loperamide has been researched along with Addiction, Opioid in 27 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Loperamide is a μ-opioid receptor agonist with antidiarrhoeal effects." | 5.48 | [Loperamide abuse - constipation or heart attack?] ( Bjarnadottir, GD; Gunnarsdottir, AK; Haraldsson, M; Johannsson, M, 2018) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 5.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| "Loperamide is a nonprescription opioid widely used for the treatment of diarrhea." | 4.95 | Clinical Review: Loperamide Toxicity. ( Juurlink, DN; Wu, PE, 2017) |
| "Loperamide, a μ-opioid receptor agonist, can cause cardiotoxicity by inhibiting the potassium ion channel and slowing cardiomyocyte repolarization." | 4.02 | Loperamide Toxicity Revealing Apical Hypertrophic Cardiomyopathy. ( Chitturi, KR; Clewing, M; Hatcher, C; Khan, N; Nagueh, SF, 2021) |
| "With the increasing amount of information available on the Internet describing techniques for using loperamide either for self-treatment of opioid withdrawal syndromes or for recreational use (so-called legal highs), the objective was to describe a statewide poison control system's experience with loperamide misuse and abuse, with specific interest in cases of cardiotoxicity, and to determine if reported loperamide misuse or abuse cases have recently increased." | 3.85 | Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015. ( Cantrell, FL; Corbett, B; Koh, CH; Lasoff, DR; Minns, AB, 2017) |
| "Loperamide is a nonprescription medication commonly used to treat diarrhea." | 2.82 | Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management. ( Juurlink, DN; Wu, PE, 2022) |
| "Loperamide is a mu-opioid receptor agonist that is available as an over-the-counter anti-motility agent in the US and UK; recommended maximum doses of 12-16 mg/day." | 1.56 | Non-medical use of loperamide in the UK and the USA. ( Amioka, E; Black, JC; Dargan, PI; Dart, RC; Webb, NE; Wood, DM, 2020) |
| "Loperamide is an over-the-counter anti-diarrhoeal agent." | 1.56 | [A young woman's loperamide abuse for the achievement of euphoric effect]. ( Fiil, S; Kamronn, TM; Livbjerg, S; Petersen, TS, 2020) |
| "Loperamide is a peripheral mu-opioid agonist that is intended to be used for diarrhea." | 1.56 | Long-term Buprenorphine Treatment for Loperamide Use Disorder: A Case Series. ( Allgaier, JT; Brar, JK; Broyan, VR; Nye, L; Saxon, AJ, 2020) |
| "Loperamide is an opioid available over the counter and in prescription form." | 1.56 | Loperamide Abuse and Its Sequelae. ( Jones, P; Key, P; Prahlow, JA; Strzyzewski, L, 2020) |
| "Loperamide is an over-the-counter anti-diarrheal medication that is inexpensive, easily accessible, and widely used." | 1.48 | Loperamide abuse cardiotoxicity. Should loperamide still be an over the counter medication? ( Idris, A; Kaye, K; Mihora, DC, 2018) |
| "Loperamide is a μ-opioid receptor agonist with antidiarrhoeal effects." | 1.48 | [Loperamide abuse - constipation or heart attack?] ( Bjarnadottir, GD; Gunnarsdottir, AK; Haraldsson, M; Johannsson, M, 2018) |
| "Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea." | 1.46 | Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse. ( El Meligy, A; Garas, MK; Minami, T; Parikh, P; Rasla, S; Shah, NR; St Amand, A, 2017) |
| "Loperamide is an over-the-counter antidiarrheal with μ-opioid agonist activity." | 1.46 | Loperamide Abuse Associated With Cardiac Dysrhythmia and Death. ( Clark, KH; Eggleston, W; Marraffa, JM, 2017) |
| "Loperamide is a μ-opioid receptor agonist commonly used to treat diarrhea and often available as an over-the-counter medication." | 1.43 | Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic. ( Compton, DR; Kang, J; Rampe, D; Vaz, RJ, 2016) |
| "Naloxone methiodide is a peripherally restricted opioid receptor antagonist." | 1.36 | Involvement of peripheral mu opioid receptors in scratching behavior in mice. ( Sugimoto, Y; Yamamoto, A, 2010) |
| "Loperamide is an opioid that stimulates opioid receptors in the gastrointestinal tract, thereby inhibiting intestinal secretion and propulsive peristalsis, probably without affecting the central nervous system." | 1.31 | [Loperamide abuse in anxiety disorder]. ( Bschor, T; Langlitz, N; Schotte, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 17 (62.96) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, PE | 2 |
| Juurlink, DN | 2 |
| Webb, NE | 1 |
| Wood, DM | 1 |
| Black, JC | 1 |
| Amioka, E | 1 |
| Dart, RC | 1 |
| Dargan, PI | 1 |
| Hill, MR | 1 |
| Hopkins, MR | 1 |
| Knezevic, CE | 1 |
| Fiil, S | 1 |
| Kamronn, TM | 1 |
| Petersen, TS | 1 |
| Livbjerg, S | 1 |
| Brar, JK | 1 |
| Broyan, VR | 1 |
| Allgaier, JT | 1 |
| Nye, L | 1 |
| Saxon, AJ | 1 |
| Strzyzewski, L | 1 |
| Key, P | 1 |
| Jones, P | 1 |
| Prahlow, JA | 1 |
| Khan, N | 1 |
| Chitturi, KR | 1 |
| Hatcher, C | 1 |
| Clewing, M | 1 |
| Nagueh, SF | 1 |
| Rasla, S | 1 |
| Parikh, P | 1 |
| St Amand, A | 1 |
| Garas, MK | 1 |
| El Meligy, A | 1 |
| Minami, T | 1 |
| Shah, NR | 1 |
| Idris, A | 1 |
| Mihora, DC | 1 |
| Kaye, K | 1 |
| Throckmorton, DC | 1 |
| Gottlieb, S | 1 |
| Woodcock, J | 1 |
| Gunnarsdottir, AK | 1 |
| Johannsson, M | 1 |
| Haraldsson, M | 1 |
| Bjarnadottir, GD | 1 |
| Ward, HB | 1 |
| Barnett, BS | 1 |
| Suzuki, J | 1 |
| Varghese, SP | 1 |
| Kumari, P | 1 |
| Wijegunaratne, H | 1 |
| Yovankin, T | 1 |
| Garlapati, V | 1 |
| Koola, MM | 1 |
| Kim, S | 1 |
| Shi, Y | 1 |
| Zhang, Y | 1 |
| Zhao, F | 1 |
| Ruan, H | 1 |
| Huang, H | 1 |
| Luo, L | 1 |
| Li, L | 1 |
| Eggleston, W | 1 |
| Clark, KH | 1 |
| Marraffa, JM | 1 |
| Vaughn, P | 1 |
| Solik, MM | 1 |
| Bagga, S | 1 |
| Padanilam, BJ | 1 |
| Kang, J | 1 |
| Compton, DR | 1 |
| Vaz, RJ | 1 |
| Rampe, D | 1 |
| Lasoff, DR | 1 |
| Koh, CH | 1 |
| Corbett, B | 1 |
| Minns, AB | 1 |
| Cantrell, FL | 1 |
| Yamamoto, A | 1 |
| Sugimoto, Y | 1 |
| Daniulaityte, R | 1 |
| Carlson, R | 1 |
| Falck, R | 1 |
| Cameron, D | 1 |
| Perera, S | 1 |
| Chen, L | 1 |
| Sheth, A | 1 |
| Wüster, M | 1 |
| Schulz, R | 1 |
| Herz, A | 1 |
| Langlitz, N | 1 |
| Schotte, K | 1 |
| Bschor, T | 1 |
| Mack, RB | 1 |
| Coupar, IM | 1 |
4 reviews available for loperamide and Addiction, Opioid
| Article | Year |
|---|---|
Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Opioid-Related Disor | 2022 |
Clinical Review: Loperamide Toxicity.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Diarrhea; Drug Overdose; Humans; Loperamide; Opioid-Relate | 2017 |
The unsuspected threat of three opioid-like substitutes.
Topics: Analgesics; Antidiarrheals; Gabapentin; Humans; Loperamide; Mitragyna; Opiate Substitution Treatment | 2019 |
Opioid action of the intestine: the importance of the intestinal mucosa.
Topics: Antidiarrheals; Body Water; Diarrhea; Diphenoxylate; Humans; Intestinal Mucosa; Intestines; Loperami | 1987 |
1 trial available for loperamide and Addiction, Opioid
| Article | Year |
|---|---|
"I just wanted to tell you that loperamide WILL WORK": a web-based study of extra-medical use of loperamide.
Topics: Advertising; Analgesics, Opioid; Humans; Internet; Loperamide; Opioid-Related Disorders; Self Care; | 2013 |
22 other studies available for loperamide and Addiction, Opioid
| Article | Year |
|---|---|
Non-medical use of loperamide in the UK and the USA.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Female; Humans; Illicit Drugs; Loperamid | 2020 |
Emerging Toxidromes: A 25-Year-Old Woman with Syncope and ECG Changes.
Topics: Adult; Electrocardiography; Female; Humans; Loperamide; Opioid-Related Disorders; Oxycodone; Self Me | 2019 |
[A young woman's loperamide abuse for the achievement of euphoric effect].
Topics: Adult; Arrhythmias, Cardiac; Female; Humans; Loperamide; Opioid-Related Disorders | 2020 |
Long-term Buprenorphine Treatment for Loperamide Use Disorder: A Case Series.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Loperamide; Opioid-Related Disorders; Substance Withdrawa | 2020 |
Loperamide Abuse and Its Sequelae.
Topics: Adult; Antidiarrheals; Crohn Disease; Fatal Outcome; Humans; Hypoxia, Brain; Loperamide; Male; Nalox | 2020 |
Loperamide Toxicity Revealing Apical Hypertrophic Cardiomyopathy.
Topics: Adult; Antidiarrheals; Cardiomyopathy, Hypertrophic; Cardiotoxicity; DNA Mutational Analysis; Electr | 2021 |
Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Drug Overdose; Electrocardiography; Heart Rate; Humans; | 2017 |
Loperamide abuse cardiotoxicity. Should loperamide still be an over the counter medication?
Topics: Adult; Antidiarrheals; Echocardiography; Electrocardiography; Female; Humans; Loperamide; Nonprescri | 2018 |
The FDA and the Next Wave of Drug Abuse - Proactive Pharmacovigilance.
Topics: Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Drug Utilization | 2018 |
[Loperamide abuse - constipation or heart attack?]
Topics: Analgesics, Opioid; Antidiarrheals; Constipation; Databases, Factual; Drug Prescriptions; Humans; Ic | 2018 |
Rapid transition from methadone to buprenorphine using naltrexone-induced withdrawal: A case report.
Topics: Adult; Antidiarrheals; Antiemetics; Antipruritics; Buprenorphine; Clonidine; Deprescriptions; Drug S | 2019 |
Loperamide Addiction: Atypical Opioid Use Disorder Treated With Buprenorphine/Naloxone.
Topics: Abuse-Deterrent Formulations; Adult; Analgesics, Opioid; Buprenorphine; Drug Therapy, Combination; F | 2019 |
Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinergic Agonists; Gastrointestinal Tract; Intestin | 2014 |
Loperamide Abuse Associated With Cardiac Dysrhythmia and Death.
Topics: Adult; Arrhythmias, Cardiac; Fatal Outcome; Humans; Loperamide; Male; Opioid-Related Disorders; Rece | 2017 |
Self-medicating in the opioid crisis.
Topics: Antidiarrheals; Humans; Loperamide; Nonprescription Drugs; Opioid-Related Disorders; Prescription Dr | 2016 |
Electrocardiographic Abnormalities, Malignant Ventricular Arrhythmias, and Cardiomyopathy Associated With Loperamide Abuse.
Topics: Action Potentials; Antidiarrheals; Cardiomyopathy, Dilated; Electrocardiography; Heart Conduction Sy | 2016 |
Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.
Topics: Action Potentials; Antidiarrheals; Cardiotoxicity; Dose-Response Relationship, Drug; ERG1 Potassium | 2016 |
Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015.
Topics: Antidiarrheals; Cardiotoxicity; Databases, Factual; Dose-Response Relationship, Drug; Humans; Lopera | 2017 |
Involvement of peripheral mu opioid receptors in scratching behavior in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2010 |
Inquiry into endorphinergic feedback mechanisms during the development of opiate tolerance/dependence.
Topics: Animals; Brain; Dextrorphan; Drug Tolerance; Endorphins; Etorphine; Feedback; Humans; Levorphanol; L | 1980 |
[Loperamide abuse in anxiety disorder].
Topics: Adult; Anxiety Disorders; Diarrhea; Female; Follow-Up Studies; Humans; Life Change Events; Loperamid | 2001 |
Dinner with De Quincey. Loperamide overdose.
Topics: History, 16th Century; History, 19th Century; Loperamide; Opioid-Related Disorders; Opium; Piperidin | 1989 |