Page last updated: 2024-10-30

lomustine and Canine Diseases

lomustine has been researched along with Canine Diseases in 55 studies

Research Excerpts

ExcerptRelevanceReference
"To investigate if triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro."8.31Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro. ( Fuchs, D; Morandi, L; Nytko, KJ; Rohrer Bley, C; Tonon, C; Weyland, MS, 2023)
"Lomustine, vincristine, procarbazine and prednisolone (LOPP) chemotherapy has been suggested to be an effective treatment for dogs with naïve non-indolent T-cell lymphoma (TCL)."8.12Prognostic indicators for naïve canine non-indolent T-cell lymphoma treated with combination lomustine, vincristine, procarbazine and prednisolone chemotherapy. ( Blaxill, J; Buzzacott, P; Finlay, J, 2022)
" The objective of the present study was to investigate if a shorter protocol combined with an oral lomustine maintenance treatment (3 × in 8 weeks) would present an acceptable result, both for B- and T-cell lymphomas, and for the different types of lymphomas normally encountered in private veterinary practice."8.12Efficacy and tolerability of a 12-week combination chemotherapy followed by lomustine consolidation treatment in canine B- and T-cell lymphoma. ( Eberle, N; Limmer, S; Nerschbach, V; Simon Betz, D; Teske, E, 2022)
"Multi-agent chemotherapy (vincristine, epirubicin and prednisolone) including either cyclophosphamide (CEOP) or lomustine (LEOP) was given as first-line chemotherapy to treatment-naïve canine lymphoma patients with measurable, high grade T-cell lymphoma (HGTCL)."7.91A Retrospective Study of Multi-agent Chemotherapy including either Cyclophosphamide or Lomustine as Initial Therapy for Canine High-grade T-cell Lymphoma (2011-2017). ( Baines, S; Elliott, J, 2019)
"The aims of this study were to report treatment outcomes for dogs with histiocytic sarcoma (HS) treated with both lomustine and epirubicin, and to report response rates to epirubicin as a rescue therapy in dogs previously treated with lomustine."7.88Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. ( Blackwood, L; Finotello, R; Mason, SL, 2018)
"To describe a chemotherapy protocol combining lomustine and doxorubicin in canine histiocytic sarcoma, including outcomes and toxicity."7.81Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma. ( Borgatti, A; Cannon, C; Henson, M; Husbands, B, 2015)
"To compare oral administration of lomustine and prednisolone with oral administration of prednisolone alone as treatment for granulomatous meningoencephalomyelitis (GME) or necrotizing encephalitis (NE) in dogs."7.77Comparison of oral administration of lomustine and prednisolone or prednisolone alone as treatment for granulomatous meningoencephalomyelitis or necrotizing encephalitis in dogs. ( Boettcher, IC; Doherr, MG; Flegel, T; Henke, D; Matiasek, K; Oechtering, G; Oevermann, A, 2011)
"The University of Florida LOPP protocol may be an acceptable alternative to the mechlorethamine, vincristine, procarbazine, and prednisone protocol as a rescue protocol for dogs with lymphoma."7.77Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009). ( Barabas, K; Clemente, M; Fahey, CE; Kow, K; Lurie, D; Lyles, S; Milner, RJ; Parfitt, S, 2011)
"To assess response rate, median duration of response, adverse effects, and prognostic factors associated with concurrent administration of lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma."7.74Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005). ( Bannink, EO; Kaneene, JB; Mullins, MN; Obradovich, JE; Sauerbrey, ML; Van Dorp, TE, 2007)
"Intracranial gliomas are a common malignancy in dogs, and are associated with a poor prognosis due to their aggressive nature and a lack of clinically effective treatments."5.48Survival times in dogs with presumptive intracranial gliomas treated with oral lomustine: A comparative retrospective study (2008-2017). ( Cohen, PW; Dewey, CW; Moirano, SJ; Wright, KZ, 2018)
"Lomustine is a well-accepted, first-line chemotherapy for dogs with HS, but its specific utility in dogs with HPHS has not been previously reported."5.48Lomustine chemotherapy for the treatment of presumptive haemophagocytic histiocytic sarcoma in Flat-coated Retrievers. ( Elliott, J, 2018)
"To investigate if triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro."4.31Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro. ( Fuchs, D; Morandi, L; Nytko, KJ; Rohrer Bley, C; Tonon, C; Weyland, MS, 2023)
"Lomustine, vincristine, procarbazine and prednisolone (LOPP) chemotherapy has been suggested to be an effective treatment for dogs with naïve non-indolent T-cell lymphoma (TCL)."4.12Prognostic indicators for naïve canine non-indolent T-cell lymphoma treated with combination lomustine, vincristine, procarbazine and prednisolone chemotherapy. ( Blaxill, J; Buzzacott, P; Finlay, J, 2022)
" The objective of the present study was to investigate if a shorter protocol combined with an oral lomustine maintenance treatment (3 × in 8 weeks) would present an acceptable result, both for B- and T-cell lymphomas, and for the different types of lymphomas normally encountered in private veterinary practice."4.12Efficacy and tolerability of a 12-week combination chemotherapy followed by lomustine consolidation treatment in canine B- and T-cell lymphoma. ( Eberle, N; Limmer, S; Nerschbach, V; Simon Betz, D; Teske, E, 2022)
"Multi-agent chemotherapy (vincristine, epirubicin and prednisolone) including either cyclophosphamide (CEOP) or lomustine (LEOP) was given as first-line chemotherapy to treatment-naïve canine lymphoma patients with measurable, high grade T-cell lymphoma (HGTCL)."3.91A Retrospective Study of Multi-agent Chemotherapy including either Cyclophosphamide or Lomustine as Initial Therapy for Canine High-grade T-cell Lymphoma (2011-2017). ( Baines, S; Elliott, J, 2019)
"The aim of this study was to describe the use of a lomustine (CCNU), vincristine, procarbazine and prednisolone (LOPP) protocol used for treatment of chemotherapy naive T-cell lymphoma patients and to describe the response rate, toxicity and disease-free interval compared historically to CHOP chemotherapy."3.88LOPP chemotherapy as a first-line treatment for dogs with T-cell lymphoma. ( Brown, PM; Langova, V; Nguyen, S; Tzannes, S; White, J, 2018)
"The aims of this study were to report treatment outcomes for dogs with histiocytic sarcoma (HS) treated with both lomustine and epirubicin, and to report response rates to epirubicin as a rescue therapy in dogs previously treated with lomustine."3.88Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. ( Blackwood, L; Finotello, R; Mason, SL, 2018)
"To describe a chemotherapy protocol combining lomustine and doxorubicin in canine histiocytic sarcoma, including outcomes and toxicity."3.81Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma. ( Borgatti, A; Cannon, C; Henson, M; Husbands, B, 2015)
"To compare oral administration of lomustine and prednisolone with oral administration of prednisolone alone as treatment for granulomatous meningoencephalomyelitis (GME) or necrotizing encephalitis (NE) in dogs."3.77Comparison of oral administration of lomustine and prednisolone or prednisolone alone as treatment for granulomatous meningoencephalomyelitis or necrotizing encephalitis in dogs. ( Boettcher, IC; Doherr, MG; Flegel, T; Henke, D; Matiasek, K; Oechtering, G; Oevermann, A, 2011)
"The University of Florida LOPP protocol may be an acceptable alternative to the mechlorethamine, vincristine, procarbazine, and prednisone protocol as a rescue protocol for dogs with lymphoma."3.77Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009). ( Barabas, K; Clemente, M; Fahey, CE; Kow, K; Lurie, D; Lyles, S; Milner, RJ; Parfitt, S, 2011)
"To assess response rate, median duration of response, adverse effects, and prognostic factors associated with concurrent administration of lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma."3.74Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005). ( Bannink, EO; Kaneene, JB; Mullins, MN; Obradovich, JE; Sauerbrey, ML; Van Dorp, TE, 2007)
"While maintaining a standard toceranib dosage [2."2.82Safety evaluation of combination CCNU and continuous toceranib phosphate (Palladia(®) ) in tumour-bearing dogs: a phase I dose-finding study. ( Kurzman, ID; Pan, X; Tsimbas, K; Vail, DM, 2016)
"Several anticancer drugs have been added to the therapeutic armamentarium in recent years."2.42New chemotherapy agents in veterinary medicine. ( Kitchell, BE; Moore, AS, 2003)
"Prednisone was continued at the same dose."1.91Metastatic Cutaneous Langerhans Cell Histiocytosis in a Flat-Coated Retriever Treated with Doxorubicin and Prednisone. ( Aubry, O; Montesanto, C; Phillips, B, 2023)
"Primary pulmonary histiocytic sarcoma (PHS) is a rare form of dendritic cell or macrophage neoplasia originating within the pulmonary parenchyma."1.72Outcome in dogs with curative-intent treatment of localized primary pulmonary histiocytic sarcoma. ( Al-Nadaf, S; Clifford, C; Cook, MR; De Mello Souza, CH; Herrera, CL; Husbands, B; Krick, E; Leeper, H; McMillan, S; Murray, CA; Pellin, M; Richardson, D; Skorupski, KA; Willcox, JL, 2022)
"Lomustine was administered every 3 weeks with three or four planned cycles."1.62Outcome of dogs with intermediate grade low mitotic index high Ki67 mast cell tumours treated with surgery and single agent lomustine. ( Mason, SL; Néčová, S; North, SM, 2021)
"Neutropenia was documented in 20 dogs (57%): 12 grade I to II, 8 grade III to IV."1.48Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas. ( Amores-Fuster, I; Blackwood, L; Finotello, R; Harper, A; Killick, DR; Maddox, TW; Mason, SL; Tanis, JB, 2018)
"Intracranial gliomas are a common malignancy in dogs, and are associated with a poor prognosis due to their aggressive nature and a lack of clinically effective treatments."1.48Survival times in dogs with presumptive intracranial gliomas treated with oral lomustine: A comparative retrospective study (2008-2017). ( Cohen, PW; Dewey, CW; Moirano, SJ; Wright, KZ, 2018)
"Lomustine is a well-accepted, first-line chemotherapy for dogs with HS, but its specific utility in dogs with HPHS has not been previously reported."1.48Lomustine chemotherapy for the treatment of presumptive haemophagocytic histiocytic sarcoma in Flat-coated Retrievers. ( Elliott, J, 2018)
"Lomustine was administered, but 1 year after surgery, the dog exhibited cluster seizures and died."1.43Case of a miniature dachshund with a primitive neuroectodermal tumor confined to the forebrain region treated with a combination of surgery and chemotherapy. ( Matsunaga, S; Nakamoto, Y; Ozawa, T; Uchida, K; Yamada, A, 2016)
"To describe a case of canine multiple cutaneous histiocytomas treated with lomustine."1.40Multiple cutaneous histiocytomas treated with lomustine in a dog. ( Colombo, S; Maina, E; Stefanello, D, 2014)
"Multifocal histiocytic sarcoma with a spindle-cell pattern was diagnosed based on morphologic features and intense expression of CD18."1.38Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping. ( Aubry, OA; Christopherson, PW; Kennis, RA; Mastrorilli, C; Moore, PF; Newton, JC; Smith, AN; Spangler, EA; Weismann, JL, 2012)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.82)18.2507
2000's11 (20.00)29.6817
2010's32 (58.18)24.3611
2020's11 (20.00)2.80

Authors

AuthorsStudies
Blaxill, J1
Buzzacott, P1
Finlay, J1
Murray, CA1
Willcox, JL1
De Mello Souza, CH1
Husbands, B2
Cook, MR1
Clifford, C1
Leeper, H1
Pellin, M1
Richardson, D1
Herrera, CL1
Krick, E1
McMillan, S1
Al-Nadaf, S1
Skorupski, KA2
Patten, S1
MacKenzie, S1
Limmer, S2
Nerschbach, V2
Eberle, N2
Teske, E2
Simon Betz, D2
Fuchs, D1
Rohrer Bley, C1
Morandi, L1
Tonon, C1
Weyland, MS1
Nytko, KJ1
Montesanto, C1
Phillips, B1
Aubry, O1
Soileau, AM1
Neto, RLALT1
Jimenez, PT1
Hamersky, J1
Smith, AA1
Purzycka, K2
Peters, LM2
Desmas, I1
Davies, O1
Chang, YM1
Lara-Garcia, A2
Elliott, J3
Lamb, CR1
Priestnall, SL1
Hardas, A1
Johnston, CA1
Rodriguez-Piza, I1
Dedeaux, AM1
Flesner, BK1
Reinhart, JM1
Langohr, IM1
Husnik, R1
Geraci, SN1
Taboada, J1
Rademacher, N1
Thombs, LA1
Bryan, JN1
Trepanier, LA1
Boudreaux, BB1
Néčová, S1
Mason, SL3
North, SM1
Brown, PM1
Tzannes, S1
Nguyen, S1
White, J1
Langova, V1
Boostrom, BO1
Moore, AS2
DeRegis, CJ1
Robat, C1
Freeman, K1
Thamm, DH1
Finotello, R2
Blackwood, L2
Bavcar, S1
de Vos, J2
Kessler, M1
de Fornel, P1
Buracco, P1
Murphy, S1
Hirschberger, J1
Argyle, DJ1
Tanis, JB1
Maddox, TW1
Killick, DR1
Amores-Fuster, I1
Harper, A1
Duffy, ME1
Anderson, CL1
Choy, K1
Fidel, JL1
Moirano, SJ1
Dewey, CW1
Wright, KZ1
Cohen, PW1
Morgan, E1
O'Connell, K1
Thomson, M1
Griffin, A1
Baines, S1
Lejeune, A1
Skorupski, K1
Frazier, S1
Vanhaezebrouck, I1
Rebhun, RB1
Reilly, CM1
Rodriguez, CO2
Ueno, H1
Miyoshi, K1
Fukui, S1
Kondo, Y1
Matsuda, K1
Uchide, T2
Pan, X1
Tsimbas, K1
Kurzman, ID1
Vail, DM1
Maina, E1
Colombo, S1
Stefanello, D1
Cannon, C1
Borgatti, A1
Henson, M1
Yamazaki, H1
Takagi, S1
Hosoya, K2
Okumura, M1
Kambayashi, S1
Minami, K1
Ogawa, Y1
Hamaji, T1
Hwang, CC1
Igase, M1
Hiraoka, H1
Miyama, TS1
Noguchi, S1
Baba, K1
Mizuno, T1
Okuda, M1
Nakamoto, Y1
Yamada, A1
Uchida, K2
Matsunaga, S1
Ozawa, T1
Laprais, A1
Olivry, T1
Vincenti, S1
Findji, F1
Fontaine, J1
Bovens, C1
Bettenay, S1
Mueller, RS1
Intile, JL3
Rassnick, KM4
Bailey, DB3
Al-Sarraf, R2
Chretin, JD1
Balkman, CE3
Flory, AB3
Kiselow, MA3
Wakshlag, JJ2
Krick, EL1
Clifford, CA1
Ward, R1
Kent, MS1
Cooper, M1
Tsai, X1
Bennett, P1
Lord, LK1
Kisseberth, WC1
London, CA1
Couto, CG1
Russell, DS2
Malone, EK3
Barnard, SM2
Ruslander, DM1
Johnson, CS1
Trump, DL1
Barlow, LL1
Waite, AH1
Flegel, T1
Boettcher, IC1
Matiasek, K1
Oevermann, A1
Doherr, MG1
Oechtering, G1
Henke, D1
Heading, KL1
Brockley, LK1
Bennett, PF1
Abrams-Ogg, AC1
Fahey, CE1
Milner, RJ1
Barabas, K1
Lurie, D1
Kow, K1
Parfitt, S1
Lyles, S1
Clemente, M1
Fukumoto, S1
Hanazono, K1
Kawasaki, N1
Hori, Y1
Higuchi, S1
Sasaki, T1
Temma, K1
Van Meervenne, S1
Verhoeven, PS1
Gielen, IM1
Polis, I1
Van Ham, LM1
Mastrorilli, C1
Spangler, EA1
Christopherson, PW1
Aubry, OA1
Newton, JC1
Smith, AN1
Kennis, RA1
Weismann, JL1
Moore, PF1
Hasegawa, D1
Kuwabara, T1
Mizoguchi, S1
Yayoshi, N1
Fujita, M1
Szabo, D1
Saveraid, TC1
Rodenas, S1
Kitchell, BE1
Jung, DI2
Kim, HJ2
Park, C2
Kim, JW2
Kang, BT2
Lim, CY2
Park, EH1
Sur, JH1
Seo, MH1
Hahm, DH1
Park, HM2
Baldi, A1
Colloca, E1
Spugnini, EP1
Jeong, SW1
Rusk, A1
Cozzi, E1
Stebbins, M1
Vail, D1
Graham, J1
Valli, V1
Henkin, J1
Sharpee, R1
Khanna, C1
Sauerbrey, ML1
Mullins, MN1
Bannink, EO1
Van Dorp, TE1
Kaneene, JB1
Obradovich, JE1
Fulton, LM1
Steinberg, HS1

Reviews

4 reviews available for lomustine and Canine Diseases

ArticleYear
Is CCNU (lomustine) valuable for treatment of cutaneous epitheliotropic lymphoma in dogs? A critically appraised topic.
    BMC veterinary research, 2017, Feb-21, Volume: 13, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Lomustine; Lymphoma, T-Cell, Cutaneo

2017
Canine cutaneous epitheliotropic T-cell lymphoma: a review.
    Veterinary and comparative oncology, 2009, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Epidermis; Female; Humans; Lomustine

2009
New chemotherapy agents in veterinary medicine.
    The Veterinary clinics of North America. Small animal practice, 2003, Volume: 33, Issue:3

    Topics: Animals; Antineoplastic Agents; Cat Diseases; Cats; Deoxycytidine; Dog Diseases; Dogs; Gemcitabine;

2003
Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques.
    Seminars in veterinary medicine and surgery (small animal), 1990, Volume: 5, Issue:4

    Topics: Animals; Brain Neoplasms; Dog Diseases; Dogs; Lomustine; Magnetic Resonance Imaging; Tomography, X-R

1990

Trials

7 trials available for lomustine and Canine Diseases

ArticleYear
Biochemical, functional, and histopathologic characterization of lomustine-induced liver injury in dogs.
    American journal of veterinary research, 2020, Volume: 81, Issue:10

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury, Chronic

2020
Safety evaluation of combination CCNU and continuous toceranib phosphate (Palladia(®) ) in tumour-bearing dogs: a phase I dose-finding study.
    Veterinary and comparative oncology, 2016, Volume: 14, Issue:2

    Topics: Animals; Antineoplastic Agents; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Combinati

2016
Combination CCNU and vinblastine chemotherapy for canine mast cell tumours: 57 cases.
    Veterinary and comparative oncology, 2009, Volume: 7, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Female; Lomustine; Male

2009
A phase II study to evaluate the toxicity and efficacy of alternating CCNU and high-dose vinblastine and prednisone (CVP) for treatment of dogs with high-grade, metastatic or nonresectable mast cell tumours.
    Veterinary and comparative oncology, 2010, Volume: 8, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agents,

2010
Calcitriol (1,25-dihydroxycholecalciferol) enhances mast cell tumour chemotherapy and receptor tyrosine kinase inhibitor activity in vitro and has single-agent activity against spontaneously occurring canine mast cell tumours.
    Veterinary and comparative oncology, 2010, Volume: 8, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzamides; Blotting, Western; Calcitriol; Calcium Channel Agonists;

2010
Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs.
    Veterinary and comparative oncology, 2010, Volume: 8, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Asparagine; Cyclophosphamide; Dog Diseases;

2010
Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Dec-15, Volume: 12, Issue:24

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Progressio

2006

Other Studies

44 other studies available for lomustine and Canine Diseases

ArticleYear
Prognostic indicators for naïve canine non-indolent T-cell lymphoma treated with combination lomustine, vincristine, procarbazine and prednisolone chemotherapy.
    Veterinary and comparative oncology, 2022, Volume: 20, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Hypercalcemia; Lomustin

2022
Outcome in dogs with curative-intent treatment of localized primary pulmonary histiocytic sarcoma.
    Veterinary and comparative oncology, 2022, Volume: 20, Issue:2

    Topics: Animals; Dog Diseases; Dogs; Histiocytic Sarcoma; Lomustine; Lung; Lung Neoplasms; Retrospective Stu

2022
Prolonged Survival Following Treatment of Histiocytic Sarcoma of the Canine Urinary Bladder.
    Journal of the American Animal Hospital Association, 2022, May-01, Volume: 58, Issue:3

    Topics: Animals; Dog Diseases; Dogs; Doxorubicin; Histiocytic Sarcoma; Lomustine; Male; Urinary Bladder

2022
Efficacy and tolerability of a 12-week combination chemotherapy followed by lomustine consolidation treatment in canine B- and T-cell lymphoma.
    Acta veterinaria Scandinavica, 2022, Dec-12, Volume: 64, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Lomustine; Lymphoma; Ly

2022
Efficacy and tolerability of a 12-week combination chemotherapy followed by lomustine consolidation treatment in canine B- and T-cell lymphoma.
    Acta veterinaria Scandinavica, 2022, Dec-12, Volume: 64, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Lomustine; Lymphoma; Ly

2022
Efficacy and tolerability of a 12-week combination chemotherapy followed by lomustine consolidation treatment in canine B- and T-cell lymphoma.
    Acta veterinaria Scandinavica, 2022, Dec-12, Volume: 64, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Lomustine; Lymphoma; Ly

2022
Efficacy and tolerability of a 12-week combination chemotherapy followed by lomustine consolidation treatment in canine B- and T-cell lymphoma.
    Acta veterinaria Scandinavica, 2022, Dec-12, Volume: 64, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Lomustine; Lymphoma; Ly

2022
Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro.
    Veterinary medicine and science, 2023, Volume: 9, Issue:4

    Topics: Animals; Cell Survival; Dacarbazine; Dog Diseases; Dogs; Glioma; Lomustine; Temozolomide

2023
Metastatic Cutaneous Langerhans Cell Histiocytosis in a Flat-Coated Retriever Treated with Doxorubicin and Prednisone.
    Journal of the American Animal Hospital Association, 2023, Sep-01, Volume: 59, Issue:5

    Topics: Animals; Dog Diseases; Dogs; Doxorubicin; Female; Lomustine; Prednisone; Vinorelbine

2023
Doxorubicin and zoledronate treatment in a dog with hemophagocytic histiocytic sarcoma.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2023, Volume: 64, Issue:12

    Topics: Animals; Dog Diseases; Dogs; Doxorubicin; Histiocytic Sarcoma; Hyperbilirubinemia; Hypoalbuminemia;

2023
Clinicopathological characteristics and prognostic factors for canine multicentric non-indolent T-cell lymphoma: 107 cases.
    Veterinary and comparative oncology, 2020, Volume: 18, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Disease Progression; Dog Diseases; Dogs; Lomustine; Lymp

2020
Histiocytic sarcoma in miniature schnauzers: 30 cases.
    The Journal of small animal practice, 2020, Volume: 61, Issue:6

    Topics: Animals; Dog Diseases; Dogs; Histiocytic Sarcoma; Lomustine; Retrospective Studies

2020
Outcome of dogs with intermediate grade low mitotic index high Ki67 mast cell tumours treated with surgery and single agent lomustine.
    Australian veterinary journal, 2021, Volume: 99, Issue:5

    Topics: Animals; Dog Diseases; Dogs; Ki-67 Antigen; Lomustine; Mast Cells; Mitotic Index; Retrospective Stud

2021
LOPP chemotherapy as a first-line treatment for dogs with T-cell lymphoma.
    Veterinary and comparative oncology, 2018, Volume: 16, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Female; Lomustine; Lymp

2018
Canine Cutaneous Plasmacytosis: 21 Cases (2005-2015).
    Journal of veterinary internal medicine, 2017, Volume: 31, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Drug Therapy, Combination; Female; L

2017
Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy.
    Veterinary and comparative oncology, 2018, Volume: 16, Issue:1

    Topics: Animals; Antineoplastic Agents; Dog Diseases; Dogs; Epirubicin; Female; Histiocytic Sarcoma; Lomusti

2018
Combination toceranib and lomustine shows frequent high grade toxicities when used for treatment of non-resectable or recurrent mast cell tumours in dogs: A European multicentre study.
    Veterinary journal (London, England : 1997), 2017, Volume: 224

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dog Dise

2017
Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas.
    Veterinary and comparative oncology, 2018, Volume: 16, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Female; Lomustine; Lymp

2018
Metronomic administration of lomustine following palliative radiation therapy for appendicular osteosarcoma in dogs.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2018, Volume: 59, Issue:2

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Dog Diseases; Dogs; Extremities; Female; Lomustine;

2018
Survival times in dogs with presumptive intracranial gliomas treated with oral lomustine: A comparative retrospective study (2008-2017).
    Veterinary and comparative oncology, 2018, Volume: 16, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dog Diseases; Dog

2018
Canine T cell lymphoma treated with lomustine, vincristine, procarbazine, and prednisolone chemotherapy in 35 dogs.
    Veterinary and comparative oncology, 2018, Volume: 16, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Dog Diseases; Dogs;

2018
Lomustine chemotherapy for the treatment of presumptive haemophagocytic histiocytic sarcoma in Flat-coated Retrievers.
    Australian veterinary journal, 2018, Volume: 96, Issue:12

    Topics: Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Histiocytic Sarcoma; Lomustine; Lymp

2018
A Retrospective Study of Multi-agent Chemotherapy including either Cyclophosphamide or Lomustine as Initial Therapy for Canine High-grade T-cell Lymphoma (2011-2017).
    Australian veterinary journal, 2019, Volume: 97, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Horm

2019
Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012).
    Veterinary and comparative oncology, 2015, Volume: 13, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agents,

2015
Extranodal lymphoma with peripheral nervous system involvement in a dog.
    The Journal of veterinary medical science, 2014, Volume: 76, Issue:5

    Topics: Animals; Brachial Plexus; Dog Diseases; Dogs; Fatal Outcome; Female; Lomustine; Lymphoma, Extranodal

2014
Multiple cutaneous histiocytomas treated with lomustine in a dog.
    Veterinary dermatology, 2014, Volume: 25, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Histiocytoma, Benign Fibrous; Lomust

2014
Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma.
    The Journal of small animal practice, 2015, Volume: 56, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs;

2015
Influence of a survivin suppressor YM155 on the chemoresistance of canine histiocytic sarcoma cells.
    Veterinary journal (London, England : 1997), 2015, Volume: 205, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dog Diseases; Dogs; Drug Resistance, N

2015
Expression of O(6)-methylguanine-DNA methyltransferase causes lomustine resistance in canine lymphoma cells.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2015, Volume: 79, Issue:3

    Topics: Animals; Antineoplastic Agents; CpG Islands; DNA Modification Methylases; Dog Diseases; Dogs; Drug R

2015
Case of a miniature dachshund with a primitive neuroectodermal tumor confined to the forebrain region treated with a combination of surgery and chemotherapy.
    The Journal of veterinary medical science, 2016, Dec-01, Volume: 78, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dog Diseases

2016
Influence of treatment on the outcome of dogs with incompletely excised grade-2 mast cell tumors.
    Schweizer Archiv fur Tierheilkunde, 2017, Volume: 159, Issue:3

    Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Dog Diseases; Dogs; Follow-Up Studies; Lo

2017
Evaluation of dexamethasone as a chemoprotectant for CCNU-induced bone marrow suppression in dogs.
    Veterinary and comparative oncology, 2009, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Dexamethasone; Dog Diseases; Dogs; Dose-Res

2009
Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy.
    Veterinary and comparative oncology, 2009, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Dog D

2009
Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)*.
    Veterinary and comparative oncology, 2009, Volume: 7, Issue:4

    Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dog Di

2009
Comparison of oral administration of lomustine and prednisolone or prednisolone alone as treatment for granulomatous meningoencephalomyelitis or necrotizing encephalitis in dogs.
    Journal of the American Veterinary Medical Association, 2011, Feb-01, Volume: 238, Issue:3

    Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Encephalitis; Encephal

2011
CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07).
    Australian veterinary journal, 2011, Volume: 89, Issue:4

    Topics: Anemia; Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Female; Gastrointestinal Dis

2011
The use of lithium carbonate to prevent lomustine-induced myelosuppression in dogs: a pilot study.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2011, Volume: 75, Issue:1

    Topics: Animals; Antidepressive Agents; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Dose-Response

2011
Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009).
    Journal of the American Veterinary Medical Association, 2011, Jul-15, Volume: 239, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Drug Resistance, Neopla

2011
Anaplastic atypical myeloma with extensive cutaneous involvement in a dog.
    The Journal of veterinary medical science, 2012, Volume: 74, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Fatal Outcome; Lomustin

2012
Comparison between symptomatic treatment and lomustine supplementation in 71 dogs with intracranial, space-occupying lesions.
    Veterinary and comparative oncology, 2014, Volume: 12, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dog Diseases; Dogs; Female; Lomustine;

2014
Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping.
    Veterinary clinical pathology, 2012, Volume: 41, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antigens, CD; Antineoplastic Agents; Biopsy, Fine-Needle; Cephalexin

2012
Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU.
    The Journal of veterinary medical science, 2012, Volume: 74, Issue:11

    Topics: Animals; Dog Diseases; Dogs; Fatal Outcome; Immunohistochemistry; Lomustine; Magnetic Resonance Imag

2012
Cervicothoracic syringohydromyelia associated with a prosencephalic mass in a dog.
    The Journal of small animal practice, 2012, Volume: 53, Issue:10

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Ne

2012
Long-term chemotherapy with lomustine of intracranial meningioma occurring in a miniature schnauzer.
    The Journal of veterinary medical science, 2006, Volume: 68, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Brain; Dog Diseases; Dogs; Drug Administra

2006
Lomustine for the treatment of gastrointestinal mast cell tumour in a dog.
    The Journal of small animal practice, 2006, Volume: 47, Issue:8

    Topics: Animals; Antineoplastic Agents, Alkylating; Dog Diseases; Dogs; Gastrointestinal Neoplasms; Lomustin

2006
Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog.
    The Journal of veterinary medical science, 2006, Volume: 68, Issue:11

    Topics: Animals; Dog Diseases; Dogs; Female; Lomustine; Magnetic Resonance Imaging; Meningeal Neoplasms; Men

2006
Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005).
    Journal of the American Veterinary Medical Association, 2007, Jun-15, Volume: 230, Issue:12

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Dog Diseases; Dogs; Dos

2007