lithium-cobalt-oxide and Pneumonia

Li-ion batteries (LIB) are increasingly used worldwide. They are made of low solubility micrometric particles, implying a potential for inhalation toxicity in occupational settings and possibly for consumers. LiCoO. By testing a set of 5 selected LIB particles (LCO, LiNiMnCoO. We conclude that HIF-1α, stabilized in lung cells by released Co and Ni ions, is a mechanism-based biomarker of lung inflammatory responses induced by LIB particles containing Co/Ni. Documenting the Co/Ni content of LIB particles, their bioaccessibility and their capacity to stabilize HIF-1α in vitro can be used to predict the lung inflammatory potential of LIB particles.

Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Culture Techniques; Cell Line; Cobalt; Cytokines; Dose-Response Relationship, Drug; Epithelial Cells; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhalation Exposure; Ions; Lung; Mice; Mice, Inbred C57BL; Oxides; Particle Size; Pneumonia

Rechargeable Li-ion batteries (LIB) are increasingly produced and used worldwide. LIB electrodes are made of micrometric and low solubility particles, consisting of toxicologically relevant elements. The health hazard of these materials is not known. Here, we investigated the respiratory hazard of three leading LIB components (LiFePO

Topics: Administration, Inhalation; Air Pollutants; Animals; Biological Availability; Bronchoalveolar Lavage Fluid; Cobalt; Electric Power Supplies; Female; Fibrosis; Iron; Lithium; Lung; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Oxides; Particle Size; Pneumonia; Titanium; Toxicity Tests