lomustine has been researched along with Disease Models, Animal in 14 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lomustine is a treatment option for patients with high-grade glioma." | 5.43 | Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. ( Gruber, HE; Huang, TT; Ibañez, CE; Jolly, DJ; Lopez Espinoza, F; Mendoza, D; Robbins, JM; Yagiz, K, 2016) |
| " First- and second-line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNU) lomustine, nimustine, fotemustine, and carmustine." | 3.83 | Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs. ( Berte, N; Borgmann, K; Kaina, B; Nikolova, T; Piecha, N; Piée-Staffa, A; Wang, M, 2016) |
| " Using immunocompetent orthotopic glioma mouse models, we identified strong anti-glioma activity of L19TNF in combination with the alkylating agent CCNU, which cured the majority of tumor-bearing mice, whereas monotherapies only had limited efficacy." | 1.91 | Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma. ( Amit, I; Becher, B; Bühler, M; De Luca, R; Di Nitto, C; Hemmerle, T; Katzenelenbogen, Y; Kirschenbaum, D; Look, T; Neri, D; Puca, E; Ravazza, D; Rindlisbacher, L; Roth, P; Stucchi, R; Weiner, A; Weiss, T; Weller, M, 2023) |
| "Lomustine is a treatment option for patients with high-grade glioma." | 1.43 | Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. ( Gruber, HE; Huang, TT; Ibañez, CE; Jolly, DJ; Lopez Espinoza, F; Mendoza, D; Robbins, JM; Yagiz, K, 2016) |
| "Procarbazine was ineffective." | 1.28 | The chemotherapeutic response of a murine (VM) model of human glioma. ( Bradford, R; Darling, JL; Thomas, DG, 1990) |
| " The depression of platelets and white blood cells was mild after a single dosage of 40 mg/kg CCNU which recovered on about the 6th day." | 1.26 | Brain tumor chemotherapy using a rat glioma model. ( Mennel, HD; Tamura, M; Zülch, KJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Look, T | 1 |
| Puca, E | 1 |
| Bühler, M | 1 |
| Kirschenbaum, D | 1 |
| De Luca, R | 1 |
| Stucchi, R | 1 |
| Ravazza, D | 1 |
| Di Nitto, C | 1 |
| Roth, P | 1 |
| Katzenelenbogen, Y | 1 |
| Weiner, A | 1 |
| Rindlisbacher, L | 1 |
| Becher, B | 1 |
| Amit, I | 1 |
| Weller, M | 1 |
| Neri, D | 1 |
| Hemmerle, T | 1 |
| Weiss, T | 1 |
| Yagiz, K | 1 |
| Huang, TT | 1 |
| Lopez Espinoza, F | 1 |
| Mendoza, D | 1 |
| Ibañez, CE | 1 |
| Gruber, HE | 1 |
| Jolly, DJ | 1 |
| Robbins, JM | 1 |
| Berte, N | 1 |
| Piée-Staffa, A | 1 |
| Piecha, N | 1 |
| Wang, M | 1 |
| Borgmann, K | 1 |
| Kaina, B | 1 |
| Nikolova, T | 1 |
| Amarasingh, S | 1 |
| Macleod, MR | 1 |
| Whittle, IR | 1 |
| Yang, SH | 1 |
| Hong, YK | 1 |
| Jeun, SS | 1 |
| Kim, IS | 1 |
| Hong, JT | 1 |
| Sung, JH | 1 |
| Son, BC | 1 |
| Lee, SW | 1 |
| Kim, MC | 1 |
| Lee, KS | 1 |
| Aguila, B | 1 |
| Coulbault, L | 1 |
| Boulouard, M | 1 |
| Léveillé, F | 1 |
| Davis, A | 1 |
| Tóth, G | 1 |
| Borsodi, A | 1 |
| Balboni, G | 1 |
| Salvadori, S | 1 |
| Jauzac, P | 1 |
| Allouche, S | 1 |
| Castronovo, FP | 1 |
| Potsaid, MS | 1 |
| Kopiwoda, SY | 1 |
| Hasegawa, H | 1 |
| Shapiro, WR | 1 |
| Posner, JB | 1 |
| Tamura, M | 1 |
| Mennel, HD | 1 |
| Zülch, KJ | 1 |
| Ommaya, AK | 1 |
| Bradford, R | 2 |
| Darling, JL | 2 |
| Sier, N | 1 |
| Thomas, DG | 2 |
| Soloway, MS | 1 |
| deKernion, JB | 1 |
| Rose, D | 1 |
| Persky, L | 1 |
2 reviews available for lomustine and Disease Models, Animal
| Article | Year |
|---|---|
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Disease Models, Animal; Drug Evaluation; Gli | 2009 |
Immunotherapy of gliomas: a review.
Topics: Adult; Animals; Azaguanine; BCG Vaccine; Brain; Brain Neoplasms; Child; Disease Models, Animal; Glio | 1976 |
12 other studies available for lomustine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma.
Topics: Animals; Disease Models, Animal; Glioblastoma; Lomustine; Mice; Neoplasm Recurrence, Local; T-Lympho | 2023 |
Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cytosine Deaminase; Diseas | 2016 |
Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Survival; Chromosome A | 2016 |
Assessment of cetuximab efficacy by bioluminescence monitoring of intracranial glioblastoma xenograft in mouse.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopl | 2009 |
In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance.
Topics: Animals; Antidepressive Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bind | 2007 |
Biodistribution of 14C-lomustine in an animal tumor model.
Topics: Animals; Antineoplastic Agents; Carbon Radioisotopes; Disease Models, Animal; Kidney; Lomustine; Neo | 1980 |
Chemotherapy of experimental metastatic brain tumors in female Wistar rats.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cul | 1979 |
Brain tumor chemotherapy using a rat glioma model.
Topics: Animals; Bone Marrow; Brain Neoplasms; Cell Nucleus; Disease Models, Animal; Dose-Response Relations | 1979 |
The VM model of glioma: preparation of multicellular tumour spheroids (MTS) and their response to chemotherapy.
Topics: Animals; Carmustine; Cell Division; Disease Models, Animal; Drug Screening Assays, Antitumor; Glioma | 1990 |
The chemotherapeutic response of a murine (VM) model of human glioma.
Topics: Animals; Astrocytoma; Brain Neoplasms; Carmustine; Disease Models, Animal; Lomustine; Mice; Mice, In | 1990 |
Effect of chemotherapeutic agents on bladder cancer: a new animal model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Cyclophosphamide; Dactinomycin; Diamin | 1973 |