lodoxamide-tromethamine and Conjunctivitis--Allergic

To observe the clinical effect of alomide and sodium cromoglycate eyedrops in the treatment of atopic conjunctivitis, vernal conjunctivitis and giant papillary conjunctivitis.. Randomized control study was used. Alomide and sodium cromoglycate eyedrops used to treat two groups of patients for two weeks. The effects of the two groups were compared.. With respect of comprehensive therapeutic effect, the effectiveness rate was 83.6% in alomide group, and 63.3% in sodium cromoglycate group, which was not significantly different statistically. With respect of itching alleviation, alomide is more effective than sodium cromoglycate. No adverse effects were found in both groups.. Our study suggests that alomide is a safe and effective drug in the treatment of allergic conjunctivitis.

Topics: Adolescent; Adult; Child; Child, Preschool; Conjunctivitis, Allergic; Cromolyn Sodium; Female; Humans; Male; Middle Aged; Nitriles; Oxamic Acid; Tromethamine

The purpose of the study is to evaluate in a double-blind, randomized study the efficacy of lodoxamide tromethamine 0.1% versus placebo.. Signs and symptoms, tear tryptase, and tear fluid cytology were evaluated in 20 asymptomatic subjects with allergic conjunctivitis. The study included three allergen challenges in skin test-positive patients. At the first visit, a threshold dose of allergen was established. At the second visit, a bilateral ocular challenge was performed without pretreatment. At the third visit, either lodoxamide or placebo eye drops were used for 1 week before ocular challenge.. Lodoxamide significantly reduced tryptase levels (P < 0.01), neutrophils (P < 0.04), and eosinophils (P < 0.01) in the tear fluid and significantly inhibited ocular itching (P < 0.02) when compared with that of placebo.. Lodoxamide is effective in reducing tryptase levels and the recruitment of inflammatory cells in the tear fluid after allergen challenge.

Topics: Administration, Topical; Adolescent; Adult; Allergens; Child; Chymases; Conjunctiva; Conjunctivitis, Allergic; Double-Blind Method; Eosinophils; Female; Histamine H1 Antagonists; Humans; Inflammation Mediators; Lolium; Male; Mast Cells; Nitriles; Ophthalmic Solutions; Oxamic Acid; Radioallergosorbent Test; Reproducibility of Results; Serine Endopeptidases; Skin Tests; Tears; Treatment Outcome; Tromethamine; Tryptases

To demonstrate the usefulness of contact lens induced conjunctivitis as a model of human ocular inflammation and to evaluate the effect of antiallergic eyedrops on this model.. We recruited 40 subjects with contact lens induced conjunctivitis. Half were treated with ketorolac tromethamine (KT), and half with iodoxamide tromethamine (LT). Signs, symptoms, contact lens wearing time, and wearing time until discomfort developed were evaluated at baseline, day 7, and day 14.. The group receiving LT showed improvement of symptoms 7 days after beginning the study (P = 0.016), and both the LT and KT groups showed improvement from baseline on day 14 (P = 0.001 and P = 0.004, respectively). Signs improved for both the KT group (P = 0.011) and the LT group (P = 0.043) on day 7 and day 14 (P = 0.033 and P = 0.007, respectively). Mean contact lens wearing time improved on day 14 for the group treated with KT (P = 0.001).. Contact lens induced conjunctivitis appears to be a useful model of human ocular inflammation. Both antiallergics KT and LT improve contact lens tolerance in subjects with contact lens induced conjunctivitis. Two weeks of treatment may be required to demonstrate therapeutic benefits of antiallergic drops.

Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Conjunctiva; Conjunctivitis, Allergic; Contact Lenses; Double-Blind Method; Follow-Up Studies; Histamine H1 Antagonists; Humans; Ketorolac Tromethamine; Models, Biological; Nitriles; Ophthalmic Solutions; Oxamic Acid; Tolmetin; Tromethamine

The author presents an account on initial experience with 0.1% lodoxamide in the treatment of atopy of the eyes. A positive effect was found in vernal catarrh. A favourable result was recorded in two sub-types of seasonal allergic conjunctivitis, mostly in the lower tarsal form with a follicular reaction in children and in purely limbal irritation in adults. The good effect in these two atypical forms of seasonal allergic conjunctivitis as a purely preventive immunopharmaceutical drug during the pollen season was remarkable.

Topics: Adult; Child, Preschool; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Nitriles; Oxamic Acid; Tromethamine