lometrexol and Lymphoma--Non-Hodgkin

lometrexol has been researched along with Lymphoma--Non-Hodgkin* in 1 studies

Other Studies

1 other study(ies) available for lometrexol and Lymphoma--Non-Hodgkin

Article	Year
The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents. Bioorganic & medicinal chemistry letters, 1999, Jan-04, Volume: 9, Issue:1 A new series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates 1-3 were synthesized through an efficient conversion of 2-pivaloyl-4-oxo-6-ethynylpyrido[2,3-d]pyrimidine 5 to the corresponding 4-amino analog 7 via the activated 1,2,4-triazole intermediate 6. Compound 7 was used as the key intermediate for the preparation of the final products. The detailed biological evaluation of these compounds both as antineoplastic and antiarthritic agents will be discussed. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arthritis, Experimental; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Hydroxymethyl and Formyl Transferases; Leukemia; Lymphoma, Non-Hodgkin; Mice; Pemetrexed; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase	1999

Article

Year

The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents.

Bioorganic & medicinal chemistry letters, 1999, Jan-04, Volume: 9, Issue:1

A new series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates 1-3 were synthesized through an efficient conversion of 2-pivaloyl-4-oxo-6-ethynylpyrido[2,3-d]pyrimidine 5 to the corresponding 4-amino analog 7 via the activated 1,2,4-triazole intermediate 6. Compound 7 was used as the key intermediate for the preparation of the final products. The detailed biological evaluation of these compounds both as antineoplastic and antiarthritic agents will be discussed.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arthritis, Experimental; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Hydroxymethyl and Formyl Transferases; Leukemia; Lymphoma, Non-Hodgkin; Mice; Pemetrexed; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase

1999