loperamide and Ache
loperamide has been researched along with Ache in 22 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary aim was to compare the efficacy of loperamide and morphine in treating pain when applied topically along with intrasite gel." | 9.41 | Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study. ( Jyothi, B; Korikanthimath, VV; Kurugodiyavar, MD; Mitragotri, MV; Shaikh, SI, 2021) |
| "Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution." | 7.74 | Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain. ( Nozaki-Taguchi, N; Shimoyama, N; Shutoh, M, 2008) |
| "In the present study, we investigated whether the peripherally acting micro-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain." | 7.74 | Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice. ( Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I, 2007) |
| "The primary aim was to compare the efficacy of loperamide and morphine in treating pain when applied topically along with intrasite gel." | 5.41 | Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study. ( Jyothi, B; Korikanthimath, VV; Kurugodiyavar, MD; Mitragotri, MV; Shaikh, SI, 2021) |
| "Peripheral opioids act as analgesics in bone cancer pain in mice." | 5.33 | Analgesic effects of loperamide in bone cancer pain in mice. ( Baamonde, A; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2005) |
| "Using the Hargreaves assay for thermal nociception, the von Frey assay for mechanical nociception and the complete Freund's adjuvant-induced model of inflammatory pain, we tested the antinociceptive and antihyperalgesic effect of loperamide, oxymorphindole, or the loperamide-oxymorphindole combination." | 3.91 | Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice. ( Akgün, E; Bruce, DJ; Fairbanks, CA; Kitto, KF; Lazzaroni, S; Peterson, CD; Portoghese, PS; Wilcox, GL, 2019) |
| "Morphine is a gold standard analgesic commonly used to alleviate pain." | 3.78 | Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels. ( Kumar, R; Ray, SB; Reeta, KH, 2012) |
| "Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution." | 3.74 | Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain. ( Nozaki-Taguchi, N; Shimoyama, N; Shutoh, M, 2008) |
| "In the present study, we investigated whether the peripherally acting micro-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain." | 3.74 | Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice. ( Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I, 2007) |
| "To reveal peripheral components of opiate analgesia, effects of loperamide, opioid agonist which does not penetrate the blood-brain barrier, were examined in formalin and acute thermal pain tests in comparison with morphine." | 3.73 | Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists. ( Bespalov, AY; Danysz, W; Sevostianova, N, 2005) |
| "Previous reports have shown that systemic administration of morphine can prevent the thermal hyperalgesia induced by the development of an osteosarcoma in C3H/HeJ mice after the implantation of NCTC 2472 cells." | 3.72 | Peripheral opioids act as analgesics in bone cancer pain in mice. ( Baamonde, A; García, E; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2003) |
| "loperamide was abolished by i." | 1.38 | Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. ( Al-Khrasani, M; Fürst, S; Khalefa, BI; Mousa, SA; Schäfer, M; Shaqura, M, 2012) |
| "Loperamide was used as a model drug since it normally does not cross the blood-brain barrier (BBB) and was bound to the nanoparticles by adsorption." | 1.35 | Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). ( Hekmatara, T; Herbert, E; Kreuter, J; Ulbrich, K, 2009) |
| "Peripheral opioids act as analgesics in bone cancer pain in mice." | 1.33 | Analgesic effects of loperamide in bone cancer pain in mice. ( Baamonde, A; Hidalgo, A; Lastra, A; Meana, A; Menéndez, L, 2005) |
| " However, with tariquidar, the loperamide dose-response curves for testes/plasma and brain/plasma concentration ratios were shifted 6- (p = 0." | 1.33 | Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier. ( Choo, EF; Glaeser, H; Higginbotham, JN; Kim, RB; Kurnik, D; Muszkat, M; Ohkubo, T; Shay, SD; Wilkinson, GR; Wood, AJ, 2006) |
| "Burn-induced pain is often inadequately managed and its mechanisms, both peripheral and central, are poorly understood." | 1.31 | Effects of full-thickness burns on nociceptor sensitization in anesthetized rats. ( Junger, H; Moore, AC; Sorkin, LS, 2002) |
Research
Studies (22)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (59.09) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Jyothi, B | 1 |
| Mitragotri, MV | 1 |
| Kurugodiyavar, MD | 1 |
| Shaikh, SI | 1 |
| Korikanthimath, VV | 1 |
| Alam, MM | 1 |
| Emon, NU | 1 |
| Alam, S | 1 |
| Rudra, S | 1 |
| Akhter, N | 1 |
| Mamun, MMR | 1 |
| Ganguly, A | 1 |
| Bruce, DJ | 1 |
| Peterson, CD | 1 |
| Kitto, KF | 1 |
| Akgün, E | 1 |
| Lazzaroni, S | 1 |
| Portoghese, PS | 1 |
| Fairbanks, CA | 1 |
| Wilcox, GL | 1 |
| Zhang, LP | 1 |
| Kline, RH | 1 |
| Deevska, G | 1 |
| Ma, F | 1 |
| Nikolova-Karakashian, M | 1 |
| Westlund, KN | 1 |
| Ulbrich, K | 1 |
| Hekmatara, T | 2 |
| Herbert, E | 2 |
| Kreuter, J | 3 |
| Nozaki-Taguchi, N | 1 |
| Shutoh, M | 1 |
| Shimoyama, N | 1 |
| Tosi, G | 1 |
| Vergoni, AV | 1 |
| Ruozi, B | 1 |
| Bondioli, L | 1 |
| Badiali, L | 1 |
| Rivasi, F | 1 |
| Costantino, L | 1 |
| Forni, F | 1 |
| Vandelli, MA | 1 |
| Ringkamp, M | 1 |
| Raja, SN | 1 |
| Khalefa, BI | 1 |
| Shaqura, M | 1 |
| Al-Khrasani, M | 1 |
| Fürst, S | 1 |
| Mousa, SA | 2 |
| Schäfer, M | 2 |
| Kumar, R | 1 |
| Reeta, KH | 1 |
| Ray, SB | 1 |
| Junger, H | 1 |
| Moore, AC | 1 |
| Sorkin, LS | 1 |
| Menéndez, L | 2 |
| Lastra, A | 2 |
| Hidalgo, A | 2 |
| Meana, A | 2 |
| García, E | 1 |
| Baamonde, A | 2 |
| Hagiwara, K | 1 |
| Nakagawasai, O | 1 |
| Murata, A | 1 |
| Yamadera, F | 1 |
| Miyoshi, I | 1 |
| Tan-No, K | 1 |
| Tadano, T | 1 |
| Yanagisawa, T | 1 |
| Iijima, T | 1 |
| Murakami, M | 1 |
| Butelman, ER | 1 |
| Harris, TJ | 1 |
| Kreek, MJ | 1 |
| Sevostianova, N | 1 |
| Danysz, W | 1 |
| Bespalov, AY | 1 |
| Choo, EF | 1 |
| Kurnik, D | 1 |
| Muszkat, M | 1 |
| Ohkubo, T | 1 |
| Shay, SD | 1 |
| Higginbotham, JN | 1 |
| Glaeser, H | 1 |
| Kim, RB | 1 |
| Wood, AJ | 1 |
| Wilkinson, GR | 1 |
| Michaelis, K | 1 |
| Hoffmann, MM | 1 |
| Dreis, S | 2 |
| Alyautdin, RN | 1 |
| Michaelis, M | 1 |
| Langer, K | 2 |
| Vogel, T | 1 |
| Gelperina, S | 1 |
| Sasaki, A | 1 |
| Nakashima, Y | 1 |
| Takasaki, I | 1 |
| Andoh, T | 1 |
| Shiraki, K | 1 |
| Kuraishi, Y | 1 |
| Labuz, D | 1 |
| Stein, C | 1 |
| Machelska, H | 1 |
| Marcus, SN | 1 |
| Heaton, KW | 1 |
Trials
1 trial available for loperamide and Ache
| Article | Year |
|---|---|
Morphine Versus Loperamide with Intrasite Gel in the Treatment of Painful Dermal Ulcers: A Randomized, Crossover Study.
Topics: Adult; Analgesics; Cross-Over Studies; Feasibility Studies; Humans; Hydrogels; Loperamide; Male; Mid | 2021 |
Other Studies
21 other studies available for loperamide and Ache
| Article | Year |
|---|---|
Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches.
Topics: Albendazole; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Antidiarrheals; Antipyret | 2021 |
Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.
Topics: Analgesia; Animals; Antidiarrheals; Disease Models, Animal; Drug Therapy, Combination; Loperamide; M | 2019 |
Alcohol and high fat induced chronic pancreatitis: TRPV4 antagonist reduces hypersensitivity.
Topics: Analgesics; Animals; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Ethanol; | 2015 |
Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB).
Topics: Analgesics; Animals; Antibodies, Monoclonal; Biological Transport; Blood-Brain Barrier; Cross-Linkin | 2009 |
Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain.
Topics: Adult; Analgesics; Bone Marrow Transplantation; Chronic Disease; Female; Graft vs Host Disease; Huma | 2008 |
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution.
Topics: Animals; Brain; Drug Carriers; Glycopeptides; Lactic Acid; Loperamide; Male; Microscopy, Electron, S | 2010 |
Dissecting the relative contribution of central versus peripheral opioid analgesia: are the analgesic and adverse effects of opioids inseparable?
Topics: Analgesics, Opioid; Animals; Fentanyl; Loperamide; Male; Morphine; Pain; Receptors, Opioid; Spinal C | 2012 |
Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids.
Topics: Analgesics, Opioid; Animals; Fentanyl; Inflammation; Loperamide; Male; Morphine; Pain; Rats; Rats, W | 2012 |
Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels.
Topics: Analgesics; Animals; Behavior, Animal; Calcium Channels; Hot Temperature; Injections, Spinal; Lopera | 2012 |
Effects of full-thickness burns on nociceptor sensitization in anesthetized rats.
Topics: Animals; Burns; Cholinergic Fibers; Loperamide; Male; Nociceptors; Ointments; Pain; Rats; Rats, Spra | 2002 |
Peripheral opioids act as analgesics in bone cancer pain in mice.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cell Culture Techniques; Hyperalgesia; Loperamide; Mice | 2003 |
Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2003 |
Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates.
Topics: Administration, Topical; Analgesics; Animals; Capsaicin; Dopamine; Female; Fentanyl; Loperamide; Mac | 2004 |
Analgesic effects of loperamide in bone cancer pain in mice.
Topics: Analgesics; Animals; Bone Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Loperamide; | 2005 |
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists.
Topics: Analgesics, Opioid; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Loper | 2005 |
Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.
Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain | 2006 |
Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain.
Topics: Animals; Apolipoproteins E; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; | 2006 |
Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain.
Topics: Animals; Apolipoprotein A-I; Apolipoprotein B-100; Biological Transport; Blood-Brain Barrier; Brain; | 2007 |
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Dru | 2007 |
Relative contribution of peripheral versus central opioid receptors to antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Aci | 2007 |
Irritable bowel-type symptoms in spontaneous and induced constipation.
Topics: Adult; Anthraquinones; Cathartics; Colonic Diseases, Functional; Constipation; Dietary Fiber; Female | 1987 |