loperamide has been researched along with Cystic Fibrosis in 4 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Excerpt | Relevance | Reference |
---|---|---|
" Oral DRAinh-A250 and tenapanor comparably reduced signs of constipation in loperamide-treated mice, with additive effects found on coadministration." | 3.88 | SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. ( Cil, O; Haggie, PM; Lee, S; Phuan, PW; Rivera, AA; Tan, JA; Verkman, AS, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (50.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Haggie, PM | 1 |
Cil, O | 1 |
Lee, S | 1 |
Tan, JA | 1 |
Rivera, AA | 1 |
Phuan, PW | 1 |
Verkman, AS | 1 |
Hardcastle, J | 1 |
Hardcastle, PT | 1 |
Taylor, CJ | 3 |
Ghosal, S | 2 |
McGaw, J | 1 |
Colledge, WH | 1 |
Ratcliff, R | 1 |
Evans, MJ | 1 |
4 other studies available for loperamide and Cystic Fibrosis
Article | Year |
---|---|
SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
Topics: Animals; Antiporters; Chloride-Bicarbonate Antiporters; Chlorides; Constipation; Cystic Fibrosis; Di | 2018 |
Loperamide inhibits the enhanced intestinal glucose absorption of cystic fibrosis in vitro.
Topics: Adolescent; Child; Child, Preschool; Cystic Fibrosis; Glucose; Humans; In Vitro Techniques; Infant; | 1994 |
Modification of nasal membrane potential difference with inhaled amiloride and loperamide in the cystic fibrosis (CF) mouse.
Topics: Amiloride; Animals; Cystic Fibrosis; Dose-Response Relationship, Drug; Female; Loperamide; Male; Mem | 1996 |
Sodium channel blockers and uridine triphosphate: effects on nasal potential difference in cystic fibrosis mice.
Topics: Amiloride; Animals; Chlorides; Cystic Fibrosis; Drug Therapy, Combination; Loperamide; Membrane Pote | 2000 |