loperamide has been researched along with Crohn Disease in 16 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Loperamide was also statistically superior to diphenoxylate at reducing the number of stools and improving the faecal consistency." | 2.65 | A comparative study of loperamide and diphenoxylate in the treatment of chronic diarrhoea caused by intestinal resection. ( Bergman, L; Djärv, L, 1981) |
| "Loperamide (R 18 553) was compared with placebo in a double-blind crossover study of 21 patients with chronic diarrhoea caused by ileocolic disease or resection." | 2.64 | Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection. ( Fiasse, R; Mainguet, P, 1977) |
| "When treating diarrhea, physicians need to control inflammatory activity using appropriate treatment algorithms." | 2.44 | Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions. ( Hanauer, SB; Shah, SB, 2007) |
| "Loperamide is an opioid available over the counter and in prescription form." | 1.56 | Loperamide Abuse and Its Sequelae. ( Jones, P; Key, P; Prahlow, JA; Strzyzewski, L, 2020) |
| "An 18-year-old male patient treated for Crohn's disease for 3 years developed buccal manifestations." | 1.30 | [Oral Crohn disease. Apropos of a case]. ( Lambert, F; Reychler, H, 1997) |
| "The diarrhea was improved by loperamide, but severe steatorrhea and malnutrition persisted." | 1.26 | Ox bile treatment of severe steatorrhea in an ileectomy-ileostomy patient. ( Bunch, F; Davis, GR; Fordtran, JS, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Strzyzewski, L | 1 |
| Key, P | 1 |
| Jones, P | 1 |
| Prahlow, JA | 1 |
| Goldsmith, JR | 1 |
| Kelly, M | 1 |
| Freeman, KB | 1 |
| Duro, D | 1 |
| Gielisse, EA | 1 |
| de Boer, NK | 1 |
| James, PD | 1 |
| Black, D | 1 |
| Kuper, A | 1 |
| Saibil, F | 1 |
| Malik, TA | 1 |
| Peter, S | 1 |
| Jhala, N | 1 |
| Gutierrez, AM | 1 |
| Frenz, MB | 1 |
| Dunckley, P | 1 |
| Camporota, L | 1 |
| Jewell, DP | 1 |
| Travis, SP | 1 |
| Shah, SB | 1 |
| Hanauer, SB | 1 |
| Bergman, L | 1 |
| Djärv, L | 1 |
| Fordtran, JS | 1 |
| Bunch, F | 1 |
| Davis, GR | 1 |
| Ferenci, P | 1 |
| Lochs, H | 1 |
| Pötzi, R | 1 |
| Cuadrado-Gómez, LM | 1 |
| Arranz-Caso, A | 1 |
| Albarrán-Hernández, F | 1 |
| Alvarez de Mon, M | 1 |
| Goerg, KJ | 1 |
| Ewe, K | 1 |
| Lambert, F | 1 |
| Reychler, H | 1 |
| Morimoto, S | 1 |
| Sasaki, S | 1 |
| Itoh, H | 1 |
| Nakata, T | 1 |
| Takeda, K | 1 |
| Nakagawa, M | 1 |
| Mainguet, P | 1 |
| Fiasse, R | 1 |
1 review available for loperamide and Crohn Disease
| Article | Year |
|---|---|
Treatment of diarrhea in patients with inflammatory bowel disease: concepts and cautions.
Topics: Animals; Antidiarrheals; Colitis, Ulcerative; Crohn Disease; Diarrhea; Gastrointestinal Transit; Hum | 2007 |
2 trials available for loperamide and Crohn Disease
| Article | Year |
|---|---|
A comparative study of loperamide and diphenoxylate in the treatment of chronic diarrhoea caused by intestinal resection.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Crohn Disease; Diarrhea; Diphenoxylate; Doub | 1981 |
Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Crohn Disease; Diarrhea; Female; Gastrointes | 1977 |
13 other studies available for loperamide and Crohn Disease
| Article | Year |
|---|---|
Loperamide Abuse and Its Sequelae.
Topics: Adult; Antidiarrheals; Crohn Disease; Fatal Outcome; Humans; Hypoxia, Brain; Loperamide; Male; Nalox | 2020 |
Combined restitutive therapy for treatment of immunosuppressive refractory Crohn disease.
Topics: Adjuvants, Immunologic; Adolescent; Analgesics, Opioid; Crohn Disease; Drug Tolerance; Female; Granu | 2015 |
Ipilimumab in a patient with known Crohn's disease: to give or not to give?
Topics: Adult; Antibodies, Monoclonal; Antidiarrheals; Antineoplastic Agents; Colitis; Crohn Disease; Endosc | 2014 |
D-lactic acidosis and ataxia in a man with Crohn disease.
Topics: Acidosis, Lactic; Anti-Inflammatory Agents; Antidiarrheals; Ataxia; Crohn Disease; Diagnosis, Differ | 2010 |
Crohn's colitis with perianal disease complicated by collagenous colitis: discourse on management options.
Topics: Antidiarrheals; Bismuth; Colitis; Colitis, Collagenous; Crohn Disease; Drug Therapy, Combination; Fe | 2010 |
Comparison between prospective and retrospective evaluation of Crohn's disease activity index.
Topics: Abdominal Pain; Antidiarrheals; Colonic Diseases; Crohn Disease; Diphenoxylate; Feces; Health Status | 2005 |
Ox bile treatment of severe steatorrhea in an ileectomy-ileostomy patient.
Topics: Bile Acids and Salts; Celiac Disease; Colectomy; Crohn Disease; Diarrhea; Female; Humans; Ileostomy; | 1982 |
[Clinical results with loperamide in the treatment of chronic diarrhoea of varied aetiology (author's transl)].
Topics: Adult; Aged; Carcinoid Tumor; Chronic Disease; Colitis, Ulcerative; Crohn Disease; Diarrhea; Exocrin | 1982 |
[Toxic megacolon caused by loperamide as initial form of Crohn disease].
Topics: Crohn Disease; Humans; Loperamide; Male; Megacolon, Toxic; Middle Aged | 1994 |
[Opium drops in diarrhea caused by Crohn disease].
Topics: Adult; Anticholesteremic Agents; Antidiarrheals; Cholestyramine Resin; Crohn Disease; Diarrhea; Drug | 1997 |
[Opium drops in diarrhea caused by Crohn disease].
Topics: Adult; Antidiarrheals; Crohn Disease; Diarrhea; Female; Humans; Loperamide; Opium; Time Factors | 1997 |
[Oral Crohn disease. Apropos of a case].
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidiarrheals; Crohn | 1997 |
Loperamide therapy in a patient with diarrhea and resistant hypertension.
Topics: Aged; Antidiarrheals; Antihypertensive Agents; Crohn Disease; Diarrhea; Humans; Hypertension; Intest | 2000 |