loperamide has been researched along with Arrhythmias, Cardiac in 28 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg." | 8.98 | Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018) |
| "Loperamide has been a safe and effective treatment for diarrhea for many years." | 8.31 | The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 5.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 5.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| "High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg." | 4.98 | Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018) |
| "Loperamide is a nonprescription opioid widely used for the treatment of diarrhea." | 4.95 | Clinical Review: Loperamide Toxicity. ( Juurlink, DN; Wu, PE, 2017) |
| "The nonprescription drugs loperamide and mitragynine are associated with disproportionate reports of life-threatening ventricular arrhythmia in North America." | 4.31 | Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids. ( Haigney, MCP; Kao, DP; Kleiman, RB; Klein, M; Krantz, MJ; Rudo, TJ; Stockbridge, N, 2023) |
| "Loperamide has been a safe and effective treatment for diarrhea for many years." | 4.31 | The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023) |
| " Following treatment for hyperkalemia with calcium, insulin, dextrose, and hypertonic sodium bicarbonate a repeat ECG had a ventricular rate of 66/min, QRS 156 ms, and QT 576 ms." | 3.83 | Not your regular high: cardiac dysrhythmias caused by loperamide. ( Biary, R; Hoffman, RS; Howland, MA; Lugassy, D; Rice, B; Wightman, RS, 2016) |
| "This case series describes several patients with cardiac conduction abnormalities and life-threatening ventricular arrhythmias temporally related to loperamide abuse." | 3.80 | Cardiac conduction disturbance after loperamide abuse. ( Hodgman, MJ; Holland, MG; Marraffa, JM; Morgan, BW; Oakes, JA; Sullivan, RW; Wiegand, TJ, 2014) |
| " Although it is an opioid, it is very poorly absorbed and well tolerated, with no systemic toxicity at standard doses." | 2.82 | Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management. ( Juurlink, DN; Wu, PE, 2022) |
| "Loperamide is an over-the-counter medication which is commonly used to treat diarrhoea." | 1.62 | Loperamide: an emerging drug of abuse and cause of prolonged QTc. ( Newman, J; Whittaker, G, 2021) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 1.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide is an over-the-counter anti-diarrhoeal agent." | 1.56 | [A young woman's loperamide abuse for the achievement of euphoric effect]. ( Fiil, S; Kamronn, TM; Livbjerg, S; Petersen, TS, 2020) |
| "Loperamide is a readily accessible nonprescription medication that is increasingly being used surreptitiously as an opioid substitute to alleviate the symptoms of acute opioid withdrawal." | 1.51 | Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk. ( Alexander, A; Brent, J; Calello, DP; Campleman, S; Lee, VR; Nelson, LS; Ruck, B; Vera, A; Wax, P, 2019) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 1.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| " Central nervous system opioid effects are not observed after therapeutic oral dosing because of poor bioavailability and minimal central nervous system penetration." | 1.46 | Loperamide Abuse Associated With Cardiac Dysrhythmia and Death. ( Clark, KH; Eggleston, W; Marraffa, JM, 2017) |
| "Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties." | 1.43 | Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016. ( Cummings, KR; Eggleston, W; Marraffa, JM; Mercurio-Zappala, M; Schier, JG; Stork, CM; Su, MK; Wightman, RS, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (64.29) | 24.3611 |
| 2020's | 10 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, PE | 2 |
| Juurlink, DN | 3 |
| Krantz, MJ | 2 |
| Rudo, TJ | 1 |
| Haigney, MCP | 2 |
| Stockbridge, N | 2 |
| Kleiman, RB | 1 |
| Klein, M | 1 |
| Kao, DP | 2 |
| Lu, HR | 1 |
| Damiano, BP | 1 |
| Kreir, M | 1 |
| Rohrbacher, J | 1 |
| van der Linde, H | 1 |
| Saidov, T | 1 |
| Teisman, A | 1 |
| Gallacher, DJ | 1 |
| Font, J | 1 |
| Alexandre, J | 1 |
| Dolladille, C | 1 |
| Milliez, P | 1 |
| Ollitrault, P | 1 |
| Klein, MG | 1 |
| Myllymäki, L | 1 |
| Westerbergh, J | 1 |
| Carlsson, H | 1 |
| Höjer, J | 1 |
| Fiil, S | 1 |
| Kamronn, TM | 1 |
| Petersen, TS | 1 |
| Livbjerg, S | 1 |
| Fayyaz, S | 1 |
| Aqeel, M | 1 |
| Wasan, J | 1 |
| Whittaker, G | 1 |
| Newman, J | 1 |
| Simon, M | 1 |
| Rague, J | 1 |
| Rasla, S | 1 |
| Parikh, P | 1 |
| St Amand, A | 1 |
| Garas, MK | 1 |
| El Meligy, A | 1 |
| Minami, T | 1 |
| Shah, NR | 1 |
| Borron, SW | 1 |
| Watts, SH | 1 |
| Tull, J | 1 |
| Baeza, S | 1 |
| Diebold, S | 1 |
| Barrow, A | 1 |
| Antoniou, T | 1 |
| Eggleston, W | 4 |
| Marraffa, JM | 5 |
| Nacca, N | 2 |
| de Lemos, ML | 1 |
| Guenter, J | 1 |
| Kletas, V | 1 |
| Nattel, S | 1 |
| Hughes, A | 1 |
| Hendrickson, RG | 1 |
| Chen, BC | 1 |
| Valento, M | 1 |
| Minhas, AS | 1 |
| Schulman, SP | 1 |
| Lee, VR | 1 |
| Vera, A | 1 |
| Alexander, A | 1 |
| Ruck, B | 1 |
| Nelson, LS | 1 |
| Wax, P | 1 |
| Campleman, S | 1 |
| Brent, J | 1 |
| Calello, DP | 1 |
| Holland, MG | 1 |
| Sullivan, RW | 1 |
| Morgan, BW | 1 |
| Oakes, JA | 1 |
| Wiegand, TJ | 1 |
| Hodgman, MJ | 1 |
| Enakpene, EO | 1 |
| Riaz, IB | 1 |
| Shirazi, FM | 1 |
| Raz, Y | 1 |
| Indik, JH | 1 |
| Lasoff, DR | 1 |
| Schneir, A | 1 |
| Hurtado-Torres, GF | 1 |
| Sandoval-Munro, RL | 1 |
| Wightman, RS | 2 |
| Hoffman, RS | 1 |
| Howland, MA | 1 |
| Rice, B | 1 |
| Biary, R | 1 |
| Lugassy, D | 1 |
| Clark, KH | 1 |
| Stork, CM | 1 |
| Mercurio-Zappala, M | 1 |
| Su, MK | 1 |
| Cummings, KR | 1 |
| Schier, JG | 1 |
3 reviews available for loperamide and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Opioid-Related Disor | 2022 |
Clinical Review: Loperamide Toxicity.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Diarrhea; Drug Overdose; Humans; Loperamide; Opioid-Relate | 2017 |
Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea?
Topics: Antidiarrheals; Arrhythmias, Cardiac; Diarrhea; Dose-Response Relationship, Drug; Female; Heart Arre | 2018 |
25 other studies available for loperamide and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Diphenoxylate; Humans; Loperamide; Methadon | 2023 |
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.
Topics: Animals; Arrhythmias, Cardiac; Cardiotoxicity; Diarrhea; Guinea Pigs; Heart; Humans; Loperamide; Rab | 2023 |
Loperamide-Associated Ventricular Arrhythmias.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Loperamide | 2023 |
Reply: Loperamide-Associated Ventricular Arrhythmias.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Loperamide | 2023 |
[Torsade de pointes following repeated massive loperamide ingestions].
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Heart Diseases; Humans; Long QT Syndrome; | 2020 |
[A young woman's loperamide abuse for the achievement of euphoric effect].
Topics: Adult; Arrhythmias, Cardiac; Female; Humans; Loperamide; Opioid-Related Disorders | 2020 |
191. Loperamide abuse associated with cardiac dysrhythmia: case report.
Topics: Arrhythmias, Cardiac; Humans; Loperamide; Substance-Related Disorders | 2020 |
Loperamide: an emerging drug of abuse and cause of prolonged QTc.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Drug Overdose; Female; Humans; Loperamide; Pharmaceutical Prep | 2021 |
A Case Report of Torsade de Pointes and Brugada Pattern Associated with Loperamide Misuse and Supratherapeutic Loperamide Concentrations.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Male; Torsades de | 2021 |
Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Heart Rate; Humans; | 2017 |
Intentional Misuse and Abuse of Loperamide: A New Look at a Drug with "Low Abuse Potential".
Topics: Adolescent; Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Drug-Seeking Behavior; Female; Humans; | 2017 |
Loperamide abuse.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Humans; Loperamide; Substance-Related Disorders | 2017 |
In response to: "Loperamide metabolite-induced cardiomyopathy and QTc prolongation".
Topics: Arrhythmias, Cardiac; Cardiomyopathies; Humans; Loperamide | 2017 |
An Emerging Malignant Arrhythmia Epidemic Due to Loperamide Abuse: Underlying Mechanisms and Clinical Relevance.
Topics: Anti-Arrhythmia Agents; Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Epidemics; Humans | 2016 |
Severe loperamide toxicity associated with the use of cimetidine to potentiate the "high".
Topics: Adult; Arrhythmias, Cardiac; Cardiotoxicity; Cimetidine; Drug Misuse; Female; Humans; Loperamide; Pa | 2018 |
Syncope With Unusual Wide Complex Arrhythmia in a Young Woman.
Topics: Adult; Arrhythmias, Cardiac; Dopamine; Electrocardiography; Female; Fibromyalgia; Humans; Loperamide | 2018 |
Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Arrhythmias, Cardiac; Atrioventricular B | 2019 |
Cardiac conduction disturbance after loperamide abuse.
Topics: Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Electric Countershock; Female; Humans; Isoprotereno | 2014 |
Loperamide toxicokinetics: serum concentrations in the overdose setting.
Topics: Adult; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Half-Life; Heart Rate; Humans; Lope | 2015 |
The long QT teaser: loperamide abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Diagnosis, Differential; Electrocardiography; Fatal Out | 2015 |
Ventricular Dysrhythmias from Loperamide Misuse.
Topics: Arrhythmias, Cardiac; Cimetidine; Heart Conduction System; Humans; Loperamide; Male; Narcotic Antago | 2016 |
An Additional Clinical Scenario of Risk for Loperamide Cardiac-Induced Toxicity.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Loperamide; Substance-Rel | 2016 |
Not your regular high: cardiac dysrhythmias caused by loperamide.
Topics: Alcoholism; Arrhythmias, Cardiac; Benzodiazepines; Blood Pressure; Calcium; Central Nervous System; | 2016 |
Loperamide Abuse Associated With Cardiac Dysrhythmia and Death.
Topics: Adult; Arrhythmias, Cardiac; Fatal Outcome; Humans; Loperamide; Male; Opioid-Related Disorders; Rece | 2017 |
Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Databases, Factual; Female; | 2016 |