lon-954 has been researched along with Seizures* in 1 studies
1 other study(ies) available for lon-954 and Seizures
Article | Year |
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Alpha 2-antagonistic effect of N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON-954).
The effect of N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON-954) on alpha 2-adrenoceptors was studied in in vivo and in vitro preparations. Like yohimbine, LON-954 antagonised the clonidine-induced inhibition of twitch responses in the Auerbach's plexus of guinea pig ileum and rat vas deferens preparations. It also reversed the anti-convulsant effect of clonidine on pentylenetetrazol (PTZ)-induced convulsions in the rat, a property shared by yohimbine. However LON-954 failed to prevent the hypothermic response to clonidine in mice. The dissimilarity in action of LON-954 and yohimbine on clonidine-induced hypothermia could be due to the fact that the anticlonidine effect of yohimbine on hypothermia is mediated through its antiserotonin action. The results indicate that LON-954 acts as an alpha 2-antagonist both centrally and peripherally. Topics: Adrenergic alpha-Antagonists; Animals; Body Temperature; Clonidine; Dopamine Antagonists; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Myenteric Plexus; Pentylenetetrazole; Rats; Seizures; Urea; Vas Deferens; Yohimbine | 1988 |