lofepramine has been researched along with Depression in 18 studies
Lofepramine: A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The improvement of depression after partial sleep deprivation in the second half of the night (sd) is tested for its predictory power for the therapeutical efficacy of pharmacotherapy with lofepramine." | 9.04 | Prediction of lofepramine-response in depression based on response to partial sleep deprivation. ( Philipp, M; Werner, C, 1979) |
| "A double-blind trial was undertaken to compare the antidepressant efficacy and the side effects of Lofepramine with those of Amitriptyline in the treatment of endogenous depression." | 9.04 | A double-blind trial with amitriptyline and lofepramine in the treatment of endogenous depression. ( Marneros, A; Philipp, M, 1979) |
| "The purpose of this study was to examine the metabolites of lofepramine (LOF), namely desipramine (DMI), desmethyl desipramine (DDMI) and desmethyl lofepramine (DML) in the forced swim and olfactory bulbectomized (OB) rat models of depression." | 7.70 | An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. ( Kelly, JP; Leonard, BE, 1999) |
| "An open pilot study on 30 in-patients with endogenous depression showed a clear-cut circadian fluctuation of the therapeutical effect of single doses of lofepramine administered at three different times of the day (8 a." | 5.04 | Chronobiology and its implications for pharmacotherapy of endogenous depression. ( Marneros, A; Philipp, M, 1978) |
| "The improvement of depression after partial sleep deprivation in the second half of the night (sd) is tested for its predictory power for the therapeutical efficacy of pharmacotherapy with lofepramine." | 5.04 | Prediction of lofepramine-response in depression based on response to partial sleep deprivation. ( Philipp, M; Werner, C, 1979) |
| "Although a 76-year-old woman with a diagnosis of depression began a course of maprotiline, the drug was discontinued after 14 days when she developed a rash." | 3.70 | [A case of allergic cross reaction between tricyclic antidepressants and maprotiline]. ( Kodama, Y; Nomura, S; Shimizu, K; Watanabe, M, 1998) |
| "The purpose of this study was to examine the metabolites of lofepramine (LOF), namely desipramine (DMI), desmethyl desipramine (DDMI) and desmethyl lofepramine (DML) in the forced swim and olfactory bulbectomized (OB) rat models of depression." | 3.70 | An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. ( Kelly, JP; Leonard, BE, 1999) |
| " Neurochemical studies show that both lofepramine and its metabolite are potent noradrenaline uptake inhibitors in vitro and evidence is presented to suggest that lofepramine may release this amine following chronic administration in vivo; both drugs slightly increase serotonin turnover under these conditions and down-regulate cortical beta-adrenoceptor function." | 2.37 | A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. ( Leonard, BE, 1987) |
| " Insufficient success in therapy was observed most often when the minimal dose of 35 mg per day was administered, while convincing results were obtained by a dosage of 70 to 140 mg of Lofepramine daily." | 1.26 | [Results of treatment with the anti-depressive agent lofepramine in neurological practice]. ( Lindner, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (83.33) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jessel, HJ | 1 |
| Jessel, I | 1 |
| Wegener, G | 2 |
| Dutt, JE | 1 |
| Lindner, M | 1 |
| Dorn, M | 1 |
| Shimizu, K | 1 |
| Watanabe, M | 1 |
| Kodama, Y | 1 |
| Nomura, S | 1 |
| Kelly, JP | 1 |
| Leonard, BE | 2 |
| Philipp, M | 4 |
| Marneros, A | 2 |
| Lehmann, E | 1 |
| Hopes, H | 1 |
| Mariategui, J | 1 |
| Chávez, H | 1 |
| Olivares, A | 1 |
| Werner, C | 1 |
| McClelland, HA | 1 |
| Kerr, TA | 1 |
| Stephens, DA | 1 |
| Howell, RW | 1 |
| Gonçalves, N | 1 |
| Beyer, J | 1 |
| Happ, J | 1 |
| Krause, U | 1 |
| Heimann, H | 1 |
| Obermair, W | 1 |
| Boller, W | 1 |
| Stoll, KD | 1 |
| Lack, SJ | 1 |
| Baldwin, DS | 1 |
| Montgomery, SA | 1 |
| Dorman, T | 1 |
1 review available for lofepramine and Depression
| Article | Year |
|---|---|
A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review.
Topics: Animals; Cardiovascular System; Chemical Phenomena; Chemistry; Depression; Desipramine; Dibenzazepin | 1987 |
10 trials available for lofepramine and Depression
| Article | Year |
|---|---|
[Therapy of elderly depressive patients. Lofepramine and amitriptyline under double-blind conditions].
Topics: Aged; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Method; Fema | 1981 |
[Psychotropic drugs in medical practice. Double-blind studies of lofepramine against amitriptyline].
Topics: Adult; Aged; Amitriptyline; Depression; Dibenzazepines; Drug Tolerance; Female; Humans; Lofepramine; | 1980 |
Chronobiology and its implications for pharmacotherapy of endogenous depression.
Topics: Adult; Circadian Rhythm; Clinical Trials as Topic; Depression; Drug Administration Schedule; Female; | 1978 |
Differential effects of a single dose of imipramine and lopramine in healthy subjects varying in their level of depression.
Topics: Adult; Clinical Trials as Topic; Depression; Dibenzazepines; Drug Evaluation; Humans; Imipramine; Lo | 1977 |
[Lofepramine: a comparative clinical study with amitriptyline].
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; | 1978 |
Prediction of lofepramine-response in depression based on response to partial sleep deprivation.
Topics: Clinical Trials as Topic; Depression; Dibenzazepines; Female; Humans; Lofepramine; Male; Middle Aged | 1979 |
The comparative antidepressant value of lofepramine and amitriptyline. Results of a controlled trial with comments on the scales used.
Topics: Aged; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Method; Drug | 1979 |
A double-blind trial with amitriptyline and lofepramine in the treatment of endogenous depression.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Metho | 1979 |
[Comparison of the effects of lofepramin and mianserin in depressed patients in a double blind trial].
Topics: Adult; Aged; Clinical Trials as Topic; Depression; Dibenzazepines; Double-Blind Method; Female; Huma | 1979 |
The management of depression, and the use of lofepramine in the elderly.
Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Depression; Dibenzazepines; Female; Humans; Lofep | 1988 |
7 other studies available for lofepramine and Depression
| Article | Year |
|---|---|
On the clinical response/serum level relationship for antidepressants II: Lofepramine and imipramine.
Topics: Depression; Dibenzazepines; Humans; Imipramine; Lofepramine | 1982 |
[Results of treatment with the anti-depressive agent lofepramine in neurological practice].
Topics: Adult; Depression; Dibenzazepines; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance | 1980 |
[A case of allergic cross reaction between tricyclic antidepressants and maprotiline].
Topics: Aged; Amoxapine; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cross R | 1998 |
An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dose-Response Relationship, Drug | 1999 |
[Endocrinological prediction of the responsiveness of depressive patients to lofepramine (author's transl)].
Topics: Adult; Blood Glucose; Depression; Dibenzazepines; Endocrine Glands; Female; Growth Hormone; Humans; | 1979 |
Videotape training in psychiatric practice.
Topics: Adult; Aged; Depression; Drug Evaluation; Female; Humans; Lofepramine; Male; Middle Aged; Psychiatri | 1977 |
Lofepramine, desipramine and abnormal tests of liver function: a case report.
Topics: Depression; Desipramine; Humans; Liver Function Tests; Lofepramine; Male; Middle Aged | 1990 |