Page last updated: 2024-08-21

lithium carbonate and ALS - Amyotrophic Lateral Sclerosis

lithium carbonate has been researched along with ALS - Amyotrophic Lateral Sclerosis in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (23.53)29.6817
2010's12 (70.59)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Al-Chalabi, A; Chiò, A; Corcia, P; de Pagter, MS; Demaegd, KC; Gijzen, M; Hardiman, O; Ingre, C; Janse, AFC; Kiernan, MC; Povedano, M; Reviers, E; Roes, KCB; Sleutjes, BTHM; Van Damme, P; van den Berg, LH; van Eijk, RPA; van Es, MA; Vink, RG; Willemse, SW; Wray, NR1
Al-Chalabi, A; Borghero, G; Chio, A; Diekstra, FP; Eijkemans, MJC; Jones, AR; Leigh, PN; Mandrioli, J; Mora, G; Shatunov, A; Shaw, CE; Shaw, PJ; Sproviero, W; van den Berg, LH; van Eijk, RPA; van Es, MA; van Rheenen, W; Veldink, JH; Verstraete, E; Volanti, P; Young, CA1
Addison-Jones, R; Al-Chalabi, A; Barrett, W; Birt, J; Burn, DJ; Clarke, J; Copeland, L; Cosby, C; Crawford, SE; Dhariwal, S; Dodds, S; Dougherty, A; Ealing, J; Ellis, CM; Eziefula, C; Hamdalla, H; Hanemann, CO; Hare, M; Hewamadduma, C; Hibberd, R; Hollinger, H; Hornabrook, R; Howard, R; Iman, I; Kelly, J; Khoo, TK; Leigh, PN; Leroi, I; Majid, T; McDermott, C; Merritt, C; Mils, G; Morrison, KE; Murphy, C; Murphy, CL; O'Hanlon, K; O'Keeffe, F; Orrell, R; Oughton, E; Panicker, J; Partington, L; Pate, L; Paterson, P; Philips, C; Rafiq, M; Ray, P; Rog, D; Sathish, A; Savage, L; Sexton, D; Shaw, PJ; Sidle, K; Smith, J; Steen, IN; Sylvester, R; Talbot, K; Taylor, A; Thornhill, M; Timings, L; Turner, MR; Vanek, H; Waines, E; Walsh, T; Whatley, C; Wijesekera, L; Williams, C; Williams, J; Williams, TL; Wyatt, L; Young, CA1
Giakalou, VV; Giotakos, O; Nisianakis, P; Tsouvelas, G1
Alcaraz-Zubeldia, M; Bayliss, L; Boll, MC; Burgos, J; Montes, S; Peñaloza-Solano, G; Rios, C; Vargas-Cañas, S1
Bendotti, C; Caron, I; Carrì, MT; Daleno, C; Minoia, C; Pizzasegola, C; Ronchi, A1
Gill, A; Kidd, J; Perrin, S; Thompson, K; Vieira, F1
England, JD; Forshew, D; Jackson, CE; Johnston, W; Kalra, S; Kasarskis, EJ; Katz, JS; Miller, RG; Mitsumoto, H; Rosenfeld, J; Shoesmith, C; Strong, MJ; Woolley, SC1
Armon, C1
Beghi, E; Borghero, G; Calvo, A; Capasso, M; Caponnetto, C; Chiò, A; Corbo, M; Giannini, F; Logroscino, G; Mandrioli, J; Marcello, N; Mazzini, L; Moglia, C; Monsurrò, MR; Mora, G; Patti, F; Perini, M; Pietrini, V; Pisano, F; Pupillo, E; Sabatelli, M; Salvi, F; Silani, V; Simone, IL; Sorarù, G; Tola, MR; Volanti, P1
Mazzini, L; Monaco, F; Nasuelli, N; Oggioni, GD; Servo, S; Testa, L1
Heywood, J; Massagli, MP; Vaughan, TE; Wicks, P1
Bedlack, R; Donofrio, PD1
Appel, SH; Barohn, RJ; Bromberg, MB; Florence, JM; Forshew, DA; Goslin, KL; Graves, MC; Katz, JS; McCluskey, LF; McVey, AL; Miller, RG; Moore, DH; Mozaffar, T; Pestronk, A; Ross, M; Simpson, EP; Valan, M1
Al-Chalabi, A; Kelly, J; Leigh, PN; Morrison, KE; Murphy, C; Shaw, PJ; Steen, IN; Thornhill, M; Young, CA1
de Visser, M; Draak, T; Huisman, MH; Schelhaas, HJ; Uijtendaal, EV; van den Berg, LH; van der Kooi, AJ; van der Tweel, I; Veldink, JH; Verstraete, E1
Cho, SI; Gwag, BJ; Joo, IS; Kim, KW; Lee, JK; Lee, YA; Lim, HR; Noh, JS; Shin, JH1

Reviews

2 review(s) available for lithium carbonate and ALS - Amyotrophic Lateral Sclerosis

ArticleYear
Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials.
    Neurology, 2017, Oct-31, Volume: 89, Issue:18

    Topics: Amyotrophic Lateral Sclerosis; C9orf72 Protein; Genotype; Lithium Carbonate; Nerve Tissue Proteins; Neuroprotective Agents; Pharmacogenetics; Proportional Hazards Models; Proteins; Randomized Controlled Trials as Topic

2017
Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.
    Neurology, 2009, Oct-13, Volume: 73, Issue:15

    Topics: Amyotrophic Lateral Sclerosis; Enteral Nutrition; Evidence-Based Medicine; Humans; Lithium Carbonate; Quality of Life; Respiratory Therapy; Riluzole

2009

Trials

6 trial(s) available for lithium carbonate and ALS - Amyotrophic Lateral Sclerosis

ArticleYear
Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial.
    Trials, 2022, Dec-05, Volume: 23, Issue:1

    Topics: Alleles; Amyotrophic Lateral Sclerosis; Humans; Lithium Carbonate; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Quality of Life; Randomized Controlled Trials as Topic; Respiratory Insufficiency

2022
Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial.
    The Lancet. Neurology, 2013, Volume: 12, Issue:4

    Topics: Aged; Amyotrophic Lateral Sclerosis; Double-Blind Method; Female; Humans; Lithium Carbonate; Male; Middle Aged; Neuroprotective Agents; Survival Rate; Treatment Outcome

2013
Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial.
    Neurology, 2010, Aug-17, Volume: 75, Issue:7

    Topics: Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Lithium Carbonate; Male; Middle Aged; Retrospective Studies; Single-Blind Method; Time Factors; Treatment Outcome; Young Adult

2010
Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: examining a more efficient trial design.
    Neurology, 2011, Sep-06, Volume: 77, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Disease Progression; Female; Humans; Lithium Carbonate; Male; Mass Screening; Middle Aged; Research Design; Young Adult

2011
Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS) [Eudract number: 2008-006891-31].
    BMC neurology, 2011, Sep-21, Volume: 11

    Topics: Adult; Amyotrophic Lateral Sclerosis; Clinical Protocols; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Male; Neuroprotective Agents; Placebos; Psychiatric Status Rating Scales; Riluzole; Severity of Illness Index

2011
Lithium lacks effect on survival in amyotrophic lateral sclerosis: a phase IIb randomised sequential trial.
    Journal of neurology, neurosurgery, and psychiatry, 2012, Volume: 83, Issue:5

    Topics: Activities of Daily Living; Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Male; Middle Aged; Pulmonary Ventilation; Riluzole; Survival Rate; Vital Capacity

2012

Other Studies

9 other study(ies) available for lithium carbonate and ALS - Amyotrophic Lateral Sclerosis

ArticleYear
Lithium in the public water supply and suicide mortality in Greece.
    Biological trace element research, 2013, Volume: 156, Issue:1-3

    Topics: Amyotrophic Lateral Sclerosis; Crime; Drinking Water; Female; Greece; Humans; Incidence; Lithium; Lithium Carbonate; Male; Retrospective Studies; Suicide

2013
Clinical and biological changes under treatment with lithium carbonate and valproic acid in sporadic amyotrophic lateral sclerosis.
    Journal of the neurological sciences, 2014, May-15, Volume: 340, Issue:1-2

    Topics: Amyotrophic Lateral Sclerosis; Cadmium; Cause of Death; Disability Evaluation; Enzyme Inhibitors; Female; Follow-Up Studies; Glutathione; Glutathione Peroxidase; Humans; Kaplan-Meier Estimate; Lithium Carbonate; Male; Middle Aged; Statistics, Nonparametric; Superoxide Dismutase; Superoxide Dismutase-1; Valproic Acid

2014
Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice.
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2009, Volume: 10, Issue:4

    Topics: Amyotrophic Lateral Sclerosis; Animals; Antimanic Agents; Behavior, Animal; Biomarkers; Body Weight; Disease Models, Animal; Disease Progression; Female; Humans; Lithium Carbonate; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Survival Rate

2009
No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS.
    PloS one, 2009, Aug-03, Volume: 4, Issue:8

    Topics: Amyotrophic Lateral Sclerosis; Animals; Body Weight; Disease Models, Animal; Female; Humans; Lithium Carbonate; Male; Mice; Proportional Hazards Models; Severity of Illness Index; Survival Analysis

2009
Is the lithium-for-ALS genie back in the bottle?: Not quite.
    Neurology, 2010, Aug-17, Volume: 75, Issue:7

    Topics: Amyotrophic Lateral Sclerosis; Enzyme Inhibitors; Humans; Lithium Carbonate

2010
Disabling Parkinsonism following brief exposure to lithium carbonate in amyotrophic lateral sclerosis.
    Journal of neurology, 2011, Volume: 258, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Enzyme Inhibitors; Humans; Lithium Carbonate; Male; Middle Aged; Neurotoxicity Syndromes; Parkinsonian Disorders

2011
Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm.
    Nature biotechnology, 2011, Volume: 29, Issue:5

    Topics: Algorithms; Amyotrophic Lateral Sclerosis; Case-Control Studies; Female; Humans; Internet; Lithium Carbonate; Male; Middle Aged; Riluzole; Risk Factors; Self Report; Sex Distribution; Treatment Outcome

2011
Historical controls in ALS trials: a high seas rescue?
    Neurology, 2011, Sep-06, Volume: 77, Issue:10

    Topics: Amyotrophic Lateral Sclerosis; Disease Progression; Female; Humans; Lithium Carbonate; Male; Mass Screening

2011
Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis.
    Molecular pharmacology, 2007, Volume: 71, Issue:4

    Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Benzoates; Cell Survival; Disease Models, Animal; Drug Therapy, Combination; fas Receptor; Fluorobenzenes; Lithium Carbonate; meta-Aminobenzoates; Mice; Mortality; Motor Activity; Motor Neurons; Oxidative Stress; Salicylates

2007