3 cycles of treatment."	5.51	An open label, randomized phase 2 trial assessing the impact of food on the tolerability of abemaciclib in patients with advanced breast cancer. ( Boyle, F; Chapman, SC; Chen, Y; Ezquerra, MB; Gable, JC; Gainford, MC; Goksu, SS; Hossain, AM; Lim, E; Loi, S; Okera, M; Price, GL; van Hal, G, 2022)
"Travelers' diarrhea is a frequent condition, especially in those traveling to high-risk areas."	5.46	Is it worth adding loperamide to antibiotic treatment of travelers diarrhea? ( Corsi, Ó; Pinos, Y; Rada, G; Ruiz, MI, 2017)
"For treatment with loperamide only, the rate was 20%; with antimicrobial drugs alone, 40%; and with loperamide and antimicrobial drugs, 71%."	5.43	Increased Risk for ESBL-Producing Bacteria from Co-administration of Loperamide and Antimicrobial Drugs for Travelers' Diarrhea. ( Kantele, A; Kirveskari, J; Lääveri, T; Mero, S, 2016)
"Diarrhea is a common adverse event of docetaxel with 20%-40% of incidence and severe diarrhea occurs in 5%-6%."	5.39	Secondary prophylaxis of docetaxel induced diarrhea with loperamide: case report. ( Kim, HK; Kim, MJ; Lee, HY; Lee, YH, 2013)
"Diarrhea is a well-recognized side effect of chemotherapy, which affects the quality of life and when refractory is potentially life threatening."	5.31	Control of irinotecan-induced diarrhea by octreotide after loperamide failure. ( Barbounis, V; Demiri, M; Efremidis, AP; Koumakis, G; Vassilomanolakis, M, 2001)
"Eighty United States students in Mexico received either loperamide (an initial dose of 4 mg, followed by 2 mg after passage of each unformed stool, up to 8 mg/d; 40 patients) or loperamide (at the same dosage schedule) plus an oral rehydration therapy (ORT) preparation (500 mL initially, followed by 250 mL after each subsequently passed unformed stool, up to 1,000 mL per 24 hours; 40 patients)."	5.30	Oral rehydration therapy plus loperamide versus loperamide alone in the treatment of traveler's diarrhea. ( Albrecht, H; Caeiro, JP; DuPont, HL; Ericsson, CD, 1999)
"Irritable bowel syndrome with diarrhea (IBS-D) is often managed with over-the-counter therapies such as loperamide, though with limited success."	5.24	Eluxadoline Efficacy in IBS-D Patients Who Report Prior Loperamide Use. ( Cash, BD; Chey, WD; Covington, PS; Dove, LS; Lacy, BE; Lembo, AJ, 2017)
"Recommended treatment for travelers' diarrhea includes the combination of an antibiotic, usually a fluoroquinolone or azithromycin, and loperamide for rapid resolution of symptoms."	5.24	Trial Evaluating Ambulatory Therapy of Travelers' Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide. ( Connor, P; Danboise, B; Fraser, J; Gutierrez, RL; Hulseberg, C; Hutley, EJ; Lalani, T; Porter, CK; Riddle, MS; Simons, MP; Swierczewski, B; Tribble, DR, 2017)
"Patients with colorectal cancer starting adjuvant or first-line treatment with a chemotherapy combination containing fluorouracil, capecitabine, and/or irinotecan were randomly assigned to receive octreotide LAR 30 mg intramuscularly every 4 weeks (experimental arm) or the physician's treatment of choice in case of diarrhea (control arm)."	5.19	Randomized phase III trial exploring the use of long-acting release octreotide in the prevention of chemotherapy-induced diarrhea in patients with colorectal cancer: the LARCID trial. ( Andrade, AC; Barrios, CH; Chinen, RN; Correa, M; Coutinho, AK; del Giglio, A; Dutra, C; Forones, NM; Hoff, PM; Passos, VQ; Portella, Mdo S; Saragiotto, DF; van Eyll, B, 2014)
"Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea."	5.14	Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. ( Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA, 2010)
"Eighty patients with diarrhea after colorectal cancer surgery were randomized into two groups equally, the control group were treated with imodium (loperamide hydrochloride) and the treatment group treated by BYP combined with imodium."	5.13	[Clinical efficacy of buzhong yiqi pill combined with imodium in treating post-operational diarrhea in patients of colonic cancer]. ( Chen, ZY; Tu, XH, 2008)
"The recommended treatment for traveler's diarrhea is the combination of an appropriate antibiotic (usually a fluoroquinolone) and loperamide."	5.12	Azithromycin and loperamide are comparable to levofloxacin and loperamide for the treatment of traveler's diarrhea in United States military personnel in Turkey. ( Frenck, RW; Johnston, JR; Monteville, MR; Putnam, SD; Riddle, MS; Rockabrand, DM; Sanders, JW; Tribble, DR; Ulukan, S, 2007)
" Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication."	5.12	Use of probiotics for prevention of radiation-induced diarrhea. ( De Renzis, C; Delia, P; Donato, V; Famularo, G; Frosina, P; Messina, G; Sansotta, G, 2007)
"Consenting adults with acute diarrhea (> or =3 unformed stools in 24 hours with > or =1 symptom of enteric infection) were randomized to receive rifaximin 200 mg 3 times daily for 3 days; loperamide 4 mg initially followed by 2 mg after each unformed stool; or a combination of both drugs using the same dosing regimen."	5.12	Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone. ( Adachi, JA; Belkind-Gerson, J; De La Cabada, FJ; Dupont, HL; Dupont, MW; Ericsson, CD; Huang, DB; Jaini, S; Jiang, ZD; Ke, S; Martinez Sandoval, F; Okhuysen, PC; Taylor, DN, 2007)
"To compare efficacy and tolerability of a loperamide/simethicone (LOP/SIM) combination product with that of loperamide (LOP) alone, simethicone (SIM) alone, and placebo (PBO) for acute nonspecific diarrhea with gas-related abdominal discomfort."	5.12	Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort. ( Cooper, KM; DuPont, HL; Hanauer, SB; Laudadio, C, 2007)
"Forty-two rectal carcinoma (T(3-4)N(0-2)M(0)) patients with grade 2 or 3 diarrhea refractory to loperamide were enrolled to receive octreotide."	5.12	Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma. ( Karaoglu, A; Topkan, E, 2006)
"We looked for the effect of two antidiarrheal drugs, diosmectite and loperamide on the psychosocial adjustment to illness, a predictor for the health-related quality of life, in chronic functional diarrhea."	5.11	The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea. ( Dumitrascu, DL; Dumitrascu, DM; Farcas, A; Mitrea, I; Stanculete, M, 2004)
"The aim of this study was to compare the efficacy and tolerability of wood creosote with those of loperamide hydrochloride in patients with acute, nonspecific diarrhea."	5.11	Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea. ( Kuge, T; Shibata, T; Willett, MS, 2004)
" Loperamide is an effective anti-diarrheal agent, but it usually induces constipation."	5.11	A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005)
"Fourteen patients with CPT-11- and seven patients with 5-FU-induced grade 3-4 (NCI/WHO) diarrhea and loperamide failure were enrolled in this study."	5.09	Substantial activity of budesonide in patients with irinotecan (CPT-11) and 5-fluorouracil induced diarrhea and failure of loperamide treatment. ( Droege, CM; Hausamen, TU; Lenfers, BH; Loeffler, TM, 1999)
"Thirty-seven colorectal cancer patients with grade 1-4 diarrhea (NCICTC) caused by chemotherapy with 5-FU-containing regimens, received oral loperamide at the initial dose of 4 mg followed by 4 mg every 8 h (total dose 16 mg/24 h)."	5.09	High-dose loperamide in the treatment of 5-fluorouracil-induced diarrhea in colorectal cancer patients. ( Agostinelli, R; Amadori, D; Bichisao, E; Cascinu, S; Catalano, G; Catalano, V; Giordani, P; Luppi, G; Sansoni, E; Silingardi, V, 2000)
"Loperamide is a synthetic piperidine derivative used for the treatment of both acute and chronic diarrhea."	5.09	Prospective, controlled, multicentre study of loperamide in pregnancy. ( Addis, A; Arnon, J; Einarson, A; Koren, G; Malm, H; Mastroiacovo, P; Ornoy, A, 2000)
"The objectives of this prospective non-concurrent cohort study were to confirm the efficacy of vaginal misoprostol for early pregnancy termination and to determine whether the incidence of side effects is lower with prophylactic loperamide and acetaminophen."	5.09	Early pregnancy termination with vaginal misoprostol combined with loperamide and acetaminophen prophylaxis. ( Harwood, B; Jain, JK; Meckstroth, KR; Mishell, DR, 2001)
"This study compares maximal daily doses of loperamide to escalating doses of continuous intravenous (CI) octreotide acetate in bone marrow transplant (BMT) and leukemia patients."	5.08	Randomized trial of loperamide versus dose escalation of octreotide acetate for chemotherapy-induced diarrhea in bone marrow transplant and leukemia patients. ( Davidson, TG; Dix, SP; Geller, RB; Gilmore, CE; Holland, HK; Lin, LS; Topping, DL; Wingard, JR, 1995)
"The present study was undertaken to compare the efficacy of a new calmodulin antagonist, zaldaride maleate, with that of placebo or loperamide in persons with traveler's diarrhea."	5.08	Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo-controlled trial. ( DuPont, HL; Ericsson, CD; Marani, S; Martinez-Sandoval, FG; Okhuysen, PC; Olesen, MA; Ravelli, GP, 1995)
" The incidence of severe diarrhea is reduced by using a starting dose of irinotecan 125 mg/m2 and by initiating loperamide at the earliest signs of diarrhea."	5.08	Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. ( Burris, HA; Eckardt, JR; Eckhardt, SG; Elfring, GL; Hilsenbeck, SG; Kuhn, JG; Nelson, J; Rinaldi, DA; Rodriguez, GI; Rothenberg, ML; Schaaf, LJ; Smith, LS; Thurman, AM; Von Hoff, DD; Weiss, GR, 1996)
" The first cohort of 14 consecutive patients explored for the mechanism of diarrhea received acetorphan (a new enkephalinase inhibitor) 100 mg three times daily; the second 14-patient cohort received, in addition to acetorphan, loperamide 4 mg three times daily."	5.08	Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. ( Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G, 1998)
"Intensive, high-dose loperamide was used in an attempt to control or downstage CPT-11-induced diarrhea and thus permit the use of higher dose intensities of CPT-11."	5.07	Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. ( Abigerges, D; Armand, JP; Chabot, GG; Cote, C; Da Costa, L; Fadel, E; Gandia, D; Hérait, P, 1994)
" coli, the median duration of diarrhea was 19 hours (25th to 75th percentiles, 6 to 42 hours) for those receiving loperamide plus ciprofloxacin compared with 42 hours (21 to 46 hours) for those receiving ciprofloxacin alone (P = 0."	5.07	Ciprofloxacin and loperamide in the treatment of bacillary dysentery. ( Bodhidatta, L; Echeverria, P; Hoge, CW; Imlarp, S; Murphy, GS; Tamura, K; Tansuphaswadikul, S, 1993)
"The effects of loperamide-N-oxide, a new peripheral opiate agonist precursor, on gastrointestinal function were evaluated in 18 patients with diarrhoea caused by chronic radiation enteritis."	5.07	Gastrointestinal function in chronic radiation enteritis--effects of loperamide-N-oxide. ( Chatterton, BE; Horowitz, M; Muecke, T; Robb, T; Russo, A; Yeoh, EK, 1993)
"To explore the optimal dosing regimen for trimethoprim-sulfamethoxazole (TMP-SMX) when used in combination with loperamide to treat traveler's diarrhea, 190 U."	5.07	Optimal dosing of trimethoprim-sulfamethoxazole when used with loperamide to treat traveler's diarrhea. ( DuPont, HL; Ericsson, CD; Mathewson, JJ; Nicholls-Vasquez, I, 1992)
"To determine the efficacy of loperamide given with long- and short-course quinolone therapy for treating traveler's diarrhea, 142 US military personnel were randomized to receive a single 750-mg dose of ciprofloxacin with placebo, 750 mg of ciprofloxacin with loperamide, or a 3-day course of 500 mg of ciprofloxacin twice daily with loperamide."	5.07	Treatment of traveler's diarrhea with ciprofloxacin and loperamide. ( DeFraites, R; Echeverria, P; Gelnett, J; Haberberger, RL; Murphy, GS; Petruccelli, BP; Sanchez, JL; Taylor, DN; Walz, S, 1992)
"To compare the safety and efficacy of loperamide used in combination with ciprofloxacin or ciprofloxacin alone for the treatment of travelers' diarrhea."	5.07	Treatment of travelers' diarrhea: ciprofloxacin plus loperamide compared with ciprofloxacin alone. A placebo-controlled, randomized trial. ( Candler, W; Echeverria, P; McQueen, C; Sanchez, JL; Taylor, DN; Thornton, S, 1991)
"An open-label, parallel comparison of loperamide hydrochloride (Imodium A-D) and bismuth subsalicylate (Pepto-Bismol) was conducted using nonprescription dosages in adult students with acute diarrhea (three or more unformed stools in the preceding 24 hours plus at least one additional symptom of enteric infection)."	5.06	Comparative efficacy of loperamide hydrochloride and bismuth subsalicylate in the management of acute diarrhea. ( Cruz Luna, A; DuPont, HL; DuPont, MW; Ericsson, CD; Flores Sanchez, J; Mathewson, JJ; Mendiola Gomez, J, 1990)
"The efficacy of nonprescription doses of loperamide hydrochloride (Imodium A-D) was compared with nonfibrous activated attapulgite (Diasorb) in a randomized, parallel, open-label study of adult patients with acute diarrhea."	5.06	A randomized, open-label comparison of nonprescription loperamide and attapulgite in the symptomatic treatment of acute diarrhea. ( Cruz Luna, A; DuPont, HL; DuPont, MW; Ericsson, CD; Mathewson, JJ, 1990)
"In a randomized, double-blind, placebo-controlled trial, 227 US adults with acute diarrhea in Mexico received a single dose of sulfamethoxazole and trimethoprim (1600/320 mg) or 3 days of therapy with loperamide hydrochloride (4-mg loading dose, then 2 mg orally after each loose stool), sulfamethoxazole-trimethoprim (800/160 mg orally twice daily), or the combination of both."	5.06	Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide. ( Bitsura, JA; DuPont, HL; Ericsson, CD; Johnson, PC; Mathewson, JJ; West, MS, 1990)
"Loperamide hydrochloride was compared with bismuth subsalicylate for the treatment of acute nondysenteric travelers' diarrhea in 219 students visiting seven countries in Latin America."	5.06	Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea. ( Bitsura, JA; DuPont, HL; Ericsson, CD; Johnson, PC; Morgan, DR; Wood, LV, 1986)
"The effect of loperamide and diphenoxylate on diarrhoea following jejuno-ileostomy for morbid obesity was investigated in 27 patients by means of a randomized fixed sample size, three-period cross-over trial."	5.05	Diarrhoea following jejuno-ileostomy for morbid obesity. A randomised trial of loperamide and diphenoxylate. ( Andersen, B; Gudmand-Høyer, E; Skovbjerg, H; Wille-Jørgensen, P, 1982)
"We have investigated the effect of loperamide (4 mg tds) on the continence to a standard volume of rectally infused saline and anorectal manometry in 26 patients complaining of chronic diarrhea complicated by fecal incontinence and severe urgency."	5.05	Effects of loperamide on anal sphincter function in patients complaining of chronic diarrhea with fecal incontinence and urgency. ( Barber, DC; Duthie, HL; Read, M; Read, NW, 1982)
"Loperamide is an effective and safe antidiarrheal agent which served as a very useful adjunct in the treatment in 79% of 47 patients with chronic diarrhea."	5.04	Loperamide, a new antidiarrheal agent in the treatment of chronic diarrhea. ( Galambos, JT, 1978)
"Twenty-seven patients with chronic diarrhea due to Crohn's disease, ulcerative colitis, short bowel syndrome, and idiopathic (functional) causes participated in a multiphase study (open, double blind, and long term open) of loperamide HCl, a new single entity, oral antidiarrheal agent."	5.04	Loperamide: a new antidiarrheal agent in the treatment of chronic diarrhea. ( Galambos, JT; Hersh, T; Schroder, S; Wenger, J, 1976)
"Loperamide, a novel antidiarrheal agent, was compared with diphenoxylate in a double blind crossover study of 23 patients with chronic diarrhea of various etiologies."	5.04	A double blind crossover comparison of loperamide with diphenoxylate in the symptomatic treatment of chronic diarrhea. ( Pelemans, W; Vantrappen, F, 1976)
"Fifteen patients (20 to 66 years) with long-standing chronic diarrhea of varying etiology were selected for an open trial of loperamide 2 mg capsules."	5.04	Loperamide in chronic diarrhea and after ileostomy: a placebo-controlled double-blind cross-over study. ( Huibregtse, K; Meuwissen, SG; Tytgat, GN, 1976)
" The Grading of Recommendations Assessment, Development, and Evaluation methodology was applied to evaluate the effect of loperamide, diphenoxylate/atropine, and elemental diet on the resolution of noninfectious diarrhea in critically ill adults based on selected outcomes: improvement in clinical diarrhea, fecal frequency, time to the diarrhea resolution, and hospital length of stay."	5.01	Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. ( Bhattacharya, B; Bugaev, N; Chiu, WC; Como, JJ; Cripps, MW; Ferrada, P; Gelbard, RB; Gondek, S; Kasotakis, G; Kim, D; Mentzer, C; Robinson, BRH; Salcedo, ES; Yeh, DD, 2019)
"High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg."	4.98	Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018)
"Loperamide is a popular antidiarrheal medication that has been used for many years."	4.98	Loperamide cardiotoxicity: "A Brief Review". ( Akel, T; Bekheit, S, 2018)
"Loperamide is a nonprescription opioid widely used for the treatment of diarrhea."	4.95	Clinical Review: Loperamide Toxicity. ( Juurlink, DN; Wu, PE, 2017)
"Racecadotril has sufficient proven efficacy in the treatment of acute diarrhea in children."	4.89	[The treatment of acute diarrhea]. ( Leemans, L, 2013)
" In children who are older than 3 y with no/minimal dehydration, loperamide may be a useful adjunct to oral rehydration and early refeeding."	4.84	Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. ( Cummings, P; Grossman, DC; Li, ST, 2007)
"Loperamide is an effective therapy for a variety of diarrheal syndromes, including acute, nonspecific (infectious) diarrhea; traveler's diarrhea; and chemotherapy-related and protease inhibitor?associated diarrhea."	4.84	The role of loperamide in gastrointestinal disorders. ( Hanauer, SB, 2008)
"Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea."	4.82	Racecadotril versus loperamide: antidiarrheal research revisited. ( Awouters, F; Huighebaert, S; Tytgat, GN, 2003)
" All strategies reduced grade ≥3 diarrhea with the lowest incidence in DE1 (DE1 13%; colestipol + loperamide [CL] 21%, DE2 27%; budesonide + loperamide [BL] 28%; loperamide [L] 31%; colestipol + loperamide as needed [CL-PRN] 33%)."	4.31	Final findings from the CONTROL trial: Strategies to reduce the incidence and severity of neratinib-associated diarrhea in patients with HER2-positive early-stage breast cancer. ( Barcenas, CH; Bose, R; Brufsky, A; Chan, A; Cheong, KA; Chien, AJ; DiPrimeo, D; Egle, D; Foruzan, N; García-Sáenz, JA; Hurvitz, SA; Marx, G; McCulloch, L; Pistilli, B; Rugo, HS; Ruiz-Borrego, M; Schnappauf, B; Semsek, D; Singer, CF; Thirlwell, M; Trudeau, M; Wassermann, J, 2023)
"Loperamide has been a safe and effective treatment for diarrhea for many years."	4.31	The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023)
"Lubeluzole, a neuroprotective anti-ischemic drug, was tested for its ability to act as both antibiotic chemosensitizing and antipropulsive agent for the treatment of infectious diarrhea."	4.02	Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. ( Budriesi, R; Caputo, L; Cavalluzzi, MM; Corazza, I; De Salvia, MA; Franchini, C; Gualdani, R; Lentini, G; Micucci, M; Milani, G; Piarulli, M; Quintieri, L; Rosato, A; Viale, M, 2021)
"Loperamide is an anti-diarrheal drug prescribed for non-infectious diarrhea."	3.85	Antibiotic Effects of Loperamide: Homology of Human Targets of Loperamide with Targets in Acanthamoeba spp. ( Ahmad, HR; Baig, AM; Mannan, M; Rana, Z; Tariq, S, 2017)
"The objective of the study was to evaluate the antidiarrheal and antinociceptive activities of ethanol extract and its chloroform and pet ether fraction of Phrynium imbricatum (Roxb."	3.85	Antidiarrheal and antinociceptive activities of ethanol extract and its chloroform and pet ether fraction of Phrynium imbricatum (Roxb.) leaves in mice. ( Arman, MSI; Dash, R; Dinar, MAM; Hosen, SMZ; Hossain, MM; Kabir, MSH; Rahman, MM; Uddin, MMN, 2017)
"75 mg/kg loperamide over 3 days as treatment for diarrhea."	3.85	Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1-1∆ mutation. ( Bracker, K; Long, WM; Sinnott, VB; Thomas, D, 2017)
"Loperamide is an antidiarrheal medication deemed by the U."	3.81	Ventricular tachycardia associated with high-dose chronic loperamide use. ( Lonardo, NW; Mulamalla, R; Spinner, HL; Stehlik, J, 2015)
"Eluxadoline, an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist developed for the treatment of diarrhea-predominant irritable bowel syndrome, normalizes gastrointestinal (GI) transit and defecation under conditions of novel environment stress or post-inflammatory altered GI function."	3.80	Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers. ( Devi, LA; Dove, LS; Fujita, W; Gomes, I; McIntyre, G; Prohaska, D, 2014)
" The aqueous leaf and shoot extract was assayed against castor oil-induced diarrhea, transit time, and enteropooling, in comparison to loperamide, a standard drug."	3.80	Safety and antidiarrheal activity of Priva adhaerens aqueous leaf extract in a murine model. ( Abimana, J; Alele, PE; Barasa, A; Kasolo, J; Nansunga, M, 2014)
"To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract of Desmodium puchellum (Family: Fabaceae) leaves."	3.79	Studies on the anti-diarrheal properties of leaf extract of Desmodium puchellum. ( Barua, S; Islam, ME; Islam, MF; Islam, MR; Parvin, MS; Rahman, MK; Sayeed, MA, 2013)
" Patients with grade 2-4 diarrhea were simultaneously tested for CDI, and initiated on antiperistaltic agents (loperamide) and preemptive anti-CDI therapy."	3.79	Risk factors, preemptive therapy, and antiperistaltic agents for Clostridium difficile infection in cancer patients. ( Anaissie, EJ; Apewokin, SK; Chepyala, P; Krishna, K; Krishna, SG; Zhao, W, 2013)
" All doses of the extract, its anti-motility fractions and loperamide individually stopped diarrhea within 6-24 h of administration, whilst significantly reducing mucus and fecal fluid content, urine production and intestinal bloating."	3.78	Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea. ( Balemba, OB; Boakye, PA; Brierley, SM; Pasilis, SP, 2012)
" The recommended dosage for phase II trial is 100 mg/m2 administered in 1 hour perfusion, every 21 days."	3.78	[Taxotere (docetaxel) and CPT 11 (irinotecan): phase I trials]. ( Armand, JP; Couteau, C; Goncalves, E; Terret, C; Yakendji, K, 1996)
" EEA-1, EEA-2, the main constituents of EEAs (mangiferin, and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice."	3.76	Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. ( Araki, Y; Hara, H; Iinuma, M; Ito, T; Izuta, H; Kakino, M; Oyama, M; Shimazawa, M; Tsuruma, K, 2010)
" Nor has the efficacy of selective serotonin reuptake inhibitor antidepressants (SSRIs) been demonstrated; (5) Alosetron and tegaserod carry a risk of potentially life-threatening adverse effects and therefore have negative risk-benefit balances; (6) Seeds of plants such as psyllium and ispaghul, as well as raw apples and pears, have a limited impact on constipation and pain."	3.75	Irritable bowel syndrome: a mild disorder; purely symptomatic treatment. ( , 2009)
" We chose PYY as an index of the intrinsic factor in diarrhea and examined the influence of changes induced in a diarrhea rat model by administration of 4 types of laxative and loperamide hydrochloride (loperamide) as an agent for the treatment of diarrhea."	3.74	Changes of intestinal mucosal and plasma PYY in a diarrhea model rat and influence of loperamide as the treatment agent for diarrhea. ( Hirotani, Y; Ikeda, K; Kurokawa, N; Mikajiri, K; Myotoku, M, 2008)
" In acute diarrhoea, loperamide provides more rapid control of symptoms than diphenoxylate when given in a flexible dosage according to unformed bowel movements, and in single dose studies 4mg loperamide has a much longer duration of effect than 5mg diphenoxylate."	3.74	Loperamide: a review of its pharmacological properties and therapeutic efficacy in diarrhoea. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1978)
"A 2-year-old girl was diagnosed as having acute gastroenteritis with severe diarrhoea, for which she was prescribed a loperamide solution."	3.72	[Ileus after the use of loperamide in a child with acute diarrhea]. ( Dudink, J; Mearin, LM; Sukhai, RN, 2003)
"Chemotherapy-induced diarrhea (CID) became first apparent during clinical studies on the combination of 5-FU with leucovorin and, furthermore, with irinotecan in the treatment of metastatic colorectal carcinoma."	3.72	[Management of chemotherapy induced diarrhea]. ( Kullmann, F; Schölmerich, J; Schultz, M, 2004)
"Experimental antidiarrheal activity of a traditionally used medication, Salicairine, was demonstrated in comparison to loperamide by significant inhibition of castor oil-induced diarrhea in mice (increases in hard faeces/total faeces ratio of 38 and 54 and 5 and 54% with respect to controls, at 0."	3.70	Experimental study of antidiarrheal activity of Salicairine. ( Brun, Y; Demenge, P; Sevenet, T; Wang, XP; Willemot, J, 1998)
" We studied the effects of KW-5617 on secretory diarrhea and gastrointestinal propulsion in rats, as compared with those of loperamide, a conventional anti-diarrheal drug."	3.70	Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. ( Aikawa, N; Karasawa, A, 1998)
"The effects of a 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 (6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-benzimidazole dimaleate) on experimental diarrhea and on intestinal fluid secretion stimulated by cholera toxin were examined and compared with those of ramosetron and loperamide."	3.70	Effect of the 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models. ( Ozaki, A; Sukamoto, T; Yoshidomi, M, 1999)
"The effect of zaldaride, a calmodulin inhibitor, on fecal pellet output in rats was compared with that of loperamide, an antidiarrheal drug."	3.70	Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats. ( Aikawa, N; Ohmori, K, 2000)
"We attempted to characterize the antidiarrheal action of Hange-shashin-to (TJ-14), a kampo medicine, by comparing its action with that of loperamide."	3.69	Pharmacological studies on antidiarrheal effects of Hange-shashin-to. ( Aburada, M; Hayakawa, T; Ishige, A; Kase, Y; Okada, M; Takeda, S, 1996)
" Because loperamide is commonly used as an antidiarrheal agent, we wondered if it would blunt the orocecal transit acceleration provoked by mild exercise."	3.68	Loperamide abolishes exercise-induced orocecal liquid transit acceleration. ( Harris, A; Keeling, WF; Martin, BJ, 1993)
"A series of N-(aminoiminomethyl)-1H-pyrrole-1-acetamides, related to guanfacine, were prepared and tested for antidiarrheal activity in castor oil dosed rats."	3.67	Synthesis and antidiarrheal activity of N-(aminoiminomethyl)-1H-pyrrole-1-acetamides related to guanfacine. ( Beattie, DE; Dover, GM; Ward, TJ, 1985)
"To determine whether the antidiarrheal effect of loperamide is due to an effect on intestinal motor function or to an acceleration of the rate of absorption by the intestine (as has been suggested recently), we studied absorption during experimental diarrhea produced by the rapid intragastric infusion of electrolyte solution."	3.67	Mechanism of the antidiarrheal effect of loperamide. ( Fordtran, JS; Morawski, SG; Santa Ana, CA; Schiller, LR, 1984)
"The antidiarrheal action of loperamide hydrochloride was tested against diarrhea experimentally induced in calves by intraduodenal infusion of castor oil or hypertonic solution of mannitol."	3.67	Effects of loperamide hydrochloride on experimental diarrhea and gastrointestinal myoelectrical activity in calves. ( Buéno, L; Fioramonti, J, 1987)
"Several neuroleptics known to bind to calmodulin were tested for anti-diarrheal activity and were compared with the opiate anti-diarrheals loperamide and diphenoxylate."	3.66	Relationship between anti-diarrheal activity and binding to calmodulin. ( Jackson, TE; Limp, GL; Yellin, TO; Zavecz, JH, 1982)
"Effects of loperamide on diarrhea induced by castor oil and prostaglandin E1 were investigated in rats and mice and compared with those of narcotic analgesics, atropine, mecamylamine and local anesthetics."	3.66	[Pharmacological studies of loperamide, an anti-diarrheal agent. I. Effects on diarrhea induced by castor oil and prostaglandin E. (author's transl)]. ( Kawashima, K; Nakamura, H; Shimizu, M; Sohji, Y, 1978)
"45 patients with diarrheas appearing after exposure of the gastro-intestinal region to ionizing radiation were given loperamide in the course of a study."	3.66	[Studies using loperamide in patients with diarrhea following telecobalt irradiation of malignant abdominal tumors (author's transl)]. ( Behdjati, F; Geginat, G; Green, E; Kaeferstein, D, 1978)
"Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins."	3.65	The effect of loperamide on prostaglandin induced diarrhoea in rat and man. ( Adaikan, PG; Karim, SM, 1977)
"To evaluate the efficacy of maropitant and loperamide for the prevention and reduction of adverse gastrointestinal effects associated with administration of paclitaxel to dogs with cancer."	2.90	Assessment of the administration of maropitant and loperamide to dogs with cancer for the prevention and reduction of adverse effects associated with the administration of paclitaxel. ( Cartagena-Albertus, JC; Engel Manchado, J; Moise, A; Montoya Alonso, JA; Moya García, S, 2019)
" Rates of adverse events were comparable in both groups (37."	2.90	Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study. ( Brenner, DM; Cash, BD; Elmes, SJR; Gutman, CR; Jo, E; Liu, LWC; Sayuk, GS, 2019)
" Dose-response studies should be performed, and standard treatment doses of loperamide should be reassessed."	2.84	The Acute Effect of Loperamide on Ileostomy Output: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study. ( Kristensen, K; Qvist, N, 2017)
"Loperamide (LOP) is an anti-diarrhoeal agent which is thought to act largely by slowing transit with an uncertain effect on the fluid content of the small and large bowel in humans."	2.77	The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea. ( Costigan, C; Cox, EF; Garsed, KC; Gowland, PA; Hoad, CL; Marciani, L; Napolitano, A; Placidi, E; Pritchard, SE; Spiller, RC, 2012)
"Racecadotril (acetorphan) is an orally active, potent inhibitor of enkephalinase, which exerts an antihypersecretory effect without increasing intestinal transit time."	2.70	A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults. ( Prado, D, 2002)
"Loperamide is an established treatment of acute diarrhoea with only rare adverse reactions."	2.68	Loperamide oxide in acute diarrhoea: a double-blind, placebo-controlled trial. The Dutch Diarrhoea Trialists Group. ( Dreverman, JW; Van der Poel, AJ, 1995)
"(1) Zaldaride 20 mg four times daily, (2) zaldaride 2 x 20 mg as initial loading dose followed by three doses of 20 mg on the first day and four doses of 20 mg on the second day, (3) loperamide 2 x 2 mg loading dose following by a flexible dosage of 2 mg after each unformed stool (maximum of 16 mg daily), (4) placebo."	2.68	Treatment of travellers' diarrhoea: zaldaride compared with loperamide and placebo. ( el-Etr, S; Gyurech, D; Kilpatrick, ME; Mathewson, JT; Mourad, AS; Murphy, JR; Oyofo, BA; Schick, MT; Silberschmidt, G; Steffen, R, 1995)
"Twenty male patients with AIDS and refractory diarrhea, with stool volume > 1000 ml/day who failed to improve after initial supportive management."	2.67	Octreotide therapy of large-volume refractory AIDS-associated diarrhea: a randomized controlled trial. ( Barragan, RF; Garcia Compean, D; Guzman de la Garza, F; Maldonado, H; Michel, H; Ramos Jimenez, J; Saenz, C, 1994)
"Microscopic colitis is a common cause of chronic watery diarrhea with a great impact on patient quality of life."	2.66	Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. ( Casanova, MJ; Gisbert, JP; Rojo, E, 2020)
"Loperamide was found to be superior to lidamidine or placebo for the control of stool consistency in patients with chronic diarrhoea."	2.66	A double-blind crossover comparison of lidamidine, loperamide and placebo for the control of chronic diarrhoea. ( Allison, MC; Pounder, RE; Sercombe, J, 1988)
"The loperamide-treated patients had significantly fewer loose stools during the observation period of 5 days than did the placebo treated patients, median five vs."	2.66	Symptomatic treatment of acute infectious diarrhoea: loperamide versus placebo in a double-blind trial. ( Alestig, K; Bergström, T; Thorén, K; Trollfors, B, 1986)
"Lidamidine HCl was also shown to be well tolerated; side-effects were generally minor and self-limiting."	2.66	A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea. ( Albano, O; Altomare, E; Banterle, C; Chiodo, F; Corazza, GR; Feliciani, M; Fontana, G; Gasbarrini, G; Stufano, N; Valpiani, D, 1986)
"Loperamide treatment accelerated gastric emptying, compared with placebo (1."	2.65	Role of loperamide and placebo in management of irritable bowel syndrome (IBS). ( Barends, D; Cann, PA; Holdsworth, CD; Read, NW, 1984)
"Loperamide was also statistically superior to diphenoxylate at reducing the number of stools and improving the faecal consistency."	2.65	A comparative study of loperamide and diphenoxylate in the treatment of chronic diarrhoea caused by intestinal resection. ( Bergman, L; Djärv, L, 1981)
"Loperamide and codeine were more effective in relieving this than was diphenoxylate."	2.65	Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. ( Corbett, CL; Holdsworth, CD; Palmer, KR, 1980)
"Loperamide was also associated with less side effects."	2.65	A double-blind crossover study of the effect of loperamide hydrochloride and codeine phosphate on ileostomy output. ( Hill, GL; King, RF; Norton, T, 1982)
"Loperamide (R 18 553) was compared with placebo in a double-blind crossover study of 21 patients with chronic diarrhoea caused by ileocolic disease or resection."	2.64	Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection. ( Fiasse, R; Mainguet, P, 1977)
"Loperamide was compared double-blind with diphenoxylate and a placebo in 59 women with diarrhoea due to prostaglandin administration for mid-trimester abortion."	2.64	Prostaglandin-induced diarrhoea treated with loperamide or diphenoxylate. A double-blind study. ( Amery, W; Lange, AP; Secher, NJ, 1977)
"Loperamide was the only intervention with more side effects than STND [Quality: moderate]."	2.58	Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. ( Acosta-Reyes, J; Al Khalifah, R; Cuello-Garcia, C; Florez, ID; Foroutan, N; Granados, CM; Guyatt, GH; Pérez-Gaxiola, G; Sierra, JM; Thabane, L; Vernooij, RWM; Veroniki, AA; Yepes-Nuñez, JJ; Zea, AM; Zhang, Y, 2018)
"Irritable bowel syndrome is categorized into one of three main categories: IBS with diarrhea, IBS with constipation, and IBS with mixed bowel habits."	2.53	Emerging treatments in neurogastroenterology: eluxadoline - a new therapeutic option for diarrhea-predominant IBS. ( Lacy, BE, 2016)
"Diarrhea is a distressing symptom which limits the quality of life in patients receiving palliative care and is associated with high morbidity and mortality."	2.49	[Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. ( Meißner, W; Pastrana, T, 2013)
"When treating diarrhea, physicians need to control inflammatory activity using appropriate treatment algorithms."	2.44	Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions. ( Hanauer, SB; Shah, SB, 2007)
"Radiation enteritis is a severe problem in patients receiving irradiation of the abdomen or pelvis in the course of cancer treatment."	2.44	Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review. ( Böcker, U; Singer, MV; Wenz, F; Zimmerer, T, 2008)
"Irinotecan is a selective inhibitor of topoisomerase I, an enzyme part of the replication and transcription system of DNA."	2.42	New approaches to prevent intestinal toxicity of irinotecan-based regimens. ( Alimonti, A; Cognetti, F; Di Palma, M; Ferretti, G; Gelibter, A; Pavese, I; Rasio, D; Satta, F; Vecchione, A, 2004)
"Oral loperamide is the treatment of choice."	2.41	Guidelines for adults on self-medication for the treatment of acute diarrhoea. ( Lewis, SJ; Malagelada, JR; Phillips, SF; Speelman, P; Steffen, R; Tytgat, GN; Wingate, D, 2001)
"Diarrhea is the most common health problem of travelers to tropical destinations, affecting up to over 50%, with however considerable regional and seasonal variation."	2.41	[Travelers' diarrhea]. ( Markwalder, K, 2001)
"Acute infectious diarrhea is a major global health problem."	2.41	Clinical evaluation and management of acute infectious diarrhea in adults. ( Ilnyckyj, A, 2001)
"Diarrhea is a multifactorial gastrointestinal disorder responsible for about 5 million deaths annually."	1.62	Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil-induced diarrhea, oxidative stress, and inflammation in rat. ( Jabri, MA; Jedidi, S; Jridi, M; Rtibi, K; Sammari, H; Sebai, H; Selmi, H; Toumi, L; Zouari, N, 2021)
"Travelers' diarrhea is a frequent condition, especially in those traveling to high-risk areas."	1.46	Is it worth adding loperamide to antibiotic treatment of travelers diarrhea? ( Corsi, Ó; Pinos, Y; Rada, G; Ruiz, MI, 2017)
"Travelers' diarrhea is a self-limiting illness; however, antibiotic treatment (with and without use of adjunct loperamide therapy) has been shown to significantly reduce clinical presentation of symptoms and duration of illness."	1.46	Preface: Guidelines for the Treatment of Travelers' Diarrhea in Deployed Military Personnel. ( Riddle, MS; Tribble, D, 2017)
"Diarrhea is one of the most common complaints in oncologic patients."	1.43	[Diarrhea caused by systemic anti-cancer treatments]. ( Anchisi, S; Berthod, G; Dischl-Antonioni, I; Hiroz, P, 2016)
"0mg/ml) on jejunal contraction were investigated and a dose-response curve constructed using the experimental data after which The ED50 dose was determined."	1.43	Freeze dried extracts of Bidens biternata (Lour.) Merr. and Sheriff. show significant antidiarrheal activity in in-vivo models of diarrhea. ( Kinuthia, DG; Muriithi, AW; Mwangi, PW, 2016)
"Microscopic colitis is characterized by chronic or intermittent watery diarrhoea."	1.39	[Microscopic colitis]. ( Lukáš, K; Mandys, V, 2013)
"Diarrhea is a common adverse event of docetaxel with 20%-40% of incidence and severe diarrhea occurs in 5%-6%."	1.39	Secondary prophylaxis of docetaxel induced diarrhea with loperamide: case report. ( Kim, HK; Kim, MJ; Lee, HY; Lee, YH, 2013)
"Collagenous colitis has been associated with autoimmune diseases."	1.34	Collagenous colitis in a patient with systemic sclerosis: a rare entity. ( Coban, S; Ekiz, F; Ensari, A; Gören, D; Ormeci, N; Savas, B, 2007)
"Loperamide is a well-known peripherally acting opiate used for the treatment of diarrhoea."	1.33	Synthesis and pharmacological activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones. ( Bertamino, A; Borrelli, F; Capasso, R; di Bosco, AM; Diurno, MV; Grieco, P; Mazzoni, O; Novellino, E, 2006)
"For biotherapeutic agents, there is a lack of information on dose-response relationships and mechanism of action."	1.32	Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats. ( Gillardin, JM; Girard, P; Lorette, I; Pansart, Y, 2003)
"Diarrhea is a well-recognized side effect of chemotherapy, which affects the quality of life and when refractory is potentially life threatening."	1.31	Control of irinotecan-induced diarrhea by octreotide after loperamide failure. ( Barbounis, V; Demiri, M; Efremidis, AP; Koumakis, G; Vassilomanolakis, M, 2001)
"Loperamide is an opioid that stimulates opioid receptors in the gastrointestinal tract, thereby inhibiting intestinal secretion and propulsive peristalsis, probably without affecting the central nervous system."	1.31	[Loperamide abuse in anxiety disorder]. ( Bschor, T; Langlitz, N; Schotte, K, 2001)
"Traveller's diarrhea is almost always due to an infection with intestinal bacteria, viruses or parasites."	1.31	[What is effective in traveler's diarrhea? Current recommendations on prevention, therapy and after care]. ( Fleischer, K; Stich, A, 2001)
"Ulcerative colitis is an illness that occurs unexpectedly in a young patient, with a generally unpredictable prognosis, and there is no medication to cure it."	1.29	[Functional results of ileo-anal anastomosis. The point of view of the gastroenterologist]. ( Bigard, MA, 1993)
"Prednisolone was most effective with a response rate of 82%, but the required dose was often high and the effect was not sustained after withdrawal."	1.29	Collagenous colitis: a retrospective study of clinical presentation and treatment in 163 patients. ( Abrahamsson, H; Bohr, J; Eriksson, S; Järnerot, G; Tysk, C, 1996)
" We had good results using oral rehydration treatment in combination with loperamide hydrochloride (Immodium) in a colony of rabbits with E."	1.27	Acute diarrhoeal disease in rabbit: bacteriological diagnosis and efficacy of oral rehydration in combination with loperamide hydrochloride. ( Angulo, AF; Banerjee, AK; Dhasmana, KM; Kong-A-San, J, 1987)
"The diarrhea was improved by loperamide, but severe steatorrhea and malnutrition persisted."	1.26	Ox bile treatment of severe steatorrhea in an ileectomy-ileostomy patient. ( Bunch, F; Davis, GR; Fordtran, JS, 1982)
" Diarrhea was controlled with a median dosage of three capsules (6 mg total dose) and a range of two to 12 capsules."	1.26	The control of acute diarrhea in a large industrial plant. ( Martins, JK; Roedl, G, 1978)

Research

Studies (336)

Authors

Clinical Trials (14)

Trial Overview

Trial Outcomes

Change From Baseline in Quality of Life Measured by the Functional Assessment of Chronic Illness Therapy-Diarrhea (FACIT-D)

Timeframe	Studies, this research(%)	All Research%
pre-1990	100 (29.76)	18.7374
1990's	77 (22.92)	18.2507
2000's	66 (19.64)	29.6817
2010's	75 (22.32)	24.3611
2020's	18 (5.36)	2.80

Authors	Studies
Beattie, DE	1
Dover, GM	1
Ward, TJ	1
Lembo, A	1
Sultan, S	1
Chang, L	1
Heidelbaugh, JJ	1
Smalley, W	1
Verne, GN	1
Lim, E	1
Boyle, F	1
Okera, M	1
Loi, S	1
Goksu, SS	1
van Hal, G	1
Chapman, SC	1
Gable, JC	1
Chen, Y	1
Price, GL	1
Hossain, AM	1
Gainford, MC	1
Ezquerra, MB	1
Fei, M	1
Zhang, J	1
Zhu, C	1
Luo, M	1
Zhang, L	2
Wu, Y	1
Chan, A	1
Ruiz-Borrego, M	1
Marx, G	1
Chien, AJ	2
Rugo, HS	2
Brufsky, A	1
Thirlwell, M	1
Trudeau, M	1
Bose, R	1
García-Sáenz, JA	1
Egle, D	1
Pistilli, B	1
Wassermann, J	1
Cheong, KA	1
Schnappauf, B	1
Semsek, D	1
Singer, CF	1
Foruzan, N	1
DiPrimeo, D	1
McCulloch, L	1
Hurvitz, SA	1
Barcenas, CH	1
Jansson-Rehnberg, AS	1
Borgfeldt, C	1
Münch, A	1
Graf, W	1
Simrén, M	1
Lindberg, G	1
Hellström, PM	1
Masuda, H	1
Tanabe, Y	1
Sakai, H	1
Matsumoto, K	1
Shimomura, A	1
Doi, M	1
Miyoshi, Y	1
Takahashi, M	1
Sagara, Y	1
Tokunaga, S	1
Iwasa, T	1
Niikura, N	1
Yoshimura, K	1
Takano, T	1
Tsurutani, J	1
Jacob, S	1
Johnson, M	1
Roque, B	1
Quintal, L	1
Melisko, M	1
Lu, HR	1
Damiano, BP	1
Kreir, M	1
Rohrbacher, J	1
van der Linde, H	1
Saidov, T	1
Teisman, A	1
Gallacher, DJ	1
Selby, A	1
Reichenbach, ZW	1
Piech, G	1
Friedenberg, FK	1
Bugaev, N	1
Bhattacharya, B	1
Chiu, WC	1
Como, JJ	1
Cripps, MW	1
Ferrada, P	1
Gelbard, RB	1
Gondek, S	1
Kasotakis, G	1
Kim, D	1
Mentzer, C	1
Robinson, BRH	1
Salcedo, ES	1
Yeh, DD	1
Rojo, E	1
Casanova, MJ	1
Gisbert, JP	1
Black, CJ	1
Houghton, LA	1
Ford, AC	1
Brenner, DM	3
Sayuk, GS	3
Gutman, CR	2
Jo, E	2
Elmes, SJR	2
Liu, LWC	2
Cash, BD	3
Cavalluzzi, MM	1
Budriesi, R	1
De Salvia, MA	1
Quintieri, L	1
Piarulli, M	1
Milani, G	1
Gualdani, R	1
Micucci, M	1
Corazza, I	1
Rosato, A	1
Viale, M	1
Caputo, L	1
Franchini, C	1
Lentini, G	1
Twardowska, A	1
Fichna, J	2
Binienda, A	1
Sammari, H	1
Jedidi, S	1
Selmi, H	1
Rtibi, K	3
Jabri, MA	2
Jridi, M	1
Zouari, N	1
Toumi, L	1
Sebai, H	3
Ahmad, MH	1
Zezi, AU	1
Anafi, SB	1
Alhassan, Z	1
Mohammed, M	1
Danraka, RN	1
Abel, JL	1
Burslem, K	1
Alam, MM	1
Emon, NU	1
Alam, S	1
Rudra, S	1
Akhter, N	1
Mamun, MMR	1
Ganguly, A	1
Gómez-Aldana, A	1
Gómez, DC	1
López-Panqueva, RDP	1
Lacy, BE	2
Chey, WD	1
Lembo, AJ	2
Dove, LS	2
Covington, PS	1
Baig, AM	1
Rana, Z	1
Mannan, M	1
Tariq, S	1
Ahmad, HR	1
Wu, PE	1
Juurlink, DN	1
Pinos, Y	1
Ruiz, MI	1
Corsi, Ó	1
Rada, G	1
Kristensen, K	1
Qvist, N	1
Dischl-Antonioni, I	1
Berthod, G	1
Hiroz, P	1
Anchisi, S	1
de Lemos, ML	1
Guenter, J	1
Kletas, V	1
Stoney, RJ	1
Han, PV	1
Barnett, ED	1
Wilson, ME	1
Jentes, ES	1
Benoit, CM	1
MacLeod, WB	1
Hamer, DH	1
Chen, LH	1
Wasilewski, A	1
Misicka, A	1
Sacharczuk, M	1
Hossain, MM	1
Kabir, MSH	1
Dinar, MAM	1
Arman, MSI	1
Rahman, MM	1
Hosen, SMZ	1
Dash, R	1
Uddin, MMN	1
Riddle, MS	4
Tribble, D	1
Yap, FHX	1
Thom, G	1
Connor, P	1
Fraser, J	1
Porter, CK	1
Swierczewski, B	1
Hutley, EJ	1
Danboise, B	1
Simons, MP	1
Hulseberg, C	1
Lalani, T	1
Gutierrez, RL	1
Tribble, DR	3
Akel, T	1
Bekheit, S	1
Selmi, S	2
Saidani, K	1
Grami, D	1
Amri, M	1
Marzouki, L	1
Linn, YH	1
Thu, KK	1
Win, NHH	1
Haigney, MC	1
Klein, MG	1
Flagg, TP	1
Fatima, N	1
Mehler, PS	1
Krantz, MJ	1
Florez, ID	1
Veroniki, AA	1
Al Khalifah, R	1
Yepes-Nuñez, JJ	1
Sierra, JM	1
Vernooij, RWM	1
Acosta-Reyes, J	1
Granados, CM	1
Pérez-Gaxiola, G	1
Cuello-Garcia, C	1
Zea, AM	1
Zhang, Y	1
Foroutan, N	1
Guyatt, GH	1
Thabane, L	1
Major, GAD	1
Gunn, D	1
Aouinti, I	1
Kaabi, W	1
Charfi, O	1
Lakhoua, G	1
Hamza, I	1
Daghfous, R	1
El Aidli, S	1
Kastalli, S	1
Zaiem, A	1
Cartagena-Albertus, JC	1
Engel Manchado, J	1
Moise, A	1
Moya García, S	1
Montoya Alonso, JA	1
Pastrana, T	1
Meißner, W	1
Lukáš, K	1
Mandys, V	1
Billah, MM	1
Islam, R	1
Khatun, H	1
Parvin, S	1
Islam, E	1
Islam, SA	1
Mia, AA	1
Rahman, MK	1
Barua, S	1
Islam, MF	1
Islam, MR	1
Sayeed, MA	1
Parvin, MS	1
Islam, ME	1
Nair, D	1
Dosso, K	1
N'guessan, BB	1
Bidie, AP	1
Gnangoran, BN	1
Méité, S	1
N'guessan, D	1
Yapo, AP	1
Ehilé, EE	1
Krishna, SG	1
Zhao, W	1
Apewokin, SK	1
Krishna, K	1
Chepyala, P	1
Anaissie, EJ	1
Lee, HY	1
Lee, YH	1
Kim, MJ	1
Kim, HK	1
Vohmann, B	1
Hoffmann, JC	1
Souli, A	1
Tebourbi, O	2
El-Benna, J	1
Sakly, M	2
Hoff, PM	1
Saragiotto, DF	1
Barrios, CH	1
del Giglio, A	1
Coutinho, AK	1
Andrade, AC	1
Dutra, C	1
Forones, NM	1
Correa, M	1
Portella, Mdo S	1
Passos, VQ	1
Chinen, RN	1
van Eyll, B	1
DuPont, HL	12
Leemans, L	1
Fujita, W	1
Gomes, I	1
Prohaska, D	1
McIntyre, G	1
Devi, LA	1
Nansunga, M	1
Barasa, A	1
Abimana, J	1
Alele, PE	1
Kasolo, J	1
Tadesse, WT	1
Hailu, AE	1
Gurmu, AE	1
Mechesso, AF	1
Shareef, H	1
Rizwani, GH	1
Mandukhail, SR	1
Watanabe, N	1
Gilani, AH	3
Chertow, DS	1
Uyeki, TM	1
Gulstad, MB	1
Thomsen, H	1
Spinner, HL	1
Lonardo, NW	1
Mulamalla, R	1
Stehlik, J	1
Hookway, C	1
Buckner, S	1
Crosland, P	1
Longson, D	1
Mackowski, A	1
Chen, HK	1
Levitt, M	1
Douma, JA	1
Smulders, YM	1
Cottrell, J	1
Koenig, K	1
Perfekt, R	1
Hofmann, R	1
Nee, J	1
Zakari, M	1
Kantele, A	1
Mero, S	1
Kirveskari, J	1
Lääveri, T	1
Marques, S	1
Carmo, J	1
Bispo, M	1
Beppu, N	1
Fumihiko, K	1
Hiroshi, D	1
Norihiko, K	1
Matsubara, N	1
Tomita, N	1
Yanagi, H	1
Yamanaka, N	1
Bello, FH	1
Maiha, BB	1
Anuka, JA	1
Ben Barka, Z	1
Aouadhi, C	1
Tlili, M	1
Alimi, H	1
Ben Miled, H	1
Ben Rhouma, K	1
Ksouri, R	1
Schneider, YJ	1
Maaroufi, A	1
Talley, NJ	1
Kinuthia, DG	1
Muriithi, AW	1
Mwangi, PW	1
Long, WM	1
Sinnott, VB	1
Bracker, K	1
Thomas, D	1
Sökeland, J	1
Sanders, JW	1
Frenck, RW	1
Putnam, SD	1
Johnston, JR	1
Ulukan, S	1
Rockabrand, DM	1
Monteville, MR	1
Kato, H	5
Iwashima, Y	1
Nakamura, M	2
Nakamura, A	2
Ueda, R	1
De Bruyn, G	1
Hirotani, Y	1
Mikajiri, K	1
Ikeda, K	1
Myotoku, M	1
Kurokawa, N	1
Butler, T	1
Arnold, S	1
Tu, XH	1
Chen, ZY	1
Bereznikov, AV	1
Mordyk, AV	1
Lysov, AV	1
Konev, VP	1
Ojewole, JA	1
Awe, EO	1
Chiwororo, WD	1
Shah, AJ	2
Gowani, SA	1
Zuberi, AJ	1
Ghayur, MN	1
Gould, M	1
Sellin, JH	1
Molist Gasa, F	1
Ywazaki, M	1
Gómez de Segura Ugalde, A	1
Hermes, RG	1
Gasa Gasó, J	1
Pérez Hernández, JF	1
Gallelli, L	1
Colosimo, M	1
Tolotta, GA	1
Falcone, D	1
Luberto, L	1
Curto, LS	1
Rende, P	1
Mazzei, F	1
Marigliano, NM	1
De Sarro, G	1
Cucchiara, S	1
Moriya, R	1
Shirakura, T	1
Hirose, H	1
Kanno, T	1
Suzuki, J	1
Kanatani, A	1
Layer, P	1
Andresen, V	1
Karim, A	1
Mekhfi, H	1
Ziyyat, A	1
Legssyer, A	1
Bnouham, M	1
Amrani, S	1
Atmani, F	1
Melhaoui, A	1
Aziz, M	1
Bhulani, NN	1
Khan, SH	1
Ur Rehman, N	1
Pitzurra, R	1
Steffen, R	6
Tschopp, A	2
Mutsch, M	1
Kakino, M	1
Izuta, H	1
Ito, T	1
Tsuruma, K	1
Araki, Y	1
Shimazawa, M	1
Oyama, M	1
Iinuma, M	1
Hara, H	1
Kuhn, BR	1
Mezoff, AG	1
Regnard, C	1
Twycross, R	1
Mihalyo, M	1
Wilcock, A	1
Placidi, E	1
Marciani, L	1
Hoad, CL	1
Napolitano, A	1
Garsed, KC	1
Pritchard, SE	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088]	Phase 2/Phase 3	0 participants (Actual)	Interventional	2022-07-01	Withdrawn (stopped due to This study did not enroll any subjects)
Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded Cross-over Study[NCT02266849]	Phase 3	12 participants (Actual)	Interventional	2014-10-31	Terminated (stopped due to Insuficcient recruiting)
Evaluating the Efficacy of a Standardized Hydration Protocol After Ileostomy Creation[NCT04669964]		0 participants (Actual)	Observational	2023-01-01	Withdrawn (stopped due to Change in routine care was not implemented at organization)
A Randomized, Double-Blind, Clinical Trial Evaluating Three Single Dose Regimens With Loperamide for Treatment of Ambulatory Watery Travelers' Diarrhea, and Azithromycin With and Without Loperamide for Treatment of Ambulatory Dysentery/Febrile Diarrhea[NCT01618591]		384 participants (Actual)	Interventional	2012-09-30	Terminated (stopped due to AWD arm was completed. ADF diarrhea arm was unable to fill completely and there are no funds remaining to continue recruiting/enrolling.)
Distinct Shifts in the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism[NCT03574051]	Early Phase 1	30 participants (Anticipated)	Interventional	2018-05-01	Recruiting
LARCID: Evaluation of Octreotide LAR in Prevention of Chemotherapy-induced Diarrhea[NCT00582426]	Phase 3	139 participants (Actual)	Interventional	2008-04-30	Completed
A Randomized, Parallel Group Comparison of Loperamide/Simeticone Caplet, Loperamide/Simeticone Chewable Tablet (IMODIUM® PLUS) and a Probiotic (Saccharomyces Boulardii) in the Treatment of Acute Diarrhea in Adults[NCT00807326]	Phase 4	415 participants (Actual)	Interventional	2008-11-30	Completed
An Open-label, Randomized, Fasting, Two-period, Single-dose, Crossover Study to Assess Bioequivalence Between a Combination Caplet With Loperamide Hydrochloride and Simethicone (Janssen-Cilag, France), and Imodium® Express Tablets-lyophilizate (Janssen-Ci[NCT04186936]	Phase 1	48 participants (Actual)	Interventional	2019-12-05	Completed
Effects of Rifaximin on Visceral Hypersensitivity in Irritable Bowel Syndrome[NCT03462966]	Phase 2	4 participants (Actual)	Interventional	2018-07-01	Terminated (stopped due to recruitment challenges)
Effect of Physical Form of Apples on Gastrointestinal Function and Satiety: a MRI Study[NCT03714464]		31 participants (Actual)	Interventional	2016-02-29	Completed
Double Blind, Placebo-Controlled Trial Assessing the Efficacy of Rifaximin in Preventing Campylobacteriosis in Subjects Challenged With Campylobacter Jejuni[NCT02280044]	Phase 2/Phase 3	30 participants (Actual)	Interventional	2014-10-31	Completed
Brain and Whole Body Imaging of P-Glycoprotein Function Using [11C]dLop[NCT00605254]		58 participants (Actual)	Observational	2008-01-24	Completed
Treatment of Diarrhea-Associated Fecal Incontinence With Eluxadoline[NCT03489265]	Phase 2	0 participants (Actual)	Interventional	2019-04-30	Withdrawn (stopped due to Difficult to recruit severely affected patients with fecal incontinence)
Single Blinded Randomised Cross-over Study of Imodium Tablets Versus Imodium Syrup for the Treatment of Faecal Incontinence[NCT00933465]	Phase 4	0 participants (Actual)	Interventional	2009-10-31	Withdrawn
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Quality of life (QoL) is evaluated using FACIT-D scale. FACIT-D is composed of 38 items, whose responses range from 0 to 4. The total FACIT-D score may range from 0 to 152. The 38 items compose five subscales, each evaluating a different component of the (QOL). For calculating the subscale score, some items are computed in a reverse fashion, so that higher FACIT-D scores indicate a better (QoL). Descriptive statistics (mean, standard deviation, median, minimum and maximum) are used to summarize FACIT-D scores (total and subscales) by study group at each time point. (NCT00582426)
Timeframe: Baseline to Day 168

Number of Episodes of Diarrhea by Patient

Intervention	Units on a scale (Mean)
Octreotide Long Acting Release	0.5
Standard Treatment	3.4

Number of episodes of diarrhea is evaluated by patient diaries recorded on a daily basis. (NCT00582426)
Timeframe: 6 months overall

Percentage of Participants Developing Diarrhea (Grade 1 to 4)

Intervention	Episodes/patients/day (Mean)
Octreotide Long Acting Release	21.6
Standard Treatment	20.4

The percentage of patients developing diarrhea (incidence of grade 1 to 4) during treatment, considering only the worst grade of diarrhea for each patient. Diarrhea was graded according to Common Toxicity Criteria where Grade 0=None, 1 = Increase of <4 stools/day over pretreatment, Grade 2 = Increase of 4-6 stools/day, or nocturnal stools, Grade 3 = Increase of ≥7 stools/day or incontinence; or need for parenteral support for dehydration and Grade 4= Physiologic consequences requiring intensive care; or hemodynamic collapse. (NCT00582426)
Timeframe: 6 month overall

Percentage of Participants Who Need Chemotherapy Dose Reduction Due to Diarrhea

Intervention	Percentage of Participants (Number)
Octreotide Long Acting Release	76.1
Standard Treatment	78.9

For patient, chemotherapy dose reduction due to diarrhea as counted each time it occurred. Chemotherapy dose reduction because of other adverse events related to chemotherapy was not considered. (NCT00582426)
Timeframe: 6 months overall

Percentage of Participants Who Need Intravenous Hydration for Control of Diarrhea

Percentage of Participants Who Need Opioids for Control of Diarrhea

Percentage of Patients Hospitalized Due to Diarrhea

Number of Episodes of Diarrhea by Patient by Cycle

Intervention	Percentage of participants (Number)
Octreotide Long Acting Release	26.9
Standard Treatment	11.3

Intervention	Percentage of Participants (Number)
Octreotide Long Acting Release	4.5
Standard Treatment	7.0

Intervention	Percentage of Participants (Number)
Octreotide Long Acting Release	1.5
Standard Treatment	1.4

Intervention	Percentage of patients (Number)
Octreotide Long Acting Release	6
Standard Treatment	4.2

Mean number of episodes of diarrhea is evaluated by patient diaries recorded by cycle. (cycle 1 to cycle 7.) (NCT00582426)
Timeframe: at each cycle (28 days per cycle)

Percentage of Episodes by Grade

Intervention	Episodes/patient/cycle (Mean)
	Cycle 1 (n=20, 18)	Cycle 2 (n=36,38)	Cycle 3 (n=33,39)	Cycle 4 (n=24, 27)	Cycle 5 (n=20,29)	Cycle 6 (n=22, 22)	Cycle 7 (n= 16, 20)
Octreotide Long Acting Release	2.6	8.2	6.9	8.6	8.1	6.1	4.8
Standard Treatment	2.2	5.9	6.7	7.1	7	5.8	6.6

Grade (severity)of episodes of diarrhea is evaluated by patient diaries recorded on a daily basis by considering only worse grade of diarrhea for each patient. Diarrhea was graded according to Common Toxicity Criteria where Grade 1 = Increase of <4 stools/day over pretreatment, Grade 2 = Increase of 4-6 stools/day, or nocturnal stools, Grade 3 = Increase of ≥7 stools/day or incontinence;or need for parenteral support for dehydration and Grade 4= Physiologic consequences requiring intensive care; or hemodynamic collapse. (NCT00582426)
Timeframe: 6 months overall

Percentage of Participants With Complete or Partial Response at Response Evaluation Criteria in Solid Tumors (RECIST)

Intervention	Percentage of Episodes (Number)
	Grade 1	Grade 2	Grade 3	Grade 4
Octreotide Long Acting Release	65.4	23.3	11.3	0
Standard Treatment	66.9	27.2	5.9	0

Lesions that can be accurately measured in at least one dimension (longest diameter (LD) to be recorded) as > 20 mm with conventional techniques (CT, MRI) or as > 10 mm with spiral CT scan. All measurable lesions up to maximum of 5 lesions per organ and 10 lesions in total representative of all involved organs should be identified as target lesions and recorded and measured at baseline. Complete Response is defined as Disappearance of all target lesions. Partial Response is defined at least a 30% decrease in the sum of LD of target lesions taking as reference the baseline sum LD. (NCT00582426)
Timeframe: Day 56, Day 84, Day 112, Day 140, Day 168

Percentage of Patients by Grade of Diarrhea

Intervention	Percentage of Participants (Number)
	Day 56 (N=11,2)	Day 84 (N=5,3)	Day 112 (N=1,1)	Day 140 (N=9,1)	Day 168 (N=2,1)
Octreotide Long Acting Release	45.5	60.0	100	44.4	100
Standard Treatment	0.0	100	0.0	100	100

Grade (severity) of episodes of diarrhea is evaluated by patient diaries recorded on a daily basis by considering only worse grade of diarrhea for each patient. Diarrhea was graded according to Common Toxicity Criteria where Grade 0 = None, 1 = Increase of <4 stools/day over pretreatment, Grade 2 = Increase of 4-6 stools/day, or nocturnal stools, Grade 3 = Increase of ≥7 stools/day or incontinence; or need for parenteral support for dehydration and Grade 4= Physiologic consequences requiring intensive care; or hemodynamic collapse. (NCT00582426)
Timeframe: 6 months overall

Association of Urgency Symptom and Rectal Sensitivity Testing.

Intervention	Percentage of Participants (Number)
	Grade 1	Grade 2	Grade 3	Grade 4
Octreotide Long Acting Release	41.2	25.5	33.3	0
Standard Treatment	26.8	51.8	21.4	0

Association of urgency symptom and rectal sensitivity will be evaluated by the mean change in the balloon pressure (measured in mmHg) that leads to first urge sensation to defecate, evaluated based on the visual analogue scale defined in the primary outcome measure. (NCT03462966)
Timeframe: After completing 14-day course of rifaximin.

Mean Change in the Balloon Volume (Measured in Cubic Centimeter) That Leads to First Urge to Defecate.

Intervention	Millimetre of mercury (Mean)
Therapeutic	106

A 100-cubic centimeter visual analogue scale with verbal descriptors (0=no sensation, 20=first sensation, 40=first sense of urge, 60=normal urge to defecate, 80=severe urge to defecate, and 100=discomfort/pain) will be used to score evoked sensations. (NCT03462966)
Timeframe: After completing 14-day course of rifaximin.

Number of Participants With a Rise of Hydrogen <20 Parts Per Million Within 90 Minutes of Lactulose Ingestion.(Which is Considered Normal )

Intervention	volume cubic centimeter (Mean)
Therapeutic	37.5

"Normalization of lactulose breath test as a potential predictor of improvement of rectal hypersensitivity will be evaluated by comparing lactulose breath test results pre- and post-treatment.~Normalization of lactulose breath test defined as rise of hydrogen <20 Parts per million within 90 minutes of lactulose ingestion.~patients with positive" (NCT03462966)
Timeframe: After completing 14-day course of rifaximin

Campylobacteriosis

Intervention	Participants (Count of Participants)
Therapeutic	2

"A clinical illness meeting at least one of the following patterns:~Moderate to severe diarrhea.~Fever (present on at least 2 occasions, at least 20 minutes apart) without diarrhea, plus an associated symptom (nausea, vomiting, abdominal cramps, tenesmus, or gross blood in ≥ 2 stools); with consideration of potential alternative diagnosis per clinical investigator based on illness time course and associated symptoms." (NCT02280044)
Timeframe: 120 hours after challenge

Recrudescent Events

Intervention	Participants (Count of Participants)
Rifaximin	13
Placebo	11

Recovered C jejuni from fecal specimen on follow-up after an apparent cure (NCT02280044)
Timeframe: 84 Days

Article	Year
Pathophysiology, Differential Diagnosis, and Treatment of Diabetic Diarrhea. Digestive diseases and sciences, 2019, Volume: 64, Issue:12 Topics: Antidiarrheals; Autonomic Nervous System Diseases; Blind Loop Syndrome; Celiac Disease; Diabetes Mel	2019
Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:4 Topics: Adult; Antidiarrheals; Critical Illness; Diarrhea; Diet Therapy; Diphenoxylate; Gastrointestinal Mot	2019
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. Revista espanola de enfermedades digestivas, 2020, Volume: 112, Issue:1 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antidiarrheals; Antimetabolites; Azathioprine; Bi	2020
Enkephalinases as a new pharmacological target in the treatment of gastrointestinal tract disorders Postepy biochemii, 2020, 09-30, Volume: 66, Issue:3 Topics: Antidiarrheals; Diarrhea; Gastrointestinal Diseases; Humans; Inflammatory Bowel Diseases; Irritable	2020
Clinical Review: Loperamide Toxicity. Annals of emergency medicine, 2017, Volume: 70, Issue:2 Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Diarrhea; Drug Overdose; Humans; Loperamide; Opioid-Relate	2017
Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2018, Volume: 24, Issue:8 Topics: Antidiarrheals; Arrhythmias, Cardiac; Diarrhea; Dose-Response Relationship, Drug; Female; Heart Arre	2018
Loperamide cardiotoxicity: "A Brief Review". Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2018, Volume: 23, Issue:2 Topics: Antidiarrheals; Cardiotoxicity; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Sche	2018
Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. PloS one, 2018, Volume: 13, Issue:12 Topics: Antidiarrheals; Bayes Theorem; Child; Diarrhea; Gastroenteritis; Humans; Loperamide; Network Meta-An	2018
Chronic diarrhoea in adults: what not to miss. Current opinion in gastroenterology, 2019, Volume: 35, Issue:3 Topics: Adenocarcinoma; Adenoma; Antidiarrheals; Bile Acids and Salts; Celiac Disease; Chronic Disease; Colo	2019
[Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. Schmerz (Berlin, Germany), 2013, Volume: 27, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Antidiarrheals; Controlled Clinical Trials as Topic; Diarrhea; D	2013
[Antidiarrheal drugs for chronic diarrhea]. Deutsche medizinische Wochenschrift (1946), 2013, Volume: 138, Issue:45 Topics: Antidiarrheals; Cholestyramine Resin; Cholinergic Antagonists; Chronic Disease; Diarrhea; Humans; La	2013
Acute infectious diarrhea in immunocompetent adults. The New England journal of medicine, 2014, Apr-17, Volume: 370, Issue:16 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Antidiarrheals; Caliciviridae Infections; Diagnosis, Di	2014
[The treatment of acute diarrhea]. Journal de pharmacie de Belgique, 2013, Issue:3 Topics: Adult; Anti-Bacterial Agents; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Loperamide; Pr	2013
Irritable bowel syndrome in adults in primary care: summary of updated NICE guidance. BMJ (Clinical research ed.), 2015, Feb-25, Volume: 350 Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Constipation; Diarrhea; Diet Therapy; Humans; Irri	2015
[Loperamide for acute infectious diarrhoea]. Nederlands tijdschrift voor geneeskunde, 2015, Volume: 159 Topics: Acute Disease; Anti-Bacterial Agents; Antidiarrheals; Communicable Diseases; Diarrhea; Dysentery; Hu	2015
Current and emerging drug options in the treatment of diarrhea predominant irritable bowel syndrome. Expert opinion on pharmacotherapy, 2015, Volume: 16, Issue:18 Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Carbolines; Diarrhea; Gastrointestinal Agents; Hum	2015
Emerging treatments in neurogastroenterology: eluxadoline - a new therapeutic option for diarrhea-predominant IBS. Neurogastroenterology and motility, 2016, Volume: 28, Issue:1 Topics: Antidiarrheals; Carbolines; Diarrhea; Gastrointestinal Agents; Humans; Imidazoles; Irritable Bowel S	2016
Effect of adjunctive loperamide in combination with antibiotics on treatment outcomes in traveler's diarrhea: a systematic review and meta-analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Oct-15, Volume: 47, Issue:8 Topics: Adult; Anti-Bacterial Agents; Clinical Trials as Topic; Diarrhea; Drug Therapy, Combination; Humans;	2008
Review article: rifaximin, a minimally absorbed oral antibacterial, for the treatment of travellers' diarrhoea. Alimentary pharmacology & therapeutics, 2010, Volume: 31, Issue:11 Topics: Administration, Oral; Anti-Infective Agents; Antidiarrheals; Ciprofloxacin; Diarrhea; Humans; Lopera	2010
Loperamide. Journal of pain and symptom management, 2011, Volume: 42, Issue:2 Topics: Antidiarrheals; Diarrhea; Drug Interactions; Humans; Loperamide	2011
[Rational approach to the patient with diarrhea]. MMW Fortschritte der Medizin, 2012, Jun-21, Volume: O 154 Suppl 2 Topics: Acute Disease; Antidiarrheals; Chronic Disease; Diagnosis, Differential; Diarrhea; Fluid Therapy; Hu	2012
Irritable bowel syndrome--diarrhoea. Best practice & research. Clinical gastroenterology, 2012, Volume: 26, Issue:5 Topics: Anti-Bacterial Agents; Antidepressive Agents, Tricyclic; Antidiarrheals; Constipation; Defecation; D	2012
[Travellers' acute diarrhea]. Revue medicale de la Suisse romande, 2002, Volume: 122, Issue:9 Topics: Anti-Infective Agents; Antidiarrheals; Diarrhea; Drug Therapy, Combination; Fluid Therapy; Fluoroqui	2002
Racecadotril versus loperamide: antidiarrheal research revisited. Digestive diseases and sciences, 2003, Volume: 48, Issue:2 Topics: Adolescent; Adult; Antidiarrheals; Child; Child, Preschool; Controlled Clinical Trials as Topic; Dia	2003
Management of acute cancer treatment-induced diarrhea. Seminars in oncology nursing, 2003, Volume: 19, Issue:4 Suppl 3 Topics: Antidiarrheals; Antineoplastic Combined Chemotherapy Protocols; Atropine; Diarrhea; Diphenoxylate; H	2003
New approaches to prevent intestinal toxicity of irinotecan-based regimens. Cancer treatment reviews, 2004, Volume: 30, Issue:6 Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Col	2004
[Traveller's diarrhea]. Ugeskrift for laeger, 2005, Oct-24, Volume: 167, Issue:43 Topics: Antibiotic Prophylaxis; Antidiarrheals; Diarrhea; Humans; Loperamide; Probiotics; Risk Factors; Trav	2005
New views on antidiarrheal effect of wood creosote: is wood creosote really a gastrointestinal antiseptic? Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2005, Volume: 125, Issue:12 Topics: Animals; Anti-Infective Agents; Antidiarrheals; Calcium; Chlorine; Clinical Trials as Topic; Colon;	2005
Prevention and self-treatment of traveler's diarrhea. Clinical microbiology reviews, 2006, Volume: 19, Issue:3 Topics: Anti-Infective Agents; Antibiotic Prophylaxis; Antidiarrheals; Developing Countries; Diarrhea; Femal	2006
[Drug treatment of irritable bowel syndrome: an unmet need]. Gastroenterologia y hepatologia, 2007, Volume: 30, Issue:3 Topics: Abdominal Pain; Analgesics; Antidepressive Agents, Tricyclic; Antidiarrheals; Carbolines; Controlled	2007
Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. PLoS medicine, 2007, Mar-27, Volume: 4, Issue:3 Topics: Age Factors; Child; Child, Preschool; Dehydration; Diarrhea; Humans; Infant; Loperamide; Models, Sta	2007
Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions. Reviews in gastroenterological disorders, 2007, Volume: 7 Suppl 3 Topics: Animals; Antidiarrheals; Colitis, Ulcerative; Crohn Disease; Diarrhea; Gastrointestinal Transit; Hum	2007
Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review. Zeitschrift fur Gastroenterologie, 2008, Volume: 46, Issue:5 Topics: Abdominal Neoplasms; Acute Disease; Chronic Disease; Combined Modality Therapy; Controlled Clinical	2008
The role of loperamide in gastrointestinal disorders. Reviews in gastroenterological disorders, 2008,Winter, Volume: 8, Issue:1 Topics: Antidiarrheals; Diarrhea; Fecal Incontinence; Humans; Irritable Bowel Syndrome; Loperamide	2008
Pharmacology of antidiarrheal drugs. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele	1983
Pharmacology of antidiarrheal drugs. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele	1983
Pharmacology of antidiarrheal drugs. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele	1983
Pharmacology of antidiarrheal drugs. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele	1983
Speculations on the role of motility in the pathogenesis and treatment of diarrhoea. Scandinavian journal of gastroenterology. Supplement, 1983, Volume: 84 Topics: Animals; Body Water; Colon; Diarrhea; Dogs; Electrolytes; Gastrointestinal Motility; Humans; Intesti	1983
Alterations in intestinal fluid movement. Scandinavian journal of gastroenterology. Supplement, 1983, Volume: 84 Topics: Acetylcholine; Animals; Catecholamines; Colon; Diarrhea; Dogs; Fluid Therapy; Gastrointestinal Motil	1983
Loperamide. Survey of studies on mechanism of its antidiarrheal activity. Digestive diseases and sciences, 1993, Volume: 38, Issue:6 Topics: Animals; Diarrhea; Drug Evaluation; Drug Evaluation, Preclinical; Gastrointestinal Motility; Gastroi	1993
[Taxotere (docetaxel) and CPT 11 (irinotecan): phase I trials]. Bulletin du cancer, 1996, Volume: 83, Issue:1 Topics: Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Docetaxel; Dose-Response	1996
Insights into opioid action in the intestinal tract. Pharmacology & therapeutics, 1996, Volume: 69, Issue:2 Topics: Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Diarrhea; Gastrointestinal Motility; Guin	1996
[Traveller's diarrhea]. Deutsche medizinische Wochenschrift (1946), 1998, Apr-24, Volume: 123, Issue:17 Topics: Anti-Infective Agents; Antidiarrheals; Bacterial Infections; Diarrhea; Diet; Electrolytes; Feces; Fl	1998
Guidelines for adults on self-medication for the treatment of acute diarrhoea. Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:6 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Antidiarrheals; Child; Chronic	2001
[Travelers' diarrhea]. Therapeutische Umschau. Revue therapeutique, 2001, Volume: 58, Issue:6 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antidiarrheals; Bacterial Infect	2001
Clinical evaluation and management of acute infectious diarrhea in adults. Gastroenterology clinics of North America, 2001, Volume: 30, Issue:3 Topics: Acute Disease; Adult; Antidiarrheals; Cost-Benefit Analysis; Diarrhea; Feces; Fluid Therapy; Humans;	2001
Traveler's diarrhea. Gastroenterology clinics of North America, 2001, Volume: 30, Issue:3 Topics: Adolescent; Adult; Antidiarrheals; Aztreonam; Benzimidazoles; Diarrhea; Humans; Infant; Loperamide;	2001
[Surgical and dietetic problems of subtotal resection of the small intestine in adults (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1978, Nov-10, Volume: 120, Issue:45 Topics: Adaptation, Physiological; Aged; Diarrhea; Female; Fluid Therapy; Humans; Intestine, Small; Loperami	1978
Loperamide: a review of its pharmacological properties and therapeutic efficacy in diarrhoea. Drugs, 1978, Volume: 15, Issue:1 Topics: Acute Disease; Animals; Chronic Disease; Clinical Trials as Topic; Diarrhea; Gastrointestinal Motili	1978
Pharmacotherapy of diarrhea. The Journal of the Maine Medical Association, 1979, Volume: 70, Issue:5 Topics: Antidiarrheals; Cholera; Cholestyramine Resin; Colon; Diarrhea; Diphenoxylate; Fluid Therapy; Giardi	1979
[Prevention and treatment of traveler's diarrhea]. Nordisk medicin, 1992, Volume: 107, Issue:11 Topics: Anti-Bacterial Agents; Developing Countries; Diarrhea; Diet; Humans; Loperamide; Risk Factors; Trave	1992
Safety and efficacy of loperamide. The American journal of medicine, 1990, Jun-20, Volume: 88, Issue:6A Topics: Acute Disease; Clinical Trials as Topic; Diarrhea; Dose-Response Relationship, Drug; Humans; Loperam	1990
Loperamide hydrochloride. American pharmacy, 1990, Volume: NS30, Issue:12 Topics: Animals; Diarrhea; Drug Administration Schedule; Drug Interactions; Female; Humans; Loperamide; Nonp	1990
Pathogenesis and pharmacology of diarrhea. Veterinary research communications, 1986, Volume: 10, Issue:5 Topics: Acetylcholine; Animals; Antidiarrheals; Bacterial Toxins; Biological Transport; Calcium; Catecholami	1986
Opioid action of the intestine: the importance of the intestinal mucosa. Life sciences, 1987, Aug-24, Volume: 41, Issue:8 Topics: Antidiarrheals; Body Water; Diarrhea; Diphenoxylate; Humans; Intestinal Mucosa; Intestines; Loperami	1987
Nonfluid therapy and selected chemoprophylaxis of acute diarrhea. The American journal of medicine, 1985, Jun-28, Volume: 78, Issue:6B Topics: Acute Disease; Adult; Anti-Infective Agents; Bismuth; Campylobacter Infections; Child; Child, Presch	1985

Article	Year
An open label, randomized phase 2 trial assessing the impact of food on the tolerability of abemaciclib in patients with advanced breast cancer. Breast cancer research and treatment, 2022, Volume: 195, Issue:3 Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Breast Neoplasms; Di	2022
Effects of Modified Baizhu Shaoyao San on Postoperative Diarrhea in Colorectal Cancer Patients: A Single-Blind, Randomized Controlled Trial. Complementary medicine research, 2023, Volume: 30, Issue:1 Topics: Colorectal Neoplasms; Diarrhea; Gastrins; Gastrointestinal Diseases; Humans; Loperamide; Motilin; Si	2023
Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B). Breast (Edinburgh, Scotland), 2023, Volume: 71 Topics: Breast Neoplasms; Constipation; Diarrhea; Female; Humans; Loperamide; Probiotics; Quality of Life; T	2023
Crofelemer for the Management of Neratinib-Associated Diarrhea in Patients With HER2+ Early-Stage Breast Cancer. Clinical breast cancer, 2023, Volume: 23, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diarrhea; Female; Humans; Loperami	2023
Eluxadoline Efficacy in IBS-D Patients Who Report Prior Loperamide Use. The American journal of gastroenterology, 2017, Volume: 112, Issue:6 Topics: Abdominal Pain; Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Female; Gastrointestinal Agent	2017
The Acute Effect of Loperamide on Ileostomy Output: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study. Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:6 Topics: Aged; Antidiarrheals; Cross-Over Studies; Diarrhea; Double-Blind Method; Female; Gastrointestinal Tr	2017
The Acute Effect of Loperamide on Ileostomy Output: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study. Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:6 Topics: Aged; Antidiarrheals; Cross-Over Studies; Diarrhea; Double-Blind Method; Female; Gastrointestinal Tr	2017
The Acute Effect of Loperamide on Ileostomy Output: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study. Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:6 Topics: Aged; Antidiarrheals; Cross-Over Studies; Diarrhea; Double-Blind Method; Female; Gastrointestinal Tr	2017
The Acute Effect of Loperamide on Ileostomy Output: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study. Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:6 Topics: Aged; Antidiarrheals; Cross-Over Studies; Diarrhea; Double-Blind Method; Female; Gastrointestinal Tr	2017
Trial Evaluating Ambulatory Therapy of Travelers' Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017, Nov-29, Volume: 65, Issue:12 Topics: Acute Disease; Adult; Afghanistan; Anti-Bacterial Agents; Azithromycin; Diarrhea; Djibouti; Double-B	2017
Effect of Probiotics for the Prevention of Acute Radiation-Induced Diarrhoea Among Cervical Cancer Patients: a Randomized Double-Blind Placebo-Controlled Study. Probiotics and antimicrobial proteins, 2019, Volume: 11, Issue:2 Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Middle Aged; Probio	2019
Assessment of the administration of maropitant and loperamide to dogs with cancer for the prevention and reduction of adverse effects associated with the administration of paclitaxel. American journal of veterinary research, 2019, Volume: 80, Issue:6 Topics: Animals; Antidiarrheals; Antiemetics; Antineoplastic Agents, Phytogenic; Diarrhea; Dog Diseases; Dog	2019
Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study. The American journal of gastroenterology, 2019, Volume: 114, Issue:9 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diarrhea; Double-Blind Method; Female; Gastrointestinal	2019
Randomized phase III trial exploring the use of long-acting release octreotide in the prevention of chemotherapy-induced diarrhea in patients with colorectal cancer: the LARCID trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Apr-01, Volume: 32, Issue:10 Topics: Adult; Aged; Antidiarrheals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitab	2014
Comparison of Two Forms of Loperamide-Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial. Drugs in R&D, 2015, Volume: 15, Issue:4 Topics: Acute Disease; Adult; Aged; Diarrhea; Drug Combinations; Female; Humans; Loperamide; Male; Middle Ag	2015
Comparison of Two Forms of Loperamide-Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial. Drugs in R&D, 2015, Volume: 15, Issue:4 Topics: Acute Disease; Adult; Aged; Diarrhea; Drug Combinations; Female; Humans; Loperamide; Male; Middle Ag	2015
Comparison of Two Forms of Loperamide-Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial. Drugs in R&D, 2015, Volume: 15, Issue:4 Topics: Acute Disease; Adult; Aged; Diarrhea; Drug Combinations; Female; Humans; Loperamide; Male; Middle Ag	2015
Comparison of Two Forms of Loperamide-Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial. Drugs in R&D, 2015, Volume: 15, Issue:4 Topics: Acute Disease; Adult; Aged; Diarrhea; Drug Combinations; Female; Humans; Loperamide; Male; Middle Ag	2015
Azithromycin and loperamide are comparable to levofloxacin and loperamide for the treatment of traveler's diarrhea in United States military personnel in Turkey. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Volume: 45, Issue:3 Topics: Adult; Azithromycin; Campylobacter Infections; Diarrhea; Double-Blind Method; Drug Therapy, Combinat	2007
[Clinical efficacy of buzhong yiqi pill combined with imodium in treating post-operational diarrhea in patients of colonic cancer]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2008, Volume: 28, Issue:8 Topics: Adult; Aged; Colonic Neoplasms; Diarrhea; Drug Therapy, Combination; Drugs, Chinese Herbal; Female;	2008
Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. European journal of clinical pharmacology, 2010, Volume: 66, Issue:2 Topics: Abdominal Pain; Aged; Aged, 80 and over; Aging; Antidiarrheals; Cytochrome P-450 Enzyme System; Dehy	2010
The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea. Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:1 Topics: Adult; Antidiarrheals; Antifoaming Agents; Body Water; Cross-Over Studies; Diarrhea; Double-Blind Me	2012
A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults. Scandinavian journal of gastroenterology, 2002, Volume: 37, Issue:6 Topics: Acute Disease; Administration, Oral; Adult; Antidiarrheals; Diarrhea; Dose-Response Relationship, Dr	2002
Yogic versus conventional treatment in diarrhea-predominant irritable bowel syndrome: a randomized control study. Applied psychophysiology and biofeedback, 2004, Volume: 29, Issue:1 Topics: Adult; Antidiarrheals; Diarrhea; Digestive System; Electrophysiology; Heart Rate; Humans; Irritable	2004
The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea. Romanian journal of internal medicine = Revue roumaine de medecine interne, 2004, Volume: 42, Issue:1 Topics: Adult; Antidiarrheals; Chronic Disease; Diarrhea; Female; Humans; Loperamide; Male; Middle Aged; Pro	2004
Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea. Clinical therapeutics, 2004, Volume: 26, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Colic; Creosote; Diarrhea; Double-Blind	2004
A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. World journal of gastroenterology, 2005, Mar-14, Volume: 11, Issue:10 Topics: Acute Disease; Adult; Antidiarrheals; Constipation; Diarrhea; Female; Humans; Loperamide; Male; Midd	2005
Use of probiotics for prevention of radiation-induced diarrhea. World journal of gastroenterology, 2007, Feb-14, Volume: 13, Issue:6 Topics: Antidiarrheals; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Double-Blind Method;	2007
Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide alone. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007, Volume: 5, Issue:4 Topics: Adolescent; Adult; Anti-Infective Agents; Diarrhea; Dose-Response Relationship, Drug; Double-Blind M	2007
Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort. Current medical research and opinion, 2007, Volume: 23, Issue:5 Topics: Abdominal Pain; Acute Disease; Adolescent; Adult; Aged; Antidiarrheals; Antifoaming Agents; Diarrhea	2007
Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma. Oncology, 2006, Volume: 71, Issue:5-6 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma; Combined Modality Therapy; Diarrhea; Dose-Response Re	2006
Role of loperamide and placebo in management of irritable bowel syndrome (IBS). Digestive diseases and sciences, 1984, Volume: 29, Issue:3 Topics: Adult; Clinical Trials as Topic; Colonic Diseases, Functional; Consumer Behavior; Diarrhea; Double-B	1984
[Results of a clinical study of the Hungarian preparation Imodium]. Vutreshni bolesti, 1984, Volume: 23, Issue:4 Topics: Adult; Aged; Antidiarrheals; Capsules; Clinical Trials as Topic; Defecation; Diarrhea; Female; Human	1984
Loperamide in acute diarrhoea in childhood: results of a double blind, placebo controlled multicentre clinical trial. Diarrhoeal Diseases Study Group (UK). British medical journal (Clinical research ed.), 1984, Nov-10, Volume: 289, Issue:6454 Topics: Acute Disease; Body Weight; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; D	1984
A comparative study of loperamide and diphenoxylate in the treatment of chronic diarrhoea caused by intestinal resection. Annals of clinical research, 1981, Volume: 13, Issue:6 Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Crohn Disease; Diarrhea; Diphenoxylate; Doub	1981
Diarrhoea following jejuno-ileostomy for morbid obesity. A randomised trial of loperamide and diphenoxylate. Acta chirurgica Scandinavica, 1982, Volume: 148, Issue:2 Topics: Adult; Clinical Trials as Topic; Diarrhea; Diphenoxylate; Female; Humans; Ileum; Isonipecotic Acids;	1982
Loperamide, diphenoxylate, and codeine phosphate in chronic diarrhoea. British medical journal, 1980, Feb-23, Volume: 280, Issue:6213 Topics: Chronic Disease; Clinical Trials as Topic; Codeine; Diarrhea; Diphenoxylate; Double-Blind Method; Hu	1980
Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Gastroenterology, 1980, Volume: 79, Issue:6 Topics: Antidiarrheals; Chronic Disease; Clinical Trials as Topic; Codeine; Diarrhea; Diphenoxylate; Double-	1980
Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Gastroenterology, 1980, Volume: 79, Issue:6 Topics: Antidiarrheals; Chronic Disease; Clinical Trials as Topic; Codeine; Diarrhea; Diphenoxylate; Double-	1980
Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Gastroenterology, 1980, Volume: 79, Issue:6 Topics: Antidiarrheals; Chronic Disease; Clinical Trials as Topic; Codeine; Diarrhea; Diphenoxylate; Double-	1980
Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Gastroenterology, 1980, Volume: 79, Issue:6 Topics: Antidiarrheals; Chronic Disease; Clinical Trials as Topic; Codeine; Diarrhea; Diphenoxylate; Double-	1980
A double-blind crossover study of the effect of loperamide hydrochloride and codeine phosphate on ileostomy output. The Australian and New Zealand journal of surgery, 1982, Volume: 52, Issue:2 Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Codeine; Diarrhea; Double-Blind Method; Electrol	1982
Effects of loperamide on anal sphincter function in patients complaining of chronic diarrhea with fecal incontinence and urgency. Digestive diseases and sciences, 1982, Volume: 27, Issue:9 Topics: Adult; Aged; Anal Canal; Diarrhea; Fecal Incontinence; Female; Humans; Loperamide; Male; Manometry;	1982
Loperamide as a symptomatic treatment in pediatric surgery: a double-blind cross-over study. Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1981, Volume: 32, Issue:3 Topics: Adolescent; Child; Child, Preschool; Diarrhea; Dose-Response Relationship, Drug; Double-Blind Method	1981
Randomized trial of loperamide versus dose escalation of octreotide acetate for chemotherapy-induced diarrhea in bone marrow transplant and leukemia patients. American journal of hematology, 1995, Volume: 50, Issue:3 Topics: Adult; Aged; Antidiarrheals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplanta	1995
Octreotide therapy of large-volume refractory AIDS-associated diarrhea: a randomized controlled trial. AIDS (London, England), 1994, Volume: 8, Issue:11 Topics: Acquired Immunodeficiency Syndrome; Adult; Age of Onset; Diarrhea; Diphenoxylate; Dose-Response Rela	1994
Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. Journal of the National Cancer Institute, 1994, Mar-16, Volume: 86, Issue:6 Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Female; Humans; Irinotecan;	1994
Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy. Anti-cancer drugs, 1993, Volume: 4, Issue:4 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Female; Humans; Inje	1993
Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:1 Topics: Adult; Aged; Diarrhea; Female; Fluorouracil; Humans; Loperamide; Male; Middle Aged; Octreotide	1993
Ciprofloxacin and loperamide in the treatment of bacillary dysentery. Annals of internal medicine, 1993, Apr-15, Volume: 118, Issue:8 Topics: Adult; Ciprofloxacin; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Dysentery, Bacillary	1993
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide. Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:4 Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; T	1993
Gastrointestinal function in chronic radiation enteritis--effects of loperamide-N-oxide. Gut, 1993, Volume: 34, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Diarrhea; Digestive System; Double-Blind Method; En	1993
Loperamide oxide in acute diarrhoea: a double-blind, placebo-controlled trial. The Dutch Diarrhoea Trialists Group. Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:4 Topics: Adolescent; Adult; Aged; Diarrhea; Double-Blind Method; Female; Follow-Up Studies; Humans; Loperamid	1995
Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo-controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:2 Topics: Acute Disease; Adult; Antidiarrheals; Bacteria; Benzimidazoles; Calmodulin; Diarrhea; Double-Blind M	1995
Treatment of travellers' diarrhoea: zaldaride compared with loperamide and placebo. European journal of gastroenterology & hepatology, 1995, Volume: 7, Issue:9 Topics: Adolescent; Adult; Aged; Antidiarrheals; Benzimidazoles; Diarrhea; Double-Blind Method; Drug Adminis	1995
Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:4 Topics: Adenocarcinoma; Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasm	1996
[Taxotere (docetaxel) and CPT 11 (irinotecan): phase I trials]. Bulletin du cancer, 1996, Volume: 83, Issue:1 Topics: Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Docetaxel; Dose-Response	1996
Effects of loperamide oxide on gastrointestinal transit time and anorectal function in patients with chronic diarrhoea and faecal incontinence. Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:1 Topics: Adult; Aged; Anal Canal; Chronic Disease; Cross-Over Studies; Diarrhea; Double-Blind Method; Fecal I	1997
Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:8 Topics: Adult; Aged; Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms;	1998
Substantial activity of budesonide in patients with irinotecan (CPT-11) and 5-fluorouracil induced diarrhea and failure of loperamide treatment. Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:10 Topics: Administration, Oral; Administration, Topical; Aged; Anti-Inflammatory Agents; Antineoplastic Agents	1999
Comparison of racecadotril and loperamide in adults with acute diarrhoea. Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6 Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; P	1999
Comparison of racecadotril and loperamide in children with acute diarrhoea. Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6 Topics: Acute Disease; Antidiarrheals; Child; Child, Preschool; Diarrhea; Double-Blind Method; Female; Human	1999
[Multicenter double-blind clinical trial comparing sucralfate vs placebo in the prevention of diarrhea secondary to pelvic irradiation]. Medicina clinica, 1999, Nov-27, Volume: 113, Issue:18 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Data Interpretation, Statistical; Diarrh	1999
High-dose loperamide in the treatment of 5-fluorouracil-induced diarrhea in colorectal cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2000, Volume: 8, Issue:1 Topics: Administration, Oral; Adult; Aged; Antidiarrheals; Antimetabolites, Antineoplastic; Antineoplastic C	2000
Prospective, controlled, multicentre study of loperamide in pregnancy. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2000, Volume: 14, Issue:3 Topics: Abnormalities, Drug-Induced; Antidiarrheals; Diarrhea; Female; Follow-Up Studies; Humans; Loperamide	2000
Early pregnancy termination with vaginal misoprostol combined with loperamide and acetaminophen prophylaxis. Contraception, 2001, Volume: 63, Issue:4 Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Administration, Intravaginal;	2001
Loperamide, a new antidiarrheal agent in the treatment of chronic diarrhea. Schweizerische medizinische Wochenschrift, 1978, Jul-15, Volume: 108, Issue:28 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Diarrhea; Female; Humans; Long-Term Care; Loperami	1978
Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection. Gut, 1977, Volume: 18, Issue:7 Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Crohn Disease; Diarrhea; Female; Gastrointes	1977
Effect of loperamide on fecal output and composition in well-established ileostomy and ileorectal anastomosis. The American journal of digestive diseases, 1977, Volume: 22, Issue:8 Topics: Adult; Aged; Bile Acids and Salts; Calcium; Chlorides; Clinical Trials as Topic; Diarrhea; Double-Bl	1977
A comparison of lomotil and imodium in acute non-specific diarrhoea. The Journal of international medical research, 1977, Volume: 5, Issue:3 Topics: Acute Disease; Adult; Clinical Trials as Topic; Diarrhea; Diphenoxylate; Female; Humans; Isonipecoti	1977
Loperamide for diarrhea. The Medical letter on drugs and therapeutics, 1977, Sep-09, Volume: 19, Issue:18 Topics: Adult; Biopharmaceutics; Child, Preschool; Clinical Trials as Topic; Diarrhea; Diphenoxylate; Double	1977
Symptomatic treatment of acute self-limiting diarrhoea in adults. The Practitioner, 1977, Volume: 219, Issue:1311 Topics: Clinical Trials as Topic; Diarrhea; Drug Combinations; Humans; Kaolin; Loperamide; Morphine; Piperid	1977
Prostaglandin-induced diarrhoea treated with loperamide or diphenoxylate. A double-blind study. Acta medica Scandinavica, 1977, Volume: 202, Issue:6 Topics: Abortion, Induced; Adult; Blood Pressure; Body Temperature; Capsules; Chemical Phenomena; Chemistry;	1977
Loperamide: a review of its pharmacological properties and therapeutic efficacy in diarrhoea. Drugs, 1978, Volume: 15, Issue:1 Topics: Acute Disease; Animals; Chronic Disease; Clinical Trials as Topic; Diarrhea; Gastrointestinal Motili	1978
Long-term survey of the treatment of diarrhoea with loperamide. Digestion, 1977, Volume: 16, Issue:1-2 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Drug Evaluation; Fe	1977
A double-blind trial of loperamide in the treatment of chronic diarrhoea. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Mar-24, Volume: 55, Issue:13 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chronic Disease; Clinical Trials as Topic; Diarrhe	1979
Multicentre general practice comparison of loperamide and diphenoxylate with atropine in the treatment of acute diarrhoea in adults. The British journal of clinical practice, 1979, Volume: 33, Issue:3 Topics: Acute Disease; Adolescent; Adult; Atropine; Diarrhea; Diphenoxylate; Drug Therapy, Combination; Huma	1979
Loperamide: a new antidiarrheal agent in the treatment of chronic diarrhea. Gastroenterology, 1976, Volume: 70, Issue:6 Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Diarrhea; Female; Humans; Loperamide; Male;	1976
A double blind crossover comparison of loperamide with diphenoxylate in the symptomatic treatment of chronic diarrhea. Gastroenterology, 1976, Volume: 70, Issue:6 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Diarrhea; Diphenoxylate; Feces; Female; Humans; Is	1976
Loperamide in chronic diarrhea and after ileostomy: a placebo-controlled double-blind cross-over study. Archivum chirurgicum Neerlandicum, 1976, Volume: 28, Issue:1 Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Colitis, Ulcerative; Colonic Diseases, Funct	1976
Loperamide in the symptomatic control of chronic diarrhoea. Double-blind placebo-controlled study. Annals of clinical research, 1975, Volume: 7, Issue:5 Topics: Adult; Capsules; Chronic Disease; Clinical Trials as Topic; Diarrhea; Female; Humans; Loperamide; Mi	1975
Optimal dosing of trimethoprim-sulfamethoxazole when used with loperamide to treat traveler's diarrhea. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:12 Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Drug Administration Schedule; Drug Interactions	1992
Treatment of traveler's diarrhea with ciprofloxacin and loperamide. The Journal of infectious diseases, 1992, Volume: 165, Issue:3 Topics: Campylobacter Infections; Ciprofloxacin; Diarrhea; Double-Blind Method; Drug Therapy, Combination; D	1992
Effects of sucralfate on acute and late bowel discomfort following radiotherapy of pelvic cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:6 Topics: Diarrhea; Double-Blind Method; Humans; Intestines; Loperamide; Male; Pelvis; Prostatic Neoplasms; Ra	1992
Treatment of travelers' diarrhea: ciprofloxacin plus loperamide compared with ciprofloxacin alone. A placebo-controlled, randomized trial. Annals of internal medicine, 1991, May-01, Volume: 114, Issue:9 Topics: Ciprofloxacin; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Dysentery, Bacillary; Esche	1991
Acute diarrhoea in expatriates in Bangladesh. Gut, 1990, Volume: 31, Issue:1 Topics: Diarrhea; Drug Combinations; Drug Therapy, Combination; Electrolytes; Glucose; Humans; Loperamide; M	1990
Safety and efficacy of loperamide. The American journal of medicine, 1990, Jun-20, Volume: 88, Issue:6A Topics: Acute Disease; Clinical Trials as Topic; Diarrhea; Dose-Response Relationship, Drug; Humans; Loperam	1990
Comparative efficacy of loperamide hydrochloride and bismuth subsalicylate in the management of acute diarrhea. The American journal of medicine, 1990, Jun-20, Volume: 88, Issue:6A Topics: Acute Disease; Adult; Bismuth; Clinical Trials as Topic; Diarrhea; Dose-Response Relationship, Drug;	1990
A randomized, open-label comparison of nonprescription loperamide and attapulgite in the symptomatic treatment of acute diarrhea. The American journal of medicine, 1990, Jun-20, Volume: 88, Issue:6A Topics: Acute Disease; Adult; Diarrhea; Dose-Response Relationship, Drug; Female; Humans; Loperamide; Magnes	1990
Loperamide (imodium)--clinical trial. Therapia Hungarica (English edition), 1990, Volume: 38, Issue:2 Topics: Acute Disease; Chronic Disease; Clinical Trials as Topic; Diarrhea; Humans; Loperamide; Piperidines	1990
Observations with Imodium in diarrhoeal women. Therapia Hungarica (English edition), 1990, Volume: 38, Issue:3 Topics: Adolescent; Adult; Aged; Defecation; Diarrhea; Female; Humans; Loperamide; Middle Aged	1990
Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide. JAMA, 1990, Jan-12, Volume: 263, Issue:2 Topics: Adult; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Fluid Therapy; Humans; Loperamide;	1990
Loperamide in acute diarrhoea in childhood: results of a double blind, placebo controlled clinical trial. Annals of tropical paediatrics, 1987, Volume: 7, Issue:2 Topics: Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Diarrhea; Dose-Response Relat	1987
Double blind trial of loperamide for treating acute watery diarrhoea in expatriates in Bangladesh. Gut, 1989, Volume: 30, Issue:4 Topics: Acute Disease; Adult; Aged; Bangladesh; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Eur	1989
A double-blind crossover comparison of lidamidine, loperamide and placebo for the control of chronic diarrhoea. Alimentary pharmacology & therapeutics, 1988, Volume: 2, Issue:4 Topics: Adult; Aged; Antidiarrheals; Chronic Disease; Diarrhea; Double-Blind Method; Female; Humans; Loperam	1988
Treatment of chronic diarrhoea: loperamide versus ispaghula husk and calcium. Scandinavian journal of gastroenterology, 1988, Volume: 23, Issue:10 Topics: Adult; Aged; Calcium; Chronic Disease; Clinical Trials as Topic; Diarrhea; Drug Combinations; Female	1988
Loperamide in treatment of irritable bowel syndrome--a double-blind placebo controlled study. Scandinavian journal of gastroenterology. Supplement, 1987, Volume: 130 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Colonic Diseases, Functional; Diarrhea; Double-Bl	1987
Symptomatic treatment of acute infectious diarrhoea: loperamide versus placebo in a double-blind trial. The Journal of infection, 1986, Volume: 12, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Diarrhea; Do	1986
[Effectiveness of imodium in the treatment of patients with peptic ulcer and chronic gastroduodenitis associated with functional intestinal disorders]. Klinicheskaia meditsina, 1986, Volume: 64, Issue:3 Topics: Antidiarrheals; Clinical Trials as Topic; Diarrhea; Duodenitis; Gastroenteritis; Humans; Loperamide;	1986
A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea. Arzneimittel-Forschung, 1986, Volume: 36, Issue:12 Topics: Acute Disease; Antidiarrheals; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Female; Huma	1986
Nonfluid therapy and selected chemoprophylaxis of acute diarrhea. The American journal of medicine, 1985, Jun-28, Volume: 78, Issue:6B Topics: Acute Disease; Adult; Anti-Infective Agents; Bismuth; Campylobacter Infections; Child; Child, Presch	1985
A comparative trial of cholestyramine and loperamide for acute diarrhoea in infants treated as outpatients. Acta paediatrica Scandinavica, 1985, Volume: 74, Issue:5 Topics: Acute Disease; Ambulatory Care; Child, Preschool; Cholestyramine Resin; Clinical Trials as Topic; Di	1985
Human intestinal motor activity and transport: effects of a synthetic opiate. Gastroenterology, 1986, Volume: 90, Issue:1 Topics: Adult; Biological Transport; Colon; Diarrhea; Gastrointestinal Motility; Humans; Ileum; Intestinal A	1986
Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea. JAMA, 1986, Feb-14, Volume: 255, Issue:6 Topics: Acute Disease; Adult; Antidiarrheals; Bismuth; Diarrhea; Humans; Latin America; Loperamide; Organome	1986

Article	Year
Synthesis and antidiarrheal activity of N-(aminoiminomethyl)-1H-pyrrole-1-acetamides related to guanfacine. Journal of medicinal chemistry, 1985, Volume: 28, Issue:11 Topics: Animals; Cardiovascular System; Castor Oil; Chemical Phenomena; Chemistry; Diarrhea; Female; Guanfac	1985
AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Diarrhea. Gastroenterology, 2022, Volume: 163, Issue:1 Topics: Antidepressive Agents, Tricyclic; Diarrhea; Gastrointestinal Agents; Humans; Irritable Bowel Syndrom	2022
Final findings from the CONTROL trial: Strategies to reduce the incidence and severity of neratinib-associated diarrhea in patients with HER2-positive early-stage breast cancer. Breast (Edinburgh, Scotland), 2023, Volume: 67 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Budesonide; Colestipol; Diarrhea;	2023
[Pharmacological treatment of idiopathic diarrhea]. Lakartidningen, 2023, 03-22, Volume: 120 Topics: Antidiarrheals; Diarrhea; Gastrointestinal Agents; Humans; Loperamide	2023
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. Biomolecules, 2023, 09-06, Volume: 13, Issue:9 Topics: Animals; Arrhythmias, Cardiac; Cardiotoxicity; Diarrhea; Guinea Pigs; Heart; Humans; Loperamide; Rab	2023
Efficacy of Eluxadoline in Irritable Bowel Syndrome With Diarrhea. The American journal of gastroenterology, 2020, Volume: 115, Issue:3 Topics: Diarrhea; Humans; Imidazoles; Irritable Bowel Syndrome; Loperamide; Phenylalanine	2020
Response to Black et al. The American journal of gastroenterology, 2020, Volume: 115, Issue:3 Topics: Diarrhea; Humans; Imidazoles; Irritable Bowel Syndrome; Loperamide; Phenylalanine	2020
Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. Pharmacological reports : PR, 2021, Volume: 73, Issue:1 Topics: Animals; Anti-Bacterial Agents; Antidiarrheals; Bacteria; Colon; Diarrhea; Dose-Response Relationshi	2021
Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil-induced diarrhea, oxidative stress, and inflammation in rat. Neurogastroenterology and motility, 2021, Volume: 33, Issue:6 Topics: Animals; Antidiarrheals; Antioxidants; Biphenyl Compounds; Castor Oil; Cathartics; Crataegus; Diarrh	2021
Mechanisms of antidiarrhoeal activity of methanol leaf extract of Combretum hypopilinum diels (combretaceae): Involvement of opioidergic and (α Journal of ethnopharmacology, 2021, Apr-06, Volume: 269 Topics: Animals; Antidiarrheals; Castor Oil; Combretum; Diarrhea; Female; Gastrointestinal Motility; Lethal	2021
Improved work productivity and health-related quality of life in patients with irritable bowel syndrome with diarrhea receiving eluxadoline following inadequate response to loperamide. Journal of managed care & specialty pharmacy, 2021, Volume: 27, Issue:4 Topics: Absenteeism; Adolescent; Adult; Aged; Aged, 80 and over; Diarrhea; Female; Gastrointestinal Agents;	2021
Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139 Topics: Albendazole; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Antidiarrheals; Antipyret	2021
Villous atrophy, an endoscopic and diagnostic challenge. Revista espanola de enfermedades digestivas, 2022, Volume: 114, Issue:3 Topics: Atrophy; Colic; Diarrhea; Female; Humans; Loperamide; Middle Aged	2022
Antibiotic Effects of Loperamide: Homology of Human Targets of Loperamide with Targets in Acanthamoeba spp. Recent patents on anti-infective drug discovery, 2017, Volume: 12, Issue:1 Topics: Acanthamoeba castellanii; Amebicides; Amino Acid Sequence; Anti-Bacterial Agents; Apoptosis; Calcium	2017
Is it worth adding loperamide to antibiotic treatment of travelers diarrhea? Medwave, 2017, May-23, Volume: 17, Issue:Suppl 2 Topics: Anti-Bacterial Agents; Antidiarrheals; Databases, Factual; Diarrhea; Drug Therapy, Combination; Huma	2017
[Diarrhea caused by systemic anti-cancer treatments]. Revue medicale suisse, 2016, Sep-07, Volume: 12, Issue:529 Topics: Antineoplastic Agents; Diarrhea; Humans; Immunotherapy; Loperamide	2016
Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. The American journal of tropical medicine and hygiene, 2017, Volume: 96, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antidiarrheals; Azithromycin; Boston; Ciprofl	2017
Prosecretory effect of loperamide in ileal and colonic mucosae of mice displaying high or low swim stress-induced analgesia associated with high and low endogenous opioid system activity. Neurogastroenterology and motility, 2018, Volume: 30, Issue:2 Topics: Analgesics, Opioid; Animals; Castor Oil; Colon; Diarrhea; Ileum; Intestinal Mucosa; Loperamide; Male	2018
Antidiarrheal and antinociceptive activities of ethanol extract and its chloroform and pet ether fraction of Phrynium imbricatum (Roxb.) leaves in mice. Journal of basic and clinical physiology and pharmacology, 2017, Sep-26, Volume: 28, Issue:5 Topics: Analgesics; Animals; Antidiarrheals; Castor Oil; Chloroform; Diarrhea; Ethanol; Female; Loperamide;	2017
Preface: Guidelines for the Treatment of Travelers' Diarrhea in Deployed Military Personnel. Military medicine, 2017, Volume: 182, Issue:S2 Topics: Anti-Bacterial Agents; Antidiarrheals; Diarrhea; Guidelines as Topic; Humans; Loperamide; Military P	2017
Perianal pseudoverrucous papules and nodules in Hirschsprung's disease: Rapid resolution with oral loperamide. Pediatric dermatology, 2017, Volume: 34, Issue:6 Topics: Antidiarrheals; Child, Preschool; Diaper Rash; Diarrhea; Giardiasis; Hirschsprung Disease; Humans; L	2017
Reverse Effect of Opuntia ficus-indica L. Juice and Seeds Aqueous Extract on Gastric Emptying and Small-Bowel Motility in Rat. Journal of food science, 2018, Volume: 83, Issue:1 Topics: Animals; Antidiarrheals; Constipation; Diarrhea; Dose-Response Relationship, Drug; Fruit; Fruit and	2018
Reply: Labeling and Drug Safety of Loperamide: Time for a Proactive Approach? JACC. Clinical electrophysiology, 2017, Volume: 3, Issue:4 Topics: Diarrhea; Humans; Loperamide; Product Labeling	2017
Community-acquired pseudomembranous colitis precipitated by loperamide. Therapie, 2019, Volume: 74, Issue:4 Topics: Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Community-Acquired Infectio	2019
[Microscopic colitis]. Casopis lekaru ceskych, 2013, Volume: 152, Issue:2 Topics: Adalimumab; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; An	2013
Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves. BMC complementary and alternative medicine, 2013, May-12, Volume: 13 Topics: Animals; Anti-Bacterial Agents; Antidiarrheals; Artemia; Bacteria; Caesalpinia; Defecation; Diarrhea	2013
Studies on the anti-diarrheal properties of leaf extract of Desmodium puchellum. Asian Pacific journal of tropical biomedicine, 2013, Volume: 3, Issue:8 Topics: Alkanes; Animals; Antidiarrheals; Castor Oil; Diarrhea; Fabaceae; Female; Fibrinolytic Agents; Gastr	2013
Travelers' diarrhea: prevention, treatment, and post-trip evaluation. The Journal of family practice, 2013, Volume: 62, Issue:7 Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antidiarrheals; Azithromycin; Beverages; Chemo	2013
Antidiarrhoeal activity of an ethanol extract of the stem bark of Piliostigma reticulatum (Caesalpiniaceae) in rats. African journal of traditional, complementary, and alternative medicines : AJTCAM, 2012, Volume: 9, Issue:2 Topics: Animals; Antidiarrheals; Atropine; Castor Oil; Charcoal; Defecation; Diarrhea; Dose-Response Relatio	2012
Risk factors, preemptive therapy, and antiperistaltic agents for Clostridium difficile infection in cancer patients. Transplant infectious disease : an official journal of the Transplantation Society, 2013, Volume: 15, Issue:5 Topics: Adult; Aged; Antidiarrheals; Clostridioides difficile; Clostridium Infections; Contraindications; Di	2013
Secondary prophylaxis of docetaxel induced diarrhea with loperamide: case report. Journal of Korean medical science, 2013, Volume: 28, Issue:10 Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cisplatin; Diarrhea; Docetaxel; Drug Therapy, Combination; Hum	2013
Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats. Journal of ethnopharmacology, 2014, Mar-14, Volume: 152, Issue:2 Topics: Administration, Oral; Animals; Antidiarrheals; Antioxidants; Castor Oil; Diarrhea; Disease Models, A	2014
Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers. Biochemical pharmacology, 2014, Dec-01, Volume: 92, Issue:3 Topics: Animals; Arrestins; beta-Arrestins; Castor Oil; Diarrhea; Humans; Imidazoles; Ligands; Loperamide; M	2014
Safety and antidiarrheal activity of Priva adhaerens aqueous leaf extract in a murine model. Journal of ethnopharmacology, 2014, Nov-18, Volume: 157 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Disease Models, Animal; Dose-Response Relationship, D	2014
Experimental assessment of antidiarrheal and antisecretory activity of 80% methanolic leaf extract of Zehneria scabra in mice. BMC complementary and alternative medicine, 2014, Dec-02, Volume: 14 Topics: Animals; Antidiarrheals; Castor Oil; Cucurbitaceae; Diarrhea; Disease Models, Animal; Ethiopia; Gast	2014
Studies on antidiarrhoeal, antispasmodic and bronchodilator activities of Operculina turpethum Linn. BMC complementary and alternative medicine, 2014, Dec-12, Volume: 14 Topics: Animals; Antidiarrheals; Asthma; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Carbachol	2014
Loperamide therapy for voluminous diarrhea in Ebola virus disease. The Journal of infectious diseases, 2015, Apr-01, Volume: 211, Issue:7 Topics: Antidiarrheals; Diarrhea; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Loperamide	2015
[Ischaemic colitis after loperamide treatment]. Ugeskrift for laeger, 2015, Jan-26, Volume: 177, Issue:2A Topics: Antidiarrheals; Colitis, Ischemic; Diarrhea; Humans; Loperamide; Male; Middle Aged; Tomography, X-Ra	2015
Ventricular tachycardia associated with high-dose chronic loperamide use. Pharmacotherapy, 2015, Volume: 35, Issue:2 Topics: Antidiarrheals; Cholecystectomy; Diarrhea; Dose-Response Relationship, Drug; Drug Overdose; Female;	2015
Successful management of chronic high-output ileostomy with high dose loperamide. BMJ case reports, 2015, Apr-22, Volume: 2015 Topics: Adult; Aged; Antidiarrheals; Chronic Disease; Dehydration; Diarrhea; Dose-Response Relationship, Dru	2015
Treatment and prevention of traveler's diarrhea. Canadian family physician Medecin de famille canadien, 2015, Volume: 61, Issue:11 Topics: Antidiarrheals; Diarrhea; Escherichia coli Infections; Female; Fluid Therapy; Foodborne Diseases; Hu	2015
Increased Risk for ESBL-Producing Bacteria from Co-administration of Loperamide and Antimicrobial Drugs for Travelers' Diarrhea. Emerging infectious diseases, 2016, Volume: 22, Issue:1 Topics: Adult; Anti-Infective Agents; beta-Lactamases; Diarrhea; Enterobacteriaceae; Female; Humans; Loperam	2016
An Unusual Cause of Chronic Diarrhea. Gastroenterology, 2016, Volume: 150, Issue:2 Topics: Adult; Antidiarrheals; Biopsy; Chronic Disease; Colitis, Lymphocytic; Colonoscopy; Diarrhea; Female;	2016
Functional Outcomes of Patients Treated with Intensive Medications for Bowel and Pain Control for Low-Lying Rectal Cancer Who Received Preoperative Chemoradiotherapy. Digestive surgery, 2016, Volume: 33, Issue:5 Topics: Acrylic Resins; Aged; Analgesics, Opioid; Anastomosis, Surgical; Antidiarrheals; Chemoradiotherapy,	2016
The effect of methanol rhizome extract of Nymphaea lotus Linn. (Nymphaeaceae) in animal models of diarrhoea. Journal of ethnopharmacology, 2016, Aug-22, Volume: 190 Topics: Animals; Antidiarrheals; Castor Oil; Defecation; Diarrhea; Disease Models, Animal; Dose-Response Rel	2016
Evaluation of the anti-diarrheal activity of the hydromethanolic root extract of Rhus tripartita (Ucria) (Anacardiacae). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 83 Topics: Animals; Anti-Bacterial Agents; Antidiarrheals; Body Fluids; Castor Oil; Diarrhea; Gastrointestinal	2016
Board Review Vignette: Irritable Bowel Syndrome. The American journal of gastroenterology, 2016, Volume: 111, Issue:9 Topics: Abdominal Pain; Adult; Anion Exchange Resins; Antidiarrheals; Carbolines; Cholestyramine Resin; Cons	2016
Freeze dried extracts of Bidens biternata (Lour.) Merr. and Sheriff. show significant antidiarrheal activity in in-vivo models of diarrhea. Journal of ethnopharmacology, 2016, Dec-04, Volume: 193 Topics: Adrenergic Antagonists; Animals; Antidiarrheals; Bidens; Castor Oil; Defecation; Diarrhea; Dinoprost	2016
Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1-1∆ mutation. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 2017, Volume: 27, Issue:3 Topics: Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Diagnosis, Differe	2017
[Topic: Treating travelers' diarrhea. When should medication be given?]. Der Urologe. Ausg. A, 2008, Volume: 47, Issue:6 Topics: Adult; Anti-Bacterial Agents; Antidiarrheals; Atropine; Bismuth; Child; Cross-Sectional Studies; Dia	2008
Drugs for traveler's diarrhea. The Medical letter on drugs and therapeutics, 2008, Jul-28, Volume: 50, Issue:1291 Topics: Adult; Anti-Bacterial Agents; Antidiarrheals; Child, Preschool; Diarrhea; Fluid Therapy; Humans; Lop	2008
Inappropriate use of loperamide worsens Clostridium difficile-associated diarrhoea. The Journal of hospital infection, 2008, Volume: 70, Issue:2 Topics: Antidiarrheals; Clostridioides difficile; Diarrhea; Enterocolitis, Pseudomembranous; Humans; Loperam	2008
Diarrhea in adults (acute). American family physician, 2008, Aug-15, Volume: 78, Issue:4 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Antidiarrheals; Combined Modality Th	2008
Changes of intestinal mucosal and plasma PYY in a diarrhea model rat and influence of loperamide as the treatment agent for diarrhea. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2008, Volume: 128, Issue:9 Topics: Animals; Antidiarrheals; Diarrhea; Disease Models, Animal; Dose-Response Relationship, Drug; Gastroi	2008
Loperamide for the treatment of traveler's diarrhea: broad or narrow usefulness? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Oct-15, Volume: 47, Issue:8 Topics: Adult; Anti-Bacterial Agents; Diarrhea; Drug Therapy, Combination; Humans; Loperamide; Travel	2008
[Antibiotic-associated diarrheas in phthisiatric care: standardization of their diagnosis, treatment, prevention, examination of health care quality]. Problemy tuberkuleza i boleznei legkikh, 2008, Issue:7 Topics: Anti-Bacterial Agents; Antidiarrheals; Antifungal Agents; Diarrhea; Fluconazole; Follow-Up Studies;	2008
Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2008, Volume: 44, Issue:6 Topics: Animals; Antidiarrheals; Atropine; Castor Oil; Diarrhea; Disease Models, Animal; Dose-Response Relat	2008
[Hazardous to give loperamide (Immodium etc) to children under three years of age]. Lakartidningen, 2008, Dec-17, Volume: 105, Issue:51-52 Topics: Antidiarrheals; Child, Preschool; Diarrhea; Diarrhea, Infantile; Humans; Infant; Loperamide; Risk Fa	2008
Antidiarrhoeal and spasmolytic activities of the methanolic crude extract of Alstonia scholaris L. are mediated through calcium channel blockade. Phytotherapy research : PTR, 2010, Volume: 24, Issue:1 Topics: Alstonia; Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Calcium Channels; Diarrhea; Fe	2010
Irritable bowel syndrome: a mild disorder; purely symptomatic treatment. Prescrire international, 2009, Volume: 18, Issue:100 Topics: Acupuncture Therapy; Antidepressive Agents, Tricyclic; Carbolines; Clinical Trials as Topic; Constip	2009
Diabetic diarrhea. Current gastroenterology reports, 2009, Volume: 11, Issue:5 Topics: Algorithms; Antidiarrheals; Celiac Disease; Clonidine; Colitis; Diabetes Complications; Diabetes Mel	2009
Administration of loperamide and addition of wheat bran to the diets of weaner pigs decrease the incidence of diarrhoea and enhance their gut maturation. The British journal of nutrition, 2010, Volume: 103, Issue:6 Topics: Acetic Acid; Animals; Antidiarrheals; Butyric Acid; Diarrhea; Diet; Dietary Fiber; Digestion; Entero	2010
NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice. Peptides, 2010, Volume: 31, Issue:4 Topics: Animals; Antidiarrheals; Diarrhea; Disease Models, Animal; Gastrointestinal Transit; Humans; Intesti	2010
Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2010, Volume: 46, Issue:2 Topics: Animals; Antidiarrheals; Castor Oil; Complex Mixtures; Diarrhea; Female; Gastrointestinal Motility;	2010
Calcium channel blocking activity of Mentha longifolia L. explains its medicinal use in diarrhoea and gut spasm. Phytotherapy research : PTR, 2010, Volume: 24, Issue:9 Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Castor Oil; Cations; Diarrhea; Jejunum;	2010
Diarrhoea in a large prospective cohort of European travellers to resource-limited destinations. BMC infectious diseases, 2010, Aug-04, Volume: 10 Topics: Adolescent; Adult; Africa, Central; Africa, Western; Aged; Antidiarrheals; Cohort Studies; Developin	2010
Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. Bioscience, biotechnology, and biochemistry, 2010, Volume: 74, Issue:8 Topics: Animals; Atropine; Cholinergic Antagonists; Constipation; Diarrhea; Ethanol; Female; Gastrointestina	2010
Pediatric lymphocytic colitis presenting with intractable diarrhea. Journal of pediatric gastroenterology and nutrition, 2011, Volume: 53, Issue:5 Topics: Child; Colitis, Lymphocytic; Diarrhea; Follow-Up Studies; Humans; Loperamide; Male; Methylprednisolo	2011
Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea. Journal of ethnopharmacology, 2012, Jul-13, Volume: 142, Issue:2 Topics: Animals; Antidiarrheals; Body Weight; Cecum; Colon; Diarrhea; Diet; Dietary Sucrose; Drinking; Feces	2012
Antidiarrhoeal and antimicrobial activity of Calpurnia aurea leaf extract. BMC complementary and alternative medicine, 2013, Jan-28, Volume: 13 Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Antidiarrheals; Bacteria; Castor Oil; Defecati	2013
Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth. Phytotherapy research : PTR, 2002, Volume: 16, Issue:6 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Fabaceae; Gastrointestinal Transit; Lethal Dose 50; L	2002
[Ileus after the use of loperamide in a child with acute diarrhea]. Nederlands tijdschrift voor geneeskunde, 2003, Apr-05, Volume: 147, Issue:14 Topics: Antidiarrheals; Child, Preschool; Diarrhea; Electrolytes; Female; Fluid Therapy; Gastroenteritis; Hu	2003
Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis). Phytotherapy research : PTR, 2003, Volume: 17, Issue:4 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Disease Models, Animal; Dose-Response Relationship, D	2003
Dose-response relationship and mechanism of action of Saccharomyces boulardii in castor oil-induced diarrhea in rats. Digestive diseases and sciences, 2003, Volume: 48, Issue:4 Topics: Animals; Antidiarrheals; Arginine; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Fungal Va	2003
I get occasional diarrhea. Is there anything nonprescription that's particularly effective for that? Mayo Clinic health letter (English ed.), 2003, Volume: 21, Issue:5 Topics: Antidiarrheals; Contraindications; Diarrhea; Humans; Loperamide; Nonprescription Drugs	2003
[Malaria--case report]. Deutsche medizinische Wochenschrift (1946), 2003, Jun-06, Volume: 128, Issue:23 Topics: Adult; Anti-Infective Agents; Antidiarrheals; Antimalarials; Chloroquine; Ciprofloxacin; Diarrhea; E	2003
Chronic diarrhoea in HIV-1-infected adults in Nairobi, Kenya: evaluation of risk factors and the WHO treatment algorithm. AIDS (London, England), 2003, Sep-26, Volume: 17, Issue:14 Topics: Adult; Algorithms; Anti-Infective Agents; Chronic Disease; Cohort Studies; Diarrhea; Drug Therapy, C	2003
[Type 1 Gaucher's disease in the adult. Nutritional management during initiation of treatment with miglustat]. Presse medicale (Paris, France : 1983), 2004, Apr-10, Volume: 33, Issue:7 Topics: Adult; Antidiarrheals; Combined Modality Therapy; Diarrhea; Dietary Carbohydrates; Disaccharides; Do	2004
[Management of chemotherapy induced diarrhea]. Zeitschrift fur Gastroenterologie, 2004, Volume: 42, Issue:6 Topics: Antidiarrheals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin;	2004
Neomycin as secondary prophylaxis for irinotecan-induced diarrhea. Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:8 Topics: Administration, Oral; Anti-Bacterial Agents; Antidiarrheals; Antineoplastic Agents, Phytogenic; Anti	2004
[Severe adverse effects of certain veterinary drugs in collies and collie-like dogs]. Tijdschrift voor diergeneeskunde, 2004, Sep-01, Volume: 129, Issue:17 Topics: Animals; Antidiarrheals; Breeding; Diarrhea; Dog Diseases; Dogs; Female; Incidence; Loperamide; Male	2004
Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice. American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 288, Issue:6 Topics: Acute Disease; Animals; Antidiarrheals; Colitis; Colon; Diarrhea; Disease Models, Animal; Gastrointe	2005
Saccharomyces boulardii inhibits water and electrolytes changes induced by castor oil in the rat colon. Digestive diseases and sciences, 2005, Volume: 50, Issue:11 Topics: Animals; Antidiarrheals; Atropine; Castor Oil; Colon; Diarrhea; Electrolytes; Loperamide; Male; Rats	2005
Synthesis and pharmacological activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones. Chemical biology & drug design, 2006, Volume: 67, Issue:6 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Loperamide; Mice; Models, Molecular; Naloxone; Struct	2006
Collagenous colitis in a patient with systemic sclerosis: a rare entity. Journal of the National Medical Association, 2007, Volume: 99, Issue:6 Topics: Abdomen; Aged; Autoimmune Diseases; Colitis, Collagenous; Comorbidity; Diarrhea; Female; Humans; Lop	2007
Chemotherapy-induced mucositis: focusing on diarrhea. The journal of supportive oncology, 2007, Volume: 5, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Budesonide; Camptothecin; Dehydration; Diar	2007
A case of toxic megacolon secondary to Clostridium difficile-associated diarrhea worsened after administration of an antimotility agent and molecular analysis of recovered isolates. Journal of gastroenterology, 2007, Volume: 42, Issue:6 Topics: Aged; Bacterial Toxins; Clostridioides difficile; Diarrhea; Enterocolitis, Pseudomembranous; Enterot	2007
Loperamide--what does it block? Lancet (London, England), 1981, Nov-14, Volume: 2, Issue:8255 Topics: Child; Diarrhea; Diarrhea, Infantile; Humans; Intestinal Mucosa; Loperamide; Piperidines; Receptors,	1981
Loperamide and calmodulin. Lancet (London, England), 1982, Jan-30, Volume: 1, Issue:8266 Topics: Calcium-Binding Proteins; Calmodulin; Diarrhea; Humans; Loperamide; Phosphoric Diester Hydrolases; P	1982
Relationship between anti-diarrheal activity and binding to calmodulin. European journal of pharmacology, 1982, Mar-12, Volume: 78, Issue:3 Topics: 16,16-Dimethylprostaglandin E2; Animals; Antidiarrheals; Antipsychotic Agents; Body Fluids; Calcium-	1982
Studies with enterotoxigenic microorganisms: effects of candidate antidiarrhoeals in experimental animals in vivo. Journal of pediatric gastroenterology and nutrition, 1984, Volume: 3, Issue:4 Topics: Aluminum Hydroxide; Animals; Antidiarrheals; Aspirin; Bacterial Infections; Charcoal; Chlorpromazine	1984
Mechanisms of action of loperamide. Scandinavian journal of gastroenterology. Supplement, 1983, Volume: 84 Topics: Animals; Body Water; Cholera Toxin; Cyclic AMP; Deoxycholic Acid; Diarrhea; Dinoprostone; Intestinal	1983
Opiate agonists and enterotoxins. Biochemical Society transactions, 1984, Volume: 12, Issue:2 Topics: Animals; Cholera Toxin; Cyclic AMP; Diarrhea; Enkephalin, Methionine; Intestinal Mucosa; Loperamide;	1984
Diarrhoea, dehydration, and drugs. British medical journal (Clinical research ed.), 1984, Nov-10, Volume: 289, Issue:6454 Topics: Antidiarrheals; Child; Dehydration; Diarrhea; Fluid Therapy; Humans; Loperamide	1984
Loperamide versus copamide. The Journal of the Association of Physicians of India, 1984, Volume: 32, Issue:5 Topics: Adult; Chlorpropamide; Diarrhea; Humans; Loperamide; Male; Medication Errors; Piperidines	1984
Practical therapeutics: approach to the therapy of diarrhoeal diseases. East African medical journal, 1984, Volume: 61, Issue:6 Topics: Child, Preschool; Developing Countries; Diarrhea; Diphenoxylate; Fluid Therapy; Humans; Loperamide	1984
Antisecretory activity of opiates in vitro and in vivo in man. Scandinavian journal of gastroenterology. Supplement, 1983, Volume: 84 Topics: Animals; Chlorides; Diarrhea; Dinoprostone; Humans; In Vitro Techniques; Intestinal Absorption; Inte	1983
Mechanism of the antidiarrheal effect of loperamide. Gastroenterology, 1984, Volume: 86, Issue:6 Topics: Adult; Antidiarrheals; Diarrhea; Electrolytes; Gastrointestinal Motility; Humans; Intestinal Absorpt	1984
Ox bile treatment of severe steatorrhea in an ileectomy-ileostomy patient. Gastroenterology, 1982, Volume: 82, Issue:3 Topics: Bile Acids and Salts; Celiac Disease; Colectomy; Crohn Disease; Diarrhea; Female; Humans; Ileostomy;	1982
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse. Digestive diseases and sciences, 1982, Volume: 27, Issue:3 Topics: Adult; Aged; Cathartics; Chronic Disease; Colon; Diarrhea; Electrolytes; Endocrine System Diseases;	1982
A semichronic diarrheal model. Journal of pharmacological methods, 1982, Volume: 7, Issue:2 Topics: Animals; Chronic Disease; Diarrhea; Dietary Carbohydrates; Diphenoxylate; Disease Models, Animal; Fe	1982
[Clinical results with loperamide in the treatment of chronic diarrhoea of varied aetiology (author's transl)]. Wiener klinische Wochenschrift, 1982, Mar-19, Volume: 94, Issue:6 Topics: Adult; Aged; Carcinoid Tumor; Chronic Disease; Colitis, Ulcerative; Crohn Disease; Diarrhea; Exocrin	1982
[Diarrhea. Physiopathological and mode of action of antidiarrheals]. Medecine & chirurgie digestives, 1982, Volume: 11, Issue:4 Topics: Antidiarrheals; Diarrhea; Humans; Intestinal Absorption; Loperamide	1982
[Acute infectious diarrhea. Treatment with loperamide]. Medecine & chirurgie digestives, 1981, Volume: 10, Issue:1 Topics: Adult; Animals; Bacterial Infections; Child; Diarrhea; Humans; Loperamide; Piperidines; Rats	1981
Toddler's diarrhoea. Archives of disease in childhood, 1980, Volume: 55, Issue:5 Topics: Child, Preschool; Colonic Diseases, Functional; Diarrhea; Diarrhea, Infantile; Humans; Infant; Loper	1980
Benefit/risk considerations with respect to OTC-descheduling of loperamide. Arzneimittel-Forschung, 1995, Volume: 45, Issue:5 Topics: Adult; Child; Child, Preschool; Cost-Benefit Analysis; Diarrhea; Humans; Loperamide; Nonprescription	1995
A new enkephalinase inhibitor as an alternative to loperamide in the prevention of diarrhea induced by CPT-11. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:8 Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Diarrhea; Female;	1995
Use of loperamide in children. The Central African journal of medicine, 1994, Volume: 40, Issue:10 Topics: Child; Diarrhea; Humans; Loperamide	1994
Loperamide intoxication in a seven-week-old pup. Veterinary and human toxicology, 1994, Volume: 36, Issue:5 Topics: Animals; Animals, Newborn; Cerebellum; Cerebral Cortex; Charcoal; Diarrhea; Dog Diseases; Dogs; Dose	1994
Do antidiarrhoeal opiates accumulate in the rat intestinal lumen? The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:12 Topics: Absorption; Animals; Antidiarrheals; Calibration; Castor Oil; Chromatography; Diarrhea; Diphenoxylat	1993
Single-dose antibiotic treatment for travellers' diarrhoea. Lancet (London, England), 1994, Dec-03, Volume: 344, Issue:8936 Topics: Ciprofloxacin; Diarrhea; Humans; Loperamide; Travel	1994
[Loperamide and childhood diarrhea]. Ugeskrift for laeger, 1994, Feb-28, Volume: 156, Issue:9 Topics: Child; Child, Preschool; Diarrhea; Diarrhea, Infantile; Humans; Infant; Loperamide	1994
Diarrhea and autonomic dysfunction in a patient with hexosaminidase B deficiency (Sandhoff disease). Gastroenterology, 1994, Volume: 106, Issue:3 Topics: Autonomic Nervous System Diseases; Biopsy; Body Fluids; Diarrhea; Feces; Gastrointestinal Motility;	1994
[Functional results of ileo-anal anastomosis. The point of view of the gastroenterologist]. Annales de chirurgie, 1993, Volume: 47, Issue:10 Topics: Adenomatous Polyposis Coli; Colectomy; Colitis, Ulcerative; Diarrhea; Fecal Incontinence; Female; Ga	1993
Loperamide abolishes exercise-induced orocecal liquid transit acceleration. Digestive diseases and sciences, 1993, Volume: 38, Issue:10 Topics: Adult; Diarrhea; Exercise; Exercise Tolerance; Female; Food, Formulated; Gastrointestinal Transit; H	1993
Fluid losses with diarrhea. American pharmacy, 1993, Volume: NS33, Issue:2 Topics: Child; Child, Preschool; Diarrhea; Fluid Therapy; Humans; Loperamide; Water-Electrolyte Imbalance	1993
Diarrhoea caused by Clostridium difficile: response time for treatment with metronidazole and vancomycin. The Journal of antimicrobial chemotherapy, 1995, Volume: 36, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antidiarrheals; Clostridioides difficile; Clo	1995
Assessing the impact of a regulatory intervention in Pakistan. Social science & medicine (1982), 1996, Volume: 42, Issue:8 Topics: Adult; Antidiarrheals; Child; Child, Preschool; Cross-Sectional Studies; Developing Countries; Diarr	1996
Antidiarrhoeal activity of new thiazolidinones related to loperamide. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:7 Topics: Animals; Antidiarrheals; Castor Oil; Diarrhea; Lethal Dose 50; Loperamide; Male; Mice; Naloxone; Nar	1996
Pharmacological studies on antidiarrheal effects of Hange-shashin-to. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:10 Topics: Animals; Atropine; Barium Compounds; Castor Oil; Chlorides; Diarrhea; Drugs, Chinese Herbal; Gastroi	1996
Collagenous colitis: a retrospective study of clinical presentation and treatment in 163 patients. Gut, 1996, Volume: 39, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anticholesteremic Agents; Anti	1996
[Opium drops in diarrhea caused by Crohn disease]. Deutsche medizinische Wochenschrift (1946), 1997, Feb-07, Volume: 122, Issue:6 Topics: Adult; Anticholesteremic Agents; Antidiarrheals; Cholestyramine Resin; Crohn Disease; Diarrhea; Drug	1997
[Opium drops in diarrhea caused by Crohn disease]. Deutsche medizinische Wochenschrift (1946), 1997, Feb-07, Volume: 122, Issue:6 Topics: Adult; Antidiarrheals; Crohn Disease; Diarrhea; Female; Humans; Loperamide; Opium; Time Factors	1997
Role of tachykinins in castor oil diarrhoea in rats. British journal of pharmacology, 1997, Volume: 121, Issue:3 Topics: Animals; Benzamides; Castor Oil; Colon; Diarrhea; Gastrointestinal Motility; Loperamide; Male; Nalox	1997
Treating diarrhoea. Children deserve special attention. BMJ (Clinical research ed.), 1997, Nov-22, Volume: 315, Issue:7119 Topics: Antidiarrheals; Child; Child, Preschool; Diarrhea; Hospitalization; Humans; Loperamide; Scotland	1997
Experimental study of antidiarrheal activity of Salicairine. Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:1 Topics: Acetylcholine; Alprostadil; Animals; Antidiarrheals; Barium Compounds; Bisacodyl; Body Water; Castor	1998
Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. Japanese journal of pharmacology, 1998, Volume: 76, Issue:2 Topics: Animals; Antidiarrheals; Benzimidazoles; Calmodulin; Diarrhea; Dinoprostone; Gastric Emptying; Loper	1998
Advice for travelers. The Medical letter on drugs and therapeutics, 1998, Apr-24, Volume: 40, Issue:1025 Topics: Anti-Infective Agents; Antidiarrheals; Bacterial Vaccines; Cholera; Ciprofloxacin; Diarrhea; Diphthe	1998
Diarrhea after resection of advanced abdominal neuroblastoma: a common management problem. Surgery, 1998, Volume: 123, Issue:5 Topics: Abdominal Neoplasms; Antidiarrheals; Child; Child, Preschool; Clinical Protocols; Combined Modality	1998
Effects of loperamide on ileoanal pouch function. The British journal of surgery, 1998, Volume: 85, Issue:10 Topics: Adenomatous Polyposis Coli; Adult; Antidiarrheals; Colitis, Ulcerative; Defecation; Diarrhea; Female	1998
[Chronic diarrhea in a young diabetic woman]. Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:1 Topics: Adult; Antidiarrheals; Chronic Disease; Diabetes Mellitus, Type 1; Diarrhea; Feces; Female; Humans;	1999
Advice for travelers. The Medical letter on drugs and therapeutics, 1999, Apr-23, Volume: 41, Issue:1051 Topics: Antibiotic Prophylaxis; Bacterial Vaccines; Diarrhea; Diphtheria-Tetanus-Pertussis Vaccine; Escheric	1999
Effect of the 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models. Japanese journal of pharmacology, 1999, Volume: 80, Issue:1 Topics: Animals; Antidiarrheals; Benzimidazoles; Diarrhea; Loperamide; Male; Mice; Rats; Rats, Wistar; Recep	1999
Oral rehydration therapy plus loperamide versus loperamide alone in the treatment of traveler's diarrhea. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1999, Volume: 28, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Antidiarrheals; Diarrhea; Female; Fluid Therapy; Huma	1999
Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components. Phytotherapy research : PTR, 1999, Volume: 13, Issue:6 Topics: Animals; Antidiarrheals; Castor Oil; Corticosterone; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors;	1999
The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats. European journal of pharmacology, 1999, Nov-12, Volume: 384, Issue:1 Topics: Analgesics; Animals; Antidiarrheals; Benzoxazines; Castor Oil; Cyclohexanols; Defecation; Diarrhea;	1999
Loperamide therapy in a patient with diarrhea and resistant hypertension. American journal of hypertension, 2000, Volume: 13, Issue:4 Pt 1 Topics: Aged; Antidiarrheals; Antihypertensive Agents; Crohn Disease; Diarrhea; Humans; Hypertension; Intest	2000
Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats. Japanese journal of pharmacology, 2000, Volume: 82, Issue:4 Topics: Animals; Antidiarrheals; Benzimidazoles; Defecation; Diarrhea; Digestive System; Digestive System Ph	2000
Calcium polycarbophil, a water absorbing polymer, increases bowel movement and prevents sennoside-induced diarrhea in dogs. Japanese journal of pharmacology, 2000, Volume: 83, Issue:3 Topics: Acrylic Resins; Animals; Anthraquinones; Antidiarrheals; Defecation; Diarrhea; Dogs; Female; Loperam	2000
Control of irinotecan-induced diarrhea by octreotide after loperamide failure. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2001, Volume: 9, Issue:4 Topics: Adult; Aged; Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Female; Huma	2001
[Loperamide abuse in anxiety disorder]. Der Nervenarzt, 2001, Volume: 72, Issue:7 Topics: Adult; Anxiety Disorders; Diarrhea; Female; Follow-Up Studies; Humans; Life Change Events; Loperamid	2001
[What is effective in traveler's diarrhea? Current recommendations on prevention, therapy and after care]. MMW Fortschritte der Medizin, 2001, Jul-19, Volume: 143, Issue:28-29 Topics: Diarrhea; Fluid Therapy; Humans; Loperamide; Probiotics; Risk Factors; Travel	2001
Advice for travelers. The Medical letter on drugs and therapeutics, 2002, Apr-15, Volume: 44, Issue:1128 Topics: Africa; Altitude Sickness; Asia; Chloroquine; Ciprofloxacin; Contraindications; Diarrhea; Female; He	2002
[Pharmacological studies of loperamide, an anti-diarrheal agent. I. Effects on diarrhea induced by castor oil and prostaglandin E. (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1978, Volume: 74, Issue:1 Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Antidiarrheals; Castor Oil; Diarrhea; D	1978
Loperamide inhibits cholera-toxin-induced small-intestinal secretion. Lancet (London, England), 1979, Sep-29, Volume: 2, Issue:8144 Topics: Animals; Cholera Toxin; Diarrhea; Electrolytes; Jejunum; Loperamide; Male; Piperidines; Rats; Water	1979
Loperamide and acute infective diarrhoea in children. Lancet (London, England), 1979, Dec-15, Volume: 2, Issue:8155 Topics: Acute Disease; Child; Child, Preschool; Diarrhea; Diphenoxylate; Dysentery, Bacillary; Humans; Infan	1979
[Loperamide in the treatment of chronic diarrhea]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1979, Jan-15, Volume: 34, Issue:3 Topics: Adolescent; Adult; Aged; Chronic Disease; Diarrhea; Female; Humans; Loperamide; Male; Middle Aged; P	1979
[Results of treating chronic diarrhea with loperamide in patients with functional intestinal disorders]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1979, Mar-12, Volume: 34, Issue:11 Topics: Adult; Chronic Disease; Colonic Diseases, Functional; Diarrhea; Female; Humans; Intestinal Diseases;	1979
[Diarrhea]. Deutsche medizinische Wochenschrift (1946), 1979, Nov-16, Volume: 104, Issue:46 Topics: Diarrhea; Humans; Loperamide	1979
[Diarrhea]. Deutsche medizinische Wochenschrift (1946), 1979, Dec-28, Volume: 104, Issue:52 Topics: Diarrhea; Humans; Loperamide; Piperidines	1979
Naloxone inhibits the anti-diarrhoeal activity of loperamide. British journal of pharmacology, 1979, Volume: 66, Issue:3 Topics: Animals; Diarrhea; Loperamide; Male; Naloxone; Piperidines; Prostaglandins E; Rats	1979
Loperamide in patients with radiotherapy-induced diarrhoea. Arzneimittel-Forschung, 1978, Volume: 28, Issue:5 Topics: Abdominal Neoplasms; Adult; Aged; Diarrhea; Female; Humans; Loperamide; Male; Middle Aged; Piperidin	1978
In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide. Arzneimittel-Forschung, 1978, Volume: 28, Issue:8a Topics: Amidines; Animals; Antidiarrheals; Carbachol; Charcoal; Cholera Toxin; Diarrhea; Diphenoxylate; Fece	1978
[Special consideration of clinical and travelling medical criteria (author's transl)]. Arzneimittel-Forschung, 1979, Volume: 29, Issue:4 Topics: Diarrhea; Diphenoxylate; Humans; Isonipecotic Acids; Loperamide; Travel	1979
The use of loperamide for treatment of "difficult to manage" chronic diarrhoea in adults. The Journal of international medical research, 1977, Volume: 5, Issue:6 Topics: Adult; Chronic Disease; Colitis; Diarrhea; Diverticulitis, Colonic; Enteritis; Humans; Loperamide; P	1977
[Studies using loperamide in patients with diarrhea following telecobalt irradiation of malignant abdominal tumors (author's transl)]. Strahlentherapie, 1978, Volume: 154, Issue:1 Topics: Abdominal Neoplasms; Adult; Aged; Diarrhea; Female; Humans; Loperamide; Middle Aged; Piperidines; Ra	1978
The control of acute diarrhea in a large industrial plant. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1978, Volume: 20, Issue:4 Topics: Absenteeism; Acute Disease; Adult; Automobiles; Diarrhea; Female; Humans; Loperamide; Male; Occupati	1978
The effect of loperamide on prostaglandin induced diarrhoea in rat and man. Prostaglandins, 1977, Volume: 13, Issue:2 Topics: Abortion, Induced; Animals; Cricetinae; Diarrhea; Drug Evaluation, Preclinical; Female; Humans; Lope	1977
[Imodium, new symptomatic treatment of diarrhea]. Medecine & chirurgie digestives, 1977, Volume: 6, Issue:1 Topics: Diarrhea; Humans; Loperamide; Piperidines	1977
[Loperamide in acute diarrhea (author's transl)]. Revista medica de Chile, 1977, Volume: 105, Issue:3 Topics: Acute Disease; Adolescent; Adult; Aged; Diarrhea; Drug Evaluation; Female; Humans; Loperamide; Male;	1977
Loperamide and other antidiarrhoeal drugs. Drug and therapeutics bulletin, 1977, Aug-05, Volume: 15, Issue:16 Topics: Antidiarrheals; Diarrhea; Humans; Loperamide; Piperidines	1977
Termination of abnormal intrauterine pregnancies with intramuscular administration of dihomo 15 methyl prostaglandin F 2alpha. British journal of obstetrics and gynaecology, 1976, Volume: 83, Issue:11 Topics: Abortion, Missed; Abortion, Therapeutic; Anencephaly; Diarrhea; Female; Fetal Death; Humans; Hydatid	1976
[A new symptomatic treatment of diarrhea]. Semaine des hopitaux. Therapeutique, 1976, Volume: 52, Issue:9 Topics: Child; Child, Preschool; Diarrhea; Drug Evaluation; Humans; Infant; Infant, Newborn; Loperamide; Pip	1976
Letter: Loperamide in treatment of persistent diarrhoea in children. British medical journal, 1975, Sep-27, Volume: 3, Issue:5986 Topics: Child, Preschool; Diarrhea; Humans; Infant; Loperamide; Piperidines	1975
Loperamide antagonism of castor oil-induced diarrhea in rats: a quantitative study. Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 217, Issue:1 Topics: Animals; Body Weight; Castor Oil; Diarrhea; Feces; Female; Loperamide; Piperidines; Rats; Time Facto	1975
Loperamide dependence. The Journal of clinical psychiatry, 1992, Volume: 53, Issue:12 Topics: Adult; Diarrhea; Humans; Loperamide; Male; Substance Withdrawal Syndrome; Substance-Related Disorder	1992
Use of loperamide hydrochloride in children. The Central African journal of medicine, 1992, Volume: 38, Issue:3 Topics: Adult; Age Factors; Child; Diarrhea; Humans; Loperamide; Pediatrics	1992
Effect of loperamide on jejunal electrolyte and water transport, prostaglandin E2-induced secretion and intestinal transit time in man. European journal of clinical pharmacology, 1991, Volume: 41, Issue:3 Topics: Adolescent; Adult; Biological Transport; Chlorides; Diarrhea; Dinoprostone; Dose-Response Relationsh	1991
Absorptive and motor components of the antidiarrhoeal action of loperamide: an in vivo study in pigs. Gut, 1991, Volume: 32, Issue:11 Topics: Animals; Colon; Diarrhea; Digestion; Gastrointestinal Motility; Gastrointestinal Transit; Intestinal	1991
Use of loperamide hydrochloride in children. The Central African journal of medicine, 1991, Volume: 37, Issue:7 Topics: Child, Preschool; Developing Countries; Diarrhea; Drug and Narcotic Control; Humans; Infant; Loperam	1991
Incidence and clinical features of traveler's diarrhea in infants and children. The Pediatric infectious disease journal, 1991, Volume: 10, Issue:10 Topics: Adolescent; Adult; Africa; Asia, Southeastern; Child; Child, Preschool; Diarrhea; Diarrhea, Infantil	1991
Loperamide not for children. American pharmacy, 1991, Volume: NS31, Issue:9 Topics: Contraindications; Diarrhea; Humans; Infant; Loperamide	1991
Withdrawal of loperamide drops. Lancet (London, England), 1990, Jun-30, Volume: 335, Issue:8705 Topics: Diarrhea; Humans; Infant; Loperamide; Pakistan; Piperidines; Product Surveillance, Postmarketing	1990
[Small intestine perforation as a complication of treatment with loperamide in a Salmonella typhimurium infection]. Nederlands tijdschrift voor geneeskunde, 1991, Jan-05, Volume: 135, Issue:1 Topics: Diarrhea; Humans; Loperamide; Salmonella Infections; Salmonella typhimurium	1991
Herpes simplex virus type 1 colitis: an unusual cause of diarrhea. The American journal of gastroenterology, 1990, Volume: 85, Issue:9 Topics: Aged; Colitis; Colonoscopy; Diarrhea; Female; Herpesviridae Infections; Humans; Loperamide; Simplexv	1990
[Diet and loperamide are better than norfloxacin in tourist diarrhea]. Lakartidningen, 1990, Aug-08, Volume: 87, Issue:32-33 Topics: Diarrhea; Humans; Loperamide; Norfloxacin; Piperidines; Travel	1990
Subacute diarrhea. To treat or to wait? Hospital practice (Office ed.), 1989, Mar-30, Volume: 24, Issue:3A Topics: Acute Disease; Adult; Diagnosis, Differential; Diarrhea; Enterobacteriaceae Infections; Female; Huma	1989
Self-prescribing and promotion of antidiarrhoeal drugs. Lancet (London, England), 1989, May-13, Volume: 1, Issue:8646 Topics: Advertising; Diarrhea; Humans; Loperamide; Nonprescription Drugs; Piperidines; Self Medication	1989
[Imodium for chronic diarrhea. Improving the quality of life. Report of the 44th meeting of the German Society for Digestive and Metabolic Diseases, 28 September 1989]. Fortschritte der Medizin. Supplement : die Kongressinformation fur die Praxis, 1989, Volume: 77 Topics: Chronic Disease; Diarrhea; Humans; Loperamide; Piperidines; Quality of Life	1989
[Treatment of the drug-induced dyspeptic syndrome]. Sovetskaia meditsina, 1988, Issue:11 Topics: Antineoplastic Agents; Diarrhea; Humans; Loperamide; Piperidines	1988
Effect of codeine and loperamide on upper intestinal transit and absorption in normal subjects and patients with postvagotomy diarrhoea. Gut, 1988, Volume: 29, Issue:3 Topics: Adult; Aged; Chronic Disease; Codeine; Diarrhea; Female; Gastrointestinal Transit; Glucose; Humans;	1988
Use of Imodium in neurotic diarrhoeas. Therapia Hungarica (English edition), 1987, Volume: 35, Issue:3 Topics: Adult; Aged; Diarrhea; Female; Humans; Loperamide; Male; Middle Aged; Neurotic Disorders; Piperidine	1987
Examination of Imodium in patients suffering from acute and chronic diarrhoea. Therapia Hungarica (English edition), 1986, Volume: 34, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Diarrhea; Female; Humans; Loperamide; Male;	1986
Treatment of diarrhoeas of gynaecological patients with Imodium. Therapia Hungarica (English edition), 1987, Volume: 35, Issue:4 Topics: Adolescent; Adult; Diarrhea; Female; Humans; Loperamide; Middle Aged; Piperidines	1987
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors. European journal of pharmacology, 1987, Dec-01, Volume: 144, Issue:2 Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Lop	1987
Effects of loperamide hydrochloride on experimental diarrhea and gastrointestinal myoelectrical activity in calves. American journal of veterinary research, 1987, Volume: 48, Issue:3 Topics: Abomasum; Animals; Cattle; Cattle Diseases; Colon; Diarrhea; Electromyography; Gastrointestinal Moti	1987
[Imodium]. Soins. Gynecologie, obstetrique, puericulture, pediatrie, 1987, Issue:69 Topics: Diarrhea; Humans; Loperamide; Piperidines	1987
Nurse & the law. Personal morals vs professional codes. The Australian nurses' journal. Royal Australian Nursing Federation, 1987, Volume: 16, Issue:11 Topics: Aged; Child; Diarrhea; Drug Industry; Ethics, Medical; Ethics, Nursing; Humans; Jurisprudence; Loper	1987
Acute diarrhoeal disease in rabbit: bacteriological diagnosis and efficacy of oral rehydration in combination with loperamide hydrochloride. Laboratory animals, 1987, Volume: 21, Issue:4 Topics: Acute Disease; Animals; Combined Modality Therapy; Diarrhea; Fluid Therapy; Loperamide; Piperidines;	1987
Toddler diarrhoea: observations on the effects of aspirin and loperamide. Journal of pediatric gastroenterology and nutrition, 1985, Volume: 4, Issue:3 Topics: Antidiarrheals; Aspirin; Child, Preschool; Cyclooxygenase Inhibitors; Diarrhea; Diarrhea, Infantile;	1985
[Effect of loperamide on 15-methyl-PGF2 alpha induced diarrhea and its uterine-stimulating action]. Yao xue xue bao = Acta pharmaceutica Sinica, 1985, Volume: 20, Issue:4 Topics: Animals; Carboprost; Diarrhea; Female; Loperamide; Male; Mice; Muscle Contraction; Piperidines; Rats	1985

loperamide and Diarrhea