Compounds > lonidamine
Page last updated: 2024-08-23

lonidamine and Neoplasms

lonidamine has been researched along with Neoplasms in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199011 (35.48)18.7374
1990's6 (19.35)18.2507
2000's2 (6.45)29.6817
2010's9 (29.03)24.3611
2020's3 (9.68)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L1
Aoyama, M; Hirano, H; Ishikawa, K; Nemoto, S; Osada, H; Semba, K; Watanabe, N; Watanabe, S1
Gong, P; Hai, L; Huang, S; Li, Y; Liang, R; Liu, Z; Xiang, C; Xiang, J; Yang, T; Yang, X; Zhang, X; Zhou, L1
Liu, J; Tang, X; Wu, C; Xu, K; Zhai, Z; Zhong, W1
Chen, B; Kankala, RK; Krastev, R; Li, X; Liu, Y; Long, R; Wang, P; Wang, S; Xiong, X; Yang, D; Zhang, Y; Zhu, M1
Ju, RJ; Li, N; Li, XY; Lu, WL; Ma, X; Wang, XX; Zhang, CX; Zhang, L; Zhao, WY; Zhou, J1
Cervantes-Madrid, D; Dueñas-González, A1
Cervantes-Madrid, D; Dueñas-González, A; Romero, Y1
Assanhou, AG; Kong, L; Li, W; Mo, R; Sun, H; Xue, L; Zhang, C; Zhang, L1
Babu, E; Bhutia, YD; Ganapathy, V1
Hu, X; Liu, H; Pan, T; Tan, R; Tan, W; Wang, S; Wang, Y; Yu, H; Zhong, Z1
Amiji, M; Duan, Z; Milane, L1
Battelli, T; D'Atri, S; De Martino, C; Floridi, A; Gallo, M; Malorni, W; Marcante, ML; Nista, A; Paggi, MG1
Band, PR; Besner, JG; Catanese, B; De Sanctis, AJ; Deschamps, M; Leclaire, R1
Band, PR; Besner, JG; De Sanctis, A; Deschamps, M; Gervais, P; Leclaire, R2
Currie, VE; Farag, FM; Kim, JH; Kinahan, JE; O'Hehir, MA; Young, CW1
Evans, WK; Mullis, B; Shepherd, FA1
Barduagni, A; Barduagni, M; Ciottoli, GB; Delle Chiaie, S; Di Lauro, L; Gallo Curcio, C; Nardi, M; Tonachella, R1
Battelli, T; Bellocci, M; Cavaliere, R; De Martino, C; Di Filippo, F; Gallo Curcio, C; Giustini, L; Manocchi, D; Mattioli, R; Rinaldi, M1
Teicher, BA1
Artico, M; Gatto, MT; Saso, L; Tita, B1
Frei, E; Teicher, BA1
Arancia, G; Donelli, G1
Danjoux, CE; DeSanctis, AJ; Feeley, MM; Fisher, B; Maroun, J; Martin, L; Raaphorst, GP1
Weinerman, B1
Alfieri, AA; He, SQ; Kim, JH; Kim, SH; Young, CW1
Hugander, A; Lagoni, RK; Longo, WL; Neville, AJ; Riggs, C; Robins, HI; Schmitt, CL1
Caputo, A; Fanciulli, M; Floridi, A; Paggi, MG; Perrotti, N; Silvestrini, B; Zeuli, M1

Reviews

8 review(s) available for lonidamine and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

2015
Reviving Lonidamine and 6-Diazo-5-oxo-L-norleucine to Be Used in Combination for Metabolic Cancer Therapy.
    BioMed research international, 2015, Volume: 2015

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Diazooxonorleucine; Humans; Indazoles; Neoplasms

2015
Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine.
    The Biochemical journal, 2016, Jun-01, Volume: 473, Issue:11

    Topics: Antineoplastic Agents; Glycolysis; Humans; Indazoles; Neoplasms; Signal Transduction

2016
The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance.
    Current medicinal chemistry, 2017, Nov-17, Volume: 24, Issue:34

    Topics: Antineoplastic Agents; Drug Design; Drug Resistance, Neoplasm; Fatty Acids; Humans; Indazoles; Metabolic Engineering; Neoplasms; Oxidative Phosphorylation; Pyruvates

2017
Lonidamine: in vitro/in vivo correlations.
    European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:10

    Topics: Antineoplastic Agents; Drug Administration Schedule; Humans; Indazoles; Neoplasms; Tumor Cells, Cultured

1994
Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids.
    Contraception, 2002, Volume: 65, Issue:4

    Topics: alpha-Macroglobulins; Animals; Antineoplastic Agents; Antispermatogenic Agents; Humans; Indazoles; Male; Neoplasms; Proteins; Rats; Testis

2002
Modulation of antitumor alkylating agents (AA).
    Cancer treatment and research, 1991, Volume: 57

    Topics: Alkylating Agents; Antineoplastic Agents; Cell Hypoxia; Cisplatin; DNA Damage; DNA Repair; Drug Combinations; Drug Interactions; Drug Resistance; Fluorocarbons; Glutathione; Glutathione Transferase; Humans; Hydroxyethyl Starch Derivatives; Indazoles; Metallothionein; Neoplasm Proteins; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Topoisomerase II Inhibitors; Xanthines

1991
Cell membranes as target for anticancer agents.
    Pharmacological research, 1991, Volume: 24, Issue:3

    Topics: Antineoplastic Agents; Cell Division; Cell Membrane; Doxorubicin; Erythrocyte Membrane; Humans; Indazoles; Lymphocytes; Microscopy, Electron; Neoplasms

1991

Trials

1 trial(s) available for lonidamine and Neoplasms

ArticleYear
Lonidamine and human lymphoblastoid alpha interferon in metastatic cancer: a phase I study.
    Cancer investigation, 1990, Volume: 8, Issue:5

    Topics: Activities of Daily Living; Adult; Aged; Drug Administration Schedule; Drug Synergism; Female; Humans; Indazoles; Interferon Type I; Male; Middle Aged; Neoplasms

1990

Other Studies

22 other study(ies) available for lonidamine and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells.
    The Journal of biological chemistry, 2022, Volume: 298, Issue:12

    Topics: Animals; Antineoplastic Agents; Domperidone; Drug Screening Assays, Antitumor; Epithelial Cells; Indazoles; Mammary Glands, Animal; Mice; Neoplasms

2022
A mitochondria-targeting self-assembled carrier-free lonidamine nanodrug for redox-activated drug release to enhance cancer chemotherapy.
    Journal of materials chemistry. B, 2023, 05-03, Volume: 11, Issue:17

    Topics: Antineoplastic Agents; Drug Liberation; Humans; Mitochondria; Nanoparticles; Neoplasms; Oxidation-Reduction; Prodrugs

2023
An enzyme-assisted self-delivery system of lonidamine-peptide conjugates for selectively killing cancer cells.
    Chemical communications (Cambridge, England), 2019, Dec-05, Volume: 55, Issue:98

    Topics: Alkaline Phosphatase; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Hydrogels; Indazoles; Mice; Neoplasms; Peptides; Transplantation, Heterologous

2019
Cancer Cytomembrane-Cloaked Prussian Blue Nanoparticles Enhance the Efficacy of Mild-Temperature Photothermal Therapy by Disrupting Mitochondrial Functions of Cancer Cells.
    ACS applied materials & interfaces, 2021, Aug-11, Volume: 13, Issue:31

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Membrane; Cell Proliferation; Drug Carriers; Drug Liberation; Female; Ferrocyanides; Hep G2 Cells; Humans; Indazoles; Infrared Rays; Mice, Nude; Mitochondria; Nanocomposites; Nanoparticles; Neoplasms; Photothermal Therapy

2021
Development of targeting lonidamine liposomes that circumvent drug-resistant cancer by acting on mitochondrial signaling pathways.
    Biomaterials, 2013, Volume: 34, Issue:13

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; bcl-2-Associated X Protein; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Cytochromes c; Drug Delivery Systems; Drug Resistance, Neoplasm; Enzyme Activation; Epirubicin; Female; Humans; Indazoles; Liposomes; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Xenograft Model Antitumor Assays

2013
Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids.
    Oncology reports, 2015, Volume: 34, Issue:3

    Topics: Animals; Apoptosis; Cell Survival; Diazooxonorleucine; Drug Synergism; Fatty Acid Synthases; Fatty Acids; Fibroblasts; Gene Expression Regulation, Neoplastic; Glutaminase; Glycolysis; Hexokinase; Humans; Indazoles; Lactones; Metabolic Networks and Pathways; Mice; Neoplasms; Orlistat

2015
Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment.
    Biomaterials, 2015, Volume: 73

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hyaluronic Acid; Indazoles; Lipids; Liposomes; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasms; Paclitaxel; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Vitamin E

2015
Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Mice; Mice, Nude; Microscopy, Electron, Scanning; Nanoparticles; Neoplasms; Paclitaxel; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays

2011
Effects of Lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Animals; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Indazoles; Lactates; Lactic Acid; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Microscopy, Electron, Scanning; Mitochondria; Neoplasms; Pyrazoles; Rats; Rats, Inbred Strains; Time Factors

1984
Pharmacokinetics of Lonidamine after oral administration in cancer patients.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Absorption; Administration, Oral; Adult; Aged; Female; Half-Life; Humans; Indazoles; Kinetics; Male; Middle Aged; Neoplasms; Pyrazoles; Time Factors

1984
Phase I toxicologic study of Lonidamine in cancer patients.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Indazoles; Male; Middle Aged; Neoplasms; Pyrazoles

1984
Phase I and clinical pharmacologic evaluation of Lonidamine in patients with advanced cancer.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Hematopoiesis; Humans; Indazoles; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles; Testis

1984
Phase II study of Lonidamine in cancer patients.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Adult; Aged; Antineoplastic Agents; Digestive System; Drug Evaluation; Female; Humans; Indazoles; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles; Time Factors

1984
Phase II evaluation of Lonidamine in patients with advanced malignancy.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Adult; Aged; Antineoplastic Agents; Auditory Perception; Digestive System; Drug Evaluation; Female; Humans; Indazoles; Lactates; Lactic Acid; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles; Testosterone; Time Factors

1984
Early observations on the administration of Lonidamine in cancer patients.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Adult; Aged; Antineoplastic Agents; Digestive System; Drug Administration Schedule; Female; Humans; Indazoles; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles

1984
Morphological damage induced in vivo by Lonidamine on human metastatic cancer cells.
    Oncology, 1984, Volume: 41 Suppl 1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Humans; Hyperthermia, Induced; Indazoles; Melanoma; Mice; Neoplasms; Pyrazoles; Skin Neoplasms

1984
The effect of lonidamine (LND) on radiation and thermal responses of human and rodent cell lines.
    International journal of radiation oncology, biology, physics, 1991, Volume: 20, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Survival; Cricetinae; Fibroblasts; Glioma; Humans; Hyperthermia, Induced; Indazoles; Melanoma; Mice; Neoplasms; Radiotherapy; Tumor Cells, Cultured

1991
Lonidamine: an innovative therapy in oncology.
    Seminars in oncology, 1991, Volume: 18, Issue:2 Suppl 4

    Topics: Antineoplastic Agents; Humans; Indazoles; Neoplasms

1991
Potentiation of radiation effects on multicellular tumor spheroids (MTS) of HeLa cells by lonidamine.
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5

    Topics: Cell Aggregation; DNA Repair; HeLa Cells; Humans; Indazoles; Models, Biological; Neoplasms; Pyrazoles; Radiation-Sensitizing Agents

1989
Phase I trial of lonidamine with whole body hyperthermia in advanced cancer.
    Cancer research, 1988, Nov-15, Volume: 48, Issue:22

    Topics: Adult; Antineoplastic Agents; Blood Cell Count; Combined Modality Therapy; Drug Evaluation; Female; Humans; Hyperthermia, Induced; Indazoles; Male; Middle Aged; Neoplasms; Pyrazoles

1988
The role of mitochondrial hexokinase in neoplastic phenotype and its sensitivity to lonidamine.
    Annals of the New York Academy of Sciences, 1988, Volume: 551

    Topics: Antineoplastic Agents; Hexokinase; Humans; Indazoles; Mitochondria; Neoplasms; Pyrazoles

1988