lithium-chloride and Neutropenia

Topics: Adult; Antimanic Agents; Antipsychotic Agents; Clozapine; Humans; Lithium Chloride; Male; Mental Disorders; Neutropenia

Topics: Agranulocytosis; Chlorides; Drug Combinations; Drug Therapy, Combination; Female; Glycogen Storage Disease Type I; Hematopoiesis; Humans; Ketoconazole; Leukocyte Count; Lithium; Lithium Chloride; Neutropenia; Skin Diseases, Infectious; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Adult; Agranulocytosis; Animals; B-Lymphocytes; Chlorides; Dogs; Female; Humans; Leukocyte Count; Lithium; Lithium Chloride; Lymphocyte Activation; Male; Mitogens; Neutropenia; Neutrophils; Periodicity; Phytohemagglutinins; T-Lymphocytes

The blood neutrophil response to lithium chloride challenge was determined in one-day-old and young adult rats to test the hypothesis that granulocytopoiesis is less efficient in neonates than in adults. Adult animals responded rapidly to lithium chloride treatment, showing a 134% increase in blood neutrophils on the second day of exposure and ultimately increasing by 260% by the tenth day. Newborn rats on the other hand, showed a 25% decrease in blood neutrophils after one day of treatment with lithium, then remained at that or at pretreatment levels throughout the subsequent 10 days. These observations suggest that hematopoietic tissue in the newborn is less responsive than is that of adults.

Topics: Age Factors; Animals; Animals, Newborn; Chlorides; Female; Leukocyte Count; Lithium; Lithium Chloride; Male; Neutropenia; Neutrophils; Rats; Rats, Inbred Strains

Topics: Agranulocytosis; Child; Child, Preschool; Chlorides; Colony-Forming Units Assay; Female; Glycogen Storage Disease Type I; Granulocytes; Humans; Infant; Leukocyte Count; Lithium; Lithium Chloride; Monocytes; Neutropenia; Neutrophils