loperamide has been researched along with Adverse Drug Event in 7 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "75 mg/kg loperamide over 3 days as treatment for diarrhea." | 3.85 | Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1-1∆ mutation. ( Bracker, K; Long, WM; Sinnott, VB; Thomas, D, 2017) |
| "Chemotherapy-induced diarrhea (CID) became first apparent during clinical studies on the combination of 5-FU with leucovorin and, furthermore, with irinotecan in the treatment of metastatic colorectal carcinoma." | 3.72 | [Management of chemotherapy induced diarrhea]. ( Kullmann, F; Schölmerich, J; Schultz, M, 2004) |
| "Psychosis is caused by interactions with other drugs or by pharmacogenetic vulnerabilities that cause heightened responses to chloroquine or mefloquine alone, mediated through dopamine, acetylcholine, serotonin, P-glycoprotein, inhibited cortical activity, deranged calcium homeostasis, and impaired synaptogenesis." | 1.33 | Drug interactions and pharmacogenetic reactions are the basis for chloroquine and mefloquine-induced psychosis. ( Alisky, JM; Chertkova, EL; Iczkowski, KA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Corrêa Benedet Baesso, K | 1 |
| Zapelini do Nascimento, D | 1 |
| De Sá Soares, A | 1 |
| Schuelter-Trevisol, F | 1 |
| Long, WM | 1 |
| Sinnott, VB | 1 |
| Bracker, K | 1 |
| Thomas, D | 1 |
| Kreisl, WC | 1 |
| Liow, JS | 1 |
| Kimura, N | 1 |
| Seneca, N | 1 |
| Zoghbi, SS | 1 |
| Morse, CL | 1 |
| Herscovitch, P | 1 |
| Pike, VW | 1 |
| Innis, RB | 1 |
| Schultz, M | 1 |
| Schölmerich, J | 1 |
| Kullmann, F | 1 |
| Alisky, JM | 1 |
| Chertkova, EL | 1 |
| Iczkowski, KA | 1 |
1 trial available for loperamide and Adverse Drug Event
| Article | Year |
|---|---|
P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Cer | 2010 |
6 other studies available for loperamide and Adverse Drug Event
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study.
Topics: Adverse Drug Reaction Reporting Systems; Cross-Sectional Studies; Diphenhydramine; Drug-Related Side | 2022 |
Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1-1∆ mutation.
Topics: Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Diagnosis, Differe | 2017 |
[Management of chemotherapy induced diarrhea].
Topics: Antidiarrheals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; | 2004 |
Drug interactions and pharmacogenetic reactions are the basis for chloroquine and mefloquine-induced psychosis.
Topics: Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chloroquine; Drug Interactio | 2006 |