Page last updated: 2024-09-05

lixivaptan and Heart Failure

lixivaptan has been researched along with Heart Failure in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (6.45)	18.2507
2000's	16 (51.61)	29.6817
2010's	13 (41.94)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alani, A; Ghali, JK; Zmily, HD	1
Iwao, H; Izumi, Y; Miura, K	1
Farmakis, D; Filippatos, G; Gheorghiade, M; Kremastinos, DT	1
Boerrigter, G; Burnett, JC; Costello-Boerrigter, LC	1
Kumar, SK; Mather, PJ	1
Goldsmith, SR	1
Campese, VM; Ku, E; Nobakht, N	1
Haass, M	1
Reilly, T; Schork, MR	1
Ghali, JK; Tam, SW	1
Singh, M; Slawsky, MT; Valania, G	1
Daifallah, S; Farah, JO; Ghali, JK; Zmily, HD	1
Cantillo, DS; Comín Colet, J; Robledo, GG	1
Villabona, C	1
Er, F; Fuhr, U; Gassanov, N; Nia, AM; Semmo, M; Semmo, N	1
Daifallah, S; Ghali, JK; Khan, NS; Zmily, HD	1
Abraham, WT; Ghali, JK; Orlandi, C	1
Dabrowska, MD; Krysiak, R; Okopień, B	1
Borne, RT; Krantz, MJ	1
Blei, AT; Blendis, LM; Thuluvath, PJ; Wong, F	1
Ferguson, JW; Hayes, PC; Newby, DE; Therapondos, G	1
Thibonnier, M	1
Gheorghiade, M; Orlandi, C; Zimmer, CA	1
Greenberg, A; Verbalis, JG	1
Omland, T; Solberg, OG	1
Ali, F; Ghali, JK; Guglin, M; Vaitkevicius, P	1
Kumar, S; Mather, PJ; Rubin, S; Whellan, DJ	1
Hobbs, RE; Tang, WH	1
Schweiger, TA; Zdanowicz, MM	1
Albright, JD; Bailey, T; Cervoni, P; Chan, PS; Coupet, J; Dusza, JP; Hartupee, D; Lai, F; Lock, TY; Mazandarani, H; Ning, X; Ochalski, L; Park, HC; Ru, X; Shepherd, C; Spinelli, W; Tanikella, T; Taylor, JR	1
Abraham, WT; Lieming, X; Martin, PY; Ohara, M; Olson, BR; Oren, RM; Schrier, RW	1

Reviews

27 review(s) available for lixivaptan and Heart Failure

Article	Year
Evaluation of lixivaptan in euvolemic and hypervolemic hyponatremia and heart failure treatment. Expert opinion on drug metabolism & toxicology, 2013, Volume: 9, Issue:5 Topics: Animals; Benzamides; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Electrolytes; Heart Failure; Humans; Hyponatremia; Outpatients; Pyrroles; Receptors, Vasopressin; Sodium; Treatment Outcome	2013
Therapeutic potential of vasopressin-receptor antagonists in heart failure. Journal of pharmacological sciences, 2014, Volume: 124, Issue:1 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Clinical Trials as Topic; Disease Models, Animal; Heart Failure; Homeostasis; Humans; Hyponatremia; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan; Ventricular Remodeling	2014
Vasopressin and vasopressin antagonists in heart failure and hyponatremia. Current heart failure reports, 2008, Volume: 5, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heart Failure; Humans; Hyponatremia; Infusions, Intravenous; Male; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Risk Assessment; Survival Rate; Tolvaptan; Water-Electrolyte Imbalance	2008
Pharmacology of vasopressin antagonists. Heart failure reviews, 2009, Volume: 14, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Benzodiazepines; Heart Failure; Humans; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan	2009
AVP receptor antagonists in patients with CHF. Heart failure reviews, 2009, Volume: 14, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Sodium	2009
Treatment options for hyponatremia in heart failure. Heart failure reviews, 2009, Volume: 14, Issue:2 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Pyrroles; Sodium Potassium Chloride Symporter Inhibitors; Tolvaptan; Treatment Outcome	2009
Lixivaptan: a novel vasopressin receptor antagonist. Expert opinion on investigational drugs, 2009, Volume: 18, Issue:5 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Clinical Trials, Phase III as Topic; Heart Failure; Humans; Kidney Diseases; Pyrroles; Receptors, Vasopressin	2009
[Vasopressin receptor antagonists and heart failure]. Therapeutische Umschau. Revue therapeutique, 2009, Volume: 66, Issue:11 Topics: Administration, Oral; Aged; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Female; Follow-Up Studies; Furosemide; Heart Failure; Hormone Antagonists; Humans; Hyponatremia; Indoles; Male; Morpholines; Platelet Aggregation Inhibitors; Pyrroles; Pyrrolidines; Sodium Potassium Chloride Symporter Inhibitors; Spiro Compounds; Time Factors; Tolvaptan	2009
Vasopressin antagonists: Pharmacotherapy for the treatment of heart failure. The Annals of pharmacotherapy, 2010, Volume: 44, Issue:4 Topics: Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Neurotransmitter Agents; Pyrroles; Tolvaptan; Vasopressins	2010
The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists. Journal of cardiac failure, 2010, Volume: 16, Issue:5 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Blood Pressure; Blood Volume; Female; Heart Failure; Humans; Hypertension; Hyponatremia; Male; Prevalence; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; United States; Water-Electrolyte Balance	2010
Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists? Current heart failure reports, 2011, Volume: 8, Issue:3 Topics: Acute Disease; Animals; Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Hyponatremia; Prognosis; Pyrroles; Tolvaptan; Vasoconstriction; Vasopressins	2011
Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia. IDrugs : the investigational drugs journal, 2010, Volume: 13, Issue:11 Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Clinical Trials as Topic; Dogs; Heart Failure; Humans; Hyponatremia; Pyrroles; Rats	2010
[Hyponatremia in heart failure: physiopathology and pharmacological approach]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Benzazepines; Body Water; Brain Edema; Demyelinating Diseases; Diuresis; Diuretics; Double-Blind Method; Heart Failure; Humans; Hyponatremia; Kidney; Multicenter Studies as Topic; Natriuresis; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Renin-Angiotensin System; Saline Solution, Hypertonic; Sympathetic Nervous System; Tolvaptan	2010
[Vasopressin receptor antagonists: the vaptans]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2010, Volume: 57 Suppl 2 Topics: Adult; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Benzamides; Benzazepines; Calcium Signaling; Clinical Trials as Topic; Cyclic AMP; Double-Blind Method; Drug Therapy, Combination; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney Tubules, Collecting; Liver Cirrhosis; Morpholines; Multicenter Studies as Topic; Neoplasms; Pituitary Gland, Anterior; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Vasopressin; Second Messenger Systems; Spiro Compounds; Tolvaptan; Vasopressins	2010
Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH). European journal of clinical pharmacology, 2011, Volume: 67, Issue:4 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Biological; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan; Water-Electrolyte Balance	2011
The potential role for lixivaptan in heart failure and in hyponatremia. Expert opinion on investigational drugs, 2011, Volume: 20, Issue:6 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzamides; Heart Failure; Humans; Hyponatremia; Plasma Volume; Pyrroles	2011
[Hyponatremic hypervolemia in heart failure--the hot spot for vasopressin receptor antagonists?]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2012, Volume: 65, Issue:1 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Benzazepines; Diuretics; Heart Failure; Humans; Hyponatremia; Hypovolemia; Morpholines; Pyrroles; Spiro Compounds; Tolvaptan	2012
Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis. Clinical science (London, England : 1979), 2003, Volume: 105, Issue:1 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Diuretics; Heart Failure; Homeostasis; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Animal; Morpholines; Piperidines; Pyrroles; Quinolones; Rats; Spiro Compounds; Vasopressins	2003
Vasopressin receptor antagonists in heart failure. Current opinion in pharmacology, 2003, Volume: 3, Issue:6 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Randomized Controlled Trials as Topic; Tolvaptan	2003
Role of vasopressin antagonists in the management of acute decompensated heart failure. Current heart failure reports, 2005, Volume: 2, Issue:3 Topics: Acute Disease; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Stroke Volume; Tolvaptan; Treatment Outcome; Vasoconstriction; Vasopressins	2005
Vasopressin receptor antagonists. Kidney international, 2006, Volume: 69, Issue:12 Topics: Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Clinical Trials as Topic; Diabetes Insipidus, Nephrogenic; Fibrosis; Heart Failure; Humans; Hyponatremia; Osmolar Concentration; Polycystic Kidney Diseases; Pyrroles; Receptors, Vasopressin; Sodium; Tolvaptan; United States; United States Food and Drug Administration; Vasopressins	2006
[Arginine vasopressin antagonism--new treatment option in chronic heart failure]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Jan-18, Volume: 127, Issue:2 Topics: Animals; Antidiuretic Agents; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Nephrons; Prognosis; Pyrroles; Receptors, Vasopressin; Tolvaptan; Treatment Outcome; Vasoconstrictor Agents	2007
Therapeutic potential of vasopressin receptor antagonists. Drugs, 2007, Volume: 67, Issue:6 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Morpholines; Pyrroles; Receptors, Vasopressin; Spiro Compounds; Tolvaptan	2007
Hyponatremia and vasopressin antagonism in congestive heart failure. Clinical cardiology, 2007, Volume: 30, Issue:11 Topics: Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Chronic Disease; Clinical Trials as Topic; Diuretics; Heart Failure; Humans; Hyponatremia; Models, Biological; Pyrroles; Registries; Renin-Angiotensin System; Sodium; Tolvaptan; Treatment Outcome; Vasopressins	2007
Vasopressin receptor antagonists in heart failure. Recent patents on cardiovascular drug discovery, 2006, Volume: 1, Issue:2 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Heart Failure; Humans; Pyrroles; Receptors, Vasopressin; Tolvaptan; Vasopressins	2006
Vasopressin-receptor antagonists in heart failure. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2008, May-01, Volume: 65, Issue:9 Topics: Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Benzazepines; Cardiovascular Agents; Chronic Disease; Heart Failure; Humans; Hyponatremia; Pyrroles; Receptors, Vasopressin; Tolvaptan	2008
VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist. Advances in experimental medicine and biology, 1998, Volume: 449 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Azepines; Benzamides; Blood Pressure; Cyclic AMP; Dogs; Heart Failure; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney; Pyrroles; Receptors, Vasopressin	1998

Trials

3 trial(s) available for lixivaptan and Heart Failure

Article	Year
The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study. European journal of heart failure, 2012, Volume: 14, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Benzamides; Body Weight; Double-Blind Method; Female; Health Status Indicators; Heart Failure; Humans; Hyponatremia; Male; Middle Aged; Outpatients; Pyrroles; Statistics as Topic; Stroke Volume; Ventricular Function, Left; Young Adult	2012
A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial. Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:1 Topics: Aldosterone; Antidiuretic Hormone Receptor Antagonists; Ascites; Azepines; Benzamides; Edema; Female; Heart Failure; Hemodynamics; Humans; Hyponatremia; Inappropriate ADH Syndrome; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Pyrroles; Renin; Sodium; Thirst; Treatment Outcome; Water-Electrolyte Balance	2003
Selective V2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure. Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:10 Topics: Administration, Oral; Aged; Aquaporin 2; Aquaporin 6; Aquaporins; Arginine Vasopressin; Azepines; Benzamides; Biomarkers; Blotting, Western; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Pyrroles; Reference Values; Sensitivity and Specificity	1999

Other Studies

1 other study(ies) available for lixivaptan and Heart Failure

Article	Year
Lixivaptan for hyponatremia--the numbers game. JAMA, 2012, Dec-12, Volume: 308, Issue:22 Topics: Antidiuretic Hormone Receptor Antagonists; Benzamides; Biomarkers; Data Interpretation, Statistical; Drug Approval; Heart Failure; Humans; Hyponatremia; Length of Stay; Pyrroles; Risk; Severity of Illness Index; Sodium; Treatment Outcome; United States; United States Food and Drug Administration	2012