loperamide has been researched along with Chemical Dependence in 43 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Excerpt | Relevance | Reference |
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"We present the case of a 14-year-old boy with obesity, hypertension, and chronic loperamide abuse who presented to our facility with symptoms of opioid withdrawal and type 1 Brugada pattern on an electrocardiogram." | 7.88 | Brugada Syndrome Associated With Adolescent Loperamide Abuse. ( Cohen, M; Stefek, B; Wolfe, LT, 2018) |
"Cardiac depression induced by loperamide is enhanced by hyperglycemia due to higher MOR expression, which is associated with higher expression of STAT3 in the heart." | 7.85 | Loperamide-induced Cardiac Depression Is Enhanced by Hyperglycemia: Evidence Relevant to Loperamide Abuse. ( Cheng, JT; Cheng, YZ; Ku, PM; Lo, SH; Niu, CS; Niu, HS, 2017) |
"We present the case of a 14-year-old boy with obesity, hypertension, and chronic loperamide abuse who presented to our facility with symptoms of opioid withdrawal and type 1 Brugada pattern on an electrocardiogram." | 3.88 | Brugada Syndrome Associated With Adolescent Loperamide Abuse. ( Cohen, M; Stefek, B; Wolfe, LT, 2018) |
"Cardiac depression induced by loperamide is enhanced by hyperglycemia due to higher MOR expression, which is associated with higher expression of STAT3 in the heart." | 3.85 | Loperamide-induced Cardiac Depression Is Enhanced by Hyperglycemia: Evidence Relevant to Loperamide Abuse. ( Cheng, JT; Cheng, YZ; Ku, PM; Lo, SH; Niu, CS; Niu, HS, 2017) |
"With the increasing amount of information available on the Internet describing techniques for using loperamide either for self-treatment of opioid withdrawal syndromes or for recreational use (so-called legal highs), the objective was to describe a statewide poison control system's experience with loperamide misuse and abuse, with specific interest in cases of cardiotoxicity, and to determine if reported loperamide misuse or abuse cases have recently increased." | 3.85 | Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015. ( Cantrell, FL; Corbett, B; Koh, CH; Lasoff, DR; Minns, AB, 2017) |
" Following treatment for hyperkalemia with calcium, insulin, dextrose, and hypertonic sodium bicarbonate a repeat ECG had a ventricular rate of 66/min, QRS 156 ms, and QT 576 ms." | 3.83 | Not your regular high: cardiac dysrhythmias caused by loperamide. ( Biary, R; Hoffman, RS; Howland, MA; Lugassy, D; Rice, B; Wightman, RS, 2016) |
"In this observational case series, patients with cardiac arrhythmias or history of loperamide abuse with cardiac arrhythmias were identified; 5 patients were identified and 4 of the 5 patients were seen directly at the bedside." | 3.80 | Cardiac conduction disturbance after loperamide abuse. ( Hodgman, MJ; Holland, MG; Marraffa, JM; Morgan, BW; Oakes, JA; Sullivan, RW; Wiegand, TJ, 2014) |
"Loperamide is a readily accessible nonprescription medication that is increasingly being used surreptitiously as an opioid substitute to alleviate the symptoms of acute opioid withdrawal." | 1.51 | Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk. ( Alexander, A; Brent, J; Calello, DP; Campleman, S; Lee, VR; Nelson, LS; Ruck, B; Vera, A; Wax, P, 2019) |
"Loperamide has been increasing in popularity recently for its effects separate from treatment of diarrhea." | 1.48 | Brugada-Type Pattern on Electrocardiogram Associated with High-Dose Loperamide Abuse. ( Brice, JA; Clark, RF; Sun, C, 2018) |
"Loperamide is an over-the-counter anti-diarrheal medication that is inexpensive, easily accessible, and widely used." | 1.48 | Loperamide abuse cardiotoxicity. Should loperamide still be an over the counter medication? ( Idris, A; Kaye, K; Mihora, DC, 2018) |
"Loperamide was used on its own in 41." | 1.48 | Is there such a thing as a 'lope' dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports. ( Chiappini, S; Schifano, F, 2018) |
"Loperamide is an over-the-counter antidiarrheal with μ-opioid agonist activity." | 1.46 | Loperamide Abuse Associated With Cardiac Dysrhythmia and Death. ( Clark, KH; Eggleston, W; Marraffa, JM, 2017) |
"Loperamide abuse has been increasing in the United States as a potential alternative to manage opioid withdrawal symptoms or to achieve euphoric effects of opioid use." | 1.46 | Epidemiologic Trends in Loperamide Abuse and Misuse. ( Charlton, NP; Holstege, CP; Vakkalanka, JP, 2017) |
"Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties." | 1.43 | Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016. ( Cummings, KR; Eggleston, W; Marraffa, JM; Mercurio-Zappala, M; Schier, JG; Stork, CM; Su, MK; Wightman, RS, 2016) |
"Loperamide is a common over-the-counter antidiarrheal considered safe in a broad range of dosages and thought devoid of abuse potential." | 1.42 | Loperamide dependence and abuse. ( Heiner, J; MacDonald, R; Strote, J; Villarreal, J, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (20.93) | 18.7374 |
1990's | 3 (6.98) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 25 (58.14) | 24.3611 |
2020's | 6 (13.95) | 2.80 |
Authors | Studies |
---|---|
Barakat, M | 1 |
Akour, A | 1 |
Malaeb, D | 1 |
Cherri, S | 1 |
Al Safadi, W | 1 |
Al Safadi, A | 1 |
Wazaify, M | 1 |
Reinert, JP | 1 |
Dunn, RL | 1 |
Eggleston, W | 4 |
Palmer, R | 1 |
Dubé, PA | 1 |
Thornton, S | 1 |
Stolbach, A | 1 |
Calello, DP | 2 |
Marraffa, JM | 5 |
Donnelly, SC | 1 |
Fayyaz, S | 1 |
Aqeel, M | 1 |
Wasan, J | 1 |
Levine, M | 1 |
Lovecchio, F | 1 |
Malinky, CA | 1 |
Lindsley, CW | 1 |
Han, C | 1 |
Borron, SW | 1 |
Watts, SH | 1 |
Tull, J | 1 |
Baeza, S | 1 |
Diebold, S | 1 |
Barrow, A | 1 |
Lo, SH | 1 |
Niu, HS | 1 |
Cheng, YZ | 1 |
Niu, CS | 1 |
Cheng, JT | 1 |
Ku, PM | 1 |
Antoniou, T | 1 |
Juurlink, DN | 1 |
Heeren, N | 1 |
Farver, D | 1 |
Sun, C | 1 |
Brice, JA | 1 |
Clark, RF | 1 |
Idris, A | 1 |
Mihora, DC | 1 |
Kaye, K | 1 |
Throckmorton, DC | 1 |
Gottlieb, S | 1 |
Woodcock, J | 1 |
Krieg, B | 1 |
Stefek, B | 1 |
Wolfe, LT | 1 |
Cohen, M | 1 |
Schifano, F | 1 |
Chiappini, S | 1 |
Lee, VR | 1 |
Vera, A | 1 |
Alexander, A | 1 |
Ruck, B | 1 |
Nelson, LS | 1 |
Wax, P | 1 |
Campleman, S | 1 |
Brent, J | 1 |
Holland, MG | 1 |
Sullivan, RW | 1 |
Morgan, BW | 1 |
Oakes, JA | 1 |
Wiegand, TJ | 1 |
Hodgman, MJ | 1 |
Nacca, N | 1 |
MacDonald, R | 1 |
Heiner, J | 1 |
Villarreal, J | 1 |
Strote, J | 1 |
Enakpene, EO | 1 |
Riaz, IB | 1 |
Shirazi, FM | 1 |
Raz, Y | 1 |
Indik, JH | 1 |
Dierksen, J | 1 |
Gonsoulin, M | 1 |
Walterscheid, JP | 1 |
Lasoff, DR | 2 |
Schneir, A | 1 |
Hurtado-Torres, GF | 1 |
Sandoval-Munro, RL | 1 |
Wightman, RS | 2 |
Hoffman, RS | 1 |
Howland, MA | 1 |
Rice, B | 1 |
Biary, R | 1 |
Lugassy, D | 1 |
Clark, KH | 1 |
Vakkalanka, JP | 1 |
Charlton, NP | 1 |
Holstege, CP | 1 |
Stork, CM | 1 |
Mercurio-Zappala, M | 1 |
Su, MK | 1 |
Cummings, KR | 1 |
Schier, JG | 1 |
Koh, CH | 1 |
Corbett, B | 1 |
Minns, AB | 1 |
Cantrell, FL | 1 |
Daniulaityte, R | 1 |
Carlson, R | 1 |
Falck, R | 1 |
Cameron, D | 1 |
Perera, S | 1 |
Chen, L | 1 |
Sheth, A | 1 |
Gorodetzky, CW | 1 |
Buchwald, WF | 1 |
Cone, EJ | 1 |
Darwin, WD | 1 |
Pickworth, WB | 1 |
Risner, ME | 1 |
Sharpe, LG | 1 |
Jaffe, JH | 2 |
Kanzler, M | 2 |
Green, J | 2 |
Nakamura, H | 1 |
Ishii, K | 1 |
Yokoyama, Y | 1 |
Motoyoshi, S | 1 |
Suzuki, K | 1 |
Sekine, Y | 1 |
Hashimoto, M | 1 |
Shimizu, M | 1 |
Read, NW | 1 |
Read, MG | 1 |
Krejs, GJ | 1 |
Hendler, RS | 1 |
Davis, G | 1 |
Fordtran, JS | 1 |
Korey, A | 1 |
Zilm, DH | 1 |
Sellers, EM | 1 |
Fletcher, P | 1 |
Steffen, R | 1 |
DuPont, H | 1 |
Katz, JP | 1 |
Sturmann, KM | 1 |
Colpaert, FC | 1 |
Yanagita, T | 1 |
Miyasato, K | 1 |
Sato, J | 1 |
Mackerer, CR | 1 |
Brougham, LR | 1 |
East, PF | 1 |
Bloss, JL | 1 |
Dajani, EZ | 1 |
Clay, GA | 1 |
Hill, MA | 1 |
Greason, FC | 1 |
5 reviews available for loperamide and Chemical Dependence
Article | Year |
---|---|
Management of overdoses of loperamide, gabapentin, and modafinil: a literature review.
Topics: Drug Overdose; Emergency Treatment; Gabapentin; Humans; Loperamide; Modafinil; Substance-Related Dis | 2019 |
Loperamide toxicity: recommendations for patient monitoring and management.
Topics: Cardiotoxicity; Humans; Loperamide; Monitoring, Physiologic; Substance-Related Disorders | 2020 |
New Designer Drugs.
Topics: Analgesics, Opioid; Buprenorphine; Cannabinoids; Designer Drugs; Drug Overdose; Fentanyl; Humans; Hy | 2021 |
DARK Classics in Chemical Neuroscience: Loperamide.
Topics: Analgesics, Opioid; Antidiarrheals; Drug Overdose; Humans; Loperamide; Substance-Related Disorders | 2021 |
Discriminative stimulus properties of narcotic analgesic drugs.
Topics: Adrenocorticotropic Hormone; Analgesics, Opioid; Buprenorphine; Cues; Discrimination, Psychological; | 1978 |
2 trials available for loperamide and Chemical Dependence
Article | Year |
---|---|
"I just wanted to tell you that loperamide WILL WORK": a web-based study of extra-medical use of loperamide.
Topics: Advertising; Analgesics, Opioid; Humans; Internet; Loperamide; Opioid-Related Disorders; Self Care; | 2013 |
Abuse potential of loperamide.
Topics: Adult; Codeine; Humans; Loperamide; Male; Naloxone; Piperidines; Pupil; Substance-Related Disorders | 1980 |
36 other studies available for loperamide and Chemical Dependence
Article | Year |
---|---|
Perspectives of and Experience toward the Abuse of Antidiarrheal Drug (Loperamide) among Community Pharmacists: A Cross-Sectional Study.
Topics: Antidiarrheals; Cross-Sectional Studies; Female; Humans; Loperamide; Male; Pharmacists; Substance-Re | 2023 |
Recreational drug use of over-the-counter (OTC) medication: loperamide and the opiate epidemic.
Topics: Humans; Loperamide; Nonprescription Drugs; Opioid Epidemic; Substance-Related Disorders | 2020 |
191. Loperamide abuse associated with cardiac dysrhythmia: case report.
Topics: Arrhythmias, Cardiac; Humans; Loperamide; Substance-Related Disorders | 2020 |
Intentional Misuse and Abuse of Loperamide: A New Look at a Drug with "Low Abuse Potential".
Topics: Adolescent; Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Drug-Seeking Behavior; Female; Humans; | 2017 |
Loperamide-induced Cardiac Depression Is Enhanced by Hyperglycemia: Evidence Relevant to Loperamide Abuse.
Topics: Animals; Blood Pressure; Cell Line; Cyclic S-Oxides; Diabetes Mellitus, Experimental; Heart Rate; Hy | 2017 |
Loperamide abuse.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Humans; Loperamide; Substance-Related Disorders | 2017 |
You Abused What? Getting High with Unique Medications.
Topics: Amines; Anticonvulsants; Antidiarrheals; Antipsychotic Agents; Antitussive Agents; Cyclohexanecarbox | 2017 |
Brugada-Type Pattern on Electrocardiogram Associated with High-Dose Loperamide Abuse.
Topics: Brugada Syndrome; Electrocardiography; Humans; Loperamide; Male; Middle Aged; Substance-Related Diso | 2018 |
Loperamide abuse cardiotoxicity. Should loperamide still be an over the counter medication?
Topics: Adult; Antidiarrheals; Echocardiography; Electrocardiography; Female; Humans; Loperamide; Nonprescri | 2018 |
The FDA and the Next Wave of Drug Abuse - Proactive Pharmacovigilance.
Topics: Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Drug Utilization | 2018 |
Topics: Buprenorphine; Drug Interactions; Germany; Humans; Loperamide; Methadone; Opiate Substitution Treatm | 2016 |
Brugada Syndrome Associated With Adolescent Loperamide Abuse.
Topics: Adolescent; Analgesics, Opioid; Antidiarrheals; Brugada Syndrome; Humans; Loperamide; Male; Mutation | 2018 |
Is there such a thing as a 'lope' dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports.
Topics: Adolescent; Adult; Cardiovascular Diseases; Databases, Pharmaceutical; Drug Misuse; Europe; Female; | 2018 |
Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Arrhythmias, Cardiac; Atrioventricular B | 2019 |
Cardiac conduction disturbance after loperamide abuse.
Topics: Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Electric Countershock; Female; Humans; Isoprotereno | 2014 |
Loperamide toxicokinetics: serum concentrations in the overdose setting.
Topics: Adult; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Half-Life; Heart Rate; Humans; Lope | 2015 |
Loperamide dependence and abuse.
Topics: Adult; Antidiarrheals; Fatal Outcome; Humans; Loperamide; Male; Substance-Related Disorders | 2015 |
The long QT teaser: loperamide abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Diagnosis, Differential; Electrocardiography; Fatal Out | 2015 |
Poor Man's Methadone: A Case Report of Loperamide Toxicity.
Topics: Alprazolam; Antidiarrheals; Chromatography, Liquid; Fluoxetine; Humans; Hypertrophy; Loperamide; Mal | 2015 |
Ventricular Dysrhythmias from Loperamide Misuse.
Topics: Arrhythmias, Cardiac; Cimetidine; Heart Conduction System; Humans; Loperamide; Male; Narcotic Antago | 2016 |
An Additional Clinical Scenario of Risk for Loperamide Cardiac-Induced Toxicity.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Loperamide; Substance-Rel | 2016 |
Not your regular high: cardiac dysrhythmias caused by loperamide.
Topics: Alcoholism; Arrhythmias, Cardiac; Benzodiazepines; Blood Pressure; Calcium; Central Nervous System; | 2016 |
Loperamide Abuse Associated With Cardiac Dysrhythmia and Death.
Topics: Adult; Arrhythmias, Cardiac; Fatal Outcome; Humans; Loperamide; Male; Opioid-Related Disorders; Rece | 2017 |
Epidemiologic Trends in Loperamide Abuse and Misuse.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Overdose; Female; Humans; Loperamide; Male; Middle | 2017 |
Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Databases, Factual; Female; | 2016 |
Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015.
Topics: Antidiarrheals; Cardiotoxicity; Databases, Factual; Dose-Response Relationship, Drug; Humans; Lopera | 2017 |
Progress report from the NIDA Addiction Research Center (preclinical laboratory), Lexington, Kentucky (1984).
Topics: Aging; Animals; Behavior, Animal; beta-Endorphin; Cats; Cocaine; Discrimination Learning; Dogs; Endo | 1984 |
Abuse potential of loperamide: adaptation of established evaluative methods to volunteer subjects.
Topics: Codeine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Kinetics; Loperamide; Placeb | 1981 |
[Physical dependence on loperamide hydrochloride in mice and rats].
Topics: Administration, Oral; Animals; Antidiarrheals; Behavior, Animal; Body Weight; Dose-Response Relation | 1982 |
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse.
Topics: Adult; Aged; Cathartics; Chronic Disease; Colon; Diarrhea; Electrolytes; Endocrine System Diseases; | 1982 |
Dependence liability of two antidiarrheals, nufenoxole and loperamide.
Topics: Adult; Antidiarrheals; Body Temperature; Electromyography; Humans; Loperamide; Male; Naloxone; Oxadi | 1980 |
Benefit/risk considerations with respect to OTC-descheduling of loperamide.
Topics: Adult; Child; Child, Preschool; Cost-Benefit Analysis; Diarrhea; Humans; Loperamide; Nonprescription | 1995 |
Appendicitis associated with loperamide hydrochloride abuse.
Topics: Adult; Appendicitis; Humans; Loperamide; Male; Nonprescription Drugs; Substance-Related Disorders | 1993 |
Dependence potential of loperamide studied in rhesus monkeys.
Topics: Administration, Oral; Animals; Behavior, Animal; Female; Haplorhini; Humans; Injections, Intravenous | 1979 |
Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brai
Topics: Animals; Antidiarrheals; Brain; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Central Nervous S | 1977 |
Loperamide dependence.
Topics: Adult; Diarrhea; Humans; Loperamide; Male; Substance Withdrawal Syndrome; Substance-Related Disorder | 1992 |