Page last updated: 2024-10-30

loperamide and Ache

loperamide has been researched along with Ache in 22 studies

Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

Research Excerpts

ExcerptRelevanceReference
"The primary aim was to compare the efficacy of loperamide and morphine in treating pain when applied topically along with intrasite gel."9.41Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study. ( Jyothi, B; Korikanthimath, VV; Kurugodiyavar, MD; Mitragotri, MV; Shaikh, SI, 2021)
"Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution."7.74Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain. ( Nozaki-Taguchi, N; Shimoyama, N; Shutoh, M, 2008)
"In the present study, we investigated whether the peripherally acting micro-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain."7.74Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice. ( Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I, 2007)
"The primary aim was to compare the efficacy of loperamide and morphine in treating pain when applied topically along with intrasite gel."5.41Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study. ( Jyothi, B; Korikanthimath, VV; Kurugodiyavar, MD; Mitragotri, MV; Shaikh, SI, 2021)
"Peripheral opioids act as analgesics in bone cancer pain in mice."5.33Analgesic effects of loperamide in bone cancer pain in mice. ( Baamonde, A; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2005)
"Using the Hargreaves assay for thermal nociception, the von Frey assay for mechanical nociception and the complete Freund's adjuvant-induced model of inflammatory pain, we tested the antinociceptive and antihyperalgesic effect of loperamide, oxymorphindole, or the loperamide-oxymorphindole combination."3.91Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice. ( Akgün, E; Bruce, DJ; Fairbanks, CA; Kitto, KF; Lazzaroni, S; Peterson, CD; Portoghese, PS; Wilcox, GL, 2019)
"Morphine is a gold standard analgesic commonly used to alleviate pain."3.78Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels. ( Kumar, R; Ray, SB; Reeta, KH, 2012)
"Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution."3.74Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain. ( Nozaki-Taguchi, N; Shimoyama, N; Shutoh, M, 2008)
"In the present study, we investigated whether the peripherally acting micro-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain."3.74Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice. ( Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I, 2007)
"To reveal peripheral components of opiate analgesia, effects of loperamide, opioid agonist which does not penetrate the blood-brain barrier, were examined in formalin and acute thermal pain tests in comparison with morphine."3.73Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists. ( Bespalov, AY; Danysz, W; Sevostianova, N, 2005)
"Previous reports have shown that systemic administration of morphine can prevent the thermal hyperalgesia induced by the development of an osteosarcoma in C3H/HeJ mice after the implantation of NCTC 2472 cells."3.72Peripheral opioids act as analgesics in bone cancer pain in mice. ( Baamonde, A; García, E; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2003)
"loperamide was abolished by i."1.38Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. ( Al-Khrasani, M; Fürst, S; Khalefa, BI; Mousa, SA; Schäfer, M; Shaqura, M, 2012)
"Loperamide was used as a model drug since it normally does not cross the blood-brain barrier (BBB) and was bound to the nanoparticles by adsorption."1.35Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). ( Hekmatara, T; Herbert, E; Kreuter, J; Ulbrich, K, 2009)
"Peripheral opioids act as analgesics in bone cancer pain in mice."1.33Analgesic effects of loperamide in bone cancer pain in mice. ( Baamonde, A; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2005)
" However, with tariquidar, the loperamide dose-response curves for testes/plasma and brain/plasma concentration ratios were shifted 6- (p = 0."1.33Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier. ( Choo, EF; Glaeser, H; Higginbotham, JN; Kim, RB; Kurnik, D; Muszkat, M; Ohkubo, T; Shay, SD; Wilkinson, GR; Wood, AJ, 2006)
"Burn-induced pain is often inadequately managed and its mechanisms, both peripheral and central, are poorly understood."1.31Effects of full-thickness burns on nociceptor sensitization in anesthetized rats. ( Junger, H; Moore, AC; Sorkin, LS, 2002)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.55)18.7374
1990's0 (0.00)18.2507
2000's13 (59.09)29.6817
2010's6 (27.27)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Jyothi, B1
Mitragotri, MV1
Kurugodiyavar, MD1
Shaikh, SI1
Korikanthimath, VV1
Alam, MM1
Emon, NU1
Alam, S1
Rudra, S1
Akhter, N1
Mamun, MMR1
Ganguly, A1
Bruce, DJ1
Peterson, CD1
Kitto, KF1
Akgün, E1
Lazzaroni, S1
Portoghese, PS1
Fairbanks, CA1
Wilcox, GL1
Zhang, LP1
Kline, RH1
Deevska, G1
Ma, F1
Nikolova-Karakashian, M1
Westlund, KN1
Ulbrich, K1
Hekmatara, T2
Herbert, E2
Kreuter, J3
Nozaki-Taguchi, N1
Shutoh, M1
Shimoyama, N1
Tosi, G1
Vergoni, AV1
Ruozi, B1
Bondioli, L1
Badiali, L1
Rivasi, F1
Costantino, L1
Forni, F1
Vandelli, MA1
Ringkamp, M1
Raja, SN1
Khalefa, BI1
Shaqura, M1
Al-Khrasani, M1
Fürst, S1
Mousa, SA2
Schäfer, M2
Kumar, R1
Reeta, KH1
Ray, SB1
Junger, H1
Moore, AC1
Sorkin, LS1
Menéndez, L2
Lastra, A2
Hidalgo, A2
Meana, A2
García, E1
Baamonde, A2
Hagiwara, K1
Nakagawasai, O1
Murata, A1
Yamadera, F1
Miyoshi, I1
Tan-No, K1
Tadano, T1
Yanagisawa, T1
Iijima, T1
Murakami, M1
Butelman, ER1
Harris, TJ1
Kreek, MJ1
Sevostianova, N1
Danysz, W1
Bespalov, AY1
Choo, EF1
Kurnik, D1
Muszkat, M1
Ohkubo, T1
Shay, SD1
Higginbotham, JN1
Glaeser, H1
Kim, RB1
Wood, AJ1
Wilkinson, GR1
Michaelis, K1
Hoffmann, MM1
Dreis, S2
Alyautdin, RN1
Michaelis, M1
Langer, K2
Vogel, T1
Gelperina, S1
Sasaki, A1
Nakashima, Y1
Takasaki, I1
Andoh, T1
Shiraki, K1
Kuraishi, Y1
Labuz, D1
Stein, C1
Machelska, H1
Marcus, SN1
Heaton, KW1

Trials

1 trial available for loperamide and Ache

ArticleYear
Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study.
    Pain physician, 2021, Volume: 24, Issue:1

    Topics: Adult; Analgesics; Cross-Over Studies; Feasibility Studies; Humans; Hydrogels; Loperamide; Male; Mid

2021

Other Studies

21 other studies available for loperamide and Ache

ArticleYear
Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139

    Topics: Albendazole; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Antidiarrheals; Antipyret

2021
Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.
    Anesthesiology, 2019, Volume: 131, Issue:3

    Topics: Analgesia; Animals; Antidiarrheals; Disease Models, Animal; Drug Therapy, Combination; Loperamide; M

2019
Alcohol and high fat induced chronic pancreatitis: TRPV4 antagonist reduces hypersensitivity.
    Neuroscience, 2015, Dec-17, Volume: 311

    Topics: Analgesics; Animals; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Ethanol;

2015
Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB).
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2009, Volume: 71, Issue:2

    Topics: Analgesics; Animals; Antibodies, Monoclonal; Biological Transport; Blood-Brain Barrier; Cross-Linkin

2009
Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain.
    Japanese journal of clinical oncology, 2008, Volume: 38, Issue:12

    Topics: Adult; Analgesics; Bone Marrow Transplantation; Chronic Disease; Female; Graft vs Host Disease; Huma

2008
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution.
    Journal of controlled release : official journal of the Controlled Release Society, 2010, Jul-01, Volume: 145, Issue:1

    Topics: Animals; Brain; Drug Carriers; Glycopeptides; Lactic Acid; Loperamide; Male; Microscopy, Electron, S

2010
Dissecting the relative contribution of central versus peripheral opioid analgesia: are the analgesic and adverse effects of opioids inseparable?
    European journal of pain (London, England), 2012, Volume: 16, Issue:5

    Topics: Analgesics, Opioid; Animals; Fentanyl; Loperamide; Male; Morphine; Pain; Receptors, Opioid; Spinal C

2012
Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids.
    European journal of pain (London, England), 2012, Volume: 16, Issue:5

    Topics: Analgesics, Opioid; Animals; Fentanyl; Inflammation; Loperamide; Male; Morphine; Pain; Rats; Rats, W

2012
Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels.
    European journal of pharmacology, 2012, Dec-05, Volume: 696, Issue:1-3

    Topics: Analgesics; Animals; Behavior, Animal; Calcium Channels; Hot Temperature; Injections, Spinal; Lopera

2012
Effects of full-thickness burns on nociceptor sensitization in anesthetized rats.
    Burns : journal of the International Society for Burn Injuries, 2002, Volume: 28, Issue:8

    Topics: Animals; Burns; Cholinergic Fibers; Loperamide; Male; Nociceptors; Ointments; Pain; Rats; Rats, Spra

2002
Peripheral opioids act as analgesics in bone cancer pain in mice.
    Neuroreport, 2003, May-06, Volume: 14, Issue:6

    Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cell Culture Techniques; Hyperalgesia; Loperamide; Mice

2003
Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels.
    Neuroscience research, 2003, Volume: 46, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2003
Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1

    Topics: Administration, Topical; Analgesics; Animals; Capsaicin; Dopamine; Female; Fentanyl; Loperamide; Mac

2004
Analgesic effects of loperamide in bone cancer pain in mice.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:1

    Topics: Analgesics; Animals; Bone Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Loperamide;

2005
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists.
    European journal of pharmacology, 2005, Nov-21, Volume: 525, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Loper

2005
Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:3

    Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain

2006
Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:3

    Topics: Animals; Apolipoproteins E; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites;

2006
Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain.
    Journal of controlled release : official journal of the Controlled Release Society, 2007, Mar-12, Volume: 118, Issue:1

    Topics: Animals; Apolipoprotein A-I; Apolipoprotein B-100; Biological Transport; Blood-Brain Barrier; Brain;

2007
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:3

    Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Dru

2007
Relative contribution of peripheral versus central opioid receptors to antinociception.
    Brain research, 2007, Jul-30, Volume: 1160

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Aci

2007
Irritable bowel-type symptoms in spontaneous and induced constipation.
    Gut, 1987, Volume: 28, Issue:2

    Topics: Adult; Anthraquinones; Cathartics; Colonic Diseases, Functional; Constipation; Dietary Fiber; Female

1987