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lomustine and Acute Liver Injury, Drug-Induced

lomustine has been researched along with Acute Liver Injury, Drug-Induced in 13 studies

Research Excerpts

ExcerptRelevanceReference
" No association between dosing frequency, cumulative dose, initial starting dose or concurrent medications, and increases in ALT were found."1.38Low apparent risk of CCNU (lomustine)-associated clinical hepatotoxicity in cats. ( Chretin, JD; Musser, ML; Quinn, HT, 2012)
"In 4 years (1993-1996) 206 pts."1.31Venoocclusive liver disease (VOD) as a complication of Wilms' tumour management in the series of consecutive 206 patients. ( Czauderna, P; Godziński, J; Katski, K; Kowalczyk, J; Kurylak, A; Lopatka, B; Sawicz-Birkowska, K; Skotnicka-Klonowicz, G, 2000)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19904 (30.77)18.7374
1990's1 (7.69)18.2507
2000's3 (23.08)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W2
Morgan, RE1
van Staden, CJ1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Afshari, CA1
Hamadeh, HK1
Chen, M1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Hosoya, K1
Lord, LK1
Lara-Garcia, A1
Kisseberth, WC1
London, CA1
Couto, CG1
Musser, ML1
Quinn, HT1
Chretin, JD1
Gadjeva, V1
Tolekova, A1
Vasileva, M1
Urban, C1
Benesch, M1
Pakisch, B1
Lackner, H1
Kerbl, R1
Schwinger, W1
Oberbauer, R1
Czauderna, P1
Katski, K1
Kowalczyk, J1
Kurylak, A1
Lopatka, B1
Skotnicka-Klonowicz, G1
Sawicz-Birkowska, K1
Godziński, J1
Ahmed, AE2
Grissom, M1
el-Azhary, R1
Haque, A1
Boor, PJ2
Costanzi, J1
Viotte, G2
Lahouel, M2
Ducastelle, T2
Sumereau, E1
Morin, JP1
Hemet, J2
Fillastre, JP2
Kretschmer, NW1
el Azhary, RA1
Reynolds, ES1

Reviews

1 review available for lomustine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016

Trials

1 trial available for lomustine and Acute Liver Injury, Drug-Induced

ArticleYear
Synchronous radiochemotherapy in unfavorable brain tumors of children and young adults.
    Journal of neuro-oncology, 1998, Volume: 39, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Che

1998

Other Studies

11 other studies available for lomustine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)*.
    Veterinary and comparative oncology, 2009, Volume: 7, Issue:4

    Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dog Di

2009
Low apparent risk of CCNU (lomustine)-associated clinical hepatotoxicity in cats.
    Journal of feline medicine and surgery, 2012, Volume: 14, Issue:12

    Topics: Alanine Transaminase; Animals; Antineoplastic Agents, Alkylating; Cat Diseases; Cats; Chemical and D

2012
Effect of the spin-labelled 1-ethyl-1-nitrosourea on CCNU-induced oxidative liver injury.
    Die Pharmazie, 2007, Volume: 62, Issue:8

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Antioxidants; Catalase; Chemical and Drug Induced

2007
Venoocclusive liver disease (VOD) as a complication of Wilms' tumour management in the series of consecutive 206 patients.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2000, Volume: 10, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Chemical and Drug Induce

2000
Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital.
    Cancer chemotherapy and pharmacology, 1987, Volume: 19, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Chemical and Drug Induced Liver In

1987
[Hepatotoxicity of (chloro-2-ethyl)-1-cyclohexyl-3-nitroso-1-urea (CCNU) in the rat].
    Pathologie-biologie, 1986, Volume: 34, Issue:1

    Topics: Alkaline Phosphatase; Animals; Bilirubin; Body Weight; Chemical and Drug Induced Liver Injury; Edema

1986
[Hepatopathy with a progressive course after one-time administration of (chloro-2-ethyl)-1-cyclohexyl-3-nitroso-1-uréa (CCNU) in rats].
    Pathologie-biologie, 1987, Volume: 35, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Liver; Lomustine; Rats; Rats, Inbred Strain

1987
Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. III. Ultrastructural characterization of bile duct injury.
    Cancer chemotherapy and pharmacology, 1987, Volume: 19, Issue:2

    Topics: Animals; Bile Ducts; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Liver Disease

1987