lomustine has been researched along with Diffuse Mixed Small and Large Cell Lymphoma in 34 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To improve survival of elderly patients with primary central nervous system lymphoma (PCNSL), we conducted a phase II study with high-dose methotrexate (MTX) combined with procarbazine and CCNU." | 2.74 | High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: results of a prospective pilot and phase II study. ( Deckert, M; Feuerhake, F; Finke, J; Ihorst, G; Illerhaus, G; Marks, R; Müller, F; Ostertag, C, 2009) |
| "A decreased incidence of interstitial pneumonitis as well as a possible benefit in efficacy has been reported with lomustine (CCNU) compared to BCNU in the standard dose setting." | 2.70 | Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease. ( Blume, KG; Chao, NS; Horning, SJ; Johnston, LJ; Long, GD; Negrin, RS; Shizuru, JA; Stockerl-Goldstein, KE; Stuart, MJ; Wong, RM, 2001) |
| "Neutropenia was documented in 20 dogs (57%): 12 grade I to II, 8 grade III to IV." | 1.48 | Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas. ( Amores-Fuster, I; Blackwood, L; Finotello, R; Harper, A; Killick, DR; Maddox, TW; Mason, SL; Tanis, JB, 2018) |
| "Ninety-two patients with Hodgkin lymphoma and 47 with non-Hodgkin lymphoma were enrolled." | 1.43 | LACE versus BEAM conditioning in relapsed and refractory lymphoma transplant: retrospective multicenter analysis of toxicity and efficacy. ( Gore, A; Gupta, A; Jain, R; Jeevangi, N; Kannan, S; Khattry, N; Nair, R; Saikia, T; Thippeswamy, R, 2016) |
| "SHR mice with intracranial transplanted lymphosarcoma LIO-1 received a single intraperitoneal gemcitabine injection in maximal tolerated dose of 25 mg/kg or single maximal tolerated oral dose of lomustine, 50 mg/kg." | 1.38 | [Combined effect of gemcitabine and lomustine in mice with intracranial transplanted lymphosarcoma LIO-1]. ( Filatova, LV; Gershanovich, ML; Latinova, DKh; Semiglazova, TIu; Stukov, AN; Tarasenkova, AA; Vershinina, SF; Zargarova, NI, 2012) |
| " Data were analysed using noncompartmental pharmacokinetic methods." | 1.29 | Pharmacokinetics of high-dose oral CCNU in bone marrow transplant patients. ( Blaschke, TF; Chao, NJ; Kastrissios, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.71) | 18.7374 |
| 1990's | 14 (41.18) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 6 (17.65) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Russler-Germain, DA | 1 |
| Watkins, MP | 1 |
| Bartlett, NL | 1 |
| Tanis, JB | 1 |
| Mason, SL | 1 |
| Maddox, TW | 1 |
| Blackwood, L | 1 |
| Killick, DR | 1 |
| Amores-Fuster, I | 1 |
| Harper, A | 1 |
| Finotello, R | 1 |
| Khattry, N | 1 |
| Gupta, A | 1 |
| Jain, R | 1 |
| Gore, A | 1 |
| Thippeswamy, R | 1 |
| Jeevangi, N | 1 |
| Kannan, S | 1 |
| Nair, R | 1 |
| Saikia, T | 1 |
| Illerhaus, G | 2 |
| Marks, R | 1 |
| Müller, F | 1 |
| Ihorst, G | 2 |
| Feuerhake, F | 1 |
| Deckert, M | 1 |
| Ostertag, C | 1 |
| Finke, J | 2 |
| Mwanda, WO | 1 |
| Orem, J | 1 |
| Fu, P | 1 |
| Banura, C | 1 |
| Kakembo, J | 1 |
| Onyango, CA | 1 |
| Ness, A | 1 |
| Reynolds, S | 1 |
| Johnson, JL | 1 |
| Subbiah, V | 1 |
| Bako, J | 1 |
| Wabinga, H | 1 |
| Abdallah, FK | 1 |
| Meyerson, HJ | 1 |
| Whalen, CC | 1 |
| Lederman, MM | 1 |
| Black, J | 1 |
| Ayers, LW | 1 |
| Katongole-Mbidde, E | 1 |
| Remick, SC | 2 |
| Fritsch, K | 1 |
| Kasenda, B | 1 |
| Hader, C | 1 |
| Nikkhah, G | 1 |
| Prinz, M | 1 |
| Haug, V | 1 |
| Haug, S | 1 |
| Stukov, AN | 2 |
| Tarasenkova, AA | 2 |
| Gershanovich, ML | 3 |
| Filatova, LV | 2 |
| Semiglazova, TIu | 2 |
| Latipova, DKh | 1 |
| Vershinina, SF | 2 |
| Latinova, DKh | 1 |
| Zargarova, NI | 1 |
| Hallack Neto, AE | 1 |
| Borges dos Santos, K | 1 |
| Atalla, A | 1 |
| Stewart, AJ | 1 |
| Southcott, BM | 1 |
| Musolino, A | 1 |
| Perrone, MA | 1 |
| Michiara, M | 1 |
| Delnevo, D | 1 |
| Franciosi, V | 1 |
| Di Blasio, B | 1 |
| Ceci, G | 1 |
| Camisa, R | 1 |
| Ardizzoni, A | 1 |
| Cocconi, G | 1 |
| Alexandrescu, DT | 1 |
| Karri, S | 1 |
| Wiernik, PH | 1 |
| Dutcher, JP | 1 |
| Rusk, A | 1 |
| Cozzi, E | 1 |
| Stebbins, M | 1 |
| Vail, D | 1 |
| Graham, J | 1 |
| Valli, V | 1 |
| Henkin, J | 1 |
| Sharpee, R | 1 |
| Khanna, C | 1 |
| Lishner, M | 1 |
| Slingerland, J | 1 |
| Theresa, C | 1 |
| Sutcliffe, SB | 1 |
| Sardaş, S | 1 |
| Erdoğan, F | 1 |
| Sardaş, OS | 1 |
| Cengel, M | 1 |
| Karakaya, AE | 1 |
| Da, WM | 1 |
| Zhong, JT | 1 |
| Liu, Y | 1 |
| Huang, YS | 1 |
| Bai, H | 1 |
| Wu, XX | 1 |
| Ou, YX | 1 |
| Wang, CB | 1 |
| Xu, SF | 1 |
| McSharry, JJ | 1 |
| Wolf, BC | 1 |
| Blanchard, CG | 1 |
| Eastman, AY | 1 |
| Wagner, H | 1 |
| Portuese, E | 1 |
| Wighton, T | 1 |
| Powell, D | 1 |
| Pearce, T | 1 |
| Sweetenham, JW | 1 |
| McKendrick, JJ | 1 |
| Mead, GM | 1 |
| Whitehouse, JM | 1 |
| Dorigo, A | 1 |
| Mansberg, R | 1 |
| Kwan, YL | 1 |
| Kastrissios, H | 1 |
| Chao, NJ | 1 |
| Blaschke, TF | 1 |
| Palmieri, G | 1 |
| Morabito, A | 1 |
| Rea, A | 1 |
| Biondi, E | 1 |
| Lauria, R | 1 |
| Matano, E | 1 |
| Pagliarulo, C | 1 |
| Montesarchio, V | 1 |
| Tagliaferri, P | 1 |
| Bianco, AR | 1 |
| Akimov, MA | 1 |
| Shamash, J | 1 |
| Walewski, J | 1 |
| Apostolidis, J | 1 |
| Wilson, AM | 1 |
| Foran, JM | 1 |
| Gupta, RK | 1 |
| Rohatiner, AZ | 1 |
| Kelsey, SM | 1 |
| Lister, TA | 1 |
| Stuart, MJ | 1 |
| Chao, NS | 1 |
| Horning, SJ | 1 |
| Wong, RM | 1 |
| Negrin, RS | 1 |
| Johnston, LJ | 1 |
| Shizuru, JA | 1 |
| Long, GD | 1 |
| Blume, KG | 1 |
| Stockerl-Goldstein, KE | 1 |
| Nissen, NI | 2 |
| Pajak, T | 1 |
| Glidewell, O | 2 |
| Blom, H | 1 |
| Flaherty, M | 1 |
| Hayes, D | 1 |
| McIntyre, R | 1 |
| Holland, JF | 2 |
| Maurice, P | 1 |
| Jacquillat, C | 1 |
| Silver, RT | 1 |
| Carey, R | 1 |
| Pas, AT | 1 |
| Cornell, CJ | 1 |
| Burningham, RA | 1 |
| Chamberlain, MC | 2 |
| Levin, VA | 2 |
| Fouillard, L | 1 |
| Gorin, NC | 1 |
| Laporte, JP | 1 |
| Douay, L | 1 |
| Lopez, M | 1 |
| Isnard, F | 1 |
| Jouet, JP | 1 |
| Walter, MP | 1 |
| Morel, P | 1 |
| Fenaux, P | 1 |
| Jackson, DV | 1 |
| Craig, JB | 1 |
| Spurr, CL | 1 |
| White, DR | 1 |
| Muss, HB | 1 |
| Cruz, JM | 1 |
| Richards, F | 1 |
| Powell, BL | 1 |
| Ruit, JB | 1 |
| Löwenberg, B | 1 |
| Hagenbeek, A | 1 |
| Verhoef, GE | 1 |
| Wielenga, JJ | 1 |
| Michiels, J | 1 |
| Sizoo, W | 1 |
| Domingo Albós, A | 1 |
| Callís, M | 1 |
| Juliá, A | 1 |
| Vilá, J | 1 |
| Zuazu, J | 1 |
| Puig, J | 1 |
| Petit, J | 1 |
| Fernández-Sevilla, A | 1 |
| Kindzel'skiĭ, LP | 1 |
| Gubareva, AA | 1 |
| Haioun, C | 1 |
| Kuentz, M | 1 |
| Jouault, H | 1 |
| Gaulard, P | 1 |
| Divine, M | 1 |
| Farcet, JP | 1 |
| Reyes, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Patients Over 65 Years With Primary CNS Lymphoma: High-dose Methotrexate Combined With Chemo-immunotherapy Followed by Maintenance Therapy[NCT00989352] | Phase 2 | 56 participants (Anticipated) | Interventional | 2009-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lomustine and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
Overview of four clinical studies of chemotherapy for stage III and IV non-Hodgkin's lymphomas by the Cancer and Leukemia Group B.
Topics: Adult; Bleomycin; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Drug The | 1977 |
9 trials available for lomustine and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: results of a prospective pilot and phase II study.
Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Comb | 2009 |
Immunochemotherapy with rituximab, methotrexate, procarbazine, and lomustine for primary CNS lymphoma (PCNSL) in the elderly.
Topics: Age Factors; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combine | 2011 |
Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Progressio | 2006 |
Tailored therapy for aggressive non-Hodgkin's lymphoma: results of a phase II study with a long-term follow-up.
Topics: Adolescent; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogen | 1998 |
Low-dose continuous chemotherapy (LBCMVD-56) for refractory and relapsing lymphoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; De | 2000 |
Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Pro | 2001 |
Overview of four clinical studies of chemotherapy for stage III and IV non-Hodgkin's lymphomas by the Cancer and Leukemia Group B.
Topics: Adult; Bleomycin; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Drug The | 1977 |
Comparison of methyl-CCNU and CCNU in patients with advanced forms of Hodgkin's disease, lymphosarcoma nad reticulum cell sarcoma.
Topics: Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leukopenia; Lomustine; Lymphoma, Non-Hodg | 1978 |
Vincristine infusion with CHOP-CCNU in diffuse large-cell lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cyclophospham | 1990 |
25 other studies available for lomustine and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
A forgotten friend: CCNU as palliative monotherapy in relapsed Hodgkin lymphoma.
Topics: Friends; Hodgkin Disease; Humans; Lomustine; Lymphoma, Non-Hodgkin; Palliative Care | 2021 |
Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Female; Lomustine; Lymp | 2018 |
LACE versus BEAM conditioning in relapsed and refractory lymphoma transplant: retrospective multicenter analysis of toxicity and efficacy.
Topics: Adolescent; Adult; Autografts; Carmustine; Child; Child, Preschool; Cohort Studies; Cyclophosphamide | 2016 |
Dose-modified oral chemotherapy in the treatment of AIDS-related non-Hodgkin's lymphoma in East Africa.
Topics: Administration, Oral; Adolescent; Adult; Africa South of the Sahara; Antineoplastic Combined Chemoth | 2009 |
[Investigation of gemcitabine plus lomustine treatment in mice with transplantable lymphosarcoma LIO-1].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined | 2011 |
[Combined effect of gemcitabine and lomustine in mice with intracranial transplanted lymphosarcoma LIO-1].
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; A | 2012 |
Modified BEAM conditioning regimen in patients with Hodgkin and non-Hodgkin lymphomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Hematopoietic Stem Cell Trans | 2012 |
Coeliac disease following high-dose chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Celiac Disease; Cisplatin; Cyclophosphami | 2002 |
Lomustine (chloroethylnitrosourea [CCNU]), ifosfamide, bleomycin, vincristine, and cisplatin (CIBO-P) is an effective regimen for patients with poor prognostic refractory or multiple disease recurrent aggressive non-Hodgkin lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic A | 2005 |
Mitoxantrone, vinblastine and CCNU: long-term follow-up of patients treated for advanced and poor-prognosis Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Female; Follow-Up Studies; Humans; Lomustine; Lympho | 2006 |
The response of diffuse large cell and other intermediate grade non-Hodgkin's lymphomas to adriamycin containing combination chemotherapy.
Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosp | 1994 |
Sister chromatid exchange studies for monitoring DNA damage in lymphocytes of malignant lymphoma patients under cytostatic therapy.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosph | 1994 |
Prolonged disease-free survival after ablative chemoradiotherapy and autologous bone marrow transplantation in adult malignant lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Marrow | 1993 |
Novel oral combination chemotherapy in the treatment of intermediate-grade and high-grade AIDS-related non-Hodgkin's lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Etoposide; Female; Flow Cyt | 1993 |
Prednisolone, cytosine arabinoside, lomustine (CCNU), etoposide and thioguanine (PACET) combination chemotherapy for relapsed or refractory non-Hodgkin lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Female; Humans; | 1993 |
Lomustine, etoposide, methotrexate and prednisone (LEMP) therapy for relapsed and refractory non-Hodgkin's lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Humans; Lomustine; L | 1993 |
Pharmacokinetics of high-dose oral CCNU in bone marrow transplant patients.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Biotransformation; Bone Marrow Transplantation; | 1996 |
[Evaluation of the CCNU-COP regimen for primary refractory and recurrent non-Hodgkin's lymphoma].
Topics: Adult; Aged; Anemia; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protoco | 1999 |
Primary central nervous system lymphoma: a role for adjuvant chemotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neop | 1992 |
Feasibility of autologous bone marrow transplantation for early consolidation of follicular non-Hodgkin's lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cyclophosphamide | 1991 |
Adjuvant chemotherapy for primary lymphoma of the central nervous system.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Dise | 1990 |
Phase II study of lomustine, cytarabine, mitoxantrone, and prednisone (CAMP) combination chemotherapy for doxorubicin-resistant intermediate- and high-grade malignant non-Hodgkin's lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytarabine; Doxorubicin; | 1990 |
[Vindesine, CCNU, high-dosage ara-C, and prednisolone (VINAP regimen) in the treatment of relapsing or refractory non-Hodgkin's lymphomas].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Evaluation; Drug | 1989 |
[Indirect endolymphatic chemotherapy of patients with lymphoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Hodgkin Disease; Humans; Injection | 1989 |
Failure of combination chemotherapy of advanced follicular (low-grade) non-Hodgkin's lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Adm | 1987 |