lomustine has been researched along with Ependymoma in 21 studies
Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-one patients with recurrent malignant central nervous system gliomas were treated with a combination of 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine." | 7.67 | Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. ( Edwards, MS; Fulton, D; Levin, V; Prados, M; Rodriguez, LA; Silver, P, 1988) |
| "The aim of this study was to examine the range of sensitivity of a panel of short-term cultures derived from different types of malignant childhood brain tumours including medulloblastoma, ependymoma and glioblastoma multiforme to three cytotoxic drugs, lomustine (CCNU), vincristine (VCR) and procarbazine (PCB)." | 3.70 | Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine. ( Darling, JL; Harding, B; Harkness, W; Hayward, R; Lewandowicz, GM; Thomas, DG, 2000) |
| "Twenty-one patients with recurrent malignant central nervous system gliomas were treated with a combination of 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine." | 3.67 | Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. ( Edwards, MS; Fulton, D; Levin, V; Prados, M; Rodriguez, LA; Silver, P, 1988) |
| "Forty ependymomas were grade I and 13 were grades II to IV (in five patients there was insufficient material for grading)." | 1.28 | Postoperative radiotherapy in the management of spinal cord ependymoma. ( Ashley, SE; Bell, BA; Bessell, EM; Bloom, HJ; Brada, M; Whitaker, SJ, 1991) |
| " However, with certain dosage schedules such as every 2 hr for 5 injections daily on 2 consecutive days, i." | 1.26 | Chemotherapy of an experimental glioma with nitrosoureas. ( Day, A; Liberman, L; Ng, R; Tator, CH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (71.43) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gramatzki, D | 1 |
| Roth, P | 1 |
| Felsberg, J | 1 |
| Hofer, S | 1 |
| Rushing, EJ | 1 |
| Hentschel, B | 1 |
| Westphal, M | 1 |
| Krex, D | 1 |
| Simon, M | 1 |
| Schnell, O | 1 |
| Wick, W | 1 |
| Reifenberger, G | 1 |
| Weller, M | 1 |
| Vos, MJ | 1 |
| Uitdehaag, BM | 1 |
| Barkhof, F | 1 |
| Heimans, JJ | 1 |
| Baayen, HC | 1 |
| Boogerd, W | 1 |
| Castelijns, JA | 1 |
| Elkhuizen, PH | 1 |
| Postma, TJ | 1 |
| Jellinger, K | 1 |
| Volc, D | 1 |
| Grisold, W | 1 |
| Podreka, I | 1 |
| Böck, F | 1 |
| Schuster, H | 1 |
| Alth, G | 1 |
| Kogelnik, HD | 1 |
| Muller, PJ | 1 |
| Tator, CH | 3 |
| Bloom, M | 1 |
| Thuning, CA | 1 |
| Bakir, NA | 1 |
| Warren, J | 1 |
| Laurent, G | 2 |
| Dewerie-Vanhouche, J | 1 |
| Machin, D | 1 |
| Hildebrand, J | 2 |
| Evans, AE | 1 |
| Anderson, JR | 1 |
| Lefkowitz-Boudreaux, IB | 1 |
| Finlay, JL | 1 |
| Lewandowicz, GM | 1 |
| Harding, B | 1 |
| Harkness, W | 1 |
| Hayward, R | 1 |
| Thomas, DG | 1 |
| Darling, JL | 1 |
| Ertel, IJ | 1 |
| Boesel, C | 1 |
| Paoletti, P | 2 |
| Baldini, M | 1 |
| Knerich, R | 1 |
| Princi, L | 1 |
| Fumagalli, R | 1 |
| Weiss, JF | 1 |
| Pezzotta, S | 1 |
| Bloom, HJ | 2 |
| Neidhardt, MK | 1 |
| Day, A | 1 |
| Ng, R | 1 |
| Liberman, L | 1 |
| Terheggen, HG | 1 |
| Atassi, G | 1 |
| Boratyński, W | 1 |
| Whitaker, SJ | 1 |
| Bessell, EM | 1 |
| Ashley, SE | 1 |
| Bell, BA | 1 |
| Brada, M | 1 |
| Levin, VA | 1 |
| Rodriguez, LA | 1 |
| Prados, M | 1 |
| Fulton, D | 1 |
| Edwards, MS | 1 |
| Silver, P | 1 |
| Levin, V | 1 |
1 review available for lomustine and Ependymoma
| Article | Year |
|---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
1 trial available for lomustine and Ependymoma
| Article | Year |
|---|---|
Adjuvant chemotherapy of childhood posterior fossa ependymoma: cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: a Childrens Cancer Group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; | 1996 |
19 other studies available for lomustine and Ependymoma
| Article | Year |
|---|---|
Chemotherapy for intracranial ependymoma in adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dis | 2016 |
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat | 2003 |
Multimodality treatment of malignant gliomas. Comparison of several adjuvant approaches.
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Drug Therapy, Combination; Ependymoma; Glioblastoma; | 1981 |
The effect of phenobarbital on the toxicity and tumoricidal activity of CCNU in a murine brain tumor model.
Topics: Animals; Brain Neoplasms; Drug Therapy, Combination; Ependymoma; Female; Lomustine; Mice; Mice, Inbr | 1980 |
Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma.
Topics: Animals; Brain Neoplasms; Ependymoma; Female; Hot Temperature; Lomustine; Mice; Neoplasm Transplanta | 1980 |
Inhibition of RNA synthesis in murine ependymoblastoma by the combination of amphotericin B and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Topics: Amphotericin B; Animals; Biological Transport; Drug Synergism; Ependymoma; Lomustine; Mice; Neoplasm | 1980 |
Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Child; Dose-Response Relationship, Drug; | 2000 |
Brain tumors in children.
Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Diagnosis, Differential; Ependymoma; Female; | 1978 |
Treatment of primitive malignant tumors of the central nervous system. Clinical evaluation of 91 cases.
Topics: Astrocytoma; Brain Neoplasms; Carmustine; Ependymoma; Glioma; Humans; Lomustine; Oligodendroglioma | 1979 |
Desmosterol: a biochemical marker of glioma growth.
Topics: Astrocytoma; Brain Neoplasms; Carmustine; Cholesterol; Chromatography, Gas; Desmosterol; Diagnosis, | 1977 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 44-1978.
Topics: Astrocytoma; Carcinoma, Squamous Cell; Ependymoma; Female; Glioma; Hemangioma, Cavernous; Humans; Li | 1978 |
[Interim results of the SIOP study (author's transl)].
Topics: Adolescent; Brain Neoplasms; Child; Ependymoma; Humans; Lomustine; Medulloblastoma; Methods; Vincris | 1978 |
Chemotherapy of an experimental glioma with nitrosoureas.
Topics: Animals; Brain Neoplasms; Drug Administration Schedule; Ependymoma; Female; Glioma; Injections; Inje | 1977 |
Intraneoplastic injection of CCNU for experimental brain tumor chemotherapy.
Topics: Animals; Brain Neoplasms; Drug Evaluation, Preclinical; Ependymoma; Female; Lomustine; Mice; Neoplas | 1977 |
[Therapy of medulloblastoma and ependymoma in childhood].
Topics: Age Factors; Brain Neoplasms; Child; Child, Preschool; Ependymoma; Humans; Infant; Lomustine; Medull | 1977 |
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma.
Topics: Amphotericin B; Animals; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synerg | 1976 |
[Results of combined treatment of neoplasms of the posterior cranial fossa in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cerebellar Neoplasms; Child | 1992 |
Postoperative radiotherapy in the management of spinal cord ependymoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Co | 1991 |
Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Brain Stem; Chil | 1988 |