lomustine has been researched along with EHS Tumor in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recently it has been shown that less toxic analogues of RSU 1069 can be produced by the introduction of alkyl substituents to moderate the reactivity of the aziridine function." | 1.28 | The chemosensitizing and cytotoxic effects of RSU 1164 and RSU 1165 in a murine tumor model. ( Siemann, DW, 1989) |
| "Misonidazole (MISO) has been shown to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in a number of different animal tumor systems." | 1.27 | Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO. ( Hill, SA; Keng, PC; Siemann, DW, 1984) |
| "Phenobarbital pretreatment reduced both the antitumor efficacy and toxicity of CCNU (factor of approximately 0." | 1.27 | Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine. ( Siemann, DW, 1983) |
| "Misonidazole has been demonstrated to enhance the cytotoxicity of several common antineoplastic drugs in vitro and in vivo, and its mechanism of action as a chemosensitizer, though still unknown, is thought to be dependent upon hypoxia." | 1.27 | Chemosensitization by misonidazole in CCNU-treated spheroids and tumours. ( Chaplin, DJ; Durand, RE, 1987) |
| "For melphalan, neither pretreatment agent produced any change in tumor response." | 1.26 | Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU. ( Twentyman, P; Workman, P, 1982) |
| " Sensitizer dose-response curves were obtained for MISO, METRO and two of the most effective agents, benznidazole (Ro 07-1051) and Ro 07-1902." | 1.26 | Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU. ( Twentyman, PR; Workman, P, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (88.89) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Twentyman, PR | 5 |
| Siemann, DW | 16 |
| Hill, SA | 5 |
| Keng, PC | 3 |
| Bauer, KD | 1 |
| Lee, FY | 1 |
| Workman, P | 6 |
| Morrissey, S | 1 |
| Wolf, K | 2 |
| Reeve, JG | 1 |
| Wright, KA | 2 |
| Mulcahy, RT | 2 |
| Bello, JL | 1 |
| Kariev, NI | 1 |
| Mainardi, JV | 1 |
| Betancourt, M | 1 |
| Lage, A | 1 |
| Barroso, MC | 1 |
| Alfonso, L | 1 |
| Twentyman, P | 1 |
| Sutherland, RM | 1 |
| Allalunis-Turner, MJ | 1 |
| Gipp, JJ | 1 |
| Tanner, MA | 1 |
| Durand, RE | 1 |
| Chaplin, DJ | 1 |
| Alliet, KL | 1 |
| Morgan, JE | 1 |
| Talbot, K | 1 |
| Donaldson, J | 1 |
| Maddison, K | 1 |
27 other studies available for lomustine and EHS Tumor
| Article | Year |
|---|---|
Modification by WR 2721 of the response to chemotherapy of tumours and normal tissues in the mouse.
Topics: Amifostine; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cyclophosphamide; Female; Leuko | 1983 |
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte | 1982 |
Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO.
Topics: Animals; Cell Cycle; Cell Separation; Cell Survival; Drug Synergism; Drug Therapy, Combination; Flow | 1984 |
The effect in the KHT sarcoma of CCNU and MISO on cell cycle progression evaluated by flow-cytometry.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomus | 1984 |
Enhanced tumor responses through therapies combining CCNU, MISO and radiation.
Topics: Animals; Combined Modality Therapy; Drug Synergism; Drug Therapy, Combination; Female; Lomustine; Mi | 1984 |
Chemopotentiation in vivo: no loss of sensitization with fractionation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationshi | 1984 |
Misonidazole and CCNU: further evidence for a pharmacokinetic mechanism of chemosensitization and therapeutic gain.
Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; I | 1984 |
In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Mice, Inbred C3H; Misoni | 1983 |
Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine.
Topics: Animals; Female; Lomustine; Mice; Mice, Inbred C3H; Nitrosourea Compounds; Phenobarbital; Proadifen; | 1983 |
Response to X-radiation and cytotoxic drugs of clonal subpopulations of different ploidy and metastatic potential isolated from RIF-1 mouse sarcoma.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Clone Cells; Dose-Response Relationship, D | 1983 |
Chemosensitization by lipophilic nitroimidazoles.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leuk | 1983 |
In vivo chemosensitization by misonidazole in sensitive and resistant tumor lines.
Topics: Animals; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Humans; Leukemia L1210; Lomustine; | 1983 |
Experimental approach for the search of effective drug combination in cancer chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Leukemi | 1982 |
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug | 1982 |
Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; | 1982 |
In vivo combination of misonidazole and the chemotherapeutic agent CCNU.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Lomusti | 1981 |
Chemosensitization of CCNU in KHT murine tumor cells in vivo and in vitro by the agent RB 6145 and its isomer PD 144872.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Nitroimid | 1995 |
Potentiation of alkylating chemotherapy by dual function nitrofurans in multi-cell spheroids and solid tumors.
Topics: Animals; Antineoplastic Agents; Aziridines; Bone Marrow; Carcinoma; Cell Survival; Dose-Response Rel | 1992 |
Enhancement of chemotherapy and nitroimidazole-induced chemopotentiation by the vasoactive agent hydralazine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cyclophosphamide; Drug Synerg | 1990 |
The chemosensitizing and cytotoxic effects of RSU 1164 and RSU 1165 in a murine tumor model.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Synergism; Lomustine; Mice; Misonidazole; Oxygen | 1989 |
Potentiation of combination chemotherapy by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Synergism; Female; L | 1988 |
Enhancement of misonidazole chemopotentiation by mild hyperthermia (41 degrees C) in vitro and selective enhancement in vivo.
Topics: Aerobiosis; Animals; Cell Line; Combined Modality Therapy; Drug Synergism; Female; Hot Temperature; | 1987 |
Chemosensitization by misonidazole in CCNU-treated spheroids and tumours.
Topics: Animals; Cell Line; Cell Separation; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationsh | 1987 |
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069.
Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1986 |
Combinations of CCNU, MISO, and fractionated radiotherapy.
Topics: Animals; Combined Modality Therapy; Lomustine; Mice; Misonidazole; Radiation-Sensitizing Agents; Rad | 1986 |
CB 1954 revisited. II. Toxicity and antitumour activity.
Topics: Animals; Aziridines; Azirines; Colonic Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug | 1986 |
In vivo interaction between radiation and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the absence or presence of misonidazole in mice.
Topics: Animals; Combined Modality Therapy; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroim | 1985 |