loperamide has been researched along with Arrhythmia in 28 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg." | 8.98 | Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018) |
| "Loperamide has been a safe and effective treatment for diarrhea for many years." | 8.31 | The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 5.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 5.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| "High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg." | 4.98 | Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018) |
| "Loperamide is a nonprescription opioid widely used for the treatment of diarrhea." | 4.95 | Clinical Review: Loperamide Toxicity. ( Juurlink, DN; Wu, PE, 2017) |
| "The nonprescription drugs loperamide and mitragynine are associated with disproportionate reports of life-threatening ventricular arrhythmia in North America." | 4.31 | Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids. ( Haigney, MCP; Kao, DP; Kleiman, RB; Klein, M; Krantz, MJ; Rudo, TJ; Stockbridge, N, 2023) |
| "Loperamide has been a safe and effective treatment for diarrhea for many years." | 4.31 | The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose. ( Damiano, BP; Gallacher, DJ; Kreir, M; Lu, HR; Rohrbacher, J; Saidov, T; Teisman, A; van der Linde, H, 2023) |
| " Following treatment for hyperkalemia with calcium, insulin, dextrose, and hypertonic sodium bicarbonate a repeat ECG had a ventricular rate of 66/min, QRS 156 ms, and QT 576 ms." | 3.83 | Not your regular high: cardiac dysrhythmias caused by loperamide. ( Biary, R; Hoffman, RS; Howland, MA; Lugassy, D; Rice, B; Wightman, RS, 2016) |
| "This case series describes several patients with cardiac conduction abnormalities and life-threatening ventricular arrhythmias temporally related to loperamide abuse." | 3.80 | Cardiac conduction disturbance after loperamide abuse. ( Hodgman, MJ; Holland, MG; Marraffa, JM; Morgan, BW; Oakes, JA; Sullivan, RW; Wiegand, TJ, 2014) |
| " Although it is an opioid, it is very poorly absorbed and well tolerated, with no systemic toxicity at standard doses." | 2.82 | Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management. ( Juurlink, DN; Wu, PE, 2022) |
| "Loperamide is an over-the-counter medication which is commonly used to treat diarrhoea." | 1.62 | Loperamide: an emerging drug of abuse and cause of prolonged QTc. ( Newman, J; Whittaker, G, 2021) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 1.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide is an over-the-counter anti-diarrhoeal agent." | 1.56 | [A young woman's loperamide abuse for the achievement of euphoric effect]. ( Fiil, S; Kamronn, TM; Livbjerg, S; Petersen, TS, 2020) |
| "Loperamide is a readily accessible nonprescription medication that is increasingly being used surreptitiously as an opioid substitute to alleviate the symptoms of acute opioid withdrawal." | 1.51 | Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk. ( Alexander, A; Brent, J; Calello, DP; Campleman, S; Lee, VR; Nelson, LS; Ruck, B; Vera, A; Wax, P, 2019) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 1.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| " Central nervous system opioid effects are not observed after therapeutic oral dosing because of poor bioavailability and minimal central nervous system penetration." | 1.46 | Loperamide Abuse Associated With Cardiac Dysrhythmia and Death. ( Clark, KH; Eggleston, W; Marraffa, JM, 2017) |
| "Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties." | 1.43 | Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016. ( Cummings, KR; Eggleston, W; Marraffa, JM; Mercurio-Zappala, M; Schier, JG; Stork, CM; Su, MK; Wightman, RS, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (64.29) | 24.3611 |
| 2020's | 10 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, PE | 2 |
| Juurlink, DN | 3 |
| Krantz, MJ | 2 |
| Rudo, TJ | 1 |
| Haigney, MCP | 2 |
| Stockbridge, N | 2 |
| Kleiman, RB | 1 |
| Klein, M | 1 |
| Kao, DP | 2 |
| Lu, HR | 1 |
| Damiano, BP | 1 |
| Kreir, M | 1 |
| Rohrbacher, J | 1 |
| van der Linde, H | 1 |
| Saidov, T | 1 |
| Teisman, A | 1 |
| Gallacher, DJ | 1 |
| Font, J | 1 |
| Alexandre, J | 1 |
| Dolladille, C | 1 |
| Milliez, P | 1 |
| Ollitrault, P | 1 |
| Klein, MG | 1 |
| Myllymäki, L | 1 |
| Westerbergh, J | 1 |
| Carlsson, H | 1 |
| Höjer, J | 1 |
| Fiil, S | 1 |
| Kamronn, TM | 1 |
| Petersen, TS | 1 |
| Livbjerg, S | 1 |
| Fayyaz, S | 1 |
| Aqeel, M | 1 |
| Wasan, J | 1 |
| Whittaker, G | 1 |
| Newman, J | 1 |
| Simon, M | 1 |
| Rague, J | 1 |
| Rasla, S | 1 |
| Parikh, P | 1 |
| St Amand, A | 1 |
| Garas, MK | 1 |
| El Meligy, A | 1 |
| Minami, T | 1 |
| Shah, NR | 1 |
| Borron, SW | 1 |
| Watts, SH | 1 |
| Tull, J | 1 |
| Baeza, S | 1 |
| Diebold, S | 1 |
| Barrow, A | 1 |
| Antoniou, T | 1 |
| Eggleston, W | 4 |
| Marraffa, JM | 5 |
| Nacca, N | 2 |
| de Lemos, ML | 1 |
| Guenter, J | 1 |
| Kletas, V | 1 |
| Nattel, S | 1 |
| Hughes, A | 1 |
| Hendrickson, RG | 1 |
| Chen, BC | 1 |
| Valento, M | 1 |
| Minhas, AS | 1 |
| Schulman, SP | 1 |
| Lee, VR | 1 |
| Vera, A | 1 |
| Alexander, A | 1 |
| Ruck, B | 1 |
| Nelson, LS | 1 |
| Wax, P | 1 |
| Campleman, S | 1 |
| Brent, J | 1 |
| Calello, DP | 1 |
| Holland, MG | 1 |
| Sullivan, RW | 1 |
| Morgan, BW | 1 |
| Oakes, JA | 1 |
| Wiegand, TJ | 1 |
| Hodgman, MJ | 1 |
| Enakpene, EO | 1 |
| Riaz, IB | 1 |
| Shirazi, FM | 1 |
| Raz, Y | 1 |
| Indik, JH | 1 |
| Lasoff, DR | 1 |
| Schneir, A | 1 |
| Hurtado-Torres, GF | 1 |
| Sandoval-Munro, RL | 1 |
| Wightman, RS | 2 |
| Hoffman, RS | 1 |
| Howland, MA | 1 |
| Rice, B | 1 |
| Biary, R | 1 |
| Lugassy, D | 1 |
| Clark, KH | 1 |
| Stork, CM | 1 |
| Mercurio-Zappala, M | 1 |
| Su, MK | 1 |
| Cummings, KR | 1 |
| Schier, JG | 1 |
3 reviews available for loperamide and Arrhythmia
| Article | Year |
|---|---|
Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Opioid-Related Disor | 2022 |
Clinical Review: Loperamide Toxicity.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Diarrhea; Drug Overdose; Humans; Loperamide; Opioid-Relate | 2017 |
Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea?
Topics: Antidiarrheals; Arrhythmias, Cardiac; Diarrhea; Dose-Response Relationship, Drug; Female; Heart Arre | 2018 |
25 other studies available for loperamide and Arrhythmia
| Article | Year |
|---|---|
Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Diphenoxylate; Humans; Loperamide; Methadon | 2023 |
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.
Topics: Animals; Arrhythmias, Cardiac; Cardiotoxicity; Diarrhea; Guinea Pigs; Heart; Humans; Loperamide; Rab | 2023 |
Loperamide-Associated Ventricular Arrhythmias.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Loperamide | 2023 |
Reply: Loperamide-Associated Ventricular Arrhythmias.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Loperamide | 2023 |
[Torsade de pointes following repeated massive loperamide ingestions].
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Heart Diseases; Humans; Long QT Syndrome; | 2020 |
[A young woman's loperamide abuse for the achievement of euphoric effect].
Topics: Adult; Arrhythmias, Cardiac; Female; Humans; Loperamide; Opioid-Related Disorders | 2020 |
191. Loperamide abuse associated with cardiac dysrhythmia: case report.
Topics: Arrhythmias, Cardiac; Humans; Loperamide; Substance-Related Disorders | 2020 |
Loperamide: an emerging drug of abuse and cause of prolonged QTc.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Drug Overdose; Female; Humans; Loperamide; Pharmaceutical Prep | 2021 |
A Case Report of Torsade de Pointes and Brugada Pattern Associated with Loperamide Misuse and Supratherapeutic Loperamide Concentrations.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Male; Torsades de | 2021 |
Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Heart Rate; Humans; | 2017 |
Intentional Misuse and Abuse of Loperamide: A New Look at a Drug with "Low Abuse Potential".
Topics: Adolescent; Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Drug-Seeking Behavior; Female; Humans; | 2017 |
Loperamide abuse.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Humans; Loperamide; Substance-Related Disorders | 2017 |
In response to: "Loperamide metabolite-induced cardiomyopathy and QTc prolongation".
Topics: Arrhythmias, Cardiac; Cardiomyopathies; Humans; Loperamide | 2017 |
An Emerging Malignant Arrhythmia Epidemic Due to Loperamide Abuse: Underlying Mechanisms and Clinical Relevance.
Topics: Anti-Arrhythmia Agents; Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Epidemics; Humans | 2016 |
Severe loperamide toxicity associated with the use of cimetidine to potentiate the "high".
Topics: Adult; Arrhythmias, Cardiac; Cardiotoxicity; Cimetidine; Drug Misuse; Female; Humans; Loperamide; Pa | 2018 |
Syncope With Unusual Wide Complex Arrhythmia in a Young Woman.
Topics: Adult; Arrhythmias, Cardiac; Dopamine; Electrocardiography; Female; Fibromyalgia; Humans; Loperamide | 2018 |
Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Arrhythmias, Cardiac; Atrioventricular B | 2019 |
Cardiac conduction disturbance after loperamide abuse.
Topics: Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Electric Countershock; Female; Humans; Isoprotereno | 2014 |
Loperamide toxicokinetics: serum concentrations in the overdose setting.
Topics: Adult; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Half-Life; Heart Rate; Humans; Lope | 2015 |
The long QT teaser: loperamide abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Diagnosis, Differential; Electrocardiography; Fatal Out | 2015 |
Ventricular Dysrhythmias from Loperamide Misuse.
Topics: Arrhythmias, Cardiac; Cimetidine; Heart Conduction System; Humans; Loperamide; Male; Narcotic Antago | 2016 |
An Additional Clinical Scenario of Risk for Loperamide Cardiac-Induced Toxicity.
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Loperamide; Substance-Rel | 2016 |
Not your regular high: cardiac dysrhythmias caused by loperamide.
Topics: Alcoholism; Arrhythmias, Cardiac; Benzodiazepines; Blood Pressure; Calcium; Central Nervous System; | 2016 |
Loperamide Abuse Associated With Cardiac Dysrhythmia and Death.
Topics: Adult; Arrhythmias, Cardiac; Fatal Outcome; Humans; Loperamide; Male; Opioid-Related Disorders; Rece | 2017 |
Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Databases, Factual; Female; | 2016 |