loperamide has been researched along with Benign Neoplasms in 9 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intensive, high-dose loperamide was used in an attempt to control or downstage CPT-11-induced diarrhea and thus permit the use of higher dose intensities of CPT-11." | 9.07 | Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. ( Abigerges, D; Armand, JP; Chabot, GG; Cote, C; Da Costa, L; Fadel, E; Gandia, D; Hérait, P, 1994) |
| "Intensive, high-dose loperamide was used in an attempt to control or downstage CPT-11-induced diarrhea and thus permit the use of higher dose intensities of CPT-11." | 5.07 | Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. ( Abigerges, D; Armand, JP; Chabot, GG; Cote, C; Da Costa, L; Fadel, E; Gandia, D; Hérait, P, 1994) |
| " The recommended dosage for phase II trial is 100 mg/m2 administered in 1 hour perfusion, every 21 days." | 3.78 | [Taxotere (docetaxel) and CPT 11 (irinotecan): phase I trials]. ( Armand, JP; Couteau, C; Goncalves, E; Terret, C; Yakendji, K, 1996) |
| "Chemotherapy-induced diarrhea (CID) became first apparent during clinical studies on the combination of 5-FU with leucovorin and, furthermore, with irinotecan in the treatment of metastatic colorectal carcinoma." | 3.72 | [Management of chemotherapy induced diarrhea]. ( Kullmann, F; Schölmerich, J; Schultz, M, 2004) |
| "To evaluate the efficacy of maropitant and loperamide for the prevention and reduction of adverse gastrointestinal effects associated with administration of paclitaxel to dogs with cancer." | 2.90 | Assessment of the administration of maropitant and loperamide to dogs with cancer for the prevention and reduction of adverse effects associated with the administration of paclitaxel. ( Cartagena-Albertus, JC; Engel Manchado, J; Moise, A; Montoya Alonso, JA; Moya García, S, 2019) |
| "Perifosine (NSC 639966) is a synthetic, substituted heterocyclic alkylphosphocholine that acts primarily at the cell membrane targeting signal transduction pathways." | 2.71 | A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer. ( Alberti, D; Arzoomanian, R; Binger, K; Kolesar, J; Marnocha, R; Tutsch, K; Van Ummersen, L; Volkman, J; Wilding, G, 2004) |
| "In loperamide-treated cells, activation of caspase-3 was found, namely that caspase-3 was involved in the loperamide-induced apoptosis." | 1.38 | Loperamide, an antidiarrhea drug, has antitumor activity by inducing cell apoptosis. ( Chen, XL; Gong, XW; Wang, YX; Xu, YH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cartagena-Albertus, JC | 1 |
| Engel Manchado, J | 1 |
| Moise, A | 1 |
| Moya García, S | 1 |
| Montoya Alonso, JA | 1 |
| Gong, XW | 1 |
| Xu, YH | 1 |
| Chen, XL | 1 |
| Wang, YX | 1 |
| Stern, J | 1 |
| Ippoliti, C | 1 |
| Schultz, M | 1 |
| Schölmerich, J | 1 |
| Kullmann, F | 1 |
| Van Ummersen, L | 1 |
| Binger, K | 1 |
| Volkman, J | 1 |
| Marnocha, R | 1 |
| Tutsch, K | 1 |
| Kolesar, J | 1 |
| Arzoomanian, R | 1 |
| Alberti, D | 1 |
| Wilding, G | 1 |
| Read, NW | 1 |
| Read, MG | 1 |
| Krejs, GJ | 1 |
| Hendler, RS | 1 |
| Davis, G | 1 |
| Fordtran, JS | 1 |
| Abigerges, D | 1 |
| Armand, JP | 2 |
| Chabot, GG | 1 |
| Da Costa, L | 1 |
| Fadel, E | 1 |
| Cote, C | 1 |
| Hérait, P | 1 |
| Gandia, D | 1 |
| Gebbia, V | 1 |
| Carreca, I | 1 |
| Testa, A | 1 |
| Valenza, R | 1 |
| Curto, G | 1 |
| Cannata, G | 1 |
| Borsellino, N | 1 |
| Latteri, MA | 1 |
| Cipolla, C | 1 |
| Florena, M | 1 |
| Couteau, C | 1 |
| Yakendji, K | 1 |
| Terret, C | 1 |
| Goncalves, E | 1 |
2 reviews available for loperamide and Benign Neoplasms
| Article | Year |
|---|---|
Management of acute cancer treatment-induced diarrhea.
Topics: Antidiarrheals; Antineoplastic Combined Chemotherapy Protocols; Atropine; Diarrhea; Diphenoxylate; H | 2003 |
[Taxotere (docetaxel) and CPT 11 (irinotecan): phase I trials].
Topics: Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Docetaxel; Dose-Response | 1996 |
5 trials available for loperamide and Benign Neoplasms
| Article | Year |
|---|---|
Assessment of the administration of maropitant and loperamide to dogs with cancer for the prevention and reduction of adverse effects associated with the administration of paclitaxel.
Topics: Animals; Antidiarrheals; Antiemetics; Antineoplastic Agents, Phytogenic; Diarrhea; Dog Diseases; Dog | 2019 |
A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer.
Topics: Adult; Aged; Antineoplastic Agents; Dexamethasone; Dose-Response Relationship, Drug; Drug Administra | 2004 |
Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Female; Humans; Irinotecan; | 1994 |
Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Female; Humans; Inje | 1993 |
[Taxotere (docetaxel) and CPT 11 (irinotecan): phase I trials].
Topics: Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Docetaxel; Dose-Response | 1996 |
3 other studies available for loperamide and Benign Neoplasms
| Article | Year |
|---|---|
Loperamide, an antidiarrhea drug, has antitumor activity by inducing cell apoptosis.
Topics: Antidiarrheals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cytotoxins; Humans; Loperamide; | 2012 |
[Management of chemotherapy induced diarrhea].
Topics: Antidiarrheals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; | 2004 |
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse.
Topics: Adult; Aged; Cathartics; Chronic Disease; Colon; Diarrhea; Electrolytes; Endocrine System Diseases; | 1982 |