Compounds > lonafarnib
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lonafarnib and Carcinoma, Epidermoid

lonafarnib has been researched along with Carcinoma, Epidermoid in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (88.89)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Feng, L; Ginsberg, LE; Glisson, BS; Hanrahan, EO; Hong, WK; Khuri, FR; Kies, MS; Kim, ES; Tran, HT; Truong, MT1
Kang, JH; Kim, ES; Kyu Woo, J; Lee, HY; Lee, OH; Oh, SH1
Chun, KH; Hassan, K; Hong, WK; Khuri, F; Lee, HY; Lotan, R1
Jain, SR; Khuri, FR1
Chu, Z; Khuri, F; Mao, L; Ren, H; Tai, SK1
Han, JY; Hong, WK; Kim, E; Lee, HY; Morgillo, F; Myers, JN; Oh, SH1
Cohen, P; El-Naggar, AK; Hong, WK; Khuri, F; Kies, M; Kim, JH; Kim, WY; Lee, HY; Myers, JN; Oh, SH; Younes, MN1
Kong, M; Lee, JJ1
Jin, Q; Khuri, FR; Kim, ES; Lee, HY; Oh, SH1

Reviews

1 review(s) available for lonafarnib and Carcinoma, Epidermoid

ArticleYear
Novel agents and incremental advances in the treatment of head and neck cancer.
    Seminars in oncology, 2004, Volume: 31, Issue:2 Suppl 4

    Topics: Adenoviridae; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticarcinogenic Agents; Antineoplastic Agents; Carcinoma, Squamous Cell; Cetuximab; Clinical Trials as Topic; Combined Modality Therapy; ErbB Receptors; Genes, p53; Head and Neck Neoplasms; Humans; Piperidines; Pyridines; ras Proteins; Viral Vaccines

2004

Trials

1 trial(s) available for lonafarnib and Carcinoma, Epidermoid

ArticleYear
A phase II study of Lonafarnib (SCH66336) in patients with chemorefractory, advanced squamous cell carcinoma of the head and neck.
    American journal of clinical oncology, 2009, Volume: 32, Issue:3

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Drug Resistance, Neoplasm; Female; Head and Neck Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Piperidines; Prognosis; Pyridines; Survival Rate; Treatment Outcome

2009

Other Studies

7 other study(ies) available for lonafarnib and Carcinoma, Epidermoid

ArticleYear
A multiplicity of anti-invasive effects of farnesyl transferase inhibitor SCH66336 in human head and neck cancer.
    International journal of cancer, 2012, Aug-01, Volume: 131, Issue:3

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Farnesyltranstransferase; Female; Head and Neck Neoplasms; Humans; Insulin-Like Growth Factor Binding Protein 3; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Piperidines; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, IGF Type 1; RNA Interference; RNA, Small Interfering; Squamous Cell Carcinoma of Head and Neck; Urokinase-Type Plasminogen Activator

2012
Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells.
    Cancer research, 2003, Aug-15, Volume: 63, Issue:16

    Topics: Alkyl and Aryl Transferases; Apoptosis; bcl-X Protein; Carcinoma, Squamous Cell; Enzyme Inhibitors; Farnesyltranstransferase; Head and Neck Neoplasms; Humans; Piperidines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Tumor Cells, Cultured

2003
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
    Cancer research, 2005, Jul-01, Volume: 65, Issue:13

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Carcinoma, Squamous Cell; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Farnesyltranstransferase; Head and Neck Neoplasms; Humans; MAP Kinase Signaling System; Molecular Sequence Data; Neoplasm Proteins; Peptide Elongation Factor 2; Phosphorylation; Piperidines; Protein Synthesis Inhibitors; Pyridines

2005
Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer.
    Journal of the National Cancer Institute, 2005, Sep-07, Volume: 97, Issue:17

    Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Animals; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunoprecipitation; Lung Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Piperidines; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Ubiquitin; Up-Regulation; Vascular Endothelial Growth Factor A

2005
Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jan-15, Volume: 12, Issue:2

    Topics: Animals; Aorta; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Proliferation; Chickens; Chorioallantoic Membrane; Endothelium, Vascular; Enzyme Inhibitors; Farnesyltranstransferase; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Head and Neck Neoplasms; Humans; Insulin-Like Growth Factor Binding Protein 3; Mice; Mice, Nude; Neovascularization, Pathologic; Piperidines; Pyridines; rhoB GTP-Binding Protein; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A

2006
A generalized response surface model with varying relative potency for assessing drug interaction.
    Biometrics, 2006, Volume: 62, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biometry; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Synergism; Fenretinide; Humans; Models, Biological; Models, Statistical; Piperidines; Pyridines

2006
Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SCH66336 (lonafarnib) through Akt/mammalian target of rapamycin-mediated increases in survivin expression.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Mar-01, Volume: 14, Issue:5

    Topics: Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Cycle; Drug Resistance, Neoplasm; Head and Neck Neoplasms; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Survivin; TOR Serine-Threonine Kinases; Tumor Cells, Cultured

2008