Page last updated: 2024-08-23

lonidamine and Breast Cancer

lonidamine has been researched along with Breast Cancer in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.98)18.7374
1990's26 (60.47)18.2507
2000's5 (11.63)29.6817
2010's7 (16.28)24.3611
2020's2 (4.65)2.80

Authors

AuthorsStudies
Guan, Z; Li, J; Tang, R; Wang, X; Yang, L; Zhang, J1
Cohen-Erez, I; Gheber, LA; Issacson, C; Laster, B; Lavi, Y; Milam, J; Rapaport, H; Shaco-Levy, R1
Bakar-Ates, F; Ozkan, E1
Gallo, KA; Wu, X1
Baltazar, F; Miranda-Gonçalves, V; Morais-Santos, F; Paredes, J; Pinheiro, C; Pinheiro, S; Schmitt, FC; Vieira, AF1
Glickson, JD; Heitjan, DF; Leeper, DB; Nath, K; Nelson, DS; Zhou, R1
Chu, X; Shao, F; Wang, L1
Amiji, M; Duan, Z; Milane, L1
Amiji, M; Duan, ZF; Milane, L1
Alquati, P; Berruti, A; Bitossi, R; Bonazzi, G; Bottini, A; Bruzzi, P; Bumma, C; Castiglione, F; Danese, S; De Lena, M; De Matteis, A; DeFabiani, E; Dogliotti, L; Farris, A; Giardina, G; Gorzegno, G; Lorusso, V; Moro, G; Nuzzo, F; Sarobba, MG1
Carlini, P; Cognetti, F; Di Cosimo, S; Fabi, A; Ferretti, G; Papaldo, P1
Antimi, M; Barone, C; Botti, C; Cammilluzzi, E; Carlini, P; Conti, F; Cortesi, E; Di Cosimo, S; Di Lauro, L; Fabi, A; Ferretti, G; Giannarelli, D; Lepidini, G; Lopez, M; Marolla, P; Nistico, C; Papaldo, P; Terzoli, E; Vici, P; Vitucci, C1
Antimi, M; Botti, C; Carlini, P; Ceribelli, A; Cognetti, F; Cortesi, E; Di Cosimo, S; Di Filippo, F; Di Lauro, L; Ferretti, G; Giannarelli, D; Lopez, M; Marolla, P; Mottolese, M; Naso, G; Nisticò, C; Papaldo, P; Ruggeri, EM; Terzoli, E; Vici, P1
Carpano, S; Conti, F; Di Lauro, L; Giannarelli, D; Gionfra, T; Lopez, M; Paoletti, G; Pignatti, F; Vici, P1
Bucci, L; Caponigro, F; Di Martino, N; Facchini, G; Fei, L; Iaffaioli, RV; Mantovani, G; Santangelo, M; Tortoriello, A1
Arancia, G; Calcabrini, A; Citro, G; Meschini, S; Molinari, A1
Ara, G; Eder, JP; Herman, TS; Holden, SA; Korbut, T; Schwartz, GN; Teicher, BA1
Barone, C; Camoriano, A; Gardin, G; Ianniello, G; Merlini, L; Nascimben, O; Naso, C; Pronzato, P; Rosso, M; Rosso, R1
Alquati, P; Baù, MG; Berruti, A; Bottini, A; Buniva, T; Deltetto, F; Dogliotti, L; Farris, A; Gosso, P; Monzeglio, C; Moro, G; Perroni, D; Sarobba, MG; Sussio, M; Zola, P1
Barone, C; Contu, A; Gardin, G; Ianniello, G; Nascimben, O; Pronzato, P; Rosso, R; Sturba, F1
Biroccio, A; D'Angelo, C; Del Bufalo, D; Laudonio, N; Sacchi, A; Soddu, S; Zupi, G1
Bruno, T; Citro, G; Fanciulli, M; Floridi, A; Valentini, A; Zupi, G1
Ben-Horin, H; Kaplan, O; Navon, G; Tassini, M; Vivi, A1
Amadori, D; Gasperi-Campani, A; Roncuzzi, L; Zoli, W1
Bearzatto, A; De Marco, C; Gornati, D; Silvestrini, R; Zaffaroni, N1
Borsellino, N; Colucci, G; Gebbia, N; Gebbia, V; Giotta, F; Latteri, MA; Milia, V; Testa, A; Valdesi, M1
Baù, MG; Berruti, A; Bottini, A; Buniva, T; Danese, S; Dogliotti, L; Farris, A; Moro, G; Porcile, G; Richiardi, G; Zola, P1
Amadori, D; Cariello, S; De Matteis, A; Ferrari, M; Frassineti, GL; Lombardi, A; Mustacchi, G; Nanni, O; Nascimben, O; Santoro, A; Scarpi, E; Zoli, W1
D'Ottavio, AM; Fabi, A; Garufi, C; Milella, M; Nisticò, C; Terzoli, E; Vaccaro, A1
Ash, E; Cohen, JS; Kaplan, O; Mardor, Y; Ringel, I; Roth, Y; Ruiz-Cabello, J; Sterin, M1
Amadori, A; Amadori, D; Flamigni, A; Frassineti, GL; Magni, E; Nanni, O; Savini, S; Volpi, A; Zoli, W1
Citro, G; Cucco, C; Verdina, A; Zupi, G1
Button, D; de Graeff, A; Glaholm, J; Leach, MO; Mansi, JL; Newell, DR; Payne, G; Smith, IE1
Epelbaum, R; Frei, E; Herman, TS; Holden, SA; Liu, SD; Teicher, BA1
Button, D; Catanese, B; Hardy, J; Jenns, K; Mansi, J; Newell, DR; Picollo, R; Smith, IE1
Classen, S; Flath, B; Kovacs, S; Possinger, K; Wagner, H; Wilmanns, W1
Amoroso, D; Gardin, G; Guido, T; Miglietta, L; Pace, M; Pronzato, P; Repetto, L; Rosso, R1
Ballatore, P; Calabresi, F; Calabró, A; Curcio, CG; Di Lauro, L; Di Palma, M; Foggi, CM; Giannarelli, D; Marolla, P; Paoletti, G1
Benson, AB; Neuberg, DS; Pandya, KJ; Robins, HI; Tormey, DC1
Arcangeli, G; Marini, G; Marpicati, P; Meriggi, F; Montini, E; Simoncini, E; Zaniboni, A1
Brann, TW; Frei, E; Holden, SA; Rosbe, KW; Teicher, BA1
Amoroso, D; Bertelli, G; Ciottoli, GB; Conte, PF; Cusimano, MP; Gulisano, M; Lionetto, R; Pronzato, P; Rosso, R1
Band, PR; Coppin, CM; Eisenhauer, EA; Maroun, J; Pritchard, K; Stewart, D; Wilson, K1

Reviews

2 review(s) available for lonidamine and Breast Cancer

ArticleYear
Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors.
    Drugs of today (Barcelona, Spain : 1998), 2003, Volume: 39, Issue:3

    Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Female; Humans; Indazoles; Lung Neoplasms; Male; Ovarian Neoplasms; Safety

2003
Lonidamine in metastatic breast cancer.
    Seminars in oncology, 1991, Volume: 18, Issue:2 Suppl 4

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Indazoles

1991

Trials

16 trial(s) available for lonidamine and Breast Cancer

ArticleYear
Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Oct-15, Volume: 20, Issue:20

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Disease Progression; Epirubicin; Female; Humans; Indazoles; Logistic Models; Middle Aged; Survival Analysis

2002
Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Sep-15, Volume: 21, Issue:18

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Disease-Free Survival; Epirubicin; Female; Filgrastim; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Indazoles; Middle Aged; Recombinant Proteins; Survival Rate

2003
Does granulocyte colony-stimulating factor worsen anemia in early breast cancer patients treated with epirubicin and cyclophosphamide?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jul-01, Volume: 24, Issue:19

    Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Erythropoiesis; Female; Granulocyte Colony-Stimulating Factor; Humans; Indazoles

2006
Intrapatient comparison of single-agent epirubicin with or without lonidamine in metastatic breast cancer.
    European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease Progression; Drug Resistance, Neoplasm; Epirubicin; Female; Follow-Up Studies; Humans; Indazoles; Middle Aged; Neoplasm Metastasis; Survival Rate

1995
Phase II study of high-dose epirubicin, lonidamine, alpha 2b interferon in advanced breast cancer.
    Breast cancer research and treatment, 1995, Volume: 35, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Epirubicin; Female; Follow-Up Studies; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indazoles; Interferon alpha-2; Interferon-alpha; Menopause; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Postmenopause; Premenopause; Recombinant Proteins

1995
The role of lonidamine in the treatment of breast cancer patients.
    Annals of the New York Academy of Sciences, 1993, Nov-30, Volume: 698

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Humans; Indazoles; Middle Aged; Survival Analysis

1993
Lonidamine significantly increases the activity of epirubicin in patients with advanced breast cancer: results from a multicenter prospective randomized trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:4

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Synergism; Epirubicin; Female; Humans; Indazoles; Middle Aged; Neoplasm Staging; Prospective Studies; Survival Analysis; Treatment Outcome

1996
Lonidamine plus epirubicin and cyclophosphamide in advanced breast cancer. A phase II study.
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Humans; Indazoles; Middle Aged

1996
Cisplatin and epirubicin plus oral lonidamine as first-line treatment for metastatic breast cancer: a phase II study of the Southern Italy Oncology Group (GOIM).
    Anti-cancer drugs, 1997, Volume: 8, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Drug Administration Schedule; Epirubicin; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis

1997
Cisplatin, epirubicin, and lonidamine combination regimen as first-line chemotherapy for metastatic breast cancer: a pilot study.
    Cancer chemotherapy and pharmacology, 1998, Volume: 41, Issue:4

    Topics: Administration, Oral; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Epirubicin; Female; Humans; Indazoles; Infusions, Intravenous; Middle Aged; Nausea; Pilot Projects; Thrombocytopenia; Treatment Outcome; Vomiting

1998
Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: results from a multicenter prospective randomized trial.
    Breast cancer research and treatment, 1998, Volume: 49, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Protocols; Doxorubicin; Drug Interactions; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis

1998
Weekly epirubicin plus lonidamine in advanced breast carcinoma.
    Breast cancer research and treatment, 1999, Volume: 56, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Drug Synergism; Epirubicin; Female; Humans; Indazoles; Injections, Intravenous; Liver Neoplasms; Middle Aged

1999
Lonidamine in high-risk breast cancer patients.
    Seminars in oncology, 1991, Volume: 18, Issue:2 Suppl 4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Humans; Indazoles; Middle Aged; Remission Induction; Vindesine

1991
Fluorouracil, doxorubicin, and cyclophosphamide versus fluorouracil, doxorubicin, and cyclophosphamide plus lonidamine for the treatment of advanced breast cancer: a multicentric randomized clinical study.
    Seminars in oncology, 1991, Volume: 18, Issue:2 Suppl 4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Indazoles; Middle Aged; Prospective Studies; Remission Induction; Time Factors

1991
Phase II study of lonidamine in patients with metastatic breast cancer. An Eastern Cooperative Oncology Group study.
    Investigational new drugs, 1990, Volume: 8, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Drugs, Investigational; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis

1990
Mitomycin-C, vinblastine, and lonidamine as salvage treatment of advanced breast cancer. A pilot study.
    American journal of clinical oncology, 1990, Volume: 13, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Indazoles; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Pilot Projects; Vinblastine

1990

Other Studies

25 other study(ies) available for lonidamine and Breast Cancer

ArticleYear
Carrier-free prodrug nanoparticles based on lonidamine and cisplatin for synergistic treatment of breast cancer.
    Journal of biomaterials applications, 2022, Volume: 37, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cisplatin; Female; Glutathione; Humans; Indazoles; Nanoparticles; Prodrugs

2022
Antitumor Effect of Lonidamine-Polypeptide-Peptide Nanoparticles in Breast Cancer Models.
    ACS applied materials & interfaces, 2019, Sep-11, Volume: 11, Issue:36

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Humans; Indazoles; Mice, Inbred BALB C; Mitochondria; Nanoparticles; Peptides; Xenograft Model Antitumor Assays

2019
Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression.
    Anais da Academia Brasileira de Ciencias, 2020, Volume: 92, Issue:4

    Topics: Apoptosis; Breast Neoplasms; Down-Regulation; Humans; Indazoles; Matrix Metalloproteinase 2; MCF-7 Cells; Quercetin; RNA, Messenger

2020
The 18-kDa translocator protein (TSPO) disrupts mammary epithelial morphogenesis and promotes breast cancer cell migration.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Acinar Cells; Apoptosis; Benzodiazepinones; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Size; Disease Progression; Humans; Indazoles; Isoquinolines; Ligands; Mammary Glands, Human; Neoplasm Invasiveness; Receptors, GABA

2013
Differential sensitivities to lactate transport inhibitors of breast cancer cell lines.
    Endocrine-related cancer, 2014, Volume: 21, Issue:1

    Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coumaric Acids; Female; Humans; Immunohistochemistry; Indazoles; Inhibitory Concentration 50; Monocarboxylic Acid Transporters; Quercetin; RNA, Small Interfering; Transfection

2014
Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin.
    NMR in biomedicine, 2015, Volume: 28, Issue:3

    Topics: Acids; Adenosine Triphosphate; Animals; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Synergism; Energy Metabolism; Female; Humans; Hydrogen-Ion Concentration; Indazoles; Intracellular Space; Magnetic Resonance Spectroscopy; Male; Mice, Nude; Monocarboxylic Acid Transporters; Ovarian Neoplasms; Prostatic Neoplasms; Symporters; Xenograft Model Antitumor Assays

2015
[Lonidamine induces apoptosis via endoplasmic reticulum stress response and down-regulating cIAP expression in human breast carcinoma MCF-7 cells].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2015, Volume: 35, Issue:6

    Topics: Apoptosis; Breast Neoplasms; Caspase 8; Cell Proliferation; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Indazoles; Inhibitor of Apoptosis Proteins; MCF-7 Cells; Ubiquitin-Protein Ligases; Up-Regulation

2015
Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells.
    Molecular pharmaceutics, 2011, Feb-07, Volume: 8, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Resistance, Multiple; ErbB Receptors; Female; Humans; Indazoles; Nanoparticles; Ovarian Neoplasms; Paclitaxel; Polymers

2011
Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer.
    Nanomedicine : nanotechnology, biology, and medicine, 2011, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chromatography, High Pressure Liquid; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Female; Indazoles; Mice; Mice, Nude; Nanoparticles; Nanotechnology; Paclitaxel

2011
Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study.
    Journal of microscopy, 1994, Volume: 176, Issue:Pt 3

    Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Fluorescence; Humans; Indazoles; Melanoma; Microscopy, Confocal; Tumor Cells, Cultured; Verapamil

1994
Modulation of antitumor alkylating agents by novobiocin, topotecan, and lonidamine.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:6

    Topics: Adenocarcinoma; Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Drug Synergism; Female; Fibrosarcoma; Humans; Indazoles; Male; Mice; Mice, Inbred C3H; Novobiocin; Topotecan; Tumor Cells, Cultured

1993
Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.
    The Journal of clinical investigation, 1996, Sep-01, Volume: 98, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carmustine; Cell Line; Doxorubicin; Drug Resistance; Female; Glioblastoma; Humans; Indazoles; Treatment Failure; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1996
Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells.
    Oncology research, 1996, Volume: 8, Issue:3

    Topics: Adenine Nucleotides; Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glucose; Hexokinase; Humans; Indazoles; Mitochondria; Tumor Cells, Cultured

1996
Comparison of action of the anti-neoplastic drug lonidamine on drug-sensitive and drug-resistant human breast cancer cells: 31P and 13C nuclear magnetic resonance studies.
    Breast cancer research and treatment, 1997, Volume: 43, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Carbon Isotopes; Deoxyglucose; Drug Resistance, Neoplasm; Female; Humans; Indazoles; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Tumor Cells, Cultured

1997
Saporin 6 and lonidamine in primary cell cultures from human breast carcinomas: a synergistic effect.
    Anti-cancer drug design, 1997, Volume: 12, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Cycle; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Immunotoxins; Indazoles; Middle Aged; N-Glycosyl Hydrolases; Phenotype; Plant Proteins; Receptors, Estrogen; Receptors, Progesterone; Ribosome Inactivating Proteins, Type 1; Saporins; Tumor Cells, Cultured

1997
Modulation by lonidamine on the combined activity of cisplatin and epidoxorubicin in human breast cancer cells.
    Breast cancer research and treatment, 1997, Volume: 42, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; Cell Division; Cisplatin; Drug Administration Schedule; Drug Synergism; Epirubicin; Humans; Indazoles; Tumor Cells, Cultured

1997
Noninvasive real-time monitoring of intracellular cancer cell metabolism and response to lonidamine treatment using diffusion weighted proton magnetic resonance spectroscopy.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Diffusion; Dose-Response Relationship, Drug; Humans; Indazoles; Ischemia; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Mice; Monitoring, Physiologic; Protons; Signal Processing, Computer-Assisted; Tumor Cells, Cultured

2000
In vitro potentiation by lonidamine of the cytotoxic effect of adriamycin on primary and established breast cancer cell lines.
    Breast cancer research and treatment, 1992, Volume: 24, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Indazoles; Lethal Dose 50; Male; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured

1992
Reversal of adriamycin resistance by lonidamine in a human breast cancer cell line.
    British journal of cancer, 1991, Volume: 64, Issue:3

    Topics: Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Drug Synergism; Female; Humans; Indazoles; Kinetics

1991
A phase II clinical and pharmacokinetic study of Lonidamine in patients with advanced breast cancer.
    British journal of cancer, 1991, Volume: 64, Issue:3

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Humans; Indazoles; Magnetic Resonance Spectroscopy; Menopause; Middle Aged; Neoplasm Metastasis; Receptors, Estrogen

1991
Lonidamine as a modulator of alkylating agent activity in vitro and in vivo.
    Cancer research, 1991, Feb-01, Volume: 51, Issue:3

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carboplatin; Carmustine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Fibrosarcoma; Humans; Indazoles; Mammary Neoplasms, Animal; Mice; Organoplatinum Compounds; Tumor Cells, Cultured; Tumor Stem Cell Assay

1991
The pharmacokinetics of oral lonidamine in breast and lung cancer patients.
    Seminars in oncology, 1991, Volume: 18, Issue:2 Suppl 4

    Topics: Absorption; Administration, Oral; Aged; Antineoplastic Agents; Breast Neoplasms; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Tolerance; Female; Fluorescence; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Tablets; Time Factors

1991
Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro.
    Cancer chemotherapy and pharmacology, 1989, Volume: 25, Issue:1

    Topics: Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Indazoles; Pyrazoles; Time Factors; Tumor Cells, Cultured

1989
Phase II study of lonidamine in metastatic breast cancer.
    British journal of cancer, 1989, Volume: 59, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis; Pyrazoles

1989
Phase II study of lonidamine in patients with metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Canada; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis; Pyrazoles; Receptors, Estrogen

1986