lofepramine has been researched along with MS (Multiple Sclerosis) in 4 studies
Lofepramine: A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether combination therapy with lofepramine, L-phenylalanine, and intramuscular vitamin B-12 (the "Cari Loder regime") reduces disability in patients with multiple sclerosis." | 9.10 | A randomised placebo controlled exploratory study of vitamin B-12, lofepramine, and L-phenylalanine (the "Cari Loder regime") in the treatment of multiple sclerosis. ( Chaudhuri, KR; Davidson, DL; Wade, DT; Young, CA, 2002) |
| "In a randomized, placebo-controlled double-blind trial a combination of lofepramine, phenylalanine and vitamin B(12) was found to be effective in relieving the symptoms of multiple sclerosis (MS)." | 9.10 | Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. ( Allawi, J; Horrobin, DF; Loder, C, 2002) |
| "As part of a large, randomized placebo-controlled trial of inpatients with multiple sclerosis (MS), a subsample of 15 underwent cerebral MRI at baseline and 6-months (eight on lofepramine and l-phenylalanine; seven on placebo)." | 9.09 | MRI changes in multiple sclerosis following treatment with lofepramine and L-phenylalanine. ( Al Saffar, BY; Bydder, GM; Chaudhuri, KR; Curati, WL; Hajnal, JV; Horrobin, DF; Mitchell, L; Puri, BK; White, SJ, 2001) |
| "To determine whether combination therapy with lofepramine, L-phenylalanine, and intramuscular vitamin B-12 (the "Cari Loder regime") reduces disability in patients with multiple sclerosis." | 5.10 | A randomised placebo controlled exploratory study of vitamin B-12, lofepramine, and L-phenylalanine (the "Cari Loder regime") in the treatment of multiple sclerosis. ( Chaudhuri, KR; Davidson, DL; Wade, DT; Young, CA, 2002) |
| "In a randomized, placebo-controlled double-blind trial a combination of lofepramine, phenylalanine and vitamin B(12) was found to be effective in relieving the symptoms of multiple sclerosis (MS)." | 5.10 | Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. ( Allawi, J; Horrobin, DF; Loder, C, 2002) |
| "As part of a large, randomized placebo-controlled trial of inpatients with multiple sclerosis (MS), a subsample of 15 underwent cerebral MRI at baseline and 6-months (eight on lofepramine and l-phenylalanine; seven on placebo)." | 5.09 | MRI changes in multiple sclerosis following treatment with lofepramine and L-phenylalanine. ( Al Saffar, BY; Bydder, GM; Chaudhuri, KR; Curati, WL; Hajnal, JV; Horrobin, DF; Mitchell, L; Puri, BK; White, SJ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wade, DT | 1 |
| Young, CA | 1 |
| Chaudhuri, KR | 2 |
| Davidson, DL | 1 |
| Loder, C | 1 |
| Allawi, J | 1 |
| Horrobin, DF | 2 |
| Krupp, L | 1 |
| Puri, BK | 1 |
| Bydder, GM | 1 |
| Al Saffar, BY | 1 |
| Curati, WL | 1 |
| White, SJ | 1 |
| Mitchell, L | 1 |
| Hajnal, JV | 1 |
3 trials available for lofepramine and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
A randomised placebo controlled exploratory study of vitamin B-12, lofepramine, and L-phenylalanine (the "Cari Loder regime") in the treatment of multiple sclerosis.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Disability Evaluation; Double-Blind Metho | 2002 |
Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems.
Topics: Adrenergic Fibers; Adrenergic Uptake Inhibitors; Antidepressive Agents; Chronic Disease; Double-Blin | 2002 |
MRI changes in multiple sclerosis following treatment with lofepramine and L-phenylalanine.
Topics: Adult; Antidepressive Agents, Tricyclic; Atrophy; Cerebral Cortex; Drug Therapy, Combination; Female | 2001 |
1 other study available for lofepramine and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Managing MS. While a cure is sought, people with MS can help themselves.
Topics: Antidepressive Agents, Tricyclic; Drug Therapy, Combination; Exercise Therapy; Humans; Lofepramine; | 2002 |