lomustine has been researched along with Experimental Neoplasms in 85 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The in vivo response of B16 melanoma and Lewis lung carcinoma to combinations of hyperthermia and graded doses of CCNU or Melphalan was studied." | 3.66 | Response of two mouse tumours to hyperthermia with CCNU or melphalan. ( Joiner, MC; Steel, GG; Stephens, TC, 1982) |
| "Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin." | 3.66 | In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity. ( Fodstad, O; Olsnes, S; Pihl, A; Tveit, KM, 1980) |
| "Intracerebral murine glioma 26 was used as a model system for evaluating two-drug combinations of antitumor agents, BCNU was combined with either procarbazine, dianhydrogalactitol, or ellipticine." | 3.66 | Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens. ( Levin, VA; Wilson, CB, 1978) |
| "A number of chemotherapeutic agents, including L-asparaginase, actinomycin D, chloroethylcyclohexy-nitrosourea, 5-flourouracil, cyclophosphamide, hydroxyurea, cis-platinum, adriamycin and methotrexate, alone and in combination and at variable dose levels, were applied against the Dunning R3327 rat prostatic adenocarcinoma-subline G." | 3.66 | Further experience with chemotherapy in the Dunning prostatic adenocarcinoma. ( Block, NL; Camuzzi, F; Claflin, A; Politano, VA; Stover, B; Troner, M, 1978) |
| " The chemotherapeutic agent was administered simultaneously with the single sensitizer dose or 3 h into the chronic sensitizer dosing schedule." | 1.27 | Increased therapeutic benefit through the addition of misonidazole to a nitrosourea-radiation combination. ( Hill, SA; Siemann, DW, 1986) |
| " Dose-response relationships of 3 triple-drug combinations and their component agents were explored, allowing the relative contributions of single agents in each combination to be assessed." | 1.26 | Experimental combination and single-agent chemotherapy in human lung-tumour xenografts. ( Jones, JM; Peckham, MJ; Shorthouse, AJ; Steel, GG, 1982) |
| " Combination data were evaluated either by applying the simple concept that an additive combination response is equal to the sum of the single agent responses or by constructing additivity envelopes as described recently by Steel & Peckham (1979), in order to take account of non-linear dose-response curves." | 1.26 | Comparison of growth delay and cell survival as end-points of tumour response following treatment with combinations of cytotoxic agents. ( Peacock, JH; Stephens, TC, 1980) |
| "A dose-response relation for the cytotoxic activity of chloroethylnitrosourea cancer chemotherapeutic agents in cell culture has been developed." | 1.26 | Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture. ( Deen, DF; Weinkam, RJ, 1982) |
| "Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice." | 1.26 | Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours. ( Bibby, MC; Double, JA; Mughal, MA, 1981) |
| "HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series." | 1.26 | Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice. ( Smuckler, EA; Zackheim, HS, 1980) |
| "Experiments are described in which dose-response data have been obtained for EMT6 mouse tumour cells growing in vivo and exposed to various cytotoxic agents." | 1.26 | The sensitivity to cytotoxic agents of the EMT6 tumor in vivo. Comparative response of lung nodules in rapid expotential growth and of the solid flank tumour. ( Bleehen, NM; Twentyman, PR, 1976) |
| " The depression of platelets and white blood cells was mild after a single dosage of 40 mg/kg CCNU which recovered on about the 6th day." | 1.26 | Brain tumor chemotherapy using a rat glioma model. ( Mennel, HD; Tamura, M; Zülch, KJ, 1979) |
| "Pretreatment with phenytoin, sodium methylprednisolone succinate and dexamethasone had little or no effect." | 1.26 | The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma p ( Byrd, A; Finn, A; Levin, VA; Stearns, J; Weinkam, RJ, 1979) |
| " However, with certain dosage schedules such as every 2 hr for 5 injections daily on 2 consecutive days, i." | 1.26 | Chemotherapy of an experimental glioma with nitrosoureas. ( Day, A; Liberman, L; Ng, R; Tator, CH, 1977) |
| " The three drugs show similar threshold-type dose-response survival curves on asynchronous cells treated for 1 hr." | 1.26 | A comparison of the lethal effects of three nitrosourea derivatives on cultured human lymphoma cells. ( Drewinko, B; Gottlieb, JA; Loo, TL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 82 (96.47) | 18.7374 |
| 1990's | 3 (3.53) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farmer, PB | 1 |
| Foster, AB | 2 |
| Jarman, M | 2 |
| Oddy, MR | 1 |
| Reed, DJ | 1 |
| Montgomery, JA | 2 |
| McCaleb, GS | 1 |
| Johnston, TP | 1 |
| Mayo, JG | 1 |
| Laster, WR | 2 |
| Coe, PL | 1 |
| Sleigh, J | 1 |
| Tatlow, JC | 1 |
| Moldenhauer, H | 1 |
| Rose, H | 1 |
| Saul, G | 1 |
| Wolf, G | 1 |
| Kehrberg, G | 1 |
| Shorthouse, AJ | 1 |
| Jones, JM | 1 |
| Steel, GG | 3 |
| Peckham, MJ | 1 |
| Hill, SA | 2 |
| Siemann, DW | 5 |
| Horsman, MR | 1 |
| Hirst, DG | 3 |
| Brown, DM | 1 |
| Brown, JM | 3 |
| Mulcahy, RT | 3 |
| Wustrow, DJ | 1 |
| Kende, AS | 1 |
| Hazlehurst, JL | 2 |
| Muller, PJ | 3 |
| Tator, CH | 5 |
| Bloom, ML | 1 |
| Lee, FY | 1 |
| Workman, P | 2 |
| Stephens, TC | 3 |
| Peacock, JH | 2 |
| Joiner, MC | 1 |
| Weinkam, RJ | 2 |
| Deen, DF | 2 |
| Bello, JL | 1 |
| Kariev, NI | 1 |
| Mainardi, JV | 1 |
| Betancourt, M | 1 |
| Lage, A | 1 |
| Barroso, MC | 1 |
| Alfonso, L | 1 |
| Ilsen, HW | 1 |
| Petrovici, IN | 1 |
| Mennel, HD | 2 |
| Zülch, KJ | 2 |
| Szymas, J | 1 |
| Gibson, NW | 1 |
| Hickman, JA | 1 |
| Tveit, KM | 1 |
| Fodstad, O | 3 |
| Olsnes, S | 1 |
| Pihl, A | 3 |
| Klein, AS | 1 |
| Shoham, J | 1 |
| Williams, PD | 1 |
| Kantor, P | 1 |
| Murphy, GP | 3 |
| Bibby, MC | 1 |
| Double, JA | 1 |
| Mughal, MA | 1 |
| Eisenbrand, G | 1 |
| Habs, M | 1 |
| Bloom, M | 1 |
| Aass, N | 2 |
| Thuning, CA | 1 |
| Bakir, NA | 1 |
| Warren, J | 1 |
| Zackheim, HS | 1 |
| Smuckler, EA | 1 |
| Castronovo, FP | 1 |
| Potsaid, MS | 1 |
| Kopiwoda, S | 1 |
| Laurent, G | 2 |
| Dewerie-Vanhouche, J | 1 |
| Machin, D | 1 |
| Hildebrand, J | 2 |
| Radu, L | 1 |
| Preoteasa, V | 1 |
| Lenghel, Z | 1 |
| Baer, JC | 1 |
| Freeman, AA | 1 |
| Newlands, ES | 1 |
| Watson, AJ | 1 |
| Rafferty, JA | 1 |
| Margison, GP | 1 |
| Twentyman, PR | 5 |
| Bleehen, NM | 3 |
| Sufrin, G | 1 |
| Barranco, SC | 1 |
| Haenelt, BR | 1 |
| Gee, EL | 1 |
| Osieka, R | 1 |
| Houchens, DP | 1 |
| Goldin, A | 1 |
| Johnson, RK | 1 |
| Bono, VH | 1 |
| Mulder, JH | 2 |
| Smink, T | 1 |
| Van Putten, LM | 1 |
| Hrushesky, WJ | 1 |
| Marcus, SG | 1 |
| Hasegawa, H | 1 |
| Shapiro, WR | 1 |
| Posner, JB | 1 |
| Corbett, TH | 1 |
| Griswold, DP | 1 |
| Wolpert, MK | 1 |
| Venditti, JM | 1 |
| Schabel, FM | 3 |
| Tamura, M | 1 |
| Rose, WC | 1 |
| Veras, GH | 1 |
| Williams, ME | 1 |
| Wheeler, KT | 2 |
| Bateman, AE | 1 |
| Gutin, PH | 2 |
| Hilton, J | 3 |
| Walker, MD | 4 |
| Maker, HS | 2 |
| Syed, HH | 2 |
| Lehrer, GM | 2 |
| Edelstein, MB | 1 |
| Lelieveld, P | 1 |
| van Putten, IM | 1 |
| Waldbaur, H | 1 |
| Kuschnir, H | 1 |
| Engelmann, U | 1 |
| Schmidt, H | 1 |
| Schmack, B | 1 |
| Levin, VA | 2 |
| Wilson, CB | 1 |
| Block, NL | 1 |
| Camuzzi, F | 1 |
| Stover, B | 1 |
| Claflin, A | 1 |
| Troner, M | 1 |
| Politano, VA | 1 |
| Stearns, J | 1 |
| Byrd, A | 1 |
| Finn, A | 1 |
| Ommaya, AK | 1 |
| Day, A | 1 |
| Ng, R | 1 |
| Liberman, L | 1 |
| Fein, VJ | 1 |
| Allan, AE | 1 |
| Rottman, A | 1 |
| Atassi, G | 1 |
| Young, RC | 1 |
| Wasserman, TH | 1 |
| Slavik, M | 1 |
| Carter, SK | 1 |
| Rubens, RD | 1 |
| Vaughan-Smith, S | 1 |
| Dulbecco, R | 1 |
| Drewinko, B | 1 |
| Loo, TL | 1 |
| Gottlieb, JA | 1 |
| Wong, KH | 1 |
| Wallen, CA | 1 |
| Tanneberger, S | 1 |
| Keng, PC | 1 |
| Beljanski, M | 1 |
| Beljanski, MS | 1 |
| Lijinsky, W | 1 |
| Kovatch, RM | 1 |
| Singer, SS | 1 |
| Morgan, JE | 1 |
| Talbot, K | 1 |
| Wright, KA | 1 |
| Donaldson, J | 1 |
| Kwok, TT | 1 |
| Honess, DJ | 1 |
| Connors, TA | 1 |
| Hare, JR | 1 |
7 reviews available for lomustine and Experimental Neoplasms
| Article | Year |
|---|---|
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophospha | 1984 |
Potentiation of chemotherapy by hypoxic cell radiation sensitizers--a review.
Topics: Anaerobiosis; Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Synergism; Lomustin | 1982 |
Review of mechanism of action studies of the nitrosoureas.
Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Division; Cell Survival | 1976 |
Current status of the therapy of advanced renal carcinoma.
Topics: Adenocarcinoma; Androgens; Animals; Antineoplastic Agents; Drug Therapy, Combination; Female; Humans | 1977 |
Immunotherapy of gliomas: a review.
Topics: Adult; Animals; Azaguanine; BCG Vaccine; Brain; Brain Neoplasms; Child; Disease Models, Animal; Glio | 1976 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, | 1976 |
Clinical comparison of the nitrosoureas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carmustine; Chemical Phenomena; C | 1975 |
78 other studies available for lomustine and Experimental Neoplasms
| Article | Year |
|---|---|
Synthesis, metabolism, and antitumor activity of deuterated analogues of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Deuterium; In Vitro Techniques | 1978 |
Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma.
Topics: Animals; Carcinoma; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimen | 1977 |
Fluorinated analogues of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea: an attempt to control metabolism.
Topics: Animals; Antineoplastic Agents; Female; Leukemia L1210; Lomustine; Lymphoma; Mice; Neoplasms, Experi | 1980 |
Experimental combination and single-agent chemotherapy in human lung-tumour xenografts.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carc | 1982 |
Chemopotentiation in vivo: no loss of sensitization with fractionation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationshi | 1984 |
Modification of alkylating agent cytotoxicity by cisplatin.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cisplatin | 1984 |
Preliminary evaluation of isocyanate-generating nitroheterocycles as chemosensitizers, radiosensitizers and hypoxic cell cytotoxic agents.
Topics: Animals; Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relat | 1984 |
Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combinati | 1983 |
Use of phenobarbital and high doses of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the treatment of brain tumor-bearing mice.
Topics: Animals; Brain Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Female | 1983 |
Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.
Topics: Animals; Blood Proteins; Cell Line; Chromatography, High Pressure Liquid; Dose-Response Relationship | 1983 |
Comparison of growth delay and cell survival as end-points of tumour response following treatment with combinations of cytotoxic agents.
Topics: Animals; Cell Survival; Clone Cells; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therap | 1980 |
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Female; Fetal Death; Humans; Lomustine; Male; M | 1981 |
Response of two mouse tumours to hyperthermia with CCNU or melphalan.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hot Temperature; Lomustin | 1982 |
Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell culture.
Topics: Animals; Biotransformation; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Dose-Respon | 1982 |
Experimental approach for the search of effective drug combination in cancer chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Leukemi | 1982 |
[The effects of combined chemotherapy (adriamycin/VM/26/CCNU) in brian tumours in adults and animal experiments (author's transl)].
Topics: Adult; Aged; Animals; Brain Neoplasms; Doxorubicin; Drug Therapy, Combination; Ethylnitrosourea; Fem | 1982 |
The role of isocyanates in the toxicity of antitumour haloalkylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyanates; Female; Leukemia L1210; Lomustine; Lymphoma; M | 1982 |
Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; | 1982 |
In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity.
Topics: Abrin; Animals; Antineoplastic Agents; Dacarbazine; Humans; Lomustine; Melanoma; Mice; Mice, Nude; N | 1980 |
Effect of the thymic factor, thymostimulin (TP-1), on the survival rate of tumor-bearing mice.
Topics: Animals; Immunotherapy; Lomustine; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Thymus Extra | 1981 |
Evaluation of vincristine, CCNU and methyl-CCNU at high level doses in an experimental murine renal adenocarcinoma model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Kidney Neoplasms; Lomustine; Male; Mice; Neoplasm Tr | 1981 |
Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
Topics: Adenocarcinoma; Animals; Cell Survival; Drug Therapy, Combination; Female; Fluorouracil; Lethal Dose | 1981 |
Chronic toxicity and carcinogenicity of cytostatic N-nitroso-(2-chloroethyl) ureas after repeated intravenous application to rats.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carmustine; Lomustine; Lung Neoplasms; Male; Neoplasms, | 1980 |
The effect of phenobarbital on the toxicity and tumoricidal activity of CCNU in a murine brain tumor model.
Topics: Animals; Brain Neoplasms; Drug Therapy, Combination; Ependymoma; Female; Lomustine; Mice; Mice, Inbr | 1980 |
Response to chemotherapy of human, malignant melanoma xenografts in athymic, nude mice.
Topics: Abrin; Animals; Antineoplastic Agents; Dacarbazine; Humans; Lomustine; Melanoma; Mice; Mice, Nude; N | 1980 |
Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma.
Topics: Animals; Brain Neoplasms; Ependymoma; Female; Hot Temperature; Lomustine; Mice; Neoplasm Transplanta | 1980 |
Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carmustine; Lomustine; Mechlorethamine; Mice; Neopla | 1980 |
An inverse relationship between the growth rate of human melanoma xenografts and their response to some cytostatic drugs.
Topics: Animals; Dacarbazine; Humans; Lomustine; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neopl | 1980 |
Formulation and biological distribution of radiolabeled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in an animal tumor model.
Topics: Animals; Astrocytoma; Injections, Intravenous; Lomustine; Neoplasm Transplantation; Neoplasms, Exper | 1980 |
Inhibition of RNA synthesis in murine ependymoblastoma by the combination of amphotericin B and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Topics: Amphotericin B; Animals; Biological Transport; Drug Synergism; Ependymoma; Lomustine; Mice; Neoplasm | 1980 |
The combined action of thiotepa and lomustine cytostatics, of estradiol hormone and of vitamins E and A on Walker tumor chromatin structure.
Topics: Animals; Antineoplastic Agents; Chromatin; DNA, Neoplasm; Estradiol; Ethidium; Lomustine; Neoplasms, | 1993 |
Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.
Topics: Antineoplastic Agents; Dacarbazine; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Human | 1993 |
The sensitivity to cytotoxic agents of the EMT6 tumor in vivo. Comparative response of lung nodules in rapid expotential growth and of the solid flank tumour.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cell Line; Cell Survival; Cyclophosphamide; D | 1976 |
Comparative chemosensitivity of exponential- versus plateau-phase cells in both in vitro model systems.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cell Division; Cell Survival; Cells, Cultured | 1976 |
Pharmacokinetic studies of a transplantable murine renal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Bleomycin; Carmustine; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Eval | 1977 |
Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyta | 1978 |
Chemotherapy of human colon cancer xenografts in athymic nude mice.
Topics: Acridines; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Carcinoma | 1977 |
Schedule dependent effectiveness of CCNU and 5-fluorouracil in experimental chemotherapy.
Topics: Animals; Cell Survival; Drug Therapy, Combination; Fluorouracil; Hematopoietic Stem Cells; Lomustine | 1977 |
Amphotericin B and CCNU.
Topics: Amphotericin B; Animals; Blood-Brain Barrier; Lomustine; Mice; Neoplasms, Experimental | 1979 |
Chemotherapy of experimental metastatic brain tumors in female Wistar rats.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cul | 1979 |
Design and evaluation of combination chemotherapy trials in experimental animal tumor systems.
Topics: Animals; Antineoplastic Agents; Carmustine; Cisplatin; Colonic Neoplasms; Drug Evaluation, Preclinic | 1979 |
Brain tumor chemotherapy using a rat glioma model.
Topics: Animals; Bone Marrow; Brain Neoplasms; Cell Nucleus; Disease Models, Animal; Dose-Response Relations | 1979 |
Evaluation of whole-body hyperthermia as an adjunct to chemotherapy in murine tumors.
Topics: Animals; Antineoplastic Agents; Body Temperature; Cyclophosphamide; Dactinomycin; Doxorubicin; Femal | 1979 |
Comparison of the CCNU and BCNU modification of the in vitro radiation response in 9L brain tumor cells of rats.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Dr | 1979 |
The proliferative state of clonogenic cells in the Lewis lung tumour after treatment with cytotoxic agents.
Topics: Animals; Cell Cycle; Cell Division; Cell Survival; Clone Cells; Culture Techniques; Cyclophosphamide | 1978 |
Experimental brain tumor chemotherapy: DNA damage in the rat gliosarcoma 9L treated with CCNU.
Topics: Animals; Brain Neoplasms; DNA, Neoplasm; DNA, Single-Stranded; Drug Evaluation, Preclinical; Glioma; | 1977 |
Effect of phospholipids on maintenance of the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in aqueous suspension.
Topics: Cell Survival; Cells, Cultured; Glioma; Lomustine; Neoplasms, Experimental; Nitrosourea Compounds; P | 1978 |
Synergism and schedule dependent cytotoxicity of cyclophosphamide and CCNU in experimental cancer chemotherapy.
Topics: Animals; Cell Survival; Cyclophosphamide; Drug Administration Schedule; Drug Synergism; Drug Therapy | 1978 |
The effect of amphotericin B on the survival of brain-tumor-bearing mice treated with CCNU.
Topics: Amphotericin B; Animals; Brain Neoplasms; Drug Synergism; Female; Lomustine; Mice; Neoplasm Transpla | 1978 |
Experiments on the chemotheraphy of a transplantable glioblastoma in the rat, employing 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).
Topics: Animals; Brain Neoplasms; Glioma; Lomustine; Male; Methylnitrosourea; Neoplasm Transplantation; Neop | 1978 |
The contemporary role of chemotherapy in the treatment of malignant brain tumor.
Topics: Adrenal Cortex Hormones; Animals; Brain Neoplasms; Carmustine; Dose-Response Relationship, Drug; Dru | 1978 |
Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens.
Topics: Animals; Carmustine; Dianhydrogalactitol; Drug Therapy, Combination; Ellipticines; Glioma; Lomustine | 1978 |
Further experience with chemotherapy in the Dunning prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Dactinomycin; Doxoru | 1978 |
The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma p
Topics: Alkylating Agents; Animals; Biotransformation; Brain Neoplasms; Carmustine; Dexamethasone; Drug Inte | 1979 |
Chemotherapy of an experimental glioma with nitrosoureas.
Topics: Animals; Brain Neoplasms; Drug Administration Schedule; Ependymoma; Female; Glioma; Injections; Inje | 1977 |
Intraneoplastic injection of CCNU for experimental brain tumor chemotherapy.
Topics: Animals; Brain Neoplasms; Drug Evaluation, Preclinical; Ependymoma; Female; Lomustine; Mice; Neoplas | 1977 |
DNA damage in the intracerebral rat gliosarcoma 9L treated with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Topics: Animals; Brain Neoplasms; Centrifugation, Density Gradient; DNA Repair; DNA, Neoplasm; DNA, Single-S | 1977 |
Environmental factors in glial tumor response to 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea: effect of cell confluence.
Topics: Cell Cycle; Cell Survival; Cells, Cultured; DNA, Neoplasm; Glioma; Lomustine; Neoplasms, Experimenta | 1977 |
Tumour volume response, initial cell kill and cellular repopulation in B16 melanoma treated with cyclophosphamide and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Topics: Animals; Cell Survival; Cyclophosphamide; Female; Lomustine; Male; Melanoma; Mice; Mice, Inbred C57B | 1977 |
Chemistry and structure-activity studies of the nitrosoureas.
Topics: Adenocarcinoma; Animals; Leukemia L1210; Lomustine; Lung Neoplasms; Mice; Neoplasms, Experimental; N | 1976 |
Nitrosourea pharmacodynamics in relation to the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Glioma; Humans; Lomustine; Mice; Molecula | 1976 |
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma.
Topics: Amphotericin B; Animals; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synerg | 1976 |
Kinetic aids to proper chemotherapeutic scheduling: labeled nucleoside incorporation studies in vivo.
Topics: Animals; Bone Marrow; Cell Survival; Cyclophosphamide; DNA, Neoplasm; Drug Administration Schedule; | 1976 |
Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Carmustine; Cell Division; Cell Line; Cell | 1975 |
Augmentation of cytotoxic drug action and X-irradiation by antibodies.
Topics: Antibodies, Neoplasm; Antineoplastic Agents; Cell Division; Cell Line; Cell Membrane; Chlorambucil; | 1975 |
A comparison of the lethal effects of three nitrosourea derivatives on cultured human lymphoma cells.
Topics: Amphotericin B; Carmustine; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, D | 1976 |
Chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9L tumor model: pharmacokinetic and structure-activity considerations.
Topics: Animals; Carmustine; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Neoplasm Transplant | 1990 |
[Possibilities and perspectives of adjuvant chemotherapy in malignant tumors].
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Drug Evaluation; Drug Screening As | 1989 |
Responses of tumor cell subpopulations to single modality and combined modality therapies.
Topics: Animals; Antineoplastic Agents; Cell Survival; Combined Modality Therapy; Cyclophosphamide; Lomustin | 1988 |
Three alkaloids as selective destroyers of cancer cells in mice. Synergy with classic anticancer drugs.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Daunorubicin; Drug Synergism; Fl | 1986 |
Cross-link formation and chemopotentiation of EMT-6/Ro cells exposed to MISO after CCNU treatment in vitro.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Drug Synergism; In Vitro Techniques; Lomus | 1986 |
Carcinogenesis in F-344 rats induced by nitrosohydroxyalkyl-chloroethylureas.
Topics: Animals; Carmustine; Ethylnitrosourea; Female; Lomustine; Magnetic Resonance Spectroscopy; Male; Neo | 1986 |
CB 1954 revisited. II. Toxicity and antitumour activity.
Topics: Animals; Aziridines; Azirines; Colonic Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug | 1986 |
Sensitization of cancer chemotherapeutic agents by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Survival; Drug Synergism; | 1986 |
Increased therapeutic benefit through the addition of misonidazole to a nitrosourea-radiation combination.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Combined Modality Therapy; Dose | 1986 |
The response to cytotoxic drugs of EMT6 cells treated either as intact or disaggregated spheroids.
Topics: Animals; Antineoplastic Agents; Cell Aggregation; Cell Line; Cell Survival; Dose-Response Relationsh | 1985 |
Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; Chlorambucil; Cisplatin; Combined Modality | 1985 |
The binding of 14C labelled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) to macromolecules of sensitive and resistant tumours.
Topics: Animals; Binding Sites; Cell Line; DNA, Neoplasm; Female; Lomustine; Lymphoma; Mice; Neoplasm Protei | 1974 |