lofepramine has been researched along with Depressive Disorder in 38 studies
Lofepramine: A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lofepramine is a tricyclic antidepressant that is structurally similar to imipramine and is extensively metabolised to desipramine." | 3.76 | Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. ( Gonzalez, JP; Lancaster, SG, 1989) |
| "Lofepramine has been acclaimed as an effective and safe antidepressant, particularly for the elderly." | 1.29 | A prospective evaluation of the hepatotoxicity of lofepramine in the elderly. ( Kelly, C; Naguib, M; Pitt, B; Roberts, M; Roche, S; Webb, S, 1993) |
| "1." | 1.27 | Behavioural and neuropharmacological properties of the dibenzazepines, desipramine and lofepramine: studies on the olfactory bulbectomized rat model of depression. ( Leonard, BE; O'Connor, WT, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (44.74) | 18.7374 |
| 1990's | 18 (47.37) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peveler, R | 2 |
| Kendrick, T | 2 |
| Buxton, M | 2 |
| Longworth, L | 2 |
| Baldwin, D | 2 |
| Moore, M | 2 |
| Chatwin, J | 2 |
| Goddard, J | 2 |
| Thornett, A | 2 |
| Smith, H | 2 |
| Campbell, M | 2 |
| Thompson, C | 2 |
| Pugh, R | 2 |
| Bell, J | 1 |
| Cooper, AJ | 1 |
| Dunstan, S | 1 |
| Greedharry, D | 1 |
| Pomeroy, J | 1 |
| Raptopoulos, P | 1 |
| Rowsell, C | 1 |
| Steinert, J | 1 |
| Priest, RG | 1 |
| Dimitriou, E | 1 |
| Paraschos, A | 1 |
| Logothetis, J | 1 |
| Morse, PF | 2 |
| Smith, TG | 1 |
| Feighner, JP | 1 |
| Meridith, CH | 1 |
| Dutt, JE | 1 |
| Hendrickson, GG | 1 |
| Rickels, K | 1 |
| Weise, CC | 1 |
| Zal, HM | 1 |
| Csanalosi, I | 1 |
| Werblowsky, J | 1 |
| Finke, G | 1 |
| Wegener, G | 1 |
| Nutt, DJ | 1 |
| Wilson, SJ | 1 |
| Coupland, NJ | 1 |
| Lawrence, KM | 3 |
| Katona, CL | 5 |
| Abou-Saleh, MT | 5 |
| Robertson, MM | 4 |
| Nairac, BL | 2 |
| Edwards, DR | 4 |
| Lock, T | 5 |
| Burns, RA | 3 |
| Harrison, DA | 4 |
| Horton, RW | 3 |
| Nairac, BA | 1 |
| Tan, RS | 1 |
| Barlow, RJ | 1 |
| Abel, C | 1 |
| Reddy, S | 1 |
| Palmer, AJ | 1 |
| Fletcher, AE | 1 |
| Nicholl, CG | 1 |
| Pitt, BM | 2 |
| Bulpitt, CJ | 1 |
| Kelly, C | 1 |
| Roche, S | 1 |
| Naguib, M | 1 |
| Webb, S | 1 |
| Roberts, M | 1 |
| Pitt, B | 1 |
| Burns, R | 1 |
| Taylor, NS | 1 |
| Jawed, SH | 1 |
| Krishnan, VH | 1 |
| Prasher, VP | 1 |
| Corbett, JA | 1 |
| Lam, DH | 1 |
| Green, B | 1 |
| Power, MJ | 1 |
| Checkley, S | 1 |
| Nairac, B | 1 |
| Bouman, WP | 1 |
| Johnson, H | 1 |
| Trescoli-Serrano, C | 1 |
| Jones, RG | 1 |
| Hawley, CJ | 1 |
| Pattinson, HA | 1 |
| Quick, SJ | 1 |
| Echlin, D | 1 |
| Smith, V | 1 |
| McPhee, S | 1 |
| Sivakumaran, T | 1 |
| Evans, CL | 1 |
| Ha, Y | 1 |
| Saisch, S | 1 |
| Ellison, Z | 1 |
| Fombonne, E | 1 |
| Anderson, IM | 1 |
| Seymour, J | 1 |
| Wattis, JP | 1 |
| Theodorou, AE | 2 |
| Healy, D | 2 |
| Whitehouse, AM | 2 |
| White, W | 2 |
| Wilton-Cox, H | 2 |
| Kerry, SM | 2 |
| Paykel, ES | 2 |
| Kenyon, W | 1 |
| Canagasabey, B | 1 |
| Bochkarev, VK | 1 |
| Paniushkina, SV | 1 |
| Nazmutdinov, IG | 1 |
| Nikiforov, AI | 1 |
| Lancaster, SG | 1 |
| Gonzalez, JP | 1 |
| Fairbairn, AF | 1 |
| George, K | 1 |
| Dorman, T | 1 |
| Peet, M | 1 |
| Warrington, SJ | 1 |
| Hindmarch, I | 1 |
| O'Connor, WT | 1 |
| Leonard, BE | 1 |
| Holden, JM | 1 |
8 reviews available for lofepramine and Depressive Disorder
| Article | Year |
|---|---|
Use of selective serotonin reuptake inhibitors and other serotonergic drugs in the biological dissection of affective disorders.
Topics: Biomarkers; Blood Pressure; Depressive Disorder; Fluvoxamine; Heart Rate; Humans; Lithium; Lofeprami | 1995 |
Meta-analytical studies on new antidepressants.
Topics: Adult; Aged; Amoxapine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder | 2001 |
Update of antidepressants: lofepramine, amoxapine and viloxazine.
Topics: Amoxapine; Depressive Disorder; Humans; Lofepramine; Viloxazine | 1990 |
Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
Topics: Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Double-Blind Method; Humans; Lofepram | 1989 |
Lofepramine in clinical practice.
Topics: Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Humans; Lofepramine | 1988 |
Lofepramine in the elderly.
Topics: Adjustment Disorders; Aged; Depressive Disorder; Dibenzazepines; Humans; Lofepramine | 1988 |
The cardiovascular toxicity of antidepressants.
Topics: Antidepressive Agents; Cardiovascular Diseases; Depressive Disorder; Hemodynamics; Humans; Lofeprami | 1988 |
Lofepramine and psychomotor function.
Topics: Depressive Disorder; Dibenzazepines; Humans; Lofepramine; Psychomotor Performance | 1988 |
19 trials available for lofepramine and Depressive Disorder
| Article | Year |
|---|---|
A randomised controlled trial to compare the cost-effectiveness of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; | 2005 |
Cost-effectiveness and cost-utility of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine: randomised controlled trial.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Depressive Disorder; Fem | 2006 |
Does lofepramine have fewer side effects than amitriptyline? Results of a comparative trial.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Dibenzazepine | 1982 |
A double-blind comparison of lofepramine and clomipramine in depressed outpatients.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Dibenzazepines | 1984 |
A double blind comparison of lofepramine, imipramine and placebo in patients with depression.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Double-Blind | 1982 |
Lofepramine and imipramine in unipolar depressed outpatients. A placebo controlled study.
Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Double-Blind Method; Female; H | 1982 |
[Comparison of the therapeutic effects of lofepramine and maprotiline in depression].
Topics: Anthracenes; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Humans; Lofepramine; Map | 1982 |
An association between hostility and poor adherence to treatment in patients suffering from depression.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Female; Hostility; Humans; Lofepramine; Male; Middle A | 1983 |
Platelet 5-HT uptake sites, labelled with [3H] paroxetine, in controls and depressed patients before and after treatment with fluoxetine or lofepramine.
Topics: Adolescent; Adult; Aged; Blood Platelets; Cell Membrane; Depressive Disorder; Double-Blind Method; F | 1994 |
Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine.
Topics: Adolescent; Adult; Aged; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; | 1995 |
The effect of low dose lofepramine in depressed elderly patients in general medical wards.
Topics: Administration, Oral; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Pressure; Depre | 1994 |
Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine.
Topics: Depressive Disorder; Drug Therapy, Combination; Fluoxetine; Humans; Lithium; Lofepramine | 1993 |
Dependency, matching adversities, length of survival and relapse in major depression.
Topics: Adaptation, Psychological; Adult; Antidepressive Agents, Tricyclic; Dependency, Psychological; Depre | 1996 |
Predictors of response to amine-specific antidepressants.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disord | 1995 |
A protocol for the pharmacologic treatment of major depression. A field test of a potential prototype.
Topics: Adolescent; Adult; Aged; Clinical Protocols; Depressive Disorder; Female; Humans; Lithium; Lofeprami | 1998 |
Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
Topics: Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Double-Blind Method; Humans; Lofepram | 1989 |
Lofepramine versus dothiepin in the treatment of depression in elderly patients.
Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Dibenzothiep | 1989 |
Lofepramine in clinical practice.
Topics: Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Humans; Lofepramine | 1988 |
A multicentre trial of lofepramine.
Topics: Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Female; Humans; Lofepram | 1986 |
13 other studies available for lofepramine and Depressive Disorder
| Article | Year |
|---|---|
Improvement of depression with lofepramine (Gamanil). A multicentre hospital assessment of a new antidepressant.
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Depressive Disorder; Dibenzazepines; Female; Humans; Lof | 1984 |
A prospective evaluation of the hepatotoxicity of lofepramine in the elderly.
Topics: Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dep | 1993 |
Worsening of pica as a symptom of depressive illness in a person with severe mental handicap.
Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Foreign Bodies; | 1993 |
Recurrent hyponatremia associated with sertraline and lofepramine.
Topics: 1-Naphthylamine; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Humans; Hypona | 1997 |
Tricyclic antidepressants in adolescent depression. A case report.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Child; De | 1998 |
Treatment resistant depression in the elderly: three cases.
Topics: Aged; Aged, 80 and over; Depressive Disorder; Drug Resistance; Drug Therapy, Combination; Female; Fl | 1992 |
Platelet alpha 2-adrenoceptors, defined with agonist and antagonist ligands, in depressed patients, prior to and following treatment.
Topics: Adrenergic alpha-Agonists; Binding, Competitive; Blood Platelets; Brimonidine Tartrate; Depressive D | 1991 |
Sudden cardiac death and antidepressants.
Topics: Adult; Death, Sudden; Depressive Disorder; Humans; Lofepramine; Male; Risk Factors; Tachycardia | 1991 |
Capgras syndrome in association with lithium toxicity.
Topics: Aged; Capgras Syndrome; Delusions; Depressive Disorder; Drug Therapy, Combination; Female; Humans; L | 1991 |
3H-imipramine binding to previously frozen platelet membranes from depressed patients, before and after treatment.
Topics: Adult; Blood Platelets; Cell Membrane; Cohort Studies; Depressive Disorder; Dexamethasone; Electroco | 1990 |
[EEG factor analysis in the treatment with antidepressants].
Topics: Action Potentials; Adult; Amitriptyline; Antidepressive Agents; Cerebral Cortex; Depressive Disorder | 1989 |
Advances in the chemotherapy of depression: lofepramine. Proceedings of a symposium. London, 16th February 1988.
Topics: Depressive Disorder; Dibenzazepines; Humans; Lofepramine | 1988 |
Behavioural and neuropharmacological properties of the dibenzazepines, desipramine and lofepramine: studies on the olfactory bulbectomized rat model of depression.
Topics: Animals; Arousal; Avoidance Learning; Behavior, Animal; Clonidine; Depressive Disorder; Desipramine; | 1988 |