loperamide has been researched along with Colonic Inertia in 130 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Colonic Inertia: Symptom characterized by the passage of stool once a week or less.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Supportive treatment with loperamide is associated with constipation." | 9.69 | Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B). ( Doi, M; Iwasa, T; Masuda, H; Matsumoto, K; Miyoshi, Y; Niikura, N; Sagara, Y; Sakai, H; Shimomura, A; Takahashi, M; Takano, T; Tanabe, Y; Tokunaga, S; Tsurutani, J; Yoshimura, K, 2023) |
| "The purpose of this study was to examine the effectiveness and tolerability of loperamide compared with psyllium for reducing fecal incontinence." | 9.20 | Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial. ( Beasley, TM; Burgio, KL; Goode, PS; Markland, AD; Redden, DT; Richter, HE; Whitehead, WE; Wilcox, CM, 2015) |
| " Loperamide is an effective anti-diarrheal agent, but it usually induces constipation." | 9.11 | A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005) |
| "This study was to evaluate the effects of CF and CP on loperamide-induced constipation and the underlying mechanism." | 8.84 | Croton tiglium L. seeds ameliorate loperamide-induced constipation via regulating gastrointestinal hormones and gut microbiota before and after processing. ( Hu, J; Jia, ZF; Pan, W; Wang, JL, 2024) |
| "The results reveal that sticky rice fermented huangjiu may alleviate loperamide-induced constipation by the regulation of serum neurotransmitters and gut microbiota." | 8.31 | Alleviation of loperamide-induced constipation with sticky rice fermented huangjiu by the regulation of serum neurotransmitters and gut microbiota. ( Chen, S; Feng, X; Ji, Z; Mao, J; Shi, Y; Zhou, W; Zhou, Z, 2023) |
| "The effects of soluble dietary fiber (SDF) and cellulose (IDF) from Saccharina japonica by-product and their differences in improving constipation were further clarified in the present study." | 8.31 | Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. ( Cao, J; He, Y; Li, N; Miao, J; Qin, L; Qu, C; Wang, J; Wang, K; Zhang, L, 2023) |
| " A loperamide-induced mouse constipation model was developed, and all mice were randomly divided into control (Con), loperamide (Lop) and L-PA (Lop + L-PA) treatment groups (6 mice per group)." | 8.31 | Protective effect of L-pipecolic acid on constipation in C57BL/6 mice based on gut microbiome and serum metabolomic. ( Li, H; Pan, Y; Tian, PP; Xiao, HY; Yan, B; Yuan, LP; Zhang, WJ, 2023) |
| "The present study aimed to investigate the effect of oral administration of snail-derived mucin extract (SM) on ameliorating constipation symptoms of loperamide-induced constipated rats (n = 6)." | 8.31 | Modulation of gut microbiota ecosystem by a glucan-rich snail mucin heteropolysaccharide attenuates loperamide-induced constipation. ( Ahn, Y; Jeong, EJ; Kim, H; Kim, WJ; Lee, JS; Moon, SK; Park, C; Suh, HJ; Yu, KW, 2023) |
| "Constipation in rats was induced by loperamide, and rats were randomly assigned into model (saline), HHT-low (95 g/kg), HTT-medium (190 g/kg), HTT-high (380 g/kg) and positive control (mosapride) groups." | 8.31 | Hetong decoction relieves loperamide-induced constipation in rats by regulating expression of aquaporins. ( Jingbo, X; Kai, H; Qing, L; Qing, Z; Weiwei, QI; Xi, H; Youguang, X, 2023) |
| " This study determined the protective effects of BSH-1 against loperamide (Lop)-induced constipation in mice." | 8.12 | Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice. ( Huang, J; Lin, B; Wang, Q; Xiao, H; Xie, Z; Zhang, Y; Zheng, Y, 2022) |
| "Chitosan oligosaccharides (COS) can improve the symptoms of constipation." | 8.12 | Plasma metabolomic profiles reveal regulatory effect of chitosan oligosaccharides on loperamide-induced constipation in mice. ( Cheng, X; Hu, B; Hu, H; Lin, A; Liu, H; Sun, G; Yang, H; Zhang, X; Zheng, J, 2022) |
| "The present study was undertaken to assess SHTC relieved effects on the clinical symptoms of loperamide (LOP) induced constipation in Sprague Dawley (SD) rat model and to clarify the relationship between the protective effect of SHTC on constipation and the gut microbiota." | 8.12 | Chinese patent medicine shouhui tongbian capsule attenuated loperamide-induced constipation through modulating the gut microbiota in rat. ( Erhunmwunsee, F; Li, B; Lin, Q; Liu, M; Mou, Y; Tian, J; Wang, S; Zhang, G, 2022) |
| "This study was designed to explore the improvement of chitosan oligosaccharides (COS) on constipation through regulation of gut microbiota." | 8.02 | Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice. ( Bao, X; Jiang, N; Lin, A; Liu, H; Sun, G; Yang, H; Zhang, X; Zheng, J, 2021) |
| "Lactulose is a common laxative and has been widely applied to clinical treatment for constipation." | 8.02 | Modulation of gut microbiota and intestinal metabolites by lactulose improves loperamide-induced constipation in mice. ( Bao, X; Cheng, X; Jiang, N; Kong, M; Lin, A; Liu, H; Sun, G; Zhang, X; Zheng, J, 2021) |
| " Constipation was induced in rats with loperamide." | 8.02 | 7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats. ( Han, L; Han, Q; He, B; He, J; Luan, X; Ma, L; Qu, Z; Sun, Y; Wang, B; Xu, L, 2021) |
| "To investigate the role of tannin-enriched extracts of Ecklonia cava (TEE) on the regulation of oxidative balance and laxative activity in chronic constipation, we investigated alterations after exposure to TEE, on constipation phenotypes, muscarinic cholinergic regulation, and oxidative stress responses in the transverse colons of SD rats with loperamide (Lop)-induced constipation." | 8.02 | Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats. ( Choi, YJ; Gong, JE; Hong, JT; Hwang, DY; Jung, YS; Kim, JE; Lee, HS; Lee, SJ; Lee, YJ; Sung, JE, 2021) |
| " Constipation was induced by 5 mg/kg loperamide days 12 through 14 in all groups except the control." | 7.96 | Amelioration of gut dysbiosis and gastrointestinal motility by konjac oligo-glucomannan on loperamide-induced constipation in mice. ( Hayeeawaema, F; Khuituan, P; Wichienchot, S, 2020) |
| "In the present study, we investigated the laxative effects of taurine in a rat model of loperamide-induced constipation." | 7.91 | Laxative Effects of Taurine on Loperamide-Induced Constipation in Rats. ( Cheong, SH; Jo, HG; Kim, MJ; Lee, DS; Lee, H, 2019) |
| "Constipation of SD rats was induced by subcutaneous injection of loperamide (Lop) (4 mg/kg weight) in 0." | 7.88 | Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. ( Choi, JY; Choi, YW; Hong, JT; Hwang, DY; Kim, JE; Kim, KM; Lee, MR; Park, JJ; Son, HJ; Song, BR, 2018) |
| "Loperamide (2 mg/kg) was injected subcutaneously to induce constipation in rats." | 7.85 | Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats. ( Ahn, SH; Han, SH; Kim, EY; Lee, HS; Park, K; Suh, HJ, 2017) |
| " plantarum NCU116 on loperamide-induced constipation in a mouse model." | 7.81 | Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice. ( Gong, J; Li, C; Nie, SP; Xie, MY; Xiong, T; Zhu, KX, 2015) |
| " platyphylla, alterations in excretion parameters, histological structure, mucin secretion, and related protein levels were investigated in rats with loperamide (Lop)-induced constipation after treatment with aqueous extract of L." | 7.79 | Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats. ( Hong, JT; Hwang, DY; Kim, JE; Ko, J; Kwak, MH; Lee, YJ, 2013) |
| " Loperamide (2 mg/kg, twice per day) was injected intraperitoneally to induce constipation in the four experimental groups." | 7.78 | Effects of Ficus carica paste on loperamide-induced constipation in rats. ( Back, HI; Chae, HJ; Chae, SW; Ha, KC; Hwang, MH; Im, YJ; Jeon, JY; Jeung, HW; Kim, DS; Kim, HR; Kim, JH; Kim, MG; Kim, SY; Lee, CU; Lee, GH; Lee, HY; Li, B; Oh, MR; Park, SH; Shin, SJ; So, BO; Sung, MS; Yoo, WH, 2012) |
| "16 rats (study group) were evaluated in 3 phases of 6 days each: A (normal conditions), B (loperamide-induced constipation), and C (colic vein legation) and compared with rats treated in phase C with PEG 4,000 (control group)." | 7.78 | Effect of colic vein ligature in rats with loperamide-induced constipation. ( Aldini, R; Bianchi, E; Cavallari, G; Cevenini, M; Guidetti, E; Nardo, B; Neri, F; Pariali, M; Piras, GL; Tsivian, M, 2012) |
| "The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively." | 7.76 | Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium. ( An, R; Cui, B; Hu, Z; Wang, X; Wu, D; Yuan, J; Zhou, J, 2010) |
| " EEA-1, EEA-2, the main constituents of EEAs (mangiferin, and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice." | 7.76 | Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. ( Araki, Y; Hara, H; Iinuma, M; Ito, T; Izuta, H; Kakino, M; Oyama, M; Shimazawa, M; Tsuruma, K, 2010) |
| "Constipation was induced by oral administration of loperamide (3 mg/kg body weight) while the control rats received normal saline." | 7.76 | The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats. ( Afolayan, AJ; Sunmonu, TO; Wintola, OA, 2010) |
| " Rifaximin is a poorly absorbed antibiotic beneficial for regulating gut microbiota, but few studies have reported its effects on constipation." | 5.91 | Rifaximin Ameliorates Loperamide-Induced Constipation in Rats through the Regulation of Gut Microbiota and Serum Metabolites. ( Deng, X; Fan, J; Luo, M; Xie, P; Xiong, L, 2023) |
| "Constipation is one of the most common gastrointestinal tract symptoms." | 5.72 | Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice. ( Geng, F; Hou, T; Li, B; Liu, X; Xia, P; Zhan, F; Zhang, Z, 2022) |
| " Supportive treatment with loperamide is associated with constipation." | 5.69 | Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B). ( Doi, M; Iwasa, T; Masuda, H; Matsumoto, K; Miyoshi, Y; Niikura, N; Sagara, Y; Sakai, H; Shimomura, A; Takahashi, M; Takano, T; Tanabe, Y; Tokunaga, S; Tsurutani, J; Yoshimura, K, 2023) |
| "Spastic constipation was induced via oral LP administration (3 mg/kg) for 6 days, 1 h before administering each test compound in groups 1 and 2." | 5.62 | Effects of probiotics on loperamide-induced constipation in rats. ( Honma, M; Inatomi, T, 2021) |
| "Constipation is one of the most prevalent gastrointestinal tract diseases." | 5.62 | Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation. ( Pegg, RB; Sun, R; Zhang, Q; Zhang, Y; Zhong, D; Zhong, G, 2021) |
| "Constipation is a common condition that affects individuals of all ages, and prolonged constipation needs to be prevented to avoid potential complications and reduce the additional stress on individuals with pre-medical conditions." | 5.62 | Heat-inactivated Lactobacillus plantarum nF1 promotes intestinal health in Loperamide-induced constipation rats. ( Chae, HJ; Chung, MJ; Hoang, TH; Jin, JS; Kang, IY; Lee, GH; Lee, HY; Park, SA, 2021) |
| "Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life." | 5.56 | Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats. ( Abdellaoui, A; Hajji, N; Jabri, MA; Rtibi, K; Sebai, H; Tounsi, H; Wannes, D, 2020) |
| "Constipation is an acute or chronic illness attributed to various causes, ranging from lifestyle habits to side effects of a disease." | 5.51 | Synergic Laxative Effects of an Herbal Mixture of Liriope platyphylla, Glycyrrhiza uralensis, and Cinnamomum cassia in Loperamide-Induced Constipation of Sprague Dawley Rats. ( Choi, JY; Hong, JT; Hwang, DY; Kim, HR; Kim, JE; Lee, ML; Park, JJ; Song, BR; Song, HK; Yun, WB, 2019) |
| "Spastic constipation was induced via oral treatment with LP (3 mg/kg) for 6 days 1 h before the administration of each test compound." | 5.51 | Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats. ( Bashir, KMI; Cho, HR; Choi, JS; Jung, GW; Kim, YD; Ku, SK; Lim, JM; Park, DC; Park, SJ; Song, CH, 2019) |
| "Constipation is a common affliction which causes discomfort and affects the quality of life of affected individuals." | 5.48 | Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation. ( Liang, Y; Su, Q; Wang, D; Wu, D; Yan, Z; Yin, H; Yin, J, 2018) |
| "Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life." | 5.48 | The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. ( Jang, SH; Yang, DK, 2018) |
| "Constipation has a significant influence on quality of life." | 5.48 | Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats. ( Cong, LM; Deng, Y; He, CY; Li, M; Liu, Y; Mei, L; Yuan, JL; Zhang, BB; Zheng, PY, 2018) |
| "Loperamide is a μ-opioid receptor agonist with antidiarrhoeal effects." | 5.48 | [Loperamide abuse - constipation or heart attack?] ( Bjarnadottir, GD; Gunnarsdottir, AK; Haraldsson, M; Johannsson, M, 2018) |
| "Constipation is a common gastrointestinal disorder characterized by symptoms such as straining, hard stool, and infrequent defecation." | 5.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "Constipation is a risk factor of colorectal cancer." | 5.31 | Decreased colonic mucus in rats with loperamide-induced constipation. ( Hase, T; Meguro, S; Sakata, T; Shimotoyodome, A; Tokimitsu, I, 2000) |
| "Methylnaltrexone (MNTX) is approved for subcutaneous treatment (MNTX-SC) of opioid induced constipation." | 5.22 | Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects. ( Kolbow, J; Maritz, MA; Modess, C; Oswald, S; Rey, H; Siegmund, W; Wegner, D; Weitschies, W, 2016) |
| "The purpose of this study was to examine the effectiveness and tolerability of loperamide compared with psyllium for reducing fecal incontinence." | 5.20 | Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial. ( Beasley, TM; Burgio, KL; Goode, PS; Markland, AD; Redden, DT; Richter, HE; Whitehead, WE; Wilcox, CM, 2015) |
| " Loperamide is an effective anti-diarrheal agent, but it usually induces constipation." | 5.11 | A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. ( Liao, KF; Shieh, MJ; Wang, HH, 2005) |
| "Loperamide was used to provide a source of opioid-induced constipation in healthy volunteers." | 5.08 | A volunteer model for the comparison of laxatives in opioid-related constipation. ( Sykes, NP, 1996) |
| "This study was to evaluate the effects of CF and CP on loperamide-induced constipation and the underlying mechanism." | 4.84 | Croton tiglium L. seeds ameliorate loperamide-induced constipation via regulating gastrointestinal hormones and gut microbiota before and after processing. ( Hu, J; Jia, ZF; Pan, W; Wang, JL, 2024) |
| "The results reveal that sticky rice fermented huangjiu may alleviate loperamide-induced constipation by the regulation of serum neurotransmitters and gut microbiota." | 4.31 | Alleviation of loperamide-induced constipation with sticky rice fermented huangjiu by the regulation of serum neurotransmitters and gut microbiota. ( Chen, S; Feng, X; Ji, Z; Mao, J; Shi, Y; Zhou, W; Zhou, Z, 2023) |
| " Loperamide hydrochloride was used to establish a mouse model of constipation." | 4.31 | Effect and mechanism of functional compound fruit drink on gut microbiota in constipation mice. ( Cao, J; Chen, F; Li, C; Shi, Y; Wang, Z, 2023) |
| "The effects of soluble dietary fiber (SDF) and cellulose (IDF) from Saccharina japonica by-product and their differences in improving constipation were further clarified in the present study." | 4.31 | Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. ( Cao, J; He, Y; Li, N; Miao, J; Qin, L; Qu, C; Wang, J; Wang, K; Zhang, L, 2023) |
| " Animal experiments showed that the 10% SHY treatment prevented constipation by increasing feces number, fecal water content, and small intestinal transit rate and reducing inflammatory injury in loperamide-induced constipated rats." | 4.31 | Defatted hempseed meal altered the metabolic profile of fermented yogurt and enhanced the ability to alleviate constipation in rats. ( Bai, M; Hua, D; Li, J; Liu, H; Song, H; Xu, J; Xu, X; Yang, L; Yuan, Z; Zhu, D, 2023) |
| " A loperamide-induced mouse constipation model was developed, and all mice were randomly divided into control (Con), loperamide (Lop) and L-PA (Lop + L-PA) treatment groups (6 mice per group)." | 4.31 | Protective effect of L-pipecolic acid on constipation in C57BL/6 mice based on gut microbiome and serum metabolomic. ( Li, H; Pan, Y; Tian, PP; Xiao, HY; Yan, B; Yuan, LP; Zhang, WJ, 2023) |
| "The present study aimed to investigate the effect of oral administration of snail-derived mucin extract (SM) on ameliorating constipation symptoms of loperamide-induced constipated rats (n = 6)." | 4.31 | Modulation of gut microbiota ecosystem by a glucan-rich snail mucin heteropolysaccharide attenuates loperamide-induced constipation. ( Ahn, Y; Jeong, EJ; Kim, H; Kim, WJ; Lee, JS; Moon, SK; Park, C; Suh, HJ; Yu, KW, 2023) |
| "This study aimed to investigate the effects of the lychee pulp-derived dietary fiber-bound phenolic complex (DF-BPC) on a murine model of loperamide-induced constipation and its molecular mechanism associated with gut microbiota modification." | 4.31 | Lychee Pulp-Derived Dietary Fiber-Bound Phenolic Complex Upregulates the SCFAs-GPRs-ENS Pathway and Aquaporins in Loperamide-Induced Constipated Mice by Reshaping Gut Microbiome. ( Deng, M; Dong, L; Huang, F; Huang, G; Su, D; Xu, Z; Zhang, R, 2023) |
| "Constipation in rats was induced by loperamide, and rats were randomly assigned into model (saline), HHT-low (95 g/kg), HTT-medium (190 g/kg), HTT-high (380 g/kg) and positive control (mosapride) groups." | 4.31 | Hetong decoction relieves loperamide-induced constipation in rats by regulating expression of aquaporins. ( Jingbo, X; Kai, H; Qing, L; Qing, Z; Weiwei, QI; Xi, H; Youguang, X, 2023) |
| " This study determined the protective effects of BSH-1 against loperamide (Lop)-induced constipation in mice." | 4.12 | Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice. ( Huang, J; Lin, B; Wang, Q; Xiao, H; Xie, Z; Zhang, Y; Zheng, Y, 2022) |
| "Chitosan oligosaccharides (COS) can improve the symptoms of constipation." | 4.12 | Plasma metabolomic profiles reveal regulatory effect of chitosan oligosaccharides on loperamide-induced constipation in mice. ( Cheng, X; Hu, B; Hu, H; Lin, A; Liu, H; Sun, G; Yang, H; Zhang, X; Zheng, J, 2022) |
| "The present study was undertaken to assess SHTC relieved effects on the clinical symptoms of loperamide (LOP) induced constipation in Sprague Dawley (SD) rat model and to clarify the relationship between the protective effect of SHTC on constipation and the gut microbiota." | 4.12 | Chinese patent medicine shouhui tongbian capsule attenuated loperamide-induced constipation through modulating the gut microbiota in rat. ( Erhunmwunsee, F; Li, B; Lin, Q; Liu, M; Mou, Y; Tian, J; Wang, S; Zhang, G, 2022) |
| "This study was designed to explore the improvement of chitosan oligosaccharides (COS) on constipation through regulation of gut microbiota." | 4.02 | Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice. ( Bao, X; Jiang, N; Lin, A; Liu, H; Sun, G; Yang, H; Zhang, X; Zheng, J, 2021) |
| "Lactulose is a common laxative and has been widely applied to clinical treatment for constipation." | 4.02 | Modulation of gut microbiota and intestinal metabolites by lactulose improves loperamide-induced constipation in mice. ( Bao, X; Cheng, X; Jiang, N; Kong, M; Lin, A; Liu, H; Sun, G; Zhang, X; Zheng, J, 2021) |
| "In vivo, the ATE was studied in loperamide-induced constipation of mice." | 4.02 | Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca ( Chen, Y; Huang, B; Jia, Z; Liu, J; Wu, H; Xiao, H; Yu, Y; Zhao, S, 2021) |
| " Constipation was induced in rats with loperamide." | 4.02 | 7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats. ( Han, L; Han, Q; He, B; He, J; Luan, X; Ma, L; Qu, Z; Sun, Y; Wang, B; Xu, L, 2021) |
| "To investigate the role of tannin-enriched extracts of Ecklonia cava (TEE) on the regulation of oxidative balance and laxative activity in chronic constipation, we investigated alterations after exposure to TEE, on constipation phenotypes, muscarinic cholinergic regulation, and oxidative stress responses in the transverse colons of SD rats with loperamide (Lop)-induced constipation." | 4.02 | Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats. ( Choi, YJ; Gong, JE; Hong, JT; Hwang, DY; Jung, YS; Kim, JE; Lee, HS; Lee, SJ; Lee, YJ; Sung, JE, 2021) |
| "Shouhui Tongbian Capsules was used to explore the therapeutic effect and potential mechanism on slow transit constipation model mice induced by loperamide hydrochloride." | 4.02 | [Therapeutic effect and mechanism of Shouhui Tongbian Capsules on slow transit constipation model mice]. ( Guo, Q; Pan, LH; Zeng, KW; Zhang, GM; Zheng, SZ, 2021) |
| "In this paper, SD rat constipation model was established with loperamide hydrochloride to study the effect of Chrysanthemum morifolium polysaccharide on the improvement of functional constipation, and the mechanism of improving constipation was investigated with the proteomics and intestinal flora." | 4.02 | The effect of microbial composition and proteomic on improvement of functional constipation by Chrysanthemum morifolium polysaccharide. ( Ahmed, AF; Kang, W; Liang, Q; Tang, Q; Wang, J; Zhang, Y; Zhao, Q, 2021) |
| " In a loperamide constipation model, coadministration of PAT1inh-B01 with DRAinh-A270 increased stool output compared with DRAinh-A270 alone." | 4.02 | SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. ( Cil, O; Haggie, PM; Rivera, AA; Tan, JT; Verkman, AS, 2021) |
| " Constipation was induced by 5 mg/kg loperamide days 12 through 14 in all groups except the control." | 3.96 | Amelioration of gut dysbiosis and gastrointestinal motility by konjac oligo-glucomannan on loperamide-induced constipation in mice. ( Hayeeawaema, F; Khuituan, P; Wichienchot, S, 2020) |
| "In the present study, we investigated the laxative effects of taurine in a rat model of loperamide-induced constipation." | 3.91 | Laxative Effects of Taurine on Loperamide-Induced Constipation in Rats. ( Cheong, SH; Jo, HG; Kim, MJ; Lee, DS; Lee, H, 2019) |
| " polysaccharides (AABP) in loperamide-induced constipation rats." | 3.91 | Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats. ( Guan, W; Kuang, H; Li, X; Liu, Y; Xia, Y; Yang, B; Zhou, Y, 2019) |
| "Fatty acid binding protein 4 inhibitor, BMS309403, was administered acutely or chronically for 6 and 13 consecutive days and its effect on GI transit was assessed in physiological conditions and in loperamide-induced constipation." | 3.88 | FABP4 blocker attenuates colonic hypomotility and modulates white adipose tissue-derived hormone levels in mouse models mimicking constipation-predominant IBS. ( Cygankiewicz, A; Fichna, J; Jacenik, D; Krajewska, WM; Małecka-Panas, E; Mokrowiecka, A; Mosińska, P; Pintelon, I; Sałaga, M; Sibaev, A; Storr, M; Timmermans, JP; Wasilewski, A, 2018) |
| "Constipation of SD rats was induced by subcutaneous injection of loperamide (Lop) (4 mg/kg weight) in 0." | 3.88 | Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. ( Choi, JY; Choi, YW; Hong, JT; Hwang, DY; Kim, JE; Kim, KM; Lee, MR; Park, JJ; Son, HJ; Song, BR, 2018) |
| " Oral DRAinh-A250 and tenapanor comparably reduced signs of constipation in loperamide-treated mice, with additive effects found on coadministration." | 3.88 | SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. ( Cil, O; Haggie, PM; Lee, S; Phuan, PW; Rivera, AA; Tan, JA; Verkman, AS, 2018) |
| "Loperamide (2 mg/kg) was injected subcutaneously to induce constipation in rats." | 3.85 | Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats. ( Ahn, SH; Han, SH; Kim, EY; Lee, HS; Park, K; Suh, HJ, 2017) |
| " The present study was carried out to evaluate the protective effect of Malva sylvestris aqueous extract (MSAE) on constipation- induced by loperamide in male Wistar rats." | 3.85 | Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment. ( Hajji, N; Jabri, MA; Marzouki, L; Sakly, M; Sebai, H; Wannes, D, 2017) |
| " plantarum NCU116 on loperamide-induced constipation in a mouse model." | 3.81 | Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice. ( Gong, J; Li, C; Nie, SP; Xie, MY; Xiong, T; Zhu, KX, 2015) |
| "The loperamide-induced constipation reduced the absorption of rhein." | 3.80 | Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes. ( Chang, LW; Hou, ML; Lin, CH; Lin, LC; Tsai, TH, 2014) |
| " platyphylla, alterations in excretion parameters, histological structure, mucin secretion, and related protein levels were investigated in rats with loperamide (Lop)-induced constipation after treatment with aqueous extract of L." | 3.79 | Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats. ( Hong, JT; Hwang, DY; Kim, JE; Ko, J; Kwak, MH; Lee, YJ, 2013) |
| " Loperamide (2 mg/kg, twice per day) was injected intraperitoneally to induce constipation in the four experimental groups." | 3.78 | Effects of Ficus carica paste on loperamide-induced constipation in rats. ( Back, HI; Chae, HJ; Chae, SW; Ha, KC; Hwang, MH; Im, YJ; Jeon, JY; Jeung, HW; Kim, DS; Kim, HR; Kim, JH; Kim, MG; Kim, SY; Lee, CU; Lee, GH; Lee, HY; Li, B; Oh, MR; Park, SH; Shin, SJ; So, BO; Sung, MS; Yoo, WH, 2012) |
| "16 rats (study group) were evaluated in 3 phases of 6 days each: A (normal conditions), B (loperamide-induced constipation), and C (colic vein legation) and compared with rats treated in phase C with PEG 4,000 (control group)." | 3.78 | Effect of colic vein ligature in rats with loperamide-induced constipation. ( Aldini, R; Bianchi, E; Cavallari, G; Cevenini, M; Guidetti, E; Nardo, B; Neri, F; Pariali, M; Piras, GL; Tsivian, M, 2012) |
| " crassna were evaluated by the frequency and weight of stools in loperamide-induced constipation model mice." | 3.78 | Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves. ( Araki, Y; Hara, H; Iinuma, M; Ito, T; Kakino, M; Maruyama, H; Oyama, M; Tazawa, S; Watarai, T, 2012) |
| " The present study evaluated the toxicological effect of aqueous leaf extract of the herb at 50, 100 and 200 mg/kg body weight for 7 days on the haematological parameters as well as liver and kidney function indices in loperamide-induced constipated rats." | 3.77 | Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats. ( Afolayan, AJ; Sunmonu, TO; Wintola, OA, 2011) |
| "), produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner." | 3.76 | Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats. ( Bahi, C; Datté, JY; Djaman, JA; Méité, S; N'guessan, DJ; Yéo, D, 2010) |
| "The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively." | 3.76 | Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium. ( An, R; Cui, B; Hu, Z; Wang, X; Wu, D; Yuan, J; Zhou, J, 2010) |
| " The effect of GBFY on colonic epithelial proliferation was investigated through loperamide (LPM)-induced constipation in rats." | 3.76 | Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. ( Choi, JH; Jeon, JR, 2010) |
| " EEA-1, EEA-2, the main constituents of EEAs (mangiferin, and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice." | 3.76 | Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. ( Araki, Y; Hara, H; Iinuma, M; Ito, T; Izuta, H; Kakino, M; Oyama, M; Shimazawa, M; Tsuruma, K, 2010) |
| "Constipation was induced by oral administration of loperamide (3 mg/kg body weight) while the control rats received normal saline." | 3.76 | The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats. ( Afolayan, AJ; Sunmonu, TO; Wintola, OA, 2010) |
| " Nor has the efficacy of selective serotonin reuptake inhibitor antidepressants (SSRIs) been demonstrated; (5) Alosetron and tegaserod carry a risk of potentially life-threatening adverse effects and therefore have negative risk-benefit balances; (6) Seeds of plants such as psyllium and ispaghul, as well as raw apples and pears, have a limited impact on constipation and pain." | 3.75 | Irritable bowel syndrome: a mild disorder; purely symptomatic treatment. ( , 2009) |
| "Although it is known that both clonidine and loperamide cause delayed colonic transit in mice, these models of drug-induced experimental constipation have not yet been fully characterized." | 3.75 | Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models. ( Doihara, H; Ito, H; Kawabata-Shoda, E; Kojima, R; Nozawa, K; Yokoyama, T, 2009) |
| "Loperamide treatment for fecal incontinence does not worsen constipation symptoms among women with normal consistency stool." | 2.94 | Impact of treatment for fecal incontinence on constipation symptoms. ( Andy, UU; Carper, B; Dyer, KY; Gantz, MG; Jelovsek, JE; Korbly, NB; Mazloomdoost, D; Meyer, I; Rogers, RG; Sassani, JC, 2020) |
| "Constipation was the most common grade 3 or higher adverse event and was reported by two (2%) of 86 participants in the loperamide and biofeedback group and two (2%) of 88 in the loperamide plus education group." | 2.90 | Controlling faecal incontinence in women by performing anal exercises with biofeedback or loperamide: a randomised clinical trial. ( Barber, MD; Carper, B; Dyer, K; Gantz, MG; Jelovsek, JE; Markland, AD; Meikle, SF; Newman, DK; Rogers, RG; Sung, VW; Sutkin, G; Visco, AG; Whitehead, WE; Zyczynski, HM, 2019) |
| "Sixty male Kunming mice were divided into control (saline), model (10 mg/kg loperamide + saline), phenolphthalein (10 mg/kg loperamide + 10 mg/kg phenolphthalein) and different dosage of BCE (10 mg/kg loperamide + 40, 80 and 160 mg/kg BCE, respectively) groups, and received intragastric administrations for eight days." | 1.91 | Therapeutic effects of ( Feng, J; Jiang, X; Wang, L; Wang, Y; Xie, S; Xu, C; Yang, B, 2023) |
| "Refractory constipation is the most severe form of constipation, and its etiology remains unknown." | 1.91 | Gut indigenous ( Chen, W; Dai, D; Li, B; Li, R; Liu, Z; Xu, S; Zhang, B, 2023) |
| "Constipation is currently one of the most common gastrointestinal disorders, and its causes are diverse." | 1.91 | The Different Ways Multi-Strain Probiotics with Different Ratios of ( Chen, W; Guo, X; Liu, X; Wang, G; Wang, L; Zhang, C; Zhao, J, 2023) |
| "Loperamide is an opioid-receptor agonist widely prescribed for treating acute diarrhea in humans." | 1.91 | Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition. ( Audrain, B; Bedu, S; Dray, N; Ghigo, JM; Pérez-Pascual, D; Stevick, RJ, 2023) |
| " Rifaximin is a poorly absorbed antibiotic beneficial for regulating gut microbiota, but few studies have reported its effects on constipation." | 1.91 | Rifaximin Ameliorates Loperamide-Induced Constipation in Rats through the Regulation of Gut Microbiota and Serum Metabolites. ( Deng, X; Fan, J; Luo, M; Xie, P; Xiong, L, 2023) |
| "Constipation is a major health concern worldwide, requiring effective and safe treatment options." | 1.72 | ( Chai, M; Chen, W; Wang, G; Wang, J; Wang, L; Yu, Q; Zhang, H; Zhao, J, 2022) |
| "Constipation is one of the most common gastrointestinal tract symptoms." | 1.72 | Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice. ( Geng, F; Hou, T; Li, B; Liu, X; Xia, P; Zhan, F; Zhang, Z, 2022) |
| "Constipation has become an epidemic enteric medical problem, accompanied with increasing long-term sequelae." | 1.72 | Shouhui Tongbian Capsule ameliorates constipation via gut microbiota-5-HT-intestinal motility axis. ( Bai, J; Cai, Y; Gu, Y; Huang, N; Huang, Z; Liu, R; Sun, R; Zhang, G, 2022) |
| "Constipation was induced in the mice via loperamide (3mg/kg body weight)." | 1.62 | In vivo acute toxicity, laxative and antiulcer effect of the extract of Dryopteris Ramose. ( Alam, W; Daglia, M; Ghaffar, R; Khan, H; Khan, SA; Khan, SHA; Nazir, S, 2021) |
| "Spastic constipation was induced via oral LP administration (3 mg/kg) for 6 days, 1 h before administering each test compound in groups 1 and 2." | 1.62 | Effects of probiotics on loperamide-induced constipation in rats. ( Honma, M; Inatomi, T, 2021) |
| "Constipation is one of the most prevalent gastrointestinal tract diseases." | 1.62 | Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation. ( Pegg, RB; Sun, R; Zhang, Q; Zhang, Y; Zhong, D; Zhong, G, 2021) |
| "Constipation is a common condition that affects individuals of all ages, and prolonged constipation needs to be prevented to avoid potential complications and reduce the additional stress on individuals with pre-medical conditions." | 1.62 | Heat-inactivated Lactobacillus plantarum nF1 promotes intestinal health in Loperamide-induced constipation rats. ( Chae, HJ; Chung, MJ; Hoang, TH; Jin, JS; Kang, IY; Lee, GH; Lee, HY; Park, SA, 2021) |
| "Constipation is a condition with a high prevalence rate worldwide and may occur in men and women of any age." | 1.62 | Different ( Chai, M; Chen, W; Li, X; Wang, G; Wang, L; Zhang, H; Zhao, J, 2021) |
| "Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life." | 1.56 | Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats. ( Abdellaoui, A; Hajji, N; Jabri, MA; Rtibi, K; Sebai, H; Tounsi, H; Wannes, D, 2020) |
| "pentosaceus B49 treatment relieved constipation in mice by shortening the defecation time, increasing the GI transit rate and stool production." | 1.56 | Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice. ( Guan, X; Huang, J; Li, J; Li, S; Lin, B; Qian, L; Wang, Q; Zheng, Y, 2020) |
| "Recently, the number of patients with spina bifida requiring management for fecal incontinence has increased." | 1.51 | Bowel management program in patients with spina bifida. ( Bischoff, A; Edmonds, T; Hall, J; Jacobson, R; Ketzer, J; Peña, A; Schletker, J; Trecartin, A, 2019) |
| "Constipation is an acute or chronic illness attributed to various causes, ranging from lifestyle habits to side effects of a disease." | 1.51 | Synergic Laxative Effects of an Herbal Mixture of Liriope platyphylla, Glycyrrhiza uralensis, and Cinnamomum cassia in Loperamide-Induced Constipation of Sprague Dawley Rats. ( Choi, JY; Hong, JT; Hwang, DY; Kim, HR; Kim, JE; Lee, ML; Park, JJ; Song, BR; Song, HK; Yun, WB, 2019) |
| "Spastic constipation was induced via oral treatment with LP (3 mg/kg) for 6 days 1 h before the administration of each test compound." | 1.51 | Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats. ( Bashir, KMI; Cho, HR; Choi, JS; Jung, GW; Kim, YD; Ku, SK; Lim, JM; Park, DC; Park, SJ; Song, CH, 2019) |
| "Constipation is a common affliction which causes discomfort and affects the quality of life of affected individuals." | 1.48 | Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation. ( Liang, Y; Su, Q; Wang, D; Wu, D; Yan, Z; Yin, H; Yin, J, 2018) |
| "Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life." | 1.48 | The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. ( Jang, SH; Yang, DK, 2018) |
| "Constipation has a significant influence on quality of life." | 1.48 | Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats. ( Cong, LM; Deng, Y; He, CY; Li, M; Liu, Y; Mei, L; Yuan, JL; Zhang, BB; Zheng, PY, 2018) |
| "Loperamide is a μ-opioid receptor agonist with antidiarrhoeal effects." | 1.48 | [Loperamide abuse - constipation or heart attack?] ( Bjarnadottir, GD; Gunnarsdottir, AK; Haraldsson, M; Johannsson, M, 2018) |
| " The results of the phase I study showed mizagliflozin increased stool frequency and loosened stool consistency; these effects increased progressively with an increase in the dosage and the number of doses of mizagliflozin." | 1.46 | Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. ( Asari, T; Fujimori, Y; Fushimi, N; Inoue, T; Isaji, M; Kobayashi, M; Kurooka, T; Nishibe, H; Onozato, T; Takeda, H; Takemura, M, 2017) |
| "Constipation is a common gastrointestinal disorder characterized by symptoms such as straining, hard stool, and infrequent defecation." | 1.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "Constipation is a major gastrointestinal motility disorder with clinical need for effective drugs." | 1.40 | Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. ( Doihara, H; Itou, H; Kaku, H; Keto, Y; Kojima, R; Nozawa, K; Yokoyama, T, 2014) |
| "Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life." | 1.39 | Laxative effects of Salecan on normal and two models of experimental constipated mice. ( Chen, J; Chen, P; Jia, P; Xiu, A; Zhan, Y; Zhang, J; Zhao, Y; Zhou, M, 2013) |
| "Constipation is a risk factor of colorectal cancer." | 1.31 | Decreased colonic mucus in rats with loperamide-induced constipation. ( Hase, T; Meguro, S; Sakata, T; Shimotoyodome, A; Tokimitsu, I, 2000) |
| " The dose-response of BYC and the effect on defecation by constipated experimental rats were also compared with the characteristics of cellulose diet (CE) group which served as a control." | 1.31 | Effects of brewer's yeast cell wall on constipation and defecation in experimentally constipated rats. ( Agata, K; Iino, H; Mizutani, M; Nakamura, T, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.54) | 18.7374 |
| 1990's | 3 (2.31) | 18.2507 |
| 2000's | 9 (6.92) | 29.6817 |
| 2010's | 52 (40.00) | 24.3611 |
| 2020's | 64 (49.23) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, S | 1 |
| Yue, Y | 1 |
| Sun, M | 1 |
| Chen, Y | 2 |
| Wang, X | 3 |
| Qian, H | 1 |
| Nazir, S | 1 |
| Khan, H | 1 |
| Khan, SA | 1 |
| Alam, W | 1 |
| Ghaffar, R | 1 |
| Khan, SHA | 1 |
| Daglia, M | 1 |
| Huang, J | 2 |
| Lin, B | 2 |
| Zhang, Y | 3 |
| Xie, Z | 1 |
| Zheng, Y | 3 |
| Wang, Q | 3 |
| Xiao, H | 2 |
| Na, JR | 2 |
| Lee, KH | 1 |
| Kim, E | 2 |
| Hwang, K | 1 |
| Na, CS | 2 |
| Kim, S | 2 |
| Inatomi, T | 1 |
| Honma, M | 1 |
| Zhang, X | 5 |
| Hu, B | 1 |
| Sun, G | 3 |
| Zheng, J | 3 |
| Hu, H | 1 |
| Yang, H | 3 |
| Cheng, X | 2 |
| Lin, A | 3 |
| Liu, H | 4 |
| Wang, L | 7 |
| Chai, M | 2 |
| Wang, J | 4 |
| Yu, Q | 1 |
| Wang, G | 4 |
| Zhang, H | 7 |
| Zhao, J | 7 |
| Chen, W | 10 |
| Xia, P | 1 |
| Liu, X | 4 |
| Hou, T | 1 |
| Zhan, F | 1 |
| Geng, F | 1 |
| Zhang, Z | 2 |
| Li, B | 7 |
| Shen, F | 1 |
| Zhang, J | 7 |
| Cai, H | 1 |
| Pan, Y | 2 |
| Sun, T | 1 |
| Gong, Y | 1 |
| Du, J | 1 |
| Zhong, H | 1 |
| Feng, F | 1 |
| Lin, Q | 1 |
| Liu, M | 1 |
| Erhunmwunsee, F | 1 |
| Mou, Y | 1 |
| Wang, S | 1 |
| Zhang, G | 2 |
| Tian, J | 4 |
| Li, L | 2 |
| Liu, B | 2 |
| Cao, J | 5 |
| Tian, F | 4 |
| Yu, L | 4 |
| Zhai, Q | 4 |
| Bai, J | 1 |
| Cai, Y | 1 |
| Huang, Z | 2 |
| Gu, Y | 1 |
| Huang, N | 1 |
| Sun, R | 2 |
| Liu, R | 1 |
| Feng, X | 1 |
| Shi, Y | 3 |
| Zhou, Z | 1 |
| Ji, Z | 1 |
| Zhou, W | 1 |
| Chen, S | 1 |
| Mao, J | 1 |
| Chen, F | 1 |
| Wang, Z | 2 |
| Li, C | 4 |
| Qiu, B | 1 |
| Zhu, L | 1 |
| Zhang, S | 1 |
| Han, S | 1 |
| Fei, Y | 1 |
| Ba, F | 1 |
| Berglund, B | 1 |
| Yao, M | 1 |
| Zhao, Y | 5 |
| Zhang, C | 4 |
| Gao, N | 3 |
| Jiang, H | 4 |
| Li, H | 5 |
| Cui, X | 3 |
| Tang, S | 3 |
| Jin, C | 3 |
| Wang, K | 2 |
| Li, N | 2 |
| Zhang, L | 2 |
| Qin, L | 2 |
| He, Y | 2 |
| Qu, C | 2 |
| Miao, J | 2 |
| Xie, S | 1 |
| Jiang, X | 1 |
| Xu, C | 1 |
| Wang, Y | 3 |
| Feng, J | 1 |
| Yang, B | 2 |
| Gan, H | 1 |
| Xiao, X | 1 |
| Huang, L | 2 |
| Li, W | 1 |
| Li, Z | 1 |
| Zeng, S | 1 |
| Wang, H | 1 |
| Liao, H | 1 |
| Song, J | 1 |
| Xu, J | 1 |
| Xu, X | 1 |
| Hua, D | 1 |
| Yuan, Z | 1 |
| Bai, M | 1 |
| Song, H | 1 |
| Yang, L | 1 |
| Li, J | 3 |
| Zhu, D | 1 |
| Parkar, N | 1 |
| Dalziel, JE | 1 |
| Spencer, NJ | 1 |
| Janssen, P | 1 |
| McNabb, WC | 1 |
| Young, W | 1 |
| Hu, Y | 1 |
| Gao, X | 1 |
| Liu, S | 1 |
| Luo, K | 1 |
| Fu, X | 1 |
| Sheng, J | 1 |
| Tian, Y | 1 |
| Fan, Y | 1 |
| Zhu, Q | 1 |
| Iwai, R | 1 |
| Okaguchi, T | 1 |
| Shirasaka, Y | 1 |
| Tamai, I | 1 |
| Xiao, HY | 1 |
| Yuan, LP | 1 |
| Yan, B | 1 |
| Tian, PP | 1 |
| Zhang, WJ | 1 |
| Li, R | 1 |
| Xu, S | 2 |
| Zhang, B | 2 |
| Dai, D | 1 |
| Liu, Z | 1 |
| Masuda, H | 1 |
| Tanabe, Y | 1 |
| Sakai, H | 1 |
| Matsumoto, K | 1 |
| Shimomura, A | 1 |
| Doi, M | 1 |
| Miyoshi, Y | 1 |
| Takahashi, M | 1 |
| Sagara, Y | 1 |
| Tokunaga, S | 1 |
| Iwasa, T | 1 |
| Niikura, N | 1 |
| Yoshimura, K | 1 |
| Takano, T | 1 |
| Tsurutani, J | 1 |
| Kim, H | 1 |
| Jeong, EJ | 1 |
| Park, C | 1 |
| Lee, JS | 1 |
| Kim, WJ | 1 |
| Yu, KW | 1 |
| Suh, HJ | 2 |
| Ahn, Y | 1 |
| Moon, SK | 1 |
| Dong, L | 1 |
| Xu, Z | 1 |
| Huang, G | 1 |
| Zhang, R | 1 |
| Deng, M | 1 |
| Huang, F | 1 |
| Su, D | 1 |
| Guo, X | 1 |
| Duan, T | 1 |
| Dong, X | 1 |
| Wang, C | 1 |
| Yang, X | 1 |
| Li, T | 2 |
| Hu, W | 1 |
| Wu, W | 1 |
| Jia, ZF | 1 |
| Wang, JL | 1 |
| Pan, W | 1 |
| Hu, J | 2 |
| Xi, H | 1 |
| Youguang, X | 1 |
| Kai, H | 1 |
| Weiwei, QI | 1 |
| Qing, L | 1 |
| Qing, Z | 1 |
| Jingbo, X | 1 |
| Stevick, RJ | 1 |
| Audrain, B | 1 |
| Bedu, S | 1 |
| Dray, N | 1 |
| Ghigo, JM | 1 |
| Pérez-Pascual, D | 1 |
| Xu, W | 1 |
| Feng, R | 1 |
| Zeng, L | 1 |
| Luo, M | 1 |
| Xie, P | 1 |
| Deng, X | 1 |
| Fan, J | 1 |
| Xiong, L | 1 |
| Li, S | 2 |
| Foreman, RD | 1 |
| Yin, J | 2 |
| Dai, N | 1 |
| Chen, JDZ | 1 |
| Lee, DS | 1 |
| Jo, HG | 1 |
| Kim, MJ | 1 |
| Lee, H | 1 |
| Cheong, SH | 1 |
| Andy, UU | 1 |
| Jelovsek, JE | 2 |
| Carper, B | 2 |
| Meyer, I | 1 |
| Dyer, KY | 1 |
| Rogers, RG | 2 |
| Mazloomdoost, D | 1 |
| Korbly, NB | 1 |
| Sassani, JC | 1 |
| Gantz, MG | 2 |
| Diwakarla, S | 1 |
| Bathgate, RAD | 1 |
| Hossain, MA | 1 |
| Furness, JB | 1 |
| Hayeeawaema, F | 1 |
| Wichienchot, S | 1 |
| Khuituan, P | 1 |
| Narita, Y | 1 |
| Fukumoto, K | 1 |
| Fukunaga, M | 1 |
| Kondo, Y | 1 |
| Ishitsuka, Y | 1 |
| Jono, H | 1 |
| Irie, T | 1 |
| Saito, H | 1 |
| Kadowaki, D | 1 |
| Hirata, S | 1 |
| Hajji, N | 2 |
| Wannes, D | 2 |
| Jabri, MA | 2 |
| Rtibi, K | 2 |
| Tounsi, H | 1 |
| Abdellaoui, A | 1 |
| Sebai, H | 3 |
| Guan, X | 1 |
| Qian, L | 1 |
| He, Q | 1 |
| Han, C | 1 |
| Chen, H | 1 |
| Dou, R | 1 |
| Ren, D | 1 |
| Lin, H | 1 |
| Yang, S | 1 |
| Sun, S | 1 |
| Si, Q | 1 |
| Zhang, Q | 3 |
| Wu, G | 1 |
| Hu, M | 2 |
| Jiang, C | 1 |
| Zhang, D | 2 |
| Gao, M | 2 |
| Xia, J | 1 |
| Miao, M | 1 |
| Shi, G | 2 |
| Yin, Z | 2 |
| Jiang, N | 2 |
| Bao, X | 2 |
| Kong, M | 1 |
| Wu, H | 1 |
| Huang, B | 1 |
| Yu, Y | 1 |
| Zhao, S | 1 |
| Liu, J | 1 |
| Jia, Z | 1 |
| Zhong, D | 2 |
| Pegg, RB | 2 |
| Zhong, G | 2 |
| Ma, L | 1 |
| Qu, Z | 1 |
| Xu, L | 1 |
| Han, L | 1 |
| Han, Q | 1 |
| He, J | 1 |
| Luan, X | 1 |
| Wang, B | 1 |
| Sun, Y | 1 |
| He, B | 1 |
| Kim, JE | 9 |
| Choi, YJ | 2 |
| Lee, SJ | 2 |
| Gong, JE | 2 |
| Lee, YJ | 4 |
| Sung, JE | 3 |
| Jung, YS | 1 |
| Lee, HS | 4 |
| Hong, JT | 9 |
| Hwang, DY | 9 |
| Zheng, SZ | 1 |
| Guo, Q | 1 |
| Zhang, GM | 1 |
| Pan, LH | 1 |
| Zeng, KW | 1 |
| Ren, YY | 1 |
| Meng, ZK | 1 |
| Makizaki, Y | 1 |
| Uemoto, T | 1 |
| Yokota, H | 1 |
| Yamamoto, M | 1 |
| Tanaka, Y | 1 |
| Ohno, H | 1 |
| Park, SA | 1 |
| Lee, GH | 2 |
| Hoang, TH | 1 |
| Lee, HY | 2 |
| Kang, IY | 1 |
| Chung, MJ | 1 |
| Jin, JS | 1 |
| Chae, HJ | 2 |
| Cao, PQ | 1 |
| Li, XP | 1 |
| Ou-Yang, J | 1 |
| Jiang, RG | 1 |
| Huang, FF | 1 |
| Wen, BB | 1 |
| Zhang, XN | 1 |
| Huang, JA | 1 |
| Liu, ZH | 1 |
| Liang, Q | 1 |
| Zhao, Q | 1 |
| Tang, Q | 1 |
| Ahmed, AF | 1 |
| Kang, W | 2 |
| Li, X | 2 |
| Cil, O | 2 |
| Haggie, PM | 2 |
| Tan, JT | 1 |
| Rivera, AA | 2 |
| Verkman, AS | 2 |
| Jang, M | 1 |
| Fang, C | 1 |
| Liu, Y | 4 |
| Zheng, R | 1 |
| Touw, K | 1 |
| Ringus, DL | 1 |
| Hubert, N | 1 |
| Leone, VA | 1 |
| Nadimpalli, A | 1 |
| Theriault, BR | 1 |
| Huang, YE | 1 |
| Tune, JD | 1 |
| Herring, PB | 1 |
| Farrugia, G | 1 |
| Kashyap, PC | 1 |
| Antonopoulos, DA | 1 |
| Chang, EB | 1 |
| Inoue, T | 1 |
| Takemura, M | 1 |
| Fushimi, N | 1 |
| Fujimori, Y | 1 |
| Onozato, T | 1 |
| Kurooka, T | 1 |
| Asari, T | 1 |
| Takeda, H | 1 |
| Kobayashi, M | 1 |
| Nishibe, H | 1 |
| Isaji, M | 1 |
| Selmi, S | 1 |
| Saidani, K | 1 |
| Grami, D | 1 |
| Amri, M | 1 |
| Marzouki, L | 2 |
| Ren, X | 1 |
| Liu, L | 1 |
| Gamallat, Y | 1 |
| Xin, Y | 1 |
| Liang, Y | 1 |
| Wang, D | 1 |
| Yan, Z | 1 |
| Yin, H | 1 |
| Wu, D | 2 |
| Su, Q | 1 |
| Mosińska, P | 1 |
| Jacenik, D | 1 |
| Sałaga, M | 1 |
| Wasilewski, A | 1 |
| Cygankiewicz, A | 1 |
| Sibaev, A | 1 |
| Mokrowiecka, A | 1 |
| Małecka-Panas, E | 1 |
| Pintelon, I | 1 |
| Storr, M | 1 |
| Timmermans, JP | 1 |
| Krajewska, WM | 1 |
| Fichna, J | 1 |
| Jang, SH | 1 |
| Yang, DK | 1 |
| Deng, Y | 1 |
| Li, M | 1 |
| Mei, L | 1 |
| Cong, LM | 1 |
| Zhang, BB | 1 |
| He, CY | 1 |
| Zheng, PY | 1 |
| Yuan, JL | 1 |
| Du, LD | 1 |
| Ren, Y | 1 |
| Niu, TH | 1 |
| Wu, GT | 1 |
| Wang, ZW | 1 |
| Liu, WZ | 1 |
| Shao, J | 1 |
| Xu, N | 1 |
| Fan, W | 1 |
| Zhou, X | 1 |
| Ma, P | 1 |
| Qi, S | 1 |
| Gu, B | 1 |
| Lee, MR | 1 |
| Park, JJ | 2 |
| Choi, JY | 2 |
| Song, BR | 2 |
| Son, HJ | 1 |
| Choi, YW | 1 |
| Kim, KM | 1 |
| Lee, S | 1 |
| Tan, JA | 1 |
| Phuan, PW | 1 |
| Schletker, J | 1 |
| Edmonds, T | 1 |
| Jacobson, R | 1 |
| Ketzer, J | 1 |
| Hall, J | 1 |
| Trecartin, A | 1 |
| Peña, A | 1 |
| Bischoff, A | 1 |
| Gunnarsdottir, AK | 1 |
| Johannsson, M | 1 |
| Haraldsson, M | 1 |
| Bjarnadottir, GD | 1 |
| Eor, JY | 1 |
| Tan, PL | 1 |
| Lim, SM | 1 |
| Choi, DH | 1 |
| Yoon, SM | 1 |
| Yang, SY | 1 |
| Kim, SH | 1 |
| Yun, WB | 1 |
| Lee, ML | 1 |
| Kim, HR | 2 |
| Song, HK | 1 |
| Park, JW | 2 |
| Kang, MJ | 2 |
| Choi, HJ | 2 |
| Bae, SJ | 2 |
| Choi, YS | 1 |
| Choi, Y | 1 |
| Seo, S | 1 |
| Guan, W | 1 |
| Xia, Y | 1 |
| Zhou, Y | 1 |
| Kuang, H | 1 |
| Lim, JM | 1 |
| Kim, YD | 1 |
| Song, CH | 1 |
| Park, SJ | 1 |
| Park, DC | 1 |
| Cho, HR | 1 |
| Jung, GW | 1 |
| Bashir, KMI | 1 |
| Ku, SK | 1 |
| Choi, JS | 1 |
| Markland, AD | 2 |
| Whitehead, WE | 2 |
| Barber, MD | 1 |
| Newman, DK | 1 |
| Dyer, K | 1 |
| Visco, AG | 1 |
| Sutkin, G | 1 |
| Zyczynski, HM | 1 |
| Meikle, SF | 1 |
| Sung, VW | 1 |
| Zhou, M | 1 |
| Jia, P | 1 |
| Chen, J | 1 |
| Xiu, A | 1 |
| Zhan, Y | 1 |
| Chen, P | 1 |
| Kwak, MH | 2 |
| Ko, J | 1 |
| Kojima, R | 2 |
| Nozawa, K | 2 |
| Doihara, H | 2 |
| Keto, Y | 1 |
| Kaku, H | 1 |
| Yokoyama, T | 2 |
| Itou, H | 1 |
| Hou, ML | 1 |
| Chang, LW | 1 |
| Lin, CH | 1 |
| Lin, LC | 1 |
| Tsai, TH | 1 |
| Hookway, C | 1 |
| Buckner, S | 1 |
| Crosland, P | 1 |
| Longson, D | 1 |
| Moezi, L | 1 |
| Pirsalami, F | 1 |
| Inaloo, S | 1 |
| Nie, SP | 1 |
| Zhu, KX | 1 |
| Xiong, T | 1 |
| Gong, J | 1 |
| Xie, MY | 1 |
| Shimoyama, T | 1 |
| Takahashi, R | 1 |
| Kimura, M | 1 |
| Fukuda, Y | 1 |
| Park, SH | 2 |
| Go, J | 2 |
| Koh, EK | 2 |
| Song, SH | 2 |
| Kolbow, J | 2 |
| Modess, C | 1 |
| Wegner, D | 1 |
| Oswald, S | 1 |
| Maritz, MA | 1 |
| Rey, H | 1 |
| Weitschies, W | 2 |
| Siegmund, W | 2 |
| Burgio, KL | 1 |
| Richter, HE | 1 |
| Wilcox, CM | 1 |
| Redden, DT | 1 |
| Beasley, TM | 1 |
| Goode, PS | 1 |
| Sabiu, S | 1 |
| Ashafa, OT | 1 |
| Talley, NJ | 1 |
| Lee, HA | 1 |
| Lee, YH | 1 |
| Han, SH | 1 |
| Park, K | 1 |
| Kim, EY | 1 |
| Ahn, SH | 1 |
| Sakly, M | 1 |
| Kawabata-Shoda, E | 1 |
| Ito, H | 1 |
| Méité, S | 1 |
| Bahi, C | 1 |
| Yéo, D | 1 |
| Datté, JY | 1 |
| Djaman, JA | 1 |
| N'guessan, DJ | 1 |
| Zhou, J | 1 |
| Yuan, J | 1 |
| Cui, B | 1 |
| An, R | 1 |
| Hu, Z | 1 |
| Wintola, OA | 2 |
| Sunmonu, TO | 2 |
| Afolayan, AJ | 2 |
| Jeon, JR | 1 |
| Choi, JH | 1 |
| Kakino, M | 2 |
| Izuta, H | 1 |
| Ito, T | 2 |
| Tsuruma, K | 1 |
| Araki, Y | 2 |
| Shimazawa, M | 1 |
| Oyama, M | 2 |
| Iinuma, M | 2 |
| Hara, H | 2 |
| Oh, DS | 1 |
| Choi, SM | 1 |
| Son, CG | 1 |
| Kim, JH | 1 |
| Jeung, HW | 1 |
| Lee, CU | 1 |
| Kim, DS | 1 |
| Sung, MS | 1 |
| Ha, KC | 1 |
| Back, HI | 1 |
| Kim, SY | 1 |
| Oh, MR | 1 |
| Kim, MG | 1 |
| Jeon, JY | 1 |
| Im, YJ | 1 |
| Hwang, MH | 1 |
| So, BO | 1 |
| Shin, SJ | 1 |
| Yoo, WH | 1 |
| Chae, SW | 1 |
| Chung, HH | 1 |
| Cheng, JT | 1 |
| Neri, F | 1 |
| Cavallari, G | 1 |
| Tsivian, M | 1 |
| Bianchi, E | 1 |
| Aldini, R | 1 |
| Cevenini, M | 1 |
| Guidetti, E | 1 |
| Piras, GL | 1 |
| Pariali, M | 1 |
| Nardo, B | 1 |
| Tazawa, S | 1 |
| Watarai, T | 1 |
| Maruyama, H | 1 |
| Wald, A | 1 |
| Wang, HH | 1 |
| Shieh, MJ | 1 |
| Liao, KF | 1 |
| Kamm, MA | 2 |
| Jordan, CC | 1 |
| Leaker, BR | 1 |
| Nicholson, FB | 1 |
| Murray, CD | 1 |
| Taylor, S | 1 |
| Marshall, M | 1 |
| Gibbs, A | 1 |
| Carter, EG | 1 |
| Emmanuel, AV | 1 |
| Ewe, K | 1 |
| Ueberschaer, B | 1 |
| Press, AG | 1 |
| Sykes, NP | 1 |
| De Luca, A | 1 |
| Coupar, IM | 1 |
| Shimotoyodome, A | 2 |
| Meguro, S | 2 |
| Hase, T | 2 |
| Tokimitsu, I | 2 |
| Sakata, T | 2 |
| Nakamura, T | 2 |
| Agata, K | 1 |
| Mizutani, M | 2 |
| Iino, H | 2 |
| Nishida, S | 1 |
| Misaki, F | 1 |
| Sasaki, Z | 1 |
| Kawai, K | 1 |
| Marcus, SN | 1 |
| Heaton, KW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Foeniculum Vulgare Ironing on Gastrointestinal Recovery After Colorectal Resection: a Randomized Controlled Trial.[NCT03711487] | Phase 2 | 300 participants (Actual) | Interventional | 2018-10-20 | Completed | ||
| Controlling Anal Incontinence by Performing Anal Exercises With Biofeedback or Loperamide (CAPABLe): a Randomized Placebo Controlled Trial[NCT02008565] | Phase 3 | 300 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| The Safety and Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) Versus Psyllium (Agio®) for the Treatment of Fecal Incontinence: Multicenter Randomized Trial (SERAFI)[NCT06166615] | Phase 2/Phase 3 | 148 participants (Anticipated) | Interventional | 2023-12-15 | Not yet recruiting | ||
| Antimuscarinic Medication for Urgency Urinary Incontinence in Women With Dual Incontinence (Darifenacin for Treatment of Women With Dual Incontinence)[NCT03543566] | 32 participants (Actual) | Observational | 2018-05-21 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Based on data collected from participant-completed diaries at baseline and 12 and 24 weeks, the outcome variable is computed as the difference in number of accident-free days at 12 and 24 weeks and the number of accident-free days at baseline. Only valid diaries were included in the analyses (e.g. completion of all 7 days for baseline and at least 3 complete days, not necessarily consecutive, for follow-up diaries). (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | accident-free days (Mean) | |
|---|---|---|
| 12 Weeks | 24 Weeks | |
| Loperamide - Education Only | 1.7 | 1.7 |
| Loperamide - Exercise Plus Biofeedback | 1.8 | 2.5 |
| Placebo - Education Only | 1.4 | 2.1 |
| Placebo - Exercise Plus Biofeedback | 1.9 | 1.9 |
Based on data collected from the manometry form, the outcome variable will be computed as the difference in maximum anal pressures during squeeze with the catheter at the high pressure zone (HPZ) at 12 and 24 weeks and maximum anal pressures during squeeze with the catheter at the HPZ at baseline. (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | max. anal canal pressure squeeze (mmHg) (Mean) | |
|---|---|---|
| 12 Week Maximum Anal Canal Pressure (Squeeze) | 24 Week Maximum Anal Canal Pressure (Squeeze) | |
| Loperamide - Education Only | 73.6 | 67.1 |
| Loperamide - Exercise Plus Biofeedback | 83.0 | 83.0 |
| Placebo - Education Only | 73.1 | 72.7 |
| Placebo - Exercise Plus Biofeedback | 76.3 | 74.6 |
Based on data collected from participant-completed diaries at baseline and 12 and 24 weeks, the outcome variable is computed as the difference in number of fecal incontinence episodes per day resulting in a change in pad, clothes or underwear at 12 and 24 weeks and the number of fecal incontinence episodes resulting in a change in pad, clothes or underwear at baseline. Only valid diaries were included in the analyses (e.g. completion of all 7 days for baseline and at least 3 complete days, not necessarily consecutive, for follow-up diaries). (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | pad-change leaks per day (Mean) | |
|---|---|---|
| 12 Weeks | 24 Weeks | |
| Loperamide - Education Only | -0.3 | -0.4 |
| Loperamide - Exercise Plus Biofeedback | -0.4 | -0.5 |
| Placebo - Education Only | -0.2 | -0.4 |
| Placebo - Exercise Plus Biofeedback | -0.2 | -0.1 |
Based on data collected from participant-completed diaries at baseline and 12 and 24 weeks, the outcome variable is computed as the difference in number of fecal incontinence episodes per week resulting in a change in pad, clothes or underwear at 12 and 24 weeks and the number of fecal incontinence episodes resulting in a change in pad, clothes or underwear at baseline. Only valid diaries were included in the analyses (e.g. completion of all 7 days for baseline and at least 3 complete days, not necessarily consecutive, for follow-up diaries). (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | pad-change leaks per week (Mean) | |
|---|---|---|
| 12 Weeks | 24 Weeks | |
| Loperamide - Education Only | -1.3 | -2.2 |
| Loperamide - Exercise Plus Biofeedback | -2.7 | -3.3 |
| Placebo - Education Only | -1.7 | -2.5 |
| Placebo - Exercise Plus Biofeedback | -1.1 | -0.7 |
Based on data collected from the manometry form, the outcome variable is computed as the difference in resting anal canal pressures (mm Hg) at 2 cm, 1 cm, and 0 cm insertion at 12 and 24 weeks and resting anal canal pressures (mm Hg) at 2 cm, 1 cm, and 0 cm insertion at baseline (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | resting anal canal pressure (mm Hg) (Mean) | |||
|---|---|---|---|---|
| 12 Week Maximum Anal Canal Pressure (Rest) | 24 Week Maximum Anal Canal Pressure (Rest) | 12 Week Maximum Anal Canal Pressure (Squeeze) | 24 Week Maximum Anal Canal Pressure (Squeeze) | |
| Loperamide - Education Only | 51.1 | 45.7 | 73.6 | 67.1 |
| Loperamide - Exercise Plus Biofeedback | 52.6 | 47.7 | 83.0 | 83.0 |
| Placebo - Education Only | 46.3 | 46.5 | 73.1 | 72.7 |
| Placebo - Exercise Plus Biofeedback | 49.4 | 47.8 | 76.3 | 74.6 |
"The primary outcome measure for all study arms is the change from baseline in St. Mark's (Vaizey) Score 24 weeks after treatment initiation to compare the marginal outcomes of anal exercise with biofeedback to usual care and loperamide to placebo.~The St. Mark's (Vaizey) score, published in 1999, is commonly used in clinical studies and reports and was based on the Jorge-Wexner score but added two further items for assessment: the use of constipating medication and the presence of fecal urgency. Minimum score is 0 = perfect continence; maximum score is 24 = totally incontinent." (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 12 Week St. Mark's Score | 24 Week St. Mark's Score | |
| Loperamide - Education Only | -4.5 | -6.2 |
| Loperamide - Exercise Plus Biofeedback | -5.5 | -9.7 |
| Placebo - Education Only | -3.4 | -4.5 |
| Placebo - Exercise Plus Biofeedback | -4.4 | -5.9 |
Based on data collected from participant-completed diaries at baseline and 12 and 24 weeks, the outcome variable is computed as the difference in daily average FI episodes at 12 and 24 weeks and the daily average FI episodes at baseline. Only valid diaries were included in the analyses (e.g. completion of all 7 days for baseline and at 3 complete days, not necessarily consecutive, for follow-up diaries). (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | leaks per day (Mean) | |
|---|---|---|
| 12 Weeks | 24 Weeks | |
| Loperamide - Education Only | -0.9 | -1.0 |
| Loperamide - Exercise Plus Biofeedback | -1.1 | -1.3 |
| Placebo - Education Only | -1.0 | -1.3 |
| Placebo - Exercise Plus Biofeedback | -0.7 | -0.7 |
Based on data collected from the manometry form, the outcome variable is computed as the difference in volume of air (mL) at first sensation for perception of rectal distention at 12 and 24 weeks and volume of air (mL) at first sensation for perception of rectal distention at baseline. (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | volume of air (mL) (Mean) | |
|---|---|---|
| 12 Week Volume of Air at First Sensation | 24 Week Volume of Air at First Sensation | |
| Loperamide - Education Only | 21.6 | 21.6 |
| Loperamide - Exercise Plus Biofeedback | 19.0 | 20.1 |
| Placebo - Education Only | 25.1 | 23.5 |
| Placebo - Exercise Plus Biofeedback | 22.7 | 24.5 |
Based on data collected from the manometry form, the outcome variable is computed as the difference in maximum tolerable rectal volume of air (mL) at 12 and 24 weeks and maximum tolerable rectal volume of air (mL) at baseline. (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | volume of air (mL) (Mean) | |
|---|---|---|
| 12 Week Volume of Air at Strong Urge | 24 Week Volume of Air at Strong Urge | |
| Loperamide - Education Only | 73.0 | 77.3 |
| Loperamide - Exercise Plus Biofeedback | 69.3 | 76.0 |
| Placebo - Education Only | 71.8 | 73.1 |
| Placebo - Exercise Plus Biofeedback | 66.9 | 78.4 |
The Pelvic Floor Impact Questionnaire short form (PFIQ-7) measuring the impact of bladder, bowel, and vaginal symptoms on a woman's daily activities, relationships and emotions is composed of 3 scales of 7 questions each: the Urinary Impact Questionnaire (UIQ; range 0-100), the Pelvic Organ Prolapse Impact Questionnaire (POPIQ; range 0-100), and the Colorectal-Anal Impact Questionnaire (CRAIQ; range 0-100). The range of responses on the CRAIQ is 0-3 with (0) Not at all, (1) Somewhat, (2) Moderately, and (3), Quite a bit. Scores are calculated by multiplying the mean value of all answered questions for a scale by 100 divided by 3. The range of responses is: 0-100 with 0 (least negative impact) to 100 (most negative impact). Change = (Week [12, 24] Score - Baseline Score). Lower scores indicate better function / fewer symptoms. (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 12 Weeks | 24 Weeks | |
| Loperamide - Education Only | -15.8 | -41.6 |
| Loperamide - Exercise Plus Biofeedback | -12.5 | -41.3 |
| Placebo - Education Only | -12.3 | -17.3 |
| Placebo - Exercise Plus Biofeedback | -10.8 | -32.4 |
"The Modified Manchester Health Questionnaire (MMHQ) includes the 4-item Fecal Incontinence Severity Index (FISI), which measures the severity of liquid, solid, mucus, or gas incontinence that occurs from 2 or more times per day, once per day, 2 or more times per week, once a week, to 1-3 times per month. Patient-weighted scores were used to determine severity and scores ranged from 0-61, with higher scores indicating worse fecal incontinence (FI) severity. An FISI score of 0 indicated continence." (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 12 Week MMHQ Severity Measures Score | 24 Week MMHQ Severity Measures Score | |
| Loperamide - Education Only | -14.4 | -19.2 |
| Loperamide - Exercise Plus Biofeedback | -12.4 | -19.1 |
| Placebo - Education Only | -7.8 | -20.0 |
| Placebo - Exercise Plus Biofeedback | -10.6 | -15.0 |
The Pelvic Floor Distress Inventory is a 20-question, validated, self-reported instrument used to evaluate pelvic floor symptoms. It consists of an overall scale (range: 0-300) comprised of 3 sub-scales: 1) Pelvic Organ Prolapse Distress Inventory (range: 0-100), 2) Colorectal Anal Distress Inventory (range: 0-100), and 3) Urinary Distress Inventory (range: 0-100). The range of responses on the CRADI is 1-4 with (1) Not at all, (2) Somewhat, (3) Moderately, and (4), Quite a bit. Scores are calculated by multiplying the mean value of all questions answered by 25 for the scale. The range of responses is: 0-100 with 0 (least distress) to 100 (most distress). Change = (Week [12, 24] Score - Baseline Score). Lower scores indicate better function / fewer symptoms. (NCT02008565)
Timeframe: 12 and 24 weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 12 Week CRADI Score | 24 Week CRADI Score | |
| Loperamide - Education Only | -16.9 | -21.7 |
| Loperamide - Exercise Plus Biofeedback | -16.3 | -21.5 |
| Placebo - Education Only | -4.6 | -15.7 |
| Placebo - Exercise Plus Biofeedback | -13.1 | -15.7 |
The Patient Global Impression of Improvement (PGI-I) is a patient-reported measure of perceived improvement with treatment, as assessed on a scale of 1 (very much better) to 7 (very much worse). Included here are participants who had improvement as indicated by a rating of 1 (very much better), 2 (much better), or 3 (a little better). (NCT02008565)
Timeframe: 12 and 24 Weeks
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| 12 Weeks | 24 Weeks | |
| Loperamide - Education Only | 61 | 60 |
| Loperamide - Exercise Plus Biofeedback | 68 | 67 |
| Placebo - Education Only | 26 | 25 |
| Placebo - Exercise Plus Biofeedback | 57 | 59 |
4 reviews available for loperamide and Colonic Inertia
| Article | Year |
|---|---|
Irritable bowel syndrome in adults in primary care: summary of updated NICE guidance.
Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Constipation; Diarrhea; Diet Therapy; Humans; Irri | 2015 |
Irritable bowel syndrome--diarrhoea.
Topics: Anti-Bacterial Agents; Antidepressive Agents, Tricyclic; Antidiarrheals; Constipation; Defecation; D | 2012 |
Insights into opioid action in the intestinal tract.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Diarrhea; Gastrointestinal Motility; Guin | 1996 |
Why the enteric nervous system is important to clinicians.
Topics: Antidiarrheals; Colonic Diseases, Functional; Constipation; Digestive System; Gastrointestinal Agent | 2000 |
9 trials available for loperamide and Colonic Inertia
| Article | Year |
|---|---|
Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B).
Topics: Breast Neoplasms; Constipation; Diarrhea; Female; Humans; Loperamide; Probiotics; Quality of Life; T | 2023 |
Impact of treatment for fecal incontinence on constipation symptoms.
Topics: Adult; Aged; Aged, 80 and over; Antidiarrheals; Biofeedback, Psychology; Combined Modality Therapy; | 2020 |
Controlling faecal incontinence in women by performing anal exercises with biofeedback or loperamide: a randomised clinical trial.
Topics: Aged; Anal Canal; Antidiarrheals; Biofeedback, Psychology; Constipation; Exercise Therapy; Fecal Inc | 2019 |
Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects.
Topics: Adult; Antidiarrheals; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; | 2016 |
Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial.
Topics: Aged; Antidiarrheals; Cathartics; Constipation; Double-Blind Method; Drug Administration Schedule; F | 2015 |
Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial.
Topics: Aged; Antidiarrheals; Cathartics; Constipation; Double-Blind Method; Drug Administration Schedule; F | 2015 |
Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial.
Topics: Aged; Antidiarrheals; Cathartics; Constipation; Double-Blind Method; Drug Administration Schedule; F | 2015 |
Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence: The Fecal Incontinence Prescription (Rx) Management (FIRM) Randomized Clinical Trial.
Topics: Aged; Antidiarrheals; Cathartics; Constipation; Double-Blind Method; Drug Administration Schedule; F | 2015 |
Effect of acupuncture for gastrointestinal activity differs depending on the pathophysiological condition.
Topics: Acupuncture Points; Acupuncture Therapy; Adult; Constipation; Gastrointestinal Motility; Gastrointes | 2011 |
A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
Topics: Acute Disease; Adult; Antidiarrheals; Constipation; Diarrhea; Female; Humans; Loperamide; Male; Midd | 2005 |
Pharmacological modulation of gut mucosal and large vessel blood flow.
Topics: Administration, Inhalation; Administration, Oral; Adult; Colon, Transverse; Constipation; Cross-Over | 2007 |
A volunteer model for the comparison of laxatives in opioid-related constipation.
Topics: Adolescent; Adult; Aged; Antidiarrheals; Cathartics; Constipation; Drug Therapy, Combination; Female | 1996 |
117 other studies available for loperamide and Colonic Inertia
| Article | Year |
|---|---|
Comparative Transcriptome Analysis Reveals Relationship among mRNAs, lncRNAs, and circRNAs of Slow Transit Constipation.
Topics: Animals; Cell Differentiation; Constipation; Disease Models, Animal; Gene Expression; Gene Expressio | 2021 |
In vivo acute toxicity, laxative and antiulcer effect of the extract of Dryopteris Ramose.
Topics: Alkaloids; Animals; Constipation; Dryopteris; Ethanol; Flavonoids; Gastrointestinal Motility; Laxati | 2021 |
Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice.
Topics: Animals; Bacteria; Colon; Constipation; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; G | 2022 |
Laxative Effects of a Standardized Extract of
Topics: Animals; Constipation; Gastrointestinal Motility; Laxatives; Loperamide; Plant Extracts; Rats | 2021 |
Effects of probiotics on loperamide-induced constipation in rats.
Topics: Acetic Acid; Administration, Oral; Animals; Antidiarrheals; Butyric Acid; Constipation; Feces; Gastr | 2021 |
Citric Acid-Enriched Extract of Ripe
Topics: Animals; Aquaporin 3; Citric Acid; Constipation; Laxatives; Loperamide; Prostaglandins; Prostaglandi | 2022 |
Plasma metabolomic profiles reveal regulatory effect of chitosan oligosaccharides on loperamide-induced constipation in mice.
Topics: Animals; Chitosan; Chromatography, Liquid; Constipation; Loperamide; Metabolomics; Mice; Oligosaccha | 2022 |
Topics: Animals; Bifidobacterium; Bifidobacterium longum; Constipation; Loperamide; Mice; Mice, Inbred BALB | 2022 |
Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice.
Topics: Animals; Candy; Constipation; Feces; Loperamide; Mice; Prebiotics; Sesamum | 2022 |
Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice.
Topics: Animals; Constipation; Gastrointestinal Hormones; Glutamic Acid; Glutamine; Humans; Loperamide; Mice | 2022 |
Chinese patent medicine shouhui tongbian capsule attenuated loperamide-induced constipation through modulating the gut microbiota in rat.
Topics: Animals; Body Weight; China; Constipation; Gastrointestinal Microbiome; Loperamide; Male; Nonprescri | 2022 |
Different effects of
Topics: Animals; Bacillus coagulans; Constipation; Dysbiosis; Gastrointestinal Microbiome; Intestinal Diseas | 2022 |
Shouhui Tongbian Capsule ameliorates constipation via gut microbiota-5-HT-intestinal motility axis.
Topics: Animals; Constipation; Dysbiosis; Gastrointestinal Microbiome; Gastrointestinal Motility; Loperamide | 2022 |
Alleviation of loperamide-induced constipation with sticky rice fermented huangjiu by the regulation of serum neurotransmitters and gut microbiota.
Topics: Animals; Constipation; Ethanol; Gastrointestinal Microbiome; Loperamide; Mice; Neurotransmitter Agen | 2023 |
Effect and mechanism of functional compound fruit drink on gut microbiota in constipation mice.
Topics: Animals; Constipation; Fatty Acids, Volatile; Feces; Fruit; Gastrointestinal Microbiome; Loperamide; | 2023 |
Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by
Topics: Animals; Aquaporins; Constipation; Ligilactobacillus salivarius; Loperamide; Mice; Serotonin; Signal | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Strain-specific effect of
Topics: Animals; Constipation; Humans; Limosilactobacillus fermentum; Loperamide; Mice; Phylogeny; Probiotic | 2022 |
Comparative study on alleviating effect of kiwi berry (Actinidia arguta) polysaccharide and polyphenol extracts on constipated mice.
Topics: Actinidia; Animals; Constipation; Dietary Carbohydrates; Fruit; Loperamide; Mice; Polyphenols; Polys | 2022 |
Comparative study on alleviating effect of kiwi berry (Actinidia arguta) polysaccharide and polyphenol extracts on constipated mice.
Topics: Actinidia; Animals; Constipation; Dietary Carbohydrates; Fruit; Loperamide; Mice; Polyphenols; Polys | 2022 |
Comparative study on alleviating effect of kiwi berry (Actinidia arguta) polysaccharide and polyphenol extracts on constipated mice.
Topics: Actinidia; Animals; Constipation; Dietary Carbohydrates; Fruit; Loperamide; Mice; Polyphenols; Polys | 2022 |
Comparative study on alleviating effect of kiwi berry (Actinidia arguta) polysaccharide and polyphenol extracts on constipated mice.
Topics: Actinidia; Animals; Constipation; Dietary Carbohydrates; Fruit; Loperamide; Mice; Polyphenols; Polys | 2022 |
Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota.
Topics: Animals; Cellulose; Constipation; Dietary Fiber; Fatty Acids, Volatile; Gastrointestinal Microbiome; | 2023 |
Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota.
Topics: Animals; Cellulose; Constipation; Dietary Fiber; Fatty Acids, Volatile; Gastrointestinal Microbiome; | 2023 |
Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota.
Topics: Animals; Cellulose; Constipation; Dietary Fiber; Fatty Acids, Volatile; Gastrointestinal Microbiome; | 2023 |
Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota.
Topics: Animals; Cellulose; Constipation; Dietary Fiber; Fatty Acids, Volatile; Gastrointestinal Microbiome; | 2023 |
Therapeutic effects of
Topics: Animals; Bombax; Constipation; Flowers; Loperamide; Mice; Phenolphthaleins; Tandem Mass Spectrometry | 2023 |
Luteolin ameliorates loperamide-induced functional constipation in mice.
Topics: Acetylcholine; Animals; Colon; Constipation; Loperamide; Luteolin; Mice | 2023 |
Polysaccharides from
Topics: Animals; Constipation; Holothuria; Loperamide; Mice; Polysaccharides; RNA, Ribosomal, 16S; Water | 2023 |
Defatted hempseed meal altered the metabolic profile of fermented yogurt and enhanced the ability to alleviate constipation in rats.
Topics: Amino Acids; Animals; Constipation; Feces; Loperamide; Metabolome; Rats; Yogurt | 2023 |
Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model.
Topics: Animals; Constipation; Gastrointestinal Microbiome; Gastrointestinal Transit; Loperamide; Male; Rats | 2023 |
Flavonoids in
Topics: Amomum; Animals; Constipation; Flavonoids; Gastrointestinal Microbiome; Laxatives; Loperamide; Mice; | 2023 |
Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT.
Topics: Animals; Bile Acids and Salts; Caco-2 Cells; Constipation; Humans; Ileum; Loperamide; Malus; Organic | 2023 |
Protective effect of L-pipecolic acid on constipation in C57BL/6 mice based on gut microbiome and serum metabolomic.
Topics: Animals; Constipation; Gastrointestinal Microbiome; Loperamide; Mice; Mice, Inbred C57BL; Quality of | 2023 |
Gut indigenous
Topics: Animals; Clostridiales; Constipation; Feces; Loperamide; Mice; Ruminococcus | 2023 |
Modulation of gut microbiota ecosystem by a glucan-rich snail mucin heteropolysaccharide attenuates loperamide-induced constipation.
Topics: Animals; Constipation; Ecosystem; Gastrointestinal Microbiome; Glucans; Loperamide; Mucins; Rats | 2023 |
Lychee Pulp-Derived Dietary Fiber-Bound Phenolic Complex Upregulates the SCFAs-GPRs-ENS Pathway and Aquaporins in Loperamide-Induced Constipated Mice by Reshaping Gut Microbiome.
Topics: Animals; Aquaporins; Constipation; Dietary Fiber; Fatty Acids, Volatile; Gastrointestinal Microbiome | 2023 |
The Different Ways Multi-Strain Probiotics with Different Ratios of
Topics: Animals; Bifidobacterium; Constipation; Gastrointestinal Diseases; Interleukin-6; Interleukin-8; Lac | 2023 |
Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism.
Topics: Animals; Brassica; Constipation; Exosomes; Gastrointestinal Microbiome; Humans; Loperamide; Mice; Na | 2023 |
Gastrointestinal Fermentable Polysaccharide Is Beneficial in Alleviating Loperamide-Induced Constipation in Mice.
Topics: Animals; Constipation; Fatty Acids, Volatile; Feces; Loperamide; Mice; Polysaccharides | 2023 |
Croton tiglium L. seeds ameliorate loperamide-induced constipation via regulating gastrointestinal hormones and gut microbiota before and after processing.
Topics: Animals; Constipation; Diterpenes; DNA, Ribosomal; Gastrointestinal Hormones; Gastrointestinal Micro | 2024 |
Hetong decoction relieves loperamide-induced constipation in rats by regulating expression of aquaporins.
Topics: Animals; Aquaporins; Colon; Constipation; Cyclic AMP; Intestines; Loperamide; Rats | 2023 |
Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition.
Topics: Animals; Bacteria; Constipation; Dysbiosis; Humans; Loperamide; Microbiota; Zebrafish | 2023 |
Yunpi Tongbian Fang alleviates slow transit constipation induced by loperamide by regulating intestinal microbiota and short-chain fatty acids in rats.
Topics: Animals; Butyric Acid; Constipation; Fatty Acids, Volatile; Gastrointestinal Microbiome; Loperamide; | 2023 |
Rifaximin Ameliorates Loperamide-Induced Constipation in Rats through the Regulation of Gut Microbiota and Serum Metabolites.
Topics: Animals; Constipation; Gastrointestinal Microbiome; Loperamide; Rats; Rats, Sprague-Dawley; Rifaximi | 2023 |
Sacral nerve stimulation with appropriate parameters improves constipation in rats by enhancing colon motility mediated via the autonomic-cholinergic mechanisms.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Colon; Constipation; Electric Stimulation Therapy; | 2019 |
Laxative Effects of Taurine on Loperamide-Induced Constipation in Rats.
Topics: Animals; Constipation; Gastrointestinal Motility; Laxatives; Loperamide; Rats; Taurine | 2019 |
Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor.
Topics: Animals; Antidiarrheals; Colon; Constipation; Gastrointestinal Motility; HEK293 Cells; Humans; Loper | 2020 |
Amelioration of gut dysbiosis and gastrointestinal motility by konjac oligo-glucomannan on loperamide-induced constipation in mice.
Topics: Amorphophallus; Animals; Constipation; Dysbiosis; Feces; Gastrointestinal Motility; Gastrointestinal | 2020 |
Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model.
Topics: Animals; Antidiarrheals; Constipation; Defecation; Disease Models, Animal; Humans; Injections, Intra | 2020 |
Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats.
Topics: Animals; Cathartics; Constipation; Disease Models, Animal; Gastrointestinal Tract; Gastrointestinal | 2020 |
Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice.
Topics: Acetylcholinesterase; Animals; Bacteria; Colon; Colostrum; Constipation; Fatty Acids, Volatile; Fece | 2020 |
Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation.
Topics: Animals; Antidiarrheals; Butyric Acid; Constipation; Feces; Female; Gastrointestinal Microbiome; Lop | 2020 |
Topics: Animals; Constipation; Fatty Acids, Volatile; Feces; Lacticaseibacillus rhamnosus; Loperamide; Mice; | 2020 |
Laxative effect and mechanism of Tiantian Capsule on loperamide-induced constipation in rats.
Topics: Animals; Chromatography, Liquid; Constipation; Drugs, Chinese Herbal; Functional Food; Gastrointesti | 2021 |
Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice.
Topics: Animals; Antidiarrheals; Base Sequence; Bile Acids and Salts; Chitosan; Constipation; Disease Models | 2021 |
Modulation of gut microbiota and intestinal metabolites by lactulose improves loperamide-induced constipation in mice.
Topics: Animals; Constipation; Gastrointestinal Microbiome; Lactulose; Loperamide; Mice; Mice, Inbred BALB C | 2021 |
Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca
Topics: Animals; Anti-Inflammatory Agents; Aster Plant; Calcium Signaling; Constipation; Defecation; Disease | 2021 |
Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation.
Topics: Animal Feed; Animals; Bacteria; Bifidobacterium; Constipation; DNA; Feces; Female; Gastrointestinal | 2021 |
7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats.
Topics: Animals; Colon; Constipation; Defecation; Disease Models, Animal; Flavones; Gastrointestinal Motilit | 2021 |
Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats.
Topics: Animals; Antioxidants; Constipation; Gastrointestinal Transit; Laxatives; Loperamide; Male; Phaeophy | 2021 |
[Therapeutic effect and mechanism of Shouhui Tongbian Capsules on slow transit constipation model mice].
Topics: Animals; Capsules; Constipation; Gastrointestinal Transit; Loperamide; Mice; Mice, Inbred ICR | 2021 |
Effect of konjac glucomannan on metabolites in the stomach, small intestine and large intestine of constipated mice and prediction of the KEGG pathway.
Topics: Animals; Cathartics; Constipation; Disease Models, Animal; Female; Intestine, Large; Intestine, Smal | 2021 |
Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.
Topics: Animals; Bifidobacterium bifidum; Butyrates; Butyric Acid; Constipation; Disease Models, Animal; Dop | 2021 |
Heat-inactivated Lactobacillus plantarum nF1 promotes intestinal health in Loperamide-induced constipation rats.
Topics: Actinobacteria; Animals; Bacteroidetes; Bisacodyl; Constipation; Cyclooxygenase 2; Feces; Firmicutes | 2021 |
The protective effects of yellow tea extract against loperamide-induced constipation in mice.
Topics: Animals; Aquaporin 3; Aquaporin 4; China; Colon; Constipation; Disease Models, Animal; Gastrointesti | 2021 |
The effect of microbial composition and proteomic on improvement of functional constipation by Chrysanthemum morifolium polysaccharide.
Topics: Animals; Chrysanthemum; Colon; Constipation; Defecation; Gastrointestinal Hormones; Gastrointestinal | 2021 |
Different
Topics: Animals; Bifidobacterium bifidum; Colon; Constipation; Disease Models, Animal; Feces; Gastrointestin | 2021 |
SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine.
Topics: Animals; Antidiarrheals; Antiporters; Colon; Constipation; Dopamine Plasma Membrane Transport Protei | 2021 |
Loperamide-induced Constipation Activates Inflammatory Signaling Pathways in the Mid Colon of SD Rats Via Complement C3 and its Receptors.
Topics: Animals; Colon; Complement C3; Constipation; Cytokines; Laxatives; Loperamide; Phosphatidylinositol | 2022 |
Comparative study of the laxative effects of konjac oligosaccharides and konjac glucomannan on loperamide-induced constipation in rats.
Topics: Amorphophallus; Animals; Constipation; Defecation; Feces; Humans; Laxatives; Loperamide; Male; Manna | 2021 |
Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.
Topics: Animals; Constipation; Fecal Microbiota Transplantation; Female; Gastrointestinal Microbiome; Host-P | 2017 |
Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation.
Topics: Amides; Animals; Chronic Disease; Clinical Trials, Phase I as Topic; Constipation; Dietary Fiber; Do | 2017 |
Reverse Effect of Opuntia ficus-indica L. Juice and Seeds Aqueous Extract on Gastric Emptying and Small-Bowel Motility in Rat.
Topics: Animals; Antidiarrheals; Constipation; Diarrhea; Dose-Response Relationship, Drug; Fruit; Fruit and | 2018 |
Enteromorpha and polysaccharides from enteromorpha ameliorate loperamide-induced constipation in mice.
Topics: Animals; Antidiarrheals; Constipation; Female; Gastrointestinal Transit; Laxatives; Loperamide; Mice | 2017 |
Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation.
Topics: Animals; Aquaporin 3; Constipation; Endothelins; Flavanones; Gastrins; Gastrointestinal Tract; Gene | 2018 |
FABP4 blocker attenuates colonic hypomotility and modulates white adipose tissue-derived hormone levels in mouse models mimicking constipation-predominant IBS.
Topics: Adipose Tissue, White; Animals; Behavior, Animal; Biphenyl Compounds; Colon; Constipation; Disease M | 2018 |
The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats.
Topics: Animals; Cassia; Chronic Disease; Colon; Constipation; Disease Models, Animal; Dose-Response Relatio | 2018 |
Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats.
Topics: Animals; Antidiarrheals; Constipation; Dysbiosis; Feces; Gastrointestinal Microbiome; Gastrointestin | 2018 |
[Establishment and effect observation on three kinds of Ti-Xu with constipation rat models].
Topics: Animals; Aquaporin 2; Colon; Constipation; Drugs, Chinese Herbal; Female; Loperamide; Male; Rats; Ra | 2017 |
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Topics: Animals; Behavior, Animal; Cell Survival; Constipation; Depression; Disease Models, Animal; Hippocam | 2018 |
Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal.
Topics: Animals; Antidiarrheals; Cells, Cultured; Cholinergic Antagonists; Constipation; Gastrointestinal Mo | 2018 |
SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
Topics: Animals; Antiporters; Chloride-Bicarbonate Antiporters; Chlorides; Constipation; Cystic Fibrosis; Di | 2018 |
Bowel management program in patients with spina bifida.
Topics: Adolescent; Adult; Antidiarrheals; Child; Child, Preschool; Constipation; Enema; Fecal Incontinence; | 2019 |
[Loperamide abuse - constipation or heart attack?]
Topics: Analgesics, Opioid; Antidiarrheals; Constipation; Databases, Factual; Drug Prescriptions; Humans; Ic | 2018 |
Laxative effect of probiotic chocolate on loperamide-induced constipation in rats.
Topics: Animals; Body Weight; Chocolate; Claudin-1; Colon; Constipation; Defecation; Faecalibacterium prausn | 2019 |
Synergic Laxative Effects of an Herbal Mixture of Liriope platyphylla, Glycyrrhiza uralensis, and Cinnamomum cassia in Loperamide-Induced Constipation of Sprague Dawley Rats.
Topics: Animals; Aquaporins; Cinnamomum aromaticum; Constipation; Drug Synergism; Glycyrrhiza uralensis; Lax | 2019 |
Anti-Inflammatory Response and Muscarinic Cholinergic Regulation during the Laxative Effect of
Topics: Animals; Anti-Inflammatory Agents; Asparagus Plant; Colon; Constipation; Cytokines; Laxatives; Loper | 2019 |
Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model.
Topics: Animals; Aquaporins; Body Weight; Cholinergic Agents; Constipation; Disease Models, Animal; Eating; | 2019 |
Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats.
Topics: Anemarrhena; Animals; Constipation; Laxatives; Loperamide; Male; Polysaccharides; Rats, Wistar | 2019 |
Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats.
Topics: Animals; Constipation; Fermented Foods; Hordeum; Humans; Laxatives; Loperamide; Male; Plant Extracts | 2019 |
Laxative effects of Salecan on normal and two models of experimental constipated mice.
Topics: Animals; beta-Glucans; Clonidine; Constipation; Defecation; Disease Models, Animal; Dose-Response Re | 2013 |
Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats.
Topics: Analysis of Variance; Animals; Body Weight; Colon, Transverse; Constipation; Defecation; Laxatives; | 2013 |
Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain.
Topics: Abdominal Pain; Analgesics; Animals; Calcium; Calcium Channels; Clonidine; Colon; Constipation; Gast | 2014 |
Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes.
Topics: Amino Acid Transport Systems, Basic; Animals; Anthraquinones; Area Under Curve; Biotransformation; C | 2014 |
Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice.
Topics: Animals; Antidiarrheals; Constipation; Convulsants; Disease Models, Animal; Drug Interactions; Gastr | 2015 |
Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice.
Topics: Animals; Antidiarrheals; Colon; Constipation; Defecation; Fatty Acids, Volatile; Feces; Gastrointest | 2015 |
Study of the mechanisms of a Japanese traditional fermented medicine in the improvement of constipation.
Topics: Animals; Aspergillus oryzae; Butyric Acid; Constipation; Dose-Response Relationship, Drug; Fatty Aci | 2015 |
Characterization of Changes in Global Genes Expression in the Distal Colon of Loperamide-Induced Constipation SD Rats in Response to the Laxative Effects of Liriope platyphylla.
Topics: Animals; Colon; Constipation; Down-Regulation; G-Protein-Coupled Receptor Kinase 2; Laxatives; Lirio | 2015 |
Rapid Tolerance to Constipating Effects of Loperamide in Healthy Subjects.
Topics: Constipation; Healthy Volunteers; Humans; Loperamide; Naltrexone | 2016 |
Toxicological implications and laxative potential of ethanol root extract of Morella serrata in loperamide-induced constipated Wistar rats.
Topics: Animals; Constipation; Ethanol; Laxatives; Loperamide; Male; Myricaceae; Plant Extracts; Plant Roots | 2016 |
Board Review Vignette: Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adult; Anion Exchange Resins; Antidiarrheals; Carbolines; Cholestyramine Resin; Cons | 2016 |
Gallotannin-Enriched Extract Isolated from Galla Rhois May Be a Functional Candidate with Laxative Effects for Treatment of Loperamide-Induced Constipation of SD Rats.
Topics: Animals; Antidiarrheals; Biological Products; Colon; Constipation; Feces; Feeding Behavior; GTP-Bind | 2016 |
Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats.
Topics: Animals; Colon; Constipation; Defecation; Gastrointestinal Transit; Humans; Loperamide; Male; Opunti | 2017 |
Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment.
Topics: Animals; Antioxidants; Constipation; Feces; Gastric Emptying; Gastrointestinal Transit; Laxatives; L | 2017 |
Irritable bowel syndrome: a mild disorder; purely symptomatic treatment.
Topics: Acupuncture Therapy; Antidepressive Agents, Tricyclic; Carbolines; Clinical Trials as Topic; Constip | 2009 |
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Topics: Animals; Atropine; Clonidine; Constipation; Disease Models, Animal; Dose-Response Relationship, Drug | 2009 |
Laxative activities of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) leaf aqueous extract in rats.
Topics: Animals; Castor Oil; Constipation; Dose-Response Relationship, Drug; Euphorbiaceae; Gastrointestinal | 2010 |
Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium.
Topics: Animals; Chlorides; Cholinergic Antagonists; Colon; Constipation; Cyclic AMP; Cyclooxygenase Inhibit | 2010 |
Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats.
Topics: Aloe; Animals; Body Weight; Constipation; Disease Models, Animal; Kidney; Kidney Function Tests; Liv | 2011 |
Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats.
Topics: Animals; Bacteria; Bifidobacterium; Cell Proliferation; Colon; Constipation; Dietary Fiber; Disease | 2010 |
Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice.
Topics: Animals; Atropine; Cholinergic Antagonists; Constipation; Diarrhea; Ethanol; Female; Gastrointestina | 2010 |
The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats.
Topics: Aloe; Animals; Body Weight; Cathartics; Constipation; Feces; Gastrointestinal Motility; Loperamide; | 2010 |
Effects of Ficus carica paste on loperamide-induced constipation in rats.
Topics: Animals; Antidiarrheals; Body Weight; Constipation; Drinking Behavior; Feces; Feeding Behavior; Gast | 2012 |
Opiate-induced constipation related to activation of small intestine opioid μ2-receptors.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Cyclic AMP; Cyclic AMP-Dep | 2012 |
Effect of colic vein ligature in rats with loperamide-induced constipation.
Topics: Animals; Colon; Constipation; Disease Models, Animal; Histocytochemistry; Intestinal Mucosa; Ligatio | 2012 |
Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves.
Topics: Animals; Chromatography, High Pressure Liquid; Constipation; Ethanol; Laxatives; Loperamide; Male; M | 2012 |
Influence of senna, fibre, and fibre + senna on colonic transit in loperamide-induced constipation.
Topics: Adolescent; Adult; Cassia; Constipation; Dietary Fiber; Drug Combinations; Feces; Female; Gastric Em | 1993 |
Decreased colonic mucus in rats with loperamide-induced constipation.
Topics: Animals; Antidiarrheals; Body Weight; Constipation; Feces; Intestinal Mucosa; Loperamide; Male; Mucu | 2000 |
Effects of brewer's yeast cell wall on constipation and defecation in experimentally constipated rats.
Topics: Antidiarrheals; Cathartics; Cell Wall; Constipation; Defecation; Diet; Dietary Fiber; Eating; Feces; | 2001 |
Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation.
Topics: Alginates; Animals; Carrageenan; Cellulose; Chondroitin Sulfates; Colon; Constipation; Dietary Fiber | 2001 |
Effects of yogurt supplemented with brewer's yeast cell wall on constipation and intestinal microflora in rats.
Topics: Animals; Antidiarrheals; Cell Wall; Constipation; Defecation; Dietary Supplements; Intestines; Loper | 2001 |
[The effects of loperamide hydrochloride on the bowel movements of healthy persons. Estimation of CD50 with the up-and-down method, and pharmacokinetic analysis of blood concentration of the drug (author's transl)].
Topics: Adult; Constipation; Gastrointestinal Motility; Humans; Loperamide; Male; Piperidines | 1979 |
Irritable bowel-type symptoms in spontaneous and induced constipation.
Topics: Adult; Anthraquinones; Cathartics; Colonic Diseases, Functional; Constipation; Dietary Fiber; Female | 1987 |