Page last updated: 2024-10-30

lomustine and Anaplastic Astrocytoma

lomustine has been researched along with Anaplastic Astrocytoma in 102 studies

Research Excerpts

ExcerptRelevanceReference
"Adding temozolomide (TMZ) to radiation for patients with newly-diagnosed anaplastic astrocytomas (AAs) is common clinical practice despite the lack of prospective studies demonstrating a survival advantage."9.22The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide. ( Abuali, I; Grossman, SA; Lu, Y; Strowd, RE; Ye, X, 2016)
"The authors investigated the results of PCV chemotherapy within a cohort of 24 patients treated within the EORTC study 26971 on temozolomide chemotherapy in recurrent oligodendroglioma."9.11Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas. ( Allgeier, A; Brandes, AA; Enting, RH; Frenay, M; Kros, JM; Menten, J; Stege, EB; Taphoorn, MJ; Tosoni, A; Triebels, VH; van den Bent, MJ; van Heuvel, I, 2004)
"After surgery, patients aged < or = 70 years, with World Health Organization grade 3 or 4 astrocytoma, were randomized to radiotherapy alone (RT) or RT plus procarbazine, lomustine, and vincristine (PCV) chemotherapy (RT-PCV) given at 6-week intervals to a maximum of 12 courses (procarbazine 100 mg/m2 days 1 to 10, lomustine 100 mg/m2 day 1, and vincristine 1."9.09Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. ( , 2001)
"There is no benefit to the treatment of high-grade astrocytomas in children with eight-drugs-in-1-day chemotherapy compared with CCNU, vincristine, and prednisone."9.08Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. ( Bertolone, SJ; Boyett, JM; Cherlow, JM; Finlay, JL; Geyer, JR; McGuire, P; Milstein, JM; Tefft, M; Wisoff, JH; Yates, AJ, 1995)
"IDH-mutant anaplastic astrocytomas (AAs) are chemosensitive tumors for which the best choice of adjuvant chemotherapy between procarbazine, lomustine, and vincristine (PCV) or temozolomide (TMZ) after radiotherapy (RT) remains unclear."8.02Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. ( Bronniman, C; Carpentier, C; Ciron, DL; Dehais, C; Ducray, F; Esteyrie, V; Figarella-Branger, D; Martin, E; Moyal, EC; Network, P; Pouessel, D; Uro-Coste, E, 2021)
"We have reported that carmustine (BCNU) and cisplatin administered before, during, and after radiotherapy did not improve the survival of patients with high-grade astrocytomas and were associated with more serious toxicities than radiotherapy plus BCNU."7.73Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. ( Jung, SM; Liau, CT; Tseng, CK; Wei, KC, 2005)
"We compared survival in patients with anaplastic astrocytoma (AA) treated with adjuvant procarbazine, lomustine, and vincristine (PCV) with survival in patients treated with temozolomide."7.73Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma. ( Brandes, AA; Ermani, M; Gardiman, M; Ghimenton, C; Iuzzolino, P; Nicolardi, L; Reni, M; Rotilio, A; Sotti, G; Tosoni, A, 2006)
"To the authors' knowledge, there is a scarcity of accurate data regarding the feasibility of standard chemotherapy with procarbazine, lomustine, and vincristine (PCV) in a homogeneous series of patients with primary anaplastic oligodendroglioma (AO) and oligoastrocytoma (AOA) that was recurrent after surgery and standard radiotherapy."7.72Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. ( Brandes, AA; Coria, B; Danieli, D; Ermani, M; Gardiman, M; Iuzzolino, P; Pasetto, LM; Talacchi, A; Tosoni, A; Vastola, F, 2004)
"To determine any differences in outcome for patients with anaplastic astrocytoma (AA) treated with adjuvant carmustine (BCNU) versus procarbazine, lomustine, and vincristine (PCV) chemotherapy."7.70Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. ( Curran, WJ; Kramer, S; Leibel, S; Nelson, DF; Prados, MD; Scott, C, 1999)
"Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole."7.675-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984)
"Twenty consecutive patients with supratentorial Grade III and IV astrocytomas were treated with postoperative radiotherapy, and a simultaneous induction chemotherapy with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), procarbazine, bleomycin, and maintenance chemotherapy with CCNU."7.66Radiotherapy combined with procarbazine, bleomycin, and CCNU in the treatment of high-grade supratentorial astrocytomas. ( Greiner, RH; Markwalder, H; Seiler, RW; Zimmerman, A, 1978)
"Adding temozolomide (TMZ) to radiation for patients with newly-diagnosed anaplastic astrocytomas (AAs) is common clinical practice despite the lack of prospective studies demonstrating a survival advantage."5.22The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide. ( Abuali, I; Grossman, SA; Lu, Y; Strowd, RE; Ye, X, 2016)
"The authors investigated the results of PCV chemotherapy within a cohort of 24 patients treated within the EORTC study 26971 on temozolomide chemotherapy in recurrent oligodendroglioma."5.11Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas. ( Allgeier, A; Brandes, AA; Enting, RH; Frenay, M; Kros, JM; Menten, J; Stege, EB; Taphoorn, MJ; Tosoni, A; Triebels, VH; van den Bent, MJ; van Heuvel, I, 2004)
"After surgery, patients aged < or = 70 years, with World Health Organization grade 3 or 4 astrocytoma, were randomized to radiotherapy alone (RT) or RT plus procarbazine, lomustine, and vincristine (PCV) chemotherapy (RT-PCV) given at 6-week intervals to a maximum of 12 courses (procarbazine 100 mg/m2 days 1 to 10, lomustine 100 mg/m2 day 1, and vincristine 1."5.09Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. ( , 2001)
"There is no benefit to the treatment of high-grade astrocytomas in children with eight-drugs-in-1-day chemotherapy compared with CCNU, vincristine, and prednisone."5.08Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. ( Bertolone, SJ; Boyett, JM; Cherlow, JM; Finlay, JL; Geyer, JR; McGuire, P; Milstein, JM; Tefft, M; Wisoff, JH; Yates, AJ, 1995)
"IDH-mutant anaplastic astrocytomas (AAs) are chemosensitive tumors for which the best choice of adjuvant chemotherapy between procarbazine, lomustine, and vincristine (PCV) or temozolomide (TMZ) after radiotherapy (RT) remains unclear."4.02Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. ( Bronniman, C; Carpentier, C; Ciron, DL; Dehais, C; Ducray, F; Esteyrie, V; Figarella-Branger, D; Martin, E; Moyal, EC; Network, P; Pouessel, D; Uro-Coste, E, 2021)
"While procarbazine with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (PC) added to vincristine (PCV) was proven beneficial in the treatment of co-deleted anaplastic oligodendroglioma (AO), the question of whether PC alone is sufficient is important, as vincristine adds toxicity with uncertain benefit."3.81PC or PCV, That Is the Question: Primary Anaplastic Oligodendroglial Tumors Treated with Procarbazine and CCNU With and Without Vincristine. ( De Groot, J; Liu, D; Shonka, N; Smith, L; Webre, C, 2015)
"We compared survival in patients with anaplastic astrocytoma (AA) treated with adjuvant procarbazine, lomustine, and vincristine (PCV) with survival in patients treated with temozolomide."3.73Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma. ( Brandes, AA; Ermani, M; Gardiman, M; Ghimenton, C; Iuzzolino, P; Nicolardi, L; Reni, M; Rotilio, A; Sotti, G; Tosoni, A, 2006)
"We have reported that carmustine (BCNU) and cisplatin administered before, during, and after radiotherapy did not improve the survival of patients with high-grade astrocytomas and were associated with more serious toxicities than radiotherapy plus BCNU."3.73Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. ( Jung, SM; Liau, CT; Tseng, CK; Wei, KC, 2005)
"We collected 6 case-reports of symptomatric non removable low grade fibrillary astrocytoma of adults treated with a procarbazine-CCNU-vincristine chemotherapy regimen."3.72[Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults]. ( Alchaar, H; Bleuse, A; Bondiau, PY; Bourg, V; Brunetto, JL; Chanalet, S; Chatel, M; Courdi, A; Darcourt, J; Fauchon, F; Fontaine, D; Frénay, M; Grellier, P; Guibert, F; Lanteri-Minet, M; Lebrun, C; Lonjon, M; Michiels, JF; Paquis, P; Paquis, V; Ramaioli, A; Rasendrarijao, D; Vandenbos, F, 2004)
"To the authors' knowledge, there is a scarcity of accurate data regarding the feasibility of standard chemotherapy with procarbazine, lomustine, and vincristine (PCV) in a homogeneous series of patients with primary anaplastic oligodendroglioma (AO) and oligoastrocytoma (AOA) that was recurrent after surgery and standard radiotherapy."3.72Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. ( Brandes, AA; Coria, B; Danieli, D; Ermani, M; Gardiman, M; Iuzzolino, P; Pasetto, LM; Talacchi, A; Tosoni, A; Vastola, F, 2004)
"The aim of this study was to examine the range of sensitivity of a panel of short-term cultures derived from different types of malignant childhood brain tumours including medulloblastoma, ependymoma and glioblastoma multiforme to three cytotoxic drugs, lomustine (CCNU), vincristine (VCR) and procarbazine (PCB)."3.70Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine. ( Darling, JL; Harding, B; Harkness, W; Hayward, R; Lewandowicz, GM; Thomas, DG, 2000)
"A 28-year-old woman with anaplastic astrocytoma was treated with partial resection and radiation therapy followed by a lomustine-containing regimen."3.69Multiorgan failure associated with lomustine overdose. ( Moreb, J; Myers, L; Trent, KC, 1995)
"We report a patient who developed aplastic anemia after three courses of cyclohexylchloroethylnitrousurea (CCNU), procarbazine and oncovine administered after craniotomy and irradiation for brain astrocytoma."3.69Aplastic anemia induced by cyclohexylchloroethylnitrousurea. ( Elis, A; Lishner, M; Ravid, M; Savin, H, 1994)
"Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole."3.675-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984)
"A patient is presented who developed nephrotoxicity after therapy with lomustine (CCNU) for astrocytoma of the brain."3.67Nephrotoxicity of lomustine. A case report and literature review. ( Ellis, ME; Kuperminc, M; Weiss, RB, 1985)
"Twenty consecutive patients with supratentorial Grade III and IV astrocytomas were treated with postoperative radiotherapy, and a simultaneous induction chemotherapy with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), procarbazine, bleomycin, and maintenance chemotherapy with CCNU."3.66Radiotherapy combined with procarbazine, bleomycin, and CCNU in the treatment of high-grade supratentorial astrocytomas. ( Greiner, RH; Markwalder, H; Seiler, RW; Zimmerman, A, 1978)
"The prognosis of patients with anaplastic oligodendrogliomas (AOD) and oligoastrocytomas (AOA) is variable."2.78New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brai ( Bernsen, HJ; Brandes, AA; Delattre, JY; Frénay, M; Gorlia, T; Kouwenhoven, MC; Kros, JM; Lacombe, D; Taphoorn, MJ; Tijssen, CC; van den Bent, MJ, 2013)
"AOA tumors with necrosis are to be considered WHO grade IV tumors (GBM)."2.74Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951. ( Allgeier, A; Brandes, AA; Bromberg, JE; Gorlia, T; Grisold, W; Ibdaih, A; Kouwenhoven, MC; Kros, JM; Lacombe, D; Mirimanoff, R; Mokhtari, K; Sipos, L; Teepen, JL; van den Bent, MJ; van Duinen, SG; Vandenbos, F; Vecht, CJ; Wesseling, P, 2009)
"Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity."2.71Initial chemotherapy in gliomatosis cerebri. ( Carpentier, A; Cartalat-Carel, S; Chinot, O; Cougnard, J; Delattre, JY; Djafari, L; Duffau, H; Gervais, H; Hoang-Xuan, K; Honnorat, J; Laigle, F; Mokhtari, K; Napolitano, M; Sanson, M; Taillandier, L; Taillibert, S, 2004)
"Histologically, 69 had anaplastic astrocytoma; 14, anaplastic oligoastrocytoma; and 7, anaplastic oligodendroglioma."2.70Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas. ( Bruner, J; Chang, E; Gleason, MJ; Hess, KR; Ictech, SA; Kyritsis, A; Leeds, N; Levin, VA; Maor, MH; Meyers, CA; Yung, WK, 2002)
" Parameters were evaluated by age at diagnosis, gender, ethnic origin, pre- and postsurgery Karnofsky Performance Status (KPS) score, limit and amount of surgical resection, histopathologic type, number of chemotherapy courses, time between surgery and radiotherapy, response to combined therapy, and dosage and type of radiotherapy."2.70Long-term follow-up in managing anaplastic astrocytoma by multimodality approach with surgery followed by postoperative radiotherapy and PCV-chemotherapy: phase II trial. ( Gal, O; Kovner, F; Ron, IG; Vishne, TH, 2002)
"Estimated 4-year survival for the anaplastic astrocytoma (AA) stratum (n = 116) is 46%."2.68Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas. ( Davis, RL; Gutin, PH; Lamborn, K; Levin, VA; Phillips, TL; Prados, MR; Wara, WM; Wilson, CB, 1995)
"The study included 26 patients with anaplastic astrocytoma and 37 patients with glioblastoma; all patients were aged ≤18 years."1.43High-grade glioma in children and adolescents: a single-center experience. ( Akalan, N; Akyuz, C; Cengiz, M; Eren, G; Gurkaynak, M; Ozyigit, G; Varan, A; Yazici, G; Yüce, D; Zorlu, F, 2016)
"We describe a case of anaplastic astrocytoma in a 14-year-old boy arising at the site of a dysembryoplastic neuroepithelial tumor (DNT) 3 years after combined radiation and chemotherapy."1.32Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy. ( Mena, H; Rushing, EJ; Thompson, LD, 2003)
"Malignant oligodendrogliomas have been shown to be responsive to chemotherapy."1.28The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. ( Glass, J; Gruber, ML; Hochberg, FH; Louis, DN; Rattner, B; Smith, D, 1992)
"Procarbazine was ineffective."1.28The chemotherapeutic response of a murine (VM) model of human glioma. ( Bradford, R; Darling, JL; Thomas, DG, 1990)
"12 patients with brain tumors were treated with a combination of procarbazine, CCNU (bis-2-chloroethyl-3-cyclohexyl-1-nitrosourea) and vincristine."1.27Procarbazine, CCNU and vincristine (PCV) combination chemotherapy for brain tumors. ( Biran, S; Brufman, G; Catane, R; Halpern, J; Sulkes, A, 1984)
"5 g/M2 every six weeks, with dosage adjustments for myelotoxicity."1.27Misonidazole and CCNU chemotherapy for recurrent primary brain tumor. ( Fulton, DS; McKinnon, S; Tanasichuk, H; Urtasun, RC, 1987)
"Three cases of pseudocysts following surgery and chemotherapy for glioblastomas are reported."1.26Cerebral pseudocysts following chemotherapy of glioblastomas. ( Philippon, J; Poisson, M; Racadot, J; Sichez, JP; van Effenterre, R, 1977)

Research

Studies (102)

TimeframeStudies, this research(%)All Research%
pre-199034 (33.33)18.7374
1990's21 (20.59)18.2507
2000's35 (34.31)29.6817
2010's11 (10.78)24.3611
2020's1 (0.98)2.80

Authors

AuthorsStudies
Esteyrie, V1
Dehais, C1
Martin, E1
Carpentier, C1
Uro-Coste, E1
Figarella-Branger, D1
Bronniman, C1
Pouessel, D1
Ciron, DL1
Ducray, F3
Moyal, EC1
Network, P1
Gorlia, T4
Delattre, JY2
Brandes, AA6
Kros, JM6
Taphoorn, MJ3
Kouwenhoven, MC2
Bernsen, HJ1
Frénay, M4
Tijssen, CC1
Lacombe, D3
van den Bent, MJ7
Chamberlain, MC3
Kaloshi, G1
Roci, E1
Rroji, A1
Petrela, M1
Webre, C1
Shonka, N1
Smith, L1
Liu, D1
De Groot, J1
Yazici, G1
Zorlu, F1
Cengiz, M1
Ozyigit, G1
Eren, G1
Yüce, D1
Varan, A2
Akyuz, C2
Akalan, N2
Gurkaynak, M1
Strowd, RE1
Abuali, I1
Ye, X1
Lu, Y1
Grossman, SA1
Buckner, JC4
Shaw, EG2
Pugh, SL1
Chakravarti, A1
Gilbert, MR1
Barger, GR1
Coons, S1
Ricci, P1
Bullard, D1
Brown, PD2
Stelzer, K1
Brachman, D1
Suh, JH1
Schultz, CJ1
Bahary, JP1
Fisher, BJ1
Kim, H1
Murtha, AD1
Bell, EH1
Won, M1
Mehta, MP1
Curran, WJ4
Combs, SE1
Schmidt-Graf, F1
Meyer, B1
Ibdaih, A2
Bromberg, JE1
Mokhtari, K3
van Duinen, SG1
Teepen, JL1
Wesseling, P2
Vandenbos, F2
Grisold, W1
Sipos, L1
Mirimanoff, R1
Vecht, CJ1
Allgeier, A2
Dubbink, HJ1
Sanson, M3
van der Lee-Haarloo, CR1
Hegi, M1
Jeuken, JW1
Dinjens, WN1
Idbaih, A1
Taphoorn, M1
Hoang-Xuan, K2
Van den Bent, M1
Pizer, B1
Salehzadeh, A1
Brodbelt, A1
Mallucci, C1
Murphy, C1
Pickles, T1
Knowling, M1
Thiesse, B1
Gesme, D1
O'Fallon, JR1
Hammack, JE1
Stafford, S1
Hawkins, R1
Scheithauer, BW1
Erickson, BJ1
Levitt, R1
Jenkins, R1
Nieder, C1
Vos, MJ1
Uitdehaag, BM1
Barkhof, F1
Heimans, JJ1
Baayen, HC1
Boogerd, W1
Castelijns, JA1
Elkhuizen, PH1
Postma, TJ1
Bertolone, SJ2
Yates, AJ3
Boyett, JM3
Wallace, D1
Finlay, JL3
Rushing, EJ1
Thompson, LD1
Mena, H1
Lichy, MP1
Bachert, P1
Henze, M1
Lichy, CM1
Debus, J1
Schlemmer, HP1
Prados, MD3
Seiferheld, W1
Sandler, HM1
Phillips, T2
Schultz, C2
Urtasun, R3
Davis, R2
Gutin, P3
Cascino, TL2
Greenberg, HS2
Lebrun, C1
Fontaine, D1
Chanalet, S1
Bourg, V1
Alchaar, H1
Bleuse, A1
Bondiau, PY1
Brunetto, JL1
Chatel, M1
Courdi, A1
Darcourt, J1
Fauchon, F1
Guibert, F1
Grellier, P1
Lanteri-Minet, M1
Lonjon, M1
Michiels, JF1
Paquis, P1
Paquis, V1
Ramaioli, A1
Rasendrarijao, D1
Cartalat-Carel, S1
Taillibert, S1
Napolitano, M1
Djafari, L1
Cougnard, J1
Gervais, H1
Laigle, F1
Carpentier, A1
Taillandier, L1
Chinot, O1
Duffau, H1
Honnorat, J1
de Wit, MC1
de Bruin, HG2
Eijkenboom, W1
Sillevis Smitt, PA1
Triebels, VH1
Menten, J1
Tosoni, A3
Stege, EB1
Enting, RH2
van Heuvel, I2
Vastola, F1
Pasetto, LM1
Coria, B1
Danieli, D1
Iuzzolino, P2
Gardiman, M2
Talacchi, A1
Ermani, M2
Stege, EM1
Looijenga, LH1
van der Rijt, CD1
Smitt, PA1
Liau, CT1
Wei, KC1
Tseng, CK1
Jung, SM1
Yimam, MA1
Bui, T1
Ho, RJ2
Nicolardi, L1
Ghimenton, C1
Reni, M1
Rotilio, A1
Sotti, G1
Atahan, L1
Söylemezoglu, F1
Selek, U1
Yalçin, B1
Kutluk, T1
Büyükpamukçu, M1
Wolff, JE1
Berrak, S1
Koontz Webb, SE1
Zhang, M1
Kobiakov, GL1
Mohile, NA1
Forsyth, P1
Stewart, D1
Raizer, JJ1
Paleologos, N1
Kewalramani, T1
Louis, DN4
Cairncross, JG1
Abrey, LE1
Levin, VA6
Edwards, MS1
Wara, WM2
Allen, J1
Ortega, J1
Vestnys, P1
Seiler, RW2
Pomodanov, AP1
Sosnov, IuD1
Perevodchikova, NI1
Dvoĭrin, VV1
Assekritova, IV1
Brufman, G1
Halpern, J1
Sulkes, A1
Catane, R1
Biran, S1
Shapiro, WR1
Trigg, ME1
Swanson, JD1
Letellier, MA1
Vats, TS1
Trueworthy, RC1
Langston, CM1
Castronovo, FP1
Potsaid, MS1
Kopiwoda, S1
Trent, KC1
Myers, L1
Moreb, J1
Geyer, JR3
Turski, PA1
Allen, JC1
Packer, RJ1
Prados, MR1
Davis, RL1
Gutin, PH1
Phillips, TL1
Lamborn, K1
Wilson, CB3
Wisoff, JH1
Milstein, JM2
McGuire, P1
Cherlow, JM1
Tefft, M1
Cole, SJ1
Fraser, DE1
Whittle, IR1
Elis, A1
Lishner, M1
Savin, H1
Ravid, M1
Kim, L1
Hochberg, FH2
Thornton, AF2
Harsh, GR1
Patel, H1
Finkelstein, D1
Abele, M1
Leonhardt, M1
Dichgans, J1
Weller, M1
Sankar, A1
Thomas, DG3
Darling, JL3
Scott, C2
Nelson, DF1
Leibel, S1
Kramer, S1
Yung, WK2
Sandler, H1
Henson, JW1
Källén, K1
Geijer, B1
Malmström, P2
Andersson, AM1
Holtås, S1
Ryding, E1
Rosén, I1
Lewandowicz, GM1
Harding, B1
Harkness, W1
Hayward, R1
Bouffet, E1
Jouvet, A1
Thiesse, P1
Sindou, M1
Lesser, GJ1
Bethune, CR1
Geyer, RJ1
Spence, AM1
Jaeckle, KA1
Bruner, J1
Kyritsis, A1
Leeds, N1
Gleason, MJ1
Hess, KR1
Meyers, CA1
Ictech, SA1
Chang, E1
Maor, MH1
Ron, IG1
Gal, O1
Vishne, TH1
Kovner, F1
Kochi, M1
Ushio, Y1
Greiner, RH1
Zimmerman, A1
Markwalder, H1
Boldrey, EB1
Drafts, D1
Enot, KJ1
Saez, RJ1
Campbell, RJ1
Laws, ER1
Poisson, M2
Philippon, J1
van Effenterre, R1
Racadot, J1
Sichez, JP1
Ertel, IJ2
Boesel, C1
Schulz, U1
Bamberg, M1
Lapukins, Z1
Paoletti, P3
Baldini, M1
Knerich, R1
Princi, L1
Pouillart, P1
Bataini, JP1
Mashaly, R1
Pertuiset, BF1
Metzger, J1
Fumagalli, R2
Weiss, JF1
Pezzotta, S2
Crafts, DC1
Townsend, J1
Heiss, WD1
Ward, HW1
Weir, B1
Band, P1
Blain, G1
Mclean, D1
Wilson, F1
Mielke, B2
Grace, M1
Racca, AR1
Jeremic, B1
Jovanovic, D1
Djuric, LJ1
Jevremovic, S1
Mijatovic, LJ1
Fulton, DS2
Urtasun, RC2
Scott-Brown, I1
Johnson, ES1
Curry, B1
Huyser-Wierenga, D1
Hanson, J1
Feldstein, M1
Boratyński, W1
Glass, J1
Gruber, ML1
Smith, D1
Rattner, B1
Ogilvy-Stuart, AL1
Shalet, SM1
Gattamaneni, HR1
Sandberg-Wollheim, M1
Strömblad, LG1
Anderson, H1
Borgström, S1
Brun, A1
Cronqvist, S1
Hougaard, K1
Salford, LG1
Arena, G1
Abbondandolo, A1
Rossi, O1
Gentile, SL1
Bruzzone, E1
Francaviglia, N1
Capellini, C1
Bradford, R1
Sposto, R1
Jenkin, RD1
Boesel, CP1
Venes, JL1
Ortega, JA1
Evans, AE1
Wara, W1
Hammond, D1
Constantinovici, A1
Cristescu, AM1
Friedman, HS1
Schold, SC1
Djang, WT1
Kurtzberg, J1
Longee, DC1
Halperin, EC1
Falletta, JM1
Coleman, RE1
Oakes, WJ1
Kapp, JP1
Vance, RB1
McKinnon, S1
Tanasichuk, H1
Pendergrass, TW1
Mulne, AF1
Kosnik, EJ1
Morris, JD1
Heideman, RL1
Ruymann, FB1
Stuntz, JT1
Bleyer, WA1
Chastagner, P1
Olive, D1
Philip, T1
Zucker, JM1
Czorny, A1
Lapras, C1
Brunat-Mentigny, M1
Hoag, G1
Sima, AA1
Rozdilsky, B1
Afra, D1
Kocsis, B1
Kerpel-Fronius, S1
Eckhardt, S1
Ellis, ME1
Weiss, RB1
Kuperminc, M1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Study of Observation in Favorable Low-Grade Glioma and a Phase II Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma[NCT00003375]Phase 2/Phase 3370 participants (Actual)Interventional1998-10-31Completed
PHASE III STUDY OF ADJUVANT PROCARBAZINE, CCNU AND VINCRISTINE CHEMOTHERAPY IN PATIENTS WITH HIGHLY ANAPLASTIC OLIGODENDROGLIOMA[NCT00002840]Phase 3350 participants (Anticipated)Interventional1996-08-31Completed
PHASE II STUDY OF PREIRRADIATION PCV CHEMOTHERAPY IN PATIENTS WITH SUPRATENTORIAL LOW-GRADE GLIOMAS[NCT00002806]Phase 243 participants (Actual)Interventional1996-07-31Completed
Phase II, Single Arm, Open Label Clinical Trial With Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas[NCT01574092]Phase 239 participants (Actual)Interventional2009-11-30Completed
A Phase I Trial of Lenalidomide and Radiotherapy in Children With Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas[NCT01222754]Phase 129 participants (Actual)Interventional2010-11-23Completed
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-Ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors[NCT00994071]Phase 19 participants (Actual)Interventional2009-09-22Completed
Does Varenicline Influence Alcohol Consumption in Alcohol Dependent Individuals?[NCT00846859]Phase 2162 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for lomustine and Anaplastic Astrocytoma

ArticleYear
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
Anaplastic oligodendroglioma and oligoastrocytoma.
    Neurologic clinics, 2007, Volume: 25, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brai

2007
[Clinical significance of mustoforan in management of malignant glioma].
    Voprosy onkologii, 2007, Volume: 53, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Blood-Brain Barr

2007
Treatment of neuroectodermal brain tumors.
    Annals of neurology, 1982, Volume: 12, Issue:3

    Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms;

1982
Chemotherapy of low-grade gliomas.
    Seminars in radiation oncology, 2001, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi

2001
[Chemo-radiotherapy for malignant brain tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Central Nervous System

2002
Chemotherapy of primary brain tumors.
    Neurologic clinics, 1985, Volume: 3, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl

1985

Trials

30 trials available for lomustine and Anaplastic Astrocytoma

ArticleYear
New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brai
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:16

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biomarkers, Tu

2013
The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide.
    Journal of neuro-oncology, 2016, Volume: 127, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazin

2016
Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
    The New England journal of medicine, 2016, Apr-07, Volume: 374, Issue:14

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modali

2016
[Not Available].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016, Volume: 192, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemoradiotherapy; Dis

2016
Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951.
    Neuro-oncology, 2009, Volume: 11, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cell Proliferation; Ch

2009
MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Dec-10, Volume: 27, Issue:35

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2009
Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951.
    Cancer, 2011, Jul-01, Volume: 117, Issue:13

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined

2011
Concurrent modified PCV chemotherapy and radiotherapy in newly diagnosed grade IV astrocytoma.
    Journal of neuro-oncology, 2002, Volume: 57, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modali

2002
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jan-15, Volume: 21, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chromosome Aber

2003
Combined modality therapy for poorly differentiated gliomas of the posterior fossa in children: a Children's Cancer Group report.
    Journal of neuro-oncology, 2003, Volume: 63, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cell Differentiation; Cereb

2003
Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404.
    International journal of radiation oncology, biology, physics, 2004, Mar-15, Volume: 58, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Che

2004
Initial chemotherapy in gliomatosis cerebri.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin

2004
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas.
    Neurology, 2004, Sep-14, Volume: 63, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2004
A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis.
    Journal of neuro-oncology, 2008, Volume: 89, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Busulfan; Combi

2008
Treatment of neuroectodermal brain tumors.
    Annals of neurology, 1982, Volume: 12, Issue:3

    Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms;

1982
Pre-irradiation chemotherapy in children with high-grade astrocytoma: tumor response to two cycles of the '8-drugs-in-1-day' regimen. A Childrens Cancer Group study, CCG-945.
    Journal of neuro-oncology, 1994, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Che

1994
Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas.
    International journal of radiation oncology, biology, physics, 1995, Apr-30, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm

1995
Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Che

1995
A phase 3 randomized study of radiotherapy plus procarbazine, CCNU, and vincristine (PCV) with or without BUdR for the treatment of anaplastic astrocytoma: a preliminary report of RTOG 9404.
    International journal of radiation oncology, biology, physics, 1999, Dec-01, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Che

1999
Quantitative 201Tl SPET imaging in the follow-up of treatment for brain tumour: a sensitive tool for the early identification of response to chemotherapy?
    Nuclear medicine communications, 2000, Volume: 21, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Female; Follow-

2000
Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jan-15, Volume: 19, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Central Nervous System Neo

2001
Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas.
    International journal of radiation oncology, biology, physics, 2002, May-01, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm

2002
Long-term follow-up in managing anaplastic astrocytoma by multimodality approach with surgery followed by postoperative radiotherapy and PCV-chemotherapy: phase II trial.
    American journal of clinical oncology, 2002, Volume: 25, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Central

2002
[Combined postoperative therapy of glial brain tumors. Initial results of the pilot study].
    Strahlentherapie. Sonderbande, 1978, Volume: 75

    Topics: Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Cobalt Radioisotopes; Glioma; Humans; Lomust

1978
Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas.
    Journal of neurosurgery, 1976, Volume: 45, Issue:2

    Topics: Astrocytoma; Brain Neoplasms; Drug Evaluation; Female; Humans; Lomustine; Male; Nitrosourea Compound

1976
Advantage of post-radiotherapy chemotherapy with CCNU, procarbazine, and vincristine (mPCV) over chemotherapy with VM-26 and CCNU for malignant gliomas.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined

1992
Increasing radiation dose intensity using hyperfractionation in patients with malignant glioma. Final report of a prospective phase I-II dose response study.
    Journal of neuro-oncology, 1992, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Astrocytoma; Brain; Brain Neoplasms; Cobalt Radioisotopes; Com

1992
A randomized study of chemotherapy with procarbazine, vincristine, and lomustine with and without radiation therapy for astrocytoma grades 3 and/or 4.
    Cancer, 1991, Jul-01, Volume: 68, Issue:1

    Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Combined Moda

1991
The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group.
    Journal of neuro-oncology, 1989, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi

1989

Other Studies

67 other studies available for lomustine and Anaplastic Astrocytoma

ArticleYear
Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort.
    The oncologist, 2021, Volume: 26, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Humans; Lomustine; Pro

2021
Salvage therapy with lomustine for temozolomide refractory recurrent anaplastic astrocytoma: a retrospective study.
    Journal of neuro-oncology, 2015, Volume: 122, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazi

2015
Kinetic evaluation of low-grade gliomas in adults before and after treatment with CCNU alone.
    Journal of neurosurgery, 2015, Volume: 123, Issue:5

    Topics: Adolescent; Adult; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy

2015
PC or PCV, That Is the Question: Primary Anaplastic Oligodendroglial Tumors Treated with Procarbazine and CCNU With and Without Vincristine.
    Anticancer research, 2015, Volume: 35, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astr

2015
High-grade glioma in children and adolescents: a single-center experience.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016, Volume: 32, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astro

2016
Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma.
    Annals of the Academy of Medicine, Singapore, 2015, Volume: 44, Issue:10

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Beva

2015
Prolonged survival associated with the use of intraoperative carmustine (Gliadel) in a paediatric patient with recurrent grade III astrocytoma.
    British journal of neurosurgery, 2013, Volume: 27, Issue:4

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Carmustine; Combi

2013
Glioma treatment, radionecrosis, and growth factors. In regard to Levin et al., IJROBP 2002;53:58-66.
    International journal of radiation oncology, biology, physics, 2003, Mar-01, Volume: 55, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Diseases; Brain Neoplasms; Carbop

2003
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
    Neurology, 2003, Mar-11, Volume: 60, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat

2003
Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy.
    Annals of diagnostic pathology, 2003, Volume: 7, Issue:4

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Cell

2003
Monitoring individual response to brain-tumour chemotherapy: proton MR spectroscopy in a patient with recurrent glioma after stereotactic radiotherapy.
    Neuroradiology, 2004, Volume: 46, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Astrocytoma; Brain Neoplasms;

2004
[Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults].
    Revue neurologique, 2004, Volume: 160, Issue:5 Pt 1

    Topics: Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2004
Gliomatosis cerebri: better definition, better treatment.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocyt

2004
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study.
    Cancer, 2004, Nov-01, Volume: 101, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Combined Modality Therapy;

2004
Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine.
    Cancer, 2005, Feb-15, Volume: 103, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neo

2005
Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma.
    Chang Gung medical journal, 2005, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm

2005
Effects of lipid association on lomustine (CCNU) administered intracerebrally to syngeneic 36B-10 rat brain tumors.
    Cancer letters, 2006, Dec-08, Volume: 244, Issue:2

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Ethylni

2006
Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma.
    Neuro-oncology, 2006, Volume: 8, Issue:3

    Topics: Adjuvants, Pharmaceutic; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; As

2006
Astrocytic tumors in children: treatment results from a single institution.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007, Volume: 23, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi

2007
Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.
    Journal of neuro-oncology, 2008, Volume: 88, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms;

2008
5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group.
    Neurosurgery, 1984, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bra

1984
Late results of multimodality therapy of high-grade supratentorial astrocytomas.
    Surgical neurology, 1981, Volume: 15, Issue:2

    Topics: Adult; Antineoplastic Agents; Astrocytoma; Bleomycin; Brain Neoplasms; Drug Therapy, Combination; Fe

1981
[Postoperative treatment of malignant glial tumors of the brain with CCNU].
    Vestnik Akademii meditsinskikh nauk SSSR, 1981, Issue:11

    Topics: Astrocytoma; Brain Neoplasms; Follow-Up Studies; Glioblastoma; Humans; Lomustine; Nitrosourea Compou

1981
Procarbazine, CCNU and vincristine (PCV) combination chemotherapy for brain tumors.
    Oncology, 1984, Volume: 41, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modali

1984
Metastasis of an optic glioma through a ventriculoperitoneal shunt.
    Cancer, 1983, Aug-15, Volume: 52, Issue:4

    Topics: Antineoplastic Agents; Ascites; Astrocytoma; Child, Preschool; Cranial Nerve Neoplasms; Drug Therapy

1983
Pulmonary fibrosis associated with lomustine (CCNU): a case report.
    Cancer treatment reports, 1982, Volume: 66, Issue:10

    Topics: Astrocytoma; Brain; Brain Neoplasms; Child; Humans; Lomustine; Male; Nitrosourea Compounds; Pulmonar

1982
Formulation and biological distribution of radiolabeled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in an animal tumor model.
    Cancer research, 1980, Volume: 40, Issue:10

    Topics: Animals; Astrocytoma; Injections, Intravenous; Lomustine; Neoplasm Transplantation; Neoplasms, Exper

1980
Multiorgan failure associated with lomustine overdose.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:4

    Topics: Adult; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Drug Overdose; Female; Frontal Lobe;

1995
Rapid resolution following chemotherapy of Broca's dysphasia due to recurrent anaplastic astrocytoma.
    British journal of neurosurgery, 1994, Volume: 8, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aphasia, Broca; Astrocytoma; Fatal Outcome; Follow-U

1994
Aplastic anemia induced by cyclohexylchloroethylnitrousurea.
    Anti-cancer drugs, 1994, Volume: 5, Issue:1

    Topics: Adult; Anemia, Aplastic; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Blood Cell Cou

1994
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for grade III and grade IV oligoastrocytomas.
    Journal of neurosurgery, 1996, Volume: 85, Issue:4

    Topics: Adult; Astrocytoma; Brain Neoplasms; Female; Humans; Lomustine; Male; Middle Aged; Procarbazine; Pro

1996
CCNU overdose during PCV chemotherapy for anaplastic astrocytoma.
    Journal of neurology, 1998, Volume: 245, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neo

1998
Sensitivity of short-term cultures derived from human malignant glioma to the anti-cancer drug temozolomide.
    Anti-cancer drugs, 1999, Volume: 10, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Dose-Response R

1999
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:11

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carm

1999
BUdR radiosensitization in anaplastic astrocytoma.
    International journal of radiation oncology, biology, physics, 1999, Dec-01, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Che

1999
Spinal cord astrocytoma: response to PCV chemotherapy.
    Neurology, 2000, Jan-25, Volume: 54, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biopsy; Fatal Outcome; Humans; L

2000
Chemosensitivity in childhood brain tumours in vitro: evidence of differential sensitivity to lomustine (CCNU) and vincristine.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:15

    Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Child; Dose-Response Relationship, Drug;

2000
Chemotherapy for aggressive or anaplastic high grade oligodendrogliomas and oligoastrocytomas: better than a salvage treatment.
    British journal of neurosurgery, 1998, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasm

1998
Lipid association improves the therapeutic index of lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea] to suppress 36B-10 tumor growth in rats.
    Cancer research, 2001, May-01, Volume: 61, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Division; Dose-Respon

2001
Medical Research Council adjuvant trial in high-grade gliomas.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Oct-01, Volume: 19, Issue:19

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2001
Radiotherapy combined with procarbazine, bleomycin, and CCNU in the treatment of high-grade supratentorial astrocytomas.
    Journal of neurosurgery, 1978, Volume: 48, Issue:6

    Topics: Adolescent; Adult; Aged; Astrocytoma; Bleomycin; Brain Neoplasms; Child; Drug Therapy, Combination;

1978
Single-agent chemotherapy of brain tumors. A five-year review.
    Archives of neurology, 1976, Volume: 33, Issue:11

    Topics: Astrocytoma; Bone Marrow Diseases; Brain Neoplasms; Carmustine; Glioma; Humans; Imidazoles; Lomustin

1976
Chemotherapeutic trials on human malignant astrocytomas in organ culture.
    Journal of neurosurgery, 1977, Volume: 46, Issue:3

    Topics: Antineoplastic Agents; Astrocytoma; Carmustine; Cell Survival; Cyanides; Drug Evaluation, Preclinica

1977
Cerebral pseudocysts following chemotherapy of glioblastomas.
    Acta neurochirurgica, 1977, Volume: 39, Issue:3-4

    Topics: Adult; Astrocytoma; Brain Diseases; Brain Neoplasms; Cysts; Glioblastoma; Humans; Lomustine; Male; M

1977
Brain tumors in children.
    Pediatric annals, 1978, Volume: 7, Issue:8

    Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Diagnosis, Differential; Ependymoma; Female;

1978
Treatment of primitive malignant tumors of the central nervous system. Clinical evaluation of 91 cases.
    Acta neurologica, 1979, Volume: 1, Issue:1

    Topics: Astrocytoma; Brain Neoplasms; Carmustine; Ependymoma; Glioma; Humans; Lomustine; Oligodendroglioma

1979
Malignant gliomas treated after surgery by combination chemotherapy and delayed irradiation. Part I: Analysis of results.
    Acta neurochirurgica, 1979, Volume: 51, Issue:1-2

    Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Cobalt Radioisotopes; Drug Therapy, Combinati

1979
Desmosterol: a biochemical marker of glioma growth.
    Surgical neurology, 1977, Volume: 8, Issue:6

    Topics: Astrocytoma; Brain Neoplasms; Carmustine; Cholesterol; Chromatography, Gas; Desmosterol; Diagnosis,

1977
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma.
    Cancer treatment reports, 1978, Volume: 62, Issue:1

    Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Therapy, Combination; Female; Hodgkin Dise

1978
Chemotherapy of malignant gliomas: comparison of the effect of polychemo- and CCNU-therapy.
    Acta neurochirurgica, 1978, Volume: 42, Issue:1-2

    Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Therapy, Combination; Humans;

1978
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 44-1978.
    The New England journal of medicine, 1978, Nov-09, Volume: 299, Issue:19

    Topics: Astrocytoma; Carcinoma, Squamous Cell; Ependymoma; Female; Glioma; Hemangioma, Cavernous; Humans; Li

1978
Central nervous system tumors of childhood treated with CCNU, vincristine, and radiation.
    Medical and pediatric oncology, 1978, Volume: 4, Issue:4

    Topics: Adolescent; Astrocytoma; Bone Marrow; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combin

1978
Sterols in cerebrospinal fluid during nitrosourea chemotherapy of human brain tumors.
    Pharmacological research communications, 1976, Volume: 8, Issue:2

    Topics: Adult; Astrocytoma; Brain Neoplasms; Carmustine; Cholesterol; Desmosterol; Female; Glioma; Humans; I

1976
[Results of combined treatment of neoplasms of the posterior cranial fossa in children].
    Neurologia i neurochirurgia polska, 1992, Volume: Suppl 1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cerebellar Neoplasms; Child

1992
The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy.
    Journal of neurosurgery, 1992, Volume: 76, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Drug Admi

1992
Thyroid function after treatment of brain tumors in children.
    The Journal of pediatrics, 1991, Volume: 119, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine

1991
[Possible role of 06-methylguanine-DNA-transferase in the response of patients with primary tumor of the brain to chemotherapy using chloro-ethyl-nitroso-urea: results of a current study].
    Bollettino della Societa italiana di biologia sperimentale, 1990, Volume: 66, Issue:5

    Topics: Astrocytoma; Brain Neoplasms; Female; Glioblastoma; Humans; Lomustine; Male; Methyltransferases; Neo

1990
The chemotherapeutic response of a murine (VM) model of human glioma.
    British journal of cancer, 1990, Volume: 61, Issue:1

    Topics: Animals; Astrocytoma; Brain Neoplasms; Carmustine; Disease Models, Animal; Lomustine; Mice; Mice, In

1990
Efficiency of the radio-chemo-surgical. Treatment in cerebral astrocytomas.
    Zentralblatt fur Neurochirurgie, 1989, Volume: 50, Issue:2

    Topics: Adult; Astrocytoma; Brain Neoplasms; Cobalt Radioisotopes; Combined Modality Therapy; Female; Gliobl

1989
Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor.
    Neurology, 1989, Volume: 39, Issue:1

    Topics: Adolescent; Antineoplastic Agents; Astrocytoma; Aziridines; Benzoquinones; Brain Neoplasms; Cohort S

1989
Supraophthalmic carotid infusion for recurrent glioma: rationale, technique, and preliminary results for cisplatin and BCNU.
    Journal of neuro-oncology, 1985, Volume: 3, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Car

1985
Misonidazole and CCNU chemotherapy for recurrent primary brain tumor.
    Journal of neuro-oncology, 1987, Volume: 4, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bone Marrow Diseases; Brain Neop

1987
Eight drugs in one day chemotherapy for brain tumors: experience in 107 children and rationale for preradiation chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Cisplatin; Comb

1987
[Efficacy of the "8 drugs in a day" protocol in brain tumors in children].
    Archives francaises de pediatrie, 1988, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cer

1988
Astroblastoma revisited: a report of three cases.
    Acta neuropathologica, 1986, Volume: 70, Issue:1

    Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Electroencephalography; Female

1986
Dibromodulcitol-based combined postoperative chemotherapy of malignant astrocytomas and glioblastomas.
    Journal of neuro-oncology, 1986, Volume: 4, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined

1986
Nephrotoxicity of lomustine. A case report and literature review.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: Adult; Astrocytoma; Brain Neoplasms; Humans; Kidney Diseases; Kidney Glomerulus; Lomustine; Male

1985