lithium-chloride and Immunologic-Deficiency-Syndromes

lithium-chloride has been researched along with Immunologic-Deficiency-Syndromes* in 2 studies

Other Studies

2 other study(ies) available for lithium-chloride and Immunologic-Deficiency-Syndromes

Article	Year
Effects of inositol, LiCl, and heparin on the antibody responses to SRBC by normal and immunodeficient XID mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 224, Issue:3 Spleen cells from naïve adult immunocompetent and immunodeficient XID mice were cultured on agar containing sheep red blood cells (SRBC) with and without myo-inositol, scyllo-inositol, lithium chloride, or heparin, and after 1 or 2 days the number of colonies of antiSRBC antibody-forming cells (PFC) were determined. It was found that myo-inositol and scyllo-inositol at one-tenth the concentration were equally effective in increasing the number of specific PFC. Myo-inositol, scyllo-inositol, and lithium chloride accelerated the appearance of direct foci in cultures of spleen cells from normal and XID mice. When heparin was added to cultures of XID spleen cells, PFC were found to be increased on Day 1; however, PFC and foci were not increased in cultures of spleen cells from competent mice until 1 day later. The addition of combinations of these agents to cultures of spleen cells had no positive or negative effect on the generation of foci or PFC. Normal mice given heparin intraperitoneally with SRBC had increased splenic PFC on Days 3 and 4 but not on Day 7. The results suggest that these agents modulate B-cell responses by increasing the rate of proliferation and/or secretion through a signaling pathway(s) distal to, or more likely, independent of Bruton's tyrosine Kinase (BTK). It is not clear that the mechanism is the same with each agent. Topics: Animals; Antibody Formation; B-Lymphocytes; Erythrocytes; Female; Heparin; Immunologic Deficiency Syndromes; Inositol; Lithium Chloride; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Mice, Mutant Strains; Sheep; Spleen	2000
[Fatal granulocyte function defect in a male infant. Results of in vitro and in vivo stimulation with ascorbic acid as well as in vitro stimulation with levamisol and lithium chloride]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1982, Volume: 130, Issue:12 We report about a boy who suffered from repeated bacterial infections starting at the age of 4 weeks. A severe defect of chemotactic activity of the neutrophils, and an additional deficient phagocytosis were discovered. The child died at the age of 3 months from septicemia. Chemotactic activity could be stimulated in vitro by ascorbic acid and levamisole but not by lithium chloride. In vivo, however, the effect of ascorbic acid was minimal and treatment with this vitamin could not prevent the lethal end. Topics: Ascorbic Acid; Chemotaxis, Leukocyte; Chlorides; Dose-Response Relationship, Drug; Granulocytes; Humans; Immunologic Deficiency Syndromes; Infant; Levamisole; Lithium; Lithium Chloride; Male; Phagocytosis	1982

Article

Year

Effects of inositol, LiCl, and heparin on the antibody responses to SRBC by normal and immunodeficient XID mice.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 224, Issue:3

Spleen cells from naïve adult immunocompetent and immunodeficient XID mice were cultured on agar containing sheep red blood cells (SRBC) with and without myo-inositol, scyllo-inositol, lithium chloride, or heparin, and after 1 or 2 days the number of colonies of antiSRBC antibody-forming cells (PFC) were determined. It was found that myo-inositol and scyllo-inositol at one-tenth the concentration were equally effective in increasing the number of specific PFC. Myo-inositol, scyllo-inositol, and lithium chloride accelerated the appearance of direct foci in cultures of spleen cells from normal and XID mice. When heparin was added to cultures of XID spleen cells, PFC were found to be increased on Day 1; however, PFC and foci were not increased in cultures of spleen cells from competent mice until 1 day later. The addition of combinations of these agents to cultures of spleen cells had no positive or negative effect on the generation of foci or PFC. Normal mice given heparin intraperitoneally with SRBC had increased splenic PFC on Days 3 and 4 but not on Day 7. The results suggest that these agents modulate B-cell responses by increasing the rate of proliferation and/or secretion through a signaling pathway(s) distal to, or more likely, independent of Bruton's tyrosine Kinase (BTK). It is not clear that the mechanism is the same with each agent.

Topics: Animals; Antibody Formation; B-Lymphocytes; Erythrocytes; Female; Heparin; Immunologic Deficiency Syndromes; Inositol; Lithium Chloride; Male; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Mice, Mutant Strains; Sheep; Spleen

2000

[Fatal granulocyte function defect in a male infant. Results of in vitro and in vivo stimulation with ascorbic acid as well as in vitro stimulation with levamisol and lithium chloride].

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1982, Volume: 130, Issue:12

We report about a boy who suffered from repeated bacterial infections starting at the age of 4 weeks. A severe defect of chemotactic activity of the neutrophils, and an additional deficient phagocytosis were discovered. The child died at the age of 3 months from septicemia. Chemotactic activity could be stimulated in vitro by ascorbic acid and levamisole but not by lithium chloride. In vivo, however, the effect of ascorbic acid was minimal and treatment with this vitamin could not prevent the lethal end.

Topics: Ascorbic Acid; Chemotaxis, Leukocyte; Chlorides; Dose-Response Relationship, Drug; Granulocytes; Humans; Immunologic Deficiency Syndromes; Infant; Levamisole; Lithium; Lithium Chloride; Male; Phagocytosis

1982