lomefloxacin has been researched along with Dermatitis, Contact, Phototoxic in 19 studies
lomefloxacin: structure given in first source
lomefloxacin : A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adverse events were monitored throughout the study." | 2.87 | Lack of phototoxicity potential with delafloxacin in healthy male and female subjects: comparison to lomefloxacin. ( Cammarata, S; Dawe, RS; Duffy, E; Ferguson, J; Ibbotson, S; Lawrence, L; Paulson, S, 2018) |
| "As expected, lomefloxacin (400 mg/day) phototoxicity was revealed at the UVA wavebands 335 +/- 30 nm and 365 +/- 30 nm (maximal at 24 h), with a phototoxic index of 3-4." | 2.69 | Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers. ( Ferguson, J; Man, I; Murphy, J, 1999) |
| "Lomefloxacin alone was found to have an antiproliferative activity on fibroblasts by affecting the cell cycle." | 1.72 | Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action. ( Banach, K; Karkoszka, M; Kowalska, J; Rok, J; Rzepka, Z; Wrześniok, D, 2022) |
| "Previously, we showed that phototoxicity assessments in Sprague-Dawley (SD) rats can detect phototoxic potential to the same degree as those in guinea pigs." | 1.46 | Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats. ( Ashizawa, H; Hashimoto, K; Miyashita, T; Nejishima, H; Ogawa, H; Yonezawa, Y, 2017) |
| "In vivo phototoxicity studies are important to predict drug-induced phototoxicity in humans; however, a standard methodology has not established." | 1.46 | The abdominal skin of female Sprague-Dawley rats is more sensitive than the back skin to drug-induced phototoxicity. ( Harada, Y; Kuga, K; Miyamoto, M; Miyamoto, Y; Sakai, Y; Sato, K; Shimizu, F; Takamatsu, Y; Yasuno, H, 2017) |
| "The results of in vivo phototoxicity test in the mice coincided with phototoxic potential of these drugs in humans." | 1.36 | Comparative study of skin phototoxicity with three drugs by an in vivo mouse model. ( Akimoto, A; Kawashima, H; Kim, S; Matsumoto, N, 2010) |
| "In vitro, phototoxicity for cultured cells of PZFX, which is active principle of PZFX mesilate, was studied, and stability for long-wavelength ultraviolet (UVA) was examined." | 1.31 | [Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies]. ( Hayakawa, H; Kawamura, Y; Miyazaki, M; Nagasawa, M; Nakamura, S; Nojima, Y, 2002) |
| " As in previous reports there are arguments favouring photoallergy, but phototoxicity appears to be the main mechanism of photosensitivity to quinolones, particularly in older patients with concomitant diseases and long-term use of the drug." | 1.31 | Photosensitivity to lomefloxacin. A clinical and photobiological study. ( Figueiredo, AC; Gonçalo, M; Oliveira, HS, 2000) |
| "The severity of phototoxicity increased with increasing duration of UVA irradiation, and statistical analysis showed a close correlation between the severity and the decreased area under the drug concentration curve under UVA irradiation (DeltaAUC(auricle))." | 1.31 | Possible relationship between phototoxicity and photodegradation of sitafloxacin, a quinolone antibacterial agent, in the auricular skin of albino mice. ( Ikeda, T; Kato, M; Okawara, S; Shimoda, K, 2000) |
| "To elucidate the mechanism of phototoxicity induced as a side effect by some of the new quinolone antibiotics, we studied sparfloxacin (SPFX), lomefloxacin, enoxacin, ofloxacin, and ciprofloxacin." | 1.30 | Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents. ( Arakane, K; Hirobe, M; Mashiko, S; Nagano, T; Ryu, A; Umezawa, N, 1997) |
| "Lomefloxacin was the strongest sensitizer, followed by fleroxacin and ciprofloxacin." | 1.30 | In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. ( Gomi, H; Hatanaka, K; Kawada, A; Matsuo, I, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Kowalska, J | 1 |
| Banach, K | 1 |
| Rzepka, Z | 2 |
| Rok, J | 2 |
| Karkoszka, M | 1 |
| Wrześniok, D | 2 |
| Yonezawa, Y | 1 |
| Miyashita, T | 1 |
| Ashizawa, H | 1 |
| Hashimoto, K | 1 |
| Nejishima, H | 1 |
| Ogawa, H | 1 |
| Kuga, K | 1 |
| Yasuno, H | 1 |
| Sakai, Y | 1 |
| Harada, Y | 1 |
| Shimizu, F | 1 |
| Miyamoto, Y | 1 |
| Takamatsu, Y | 1 |
| Miyamoto, M | 1 |
| Sato, K | 1 |
| Dawe, RS | 1 |
| Ferguson, J | 2 |
| Ibbotson, S | 1 |
| Lawrence, L | 1 |
| Paulson, S | 1 |
| Duffy, E | 1 |
| Cammarata, S | 1 |
| Beberok, A | 1 |
| Delijewski, M | 1 |
| Otręba, M | 1 |
| Respondek, M | 1 |
| Buszman, E | 1 |
| Matsumoto, N | 1 |
| Akimoto, A | 1 |
| Kawashima, H | 1 |
| Kim, S | 1 |
| Nagasawa, M | 1 |
| Nakamura, S | 1 |
| Miyazaki, M | 1 |
| Nojima, Y | 1 |
| Hayakawa, H | 1 |
| Kawamura, Y | 1 |
| Zhang, T | 1 |
| Li, JL | 1 |
| Ma, XC | 1 |
| Xin, J | 1 |
| Tu, ZH | 1 |
| Reinhardt, P | 1 |
| Cybulski, M | 1 |
| Miller, SM | 1 |
| Ferrarotto, C | 1 |
| Wilkins, R | 1 |
| Deslauriers, Y | 1 |
| Freccero, M | 1 |
| Fasani, E | 1 |
| Mella, M | 1 |
| Manet, I | 1 |
| Monti, S | 1 |
| Albini, A | 1 |
| Fujita, H | 1 |
| Matsuo, I | 2 |
| Correia, O | 1 |
| Delgado, L | 1 |
| Barros, MA | 1 |
| Mäkinen, M | 1 |
| Forbes, PD | 1 |
| Stenbäck, F | 1 |
| Umezawa, N | 1 |
| Arakane, K | 1 |
| Ryu, A | 1 |
| Mashiko, S | 1 |
| Hirobe, M | 1 |
| Nagano, T | 1 |
| Mayne, JT | 1 |
| Johnson, NJ | 1 |
| Kluwe, WM | 1 |
| Lencoski, DL | 1 |
| Polzer, RJ | 1 |
| Man, I | 1 |
| Murphy, J | 1 |
| Kawada, A | 1 |
| Hatanaka, K | 1 |
| Gomi, H | 1 |
| Oliveira, HS | 1 |
| Gonçalo, M | 1 |
| Figueiredo, AC | 1 |
| Shimoda, K | 1 |
| Ikeda, T | 1 |
| Okawara, S | 1 |
| Kato, M | 1 |
2 trials available for lomefloxacin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Lack of phototoxicity potential with delafloxacin in healthy male and female subjects: comparison to lomefloxacin.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Dermatitis, Phototoxic; Female; Fluo | 2018 |
Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers.
Topics: Adult; Anti-Infective Agents; Aza Compounds; Dermatitis, Phototoxic; Double-Blind Method; Fluoroquin | 1999 |
17 other studies available for lomefloxacin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antioxidants; Dermatitis, Phototoxic; Fibroblasts; Flu | 2022 |
Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats.
Topics: Acridines; Administration, Cutaneous; Administration, Oral; Animals; Dermatitis, Phototoxic; Fluoroq | 2017 |
The abdominal skin of female Sprague-Dawley rats is more sensitive than the back skin to drug-induced phototoxicity.
Topics: Abdomen; Administration, Oral; Animals; Back; Dermatitis, Phototoxic; Disease Models, Animal; Doxycy | 2017 |
Effect of fluoroquinolones on melanogenesis in normal human melanocytes HEMn-DP: a comparative in vitro study.
Topics: Anti-Bacterial Agents; Cell Line; Cell Survival; Ciprofloxacin; Dermatitis, Phototoxic; Epidermal Ce | 2017 |
Comparative study of skin phototoxicity with three drugs by an in vivo mouse model.
Topics: 3T3 Cells; Animals; Antitubercular Agents; Dermatitis, Phototoxic; Disease Models, Animal; Dose-Resp | 2010 |
[Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies].
Topics: Animals; Anti-Infective Agents; Cells, Cultured; Ciprofloxacin; Dermatitis, Phototoxic; Enoxacin; Fe | 2002 |
Reliability of phototoxic tests of fluoroquinolones in vitro.
Topics: 3T3 Cells; Animals; Anti-Infective Agents; Ciprofloxacin; Cricetinae; Cricetulus; Dermatitis, Photot | 2003 |
Broad-spectrum sunscreens prevent the secretion of proinflammatory cytokines in human keratinocytes exposed to ultraviolet A and phototoxic lomefloxacin.
Topics: Cell Survival; Cells, Cultured; Cytokines; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; | 2006 |
Modeling the photochemistry of the reference phototoxic drug lomefloxacin by steady-state and time-resolved experiments, and DFT and post-HF calculations.
Topics: Anti-Bacterial Agents; Computer Simulation; Dermatitis, Phototoxic; Fluoroquinolones; Models, Chemic | 2008 |
In vitro phototoxic activities of new quinolone antibacterial agents: lipid peroxidative potentials.
Topics: Absorption; Anti-Infective Agents; Azides; Ciprofloxacin; Dermatitis, Phototoxic; Enoxacin; Fluoroqu | 1994 |
Bullous photodermatosis after lomefloxacin.
Topics: Aged; Anti-Infective Agents; Dermatitis, Phototoxic; Fluoroquinolones; Humans; Male; Quinolones; Ski | 1994 |
Quinolone antibacterials: a new class of photochemical carcinogens.
Topics: Animals; Anti-Infective Agents; Carcinoma, Squamous Cell; Ciprofloxacin; Dermatitis, Phototoxic; Fle | 1997 |
Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Dermatitis, Phototoxic; DNA; DNA Damage; Enoxacin; Fl | 1997 |
A study of the phototoxic potential of trovafloxacin in BALB/c mice.
Topics: Animals; Anti-Infective Agents; Dermatitis, Phototoxic; Erythema; Female; Fluoroquinolones; Hypertro | 1997 |
In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation.
Topics: Anti-Infective Agents; Ciprofloxacin; Dermatitis, Phototoxic; DNA Damage; Fleroxacin; Fluoroquinolon | 1999 |
Photosensitivity to lomefloxacin. A clinical and photobiological study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Dermatitis, Phototoxic; Drug Hypersensitivity | 2000 |
Possible relationship between phototoxicity and photodegradation of sitafloxacin, a quinolone antibacterial agent, in the auricular skin of albino mice.
Topics: Animals; Anti-Infective Agents; Area Under Curve; Dermatitis, Phototoxic; Female; Fluoroquinolones; | 2000 |