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lomustine and Neutropenia

lomustine has been researched along with Neutropenia in 16 studies

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
"Temozolomide is an alkylating agent with activity in the treatment of melanoma metastatic to the brain."9.12A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma. ( Bate, SC; Beirne, DA; Eisen, TG; Gibbens, IM; Gore, ME; Hughes, SA; Larkin, JM; Patel, PM; Thomas, K, 2007)
"A prospective phase II study of paclitaxel was performed in adult patients with recurrent hemispheric oligodendrogliomas."9.08Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas. ( Chamberlain, MC; Kormanik, PA, 1997)
"40 patients with symptomatic metastatic melanoma were treated with procarbazine, vincristine and lomustine (POC)."9.07Phase II trial of procarbazine, vincristine and lomustine (POC) chemotherapy in metastatic cutaneous malignant melanoma. ( Evans, BD; Harvey, VJ; Mak, D; Melville, P; Mitchell, PL; Samuel, LM; Thompson, PI, 1994)
"Multi-agent chemotherapy (vincristine, epirubicin and prednisolone) including either cyclophosphamide (CEOP) or lomustine (LEOP) was given as first-line chemotherapy to treatment-naïve canine lymphoma patients with measurable, high grade T-cell lymphoma (HGTCL)."7.91A Retrospective Study of Multi-agent Chemotherapy including either Cyclophosphamide or Lomustine as Initial Therapy for Canine High-grade T-cell Lymphoma (2011-2017). ( Baines, S; Elliott, J, 2019)
" All patients required dosage modification for toxicity."5.28Results of treatment of children with recurrent medulloblastoma/primitive neuroectodermal tumors with lomustine, cisplatin, and vincristine. ( Evans, AE; Lefkowitz, IB; Packer, RJ; Schut, L; Siegel, KR; Sutton, LN, 1990)
"Temozolomide is an alkylating agent with activity in the treatment of melanoma metastatic to the brain."5.12A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma. ( Bate, SC; Beirne, DA; Eisen, TG; Gibbens, IM; Gore, ME; Hughes, SA; Larkin, JM; Patel, PM; Thomas, K, 2007)
"A prospective phase II study of paclitaxel was performed in adult patients with recurrent hemispheric oligodendrogliomas."5.08Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas. ( Chamberlain, MC; Kormanik, PA, 1997)
"40 patients with symptomatic metastatic melanoma were treated with procarbazine, vincristine and lomustine (POC)."5.07Phase II trial of procarbazine, vincristine and lomustine (POC) chemotherapy in metastatic cutaneous malignant melanoma. ( Evans, BD; Harvey, VJ; Mak, D; Melville, P; Mitchell, PL; Samuel, LM; Thompson, PI, 1994)
"Multi-agent chemotherapy (vincristine, epirubicin and prednisolone) including either cyclophosphamide (CEOP) or lomustine (LEOP) was given as first-line chemotherapy to treatment-naïve canine lymphoma patients with measurable, high grade T-cell lymphoma (HGTCL)."3.91A Retrospective Study of Multi-agent Chemotherapy including either Cyclophosphamide or Lomustine as Initial Therapy for Canine High-grade T-cell Lymphoma (2011-2017). ( Baines, S; Elliott, J, 2019)
"Lomustine is a commercially available chloroethyl nitrosourea compound whose antitumor activity in vitro and in animal tumor models exceeds its activity in humans."2.67A phase I trial of weekly lomustine in patients with advanced cancer. ( Benjamin, RS; Gorski, CC; Koller, CA; Legha, SS; Papadopoulos, NE; Plager, C, 1994)
"Neutropenia was documented in 20 dogs (57%): 12 grade I to II, 8 grade III to IV."1.48Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas. ( Amores-Fuster, I; Blackwood, L; Finotello, R; Harper, A; Killick, DR; Maddox, TW; Mason, SL; Tanis, JB, 2018)
" All patients required dosage modification for toxicity."1.28Results of treatment of children with recurrent medulloblastoma/primitive neuroectodermal tumors with lomustine, cisplatin, and vincristine. ( Evans, AE; Lefkowitz, IB; Packer, RJ; Schut, L; Siegel, KR; Sutton, LN, 1990)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (37.50)18.2507
2000's5 (31.25)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tanis, JB1
Mason, SL1
Maddox, TW1
Blackwood, L1
Killick, DR1
Amores-Fuster, I1
Harper, A1
Finotello, R1
Elliott, J1
Baines, S1
Intile, JL2
Rassnick, KM2
Bailey, DB2
Al-Sarraf, R1
Chretin, JD1
Balkman, CE2
Flory, AB2
Kiselow, MA2
Wakshlag, JJ1
Russell, DS1
Malone, EK1
Barnard, SM1
Heading, KL1
Brockley, LK1
Bennett, PF1
Abrams-Ogg, AC1
Larkin, JM1
Hughes, SA1
Beirne, DA1
Patel, PM1
Gibbens, IM1
Bate, SC1
Thomas, K1
Eisen, TG1
Gore, ME1
Samuel, LM1
Harvey, VJ1
Mitchell, PL1
Thompson, PI1
Mak, D1
Melville, P1
Evans, BD1
Koller, CA1
Gorski, CC1
Benjamin, RS1
Legha, SS1
Papadopoulos, NE1
Plager, C1
Sweetenham, JW1
McKendrick, JJ1
Mead, GM1
Whitehouse, JM1
Chamberlain, MC1
Kormanik, PA1
Abele, M1
Leonhardt, M1
Dichgans, J1
Weller, M1
Parameswaran, R1
Giles, C1
Boots, M1
Littlewood, TJ1
Mills, MJ1
Kelsey, SM2
Samson, D1
Shamash, J1
Walewski, J1
Apostolidis, J1
Wilson, AM1
Foran, JM1
Gupta, RK1
Rohatiner, AZ1
Lister, TA1
Noël, G1
Mazeron, JJ1
Lefkowitz, IB1
Packer, RJ1
Siegel, KR1
Sutton, LN1
Schut, L1
Evans, AE1

Trials

6 trials available for lomustine and Neutropenia

ArticleYear
A phase II study to evaluate the toxicity and efficacy of alternating CCNU and high-dose vinblastine and prednisone (CVP) for treatment of dogs with high-grade, metastatic or nonresectable mast cell tumours.
    Veterinary and comparative oncology, 2010, Volume: 8, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agents,

2010
A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma.
    British journal of cancer, 2007, Jan-15, Volume: 96, Issue:1

    Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarb

2007
Phase II trial of procarbazine, vincristine and lomustine (POC) chemotherapy in metastatic cutaneous malignant melanoma.
    European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:14

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Lomustine; Male; Melano

1994
A phase I trial of weekly lomustine in patients with advanced cancer.
    Cancer, 1994, Jan-01, Volume: 73, Issue:1

    Topics: Administration, Oral; Adult; Aged; Capsules; Carcinoma, Renal Cell; Drug Administration Schedule; Dr

1994
Salvage chemotherapy with paclitaxel for recurrent oligodendrogliomas.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:12

    Topics: Adult; Alopecia; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols;

1997
Low-dose continuous chemotherapy (LBCMVD-56) for refractory and relapsing lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; De

2000

Other Studies

10 other studies available for lomustine and Neutropenia

ArticleYear
Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas.
    Veterinary and comparative oncology, 2018, Volume: 16, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Female; Lomustine; Lymp

2018
A Retrospective Study of Multi-agent Chemotherapy including either Cyclophosphamide or Lomustine as Initial Therapy for Canine High-grade T-cell Lymphoma (2011-2017).
    Australian veterinary journal, 2019, Volume: 97, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Horm

2019
Evaluation of dexamethasone as a chemoprotectant for CCNU-induced bone marrow suppression in dogs.
    Veterinary and comparative oncology, 2009, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Dexamethasone; Dog Diseases; Dogs; Dose-Res

2009
CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07).
    Australian veterinary journal, 2011, Volume: 89, Issue:4

    Topics: Anemia; Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Female; Gastrointestinal Dis

2011
The use of lithium carbonate to prevent lomustine-induced myelosuppression in dogs: a pilot study.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2011, Volume: 75, Issue:1

    Topics: Animals; Antidepressive Agents; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Dose-Response

2011
Prednisolone, cytosine arabinoside, lomustine (CCNU), etoposide and thioguanine (PACET) combination chemotherapy for relapsed or refractory non-Hodgkin lymphoma.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Female; Humans;

1993
CCNU overdose during PCV chemotherapy for anaplastic astrocytoma.
    Journal of neurology, 1998, Volume: 245, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neo

1998
CCNU (lomustine), idarubicin and dexamethasone (CIDEX): an effective oral regimen for the treatment of refractory or relapsed myeloma.
    British journal of haematology, 2000, Volume: 109, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Anti

2000
[Post-operative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of German prospective randomised trial HIT'91].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2001, Volume: 5, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant;

2001
Results of treatment of children with recurrent medulloblastoma/primitive neuroectodermal tumors with lomustine, cisplatin, and vincristine.
    Cancer, 1990, Feb-01, Volume: 65, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Child; Child, Pres

1990