loperamide has been researched along with Burns in 3 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Burn-induced pain is often inadequately managed and its mechanisms, both peripheral and central, are poorly understood." | 1.31 | Effects of full-thickness burns on nociceptor sensitization in anesthetized rats. ( Junger, H; Moore, AC; Sorkin, LS, 2002) |
| "Treatment with loperamide on the normal paw produced short-lasting hypoalgesia, but the effect was not reversible with naloxone." | 1.30 | Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide. ( Nozaki-Taguchi, N; Yaksh, TL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Junger, H | 1 |
| Moore, AC | 1 |
| Sorkin, LS | 1 |
| Nozaki-Taguchi, N | 2 |
| Yaksh, TL | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Loperamide Gel for Pain Reduction During Repeat Finger Lancing: A Randomized Double Blind Trial[NCT02711891] | Early Phase 1 | 34 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for loperamide and Burns
| Article | Year |
|---|---|
Effects of full-thickness burns on nociceptor sensitization in anesthetized rats.
Topics: Animals; Burns; Cholinergic Fibers; Loperamide; Male; Nociceptors; Ointments; Pain; Rats; Rats, Spra | 2002 |
Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide.
Topics: Analgesics; Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hindlimb; Hyperalgesia; Loperamide; | 1999 |
Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Burns; Hindlimb; Hyperalgesia; Injections, Spi | 2002 |