loperamide has been researched along with Cardiac Toxicity in 9 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Loperamide is a popular antidiarrheal medication that has been used for many years." | 8.98 | Loperamide cardiotoxicity: "A Brief Review". ( Akel, T; Bekheit, S, 2018) |
| "Loperamide has been a safe and effective treatment for diarrhea for many years." | 8.31 | The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023) |
| "Loperamide is a popular antidiarrheal medication that has been used for many years." | 4.98 | Loperamide cardiotoxicity: "A Brief Review". ( Akel, T; Bekheit, S, 2018) |
| "Loperamide has been a safe and effective treatment for diarrhea for many years." | 4.31 | The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023) |
| "Loperamide, a μ-opioid receptor agonist, can cause cardiotoxicity by inhibiting the potassium ion channel and slowing cardiomyocyte repolarization." | 4.02 | Loperamide Toxicity Revealing Apical Hypertrophic Cardiomyopathy. ( Chitturi, KR; Clewing, M; Hatcher, C; Khan, N; Nagueh, SF, 2021) |
| "With the increasing amount of information available on the Internet describing techniques for using loperamide either for self-treatment of opioid withdrawal syndromes or for recreational use (so-called legal highs), the objective was to describe a statewide poison control system's experience with loperamide misuse and abuse, with specific interest in cases of cardiotoxicity, and to determine if reported loperamide misuse or abuse cases have recently increased." | 3.85 | Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015. ( Cantrell, FL; Corbett, B; Koh, CH; Lasoff, DR; Minns, AB, 2017) |
| "Loperamide is a μ-opioid receptor agonist commonly used to treat diarrhea and often available as an over-the-counter medication." | 1.43 | Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic. ( Compton, DR; Kang, J; Rampe, D; Vaz, RJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, HR | 1 |
| Damiano, BP | 1 |
| Kreir, M | 1 |
| Rohrbacher, J | 1 |
| van der Linde, H | 1 |
| Saidov, T | 1 |
| Teisman, A | 1 |
| Gallacher, DJ | 1 |
| Eggleston, W | 1 |
| Palmer, R | 1 |
| Dubé, PA | 1 |
| Thornton, S | 1 |
| Stolbach, A | 1 |
| Calello, DP | 1 |
| Marraffa, JM | 1 |
| Wolfes, J | 1 |
| Ellermann, C | 1 |
| Burde, S | 1 |
| Leitz, P | 1 |
| Bögeholz, N | 1 |
| Willy, K | 1 |
| Fehr, M | 1 |
| Reinke, F | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Khan, N | 1 |
| Chitturi, KR | 1 |
| Hatcher, C | 1 |
| Clewing, M | 1 |
| Nagueh, SF | 1 |
| Akel, T | 1 |
| Bekheit, S | 1 |
| Hughes, A | 1 |
| Hendrickson, RG | 1 |
| Chen, BC | 1 |
| Valento, M | 1 |
| Goodnough, R | 1 |
| Nomura, M | 1 |
| Badea, A | 1 |
| Lynch, KL | 1 |
| Benowitz, NL | 1 |
| Tsutaoka, B | 1 |
| Kang, J | 1 |
| Compton, DR | 1 |
| Vaz, RJ | 1 |
| Rampe, D | 1 |
| Lasoff, DR | 1 |
| Koh, CH | 1 |
| Corbett, B | 1 |
| Minns, AB | 1 |
| Cantrell, FL | 1 |
2 reviews available for loperamide and Cardiac Toxicity
| Article | Year |
|---|---|
Loperamide toxicity: recommendations for patient monitoring and management.
Topics: Cardiotoxicity; Humans; Loperamide; Monitoring, Physiologic; Substance-Related Disorders | 2020 |
Loperamide cardiotoxicity: "A Brief Review".
Topics: Antidiarrheals; Cardiotoxicity; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Sche | 2018 |
7 other studies available for loperamide and Cardiac Toxicity
| Article | Year |
|---|---|
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.
Topics: Animals; Arrhythmias, Cardiac; Cardiotoxicity; Diarrhea; Guinea Pigs; Heart; Humans; Loperamide; Rab | 2023 |
Divergent Electrophysiological Effects of Loperamide and Naloxone in a Sensitive Whole-Heart Model.
Topics: Action Potentials; Analgesics, Opioid; Animals; Antidiarrheals; Cardiac Pacing, Artificial; Cardioto | 2021 |
Loperamide Toxicity Revealing Apical Hypertrophic Cardiomyopathy.
Topics: Adult; Antidiarrheals; Cardiomyopathy, Hypertrophic; Cardiotoxicity; DNA Mutational Analysis; Electr | 2021 |
Severe loperamide toxicity associated with the use of cimetidine to potentiate the "high".
Topics: Adult; Arrhythmias, Cardiac; Cardiotoxicity; Cimetidine; Drug Misuse; Female; Humans; Loperamide; Pa | 2018 |
Loperamide associated torsades de pointes, in the setting of complete heart block at marginally supratherapeutic dosing (20mg/day).
Topics: Cardiotoxicity; Heart Block; Humans; Loperamide; Male; Middle Aged; Torsades de Pointes | 2019 |
Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.
Topics: Action Potentials; Antidiarrheals; Cardiotoxicity; Dose-Response Relationship, Drug; ERG1 Potassium | 2016 |
Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015.
Topics: Antidiarrheals; Cardiotoxicity; Databases, Factual; Dose-Response Relationship, Drug; Humans; Lopera | 2017 |