lisinopril and Skin-Neoplasms

The problem of contamination of the most commonly used medicines with nitrosamines is worsening worldwide. According to recent literature data, this "contamination" is the cause not only of skin cancer (keratinocytic/melanoma) but also of gastrointestinal neoplasms, brain tumours, neuroblastoma, rectal carcinoma, acute lymphoblastic leukaemia, and many others. It is these clinical manifestations that are associated with/ or already directly linked to the nitrosamine content of drugs and food products used by patients in previous periods. And it is this permissive availability/contamination that could prove to be the most likely, powerful inducer of acquired mutations underlying the worldwide cancer pandemic. Of further concern is the evidence of contamination of newer classes of medications by nitrosamines- namely: beta blockers, calcium antagonists and selective serotonin reuptake inhibitors (SSRIs). In practice, mankind faces the problem of certainly over 1 billion patients taking nitrosamine-contaminated drugs: 280 million patients with depression (antidepressants), over 1 billion patients with arterial hypertension (antihypertensive drugs), over half a billion patients with type 2 diabetes mellitus (oral antidiabetic drugs/metformin/ sitagliptin), over 4 billion patients with gastritis (ranitidine), over 5 million with tuberculosis (rifampicin), and probably a number of others. The calculations are apocalyptic, since even if only 20-30% of the groups were affected, the number of patients taking these drugs would, by a rough calculation, currently amount to over 1 billion. And there are certainly other classes of drugs yet to be announced. It is for this reason that we should not be surprised that the data on the development of keratinocyte cancer after intake of nitrosamine-contaminated preparations is growing at a breakneck pace. This data indirectly but strongly confirms the importance of a newly introduced concept in the medical science : Nitrosogenesis of skin cancer. A concept, until recently unknown, incomprehensible, but at the same time frightening and gradually accepted, imposing itself and which with each passing day is gaining more and more scientific significance and "visibility", "scientific tangibility, receptivity, and acceptability." This article presents, for the first time in the world literature, patients who developed single/multiple forms of keratinocytic cancer (partly in combination with melanoma precursors-dysplastic moles) aft

Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bisoprolol; Calcium; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Felodipine; Humans; Lisinopril; Melanoma; Metoprolol; Nitrosamines; Perindopril; Prospective Studies; Skin Neoplasms; Sodium Chloride Symporter Inhibitors; Thiazides

Nevus oligemicus is a rare lesion characterized by selective vasoconstriction of the deep dermal vascular plexus compared with the superficial one. It has been suggested that it may be caused by increased sympathetic tone in the deep dermal vascular plexus or an abnormality of hormone receptors, which is why it is considered a functional nevus. Clinically, it presents as an asymptomatic, fixed, livid erythematous macule with a striking decrease in local temperature compared with surrounding healthy skin.. We report the case of a 59-year-old man with a 2-year history of three large areas of persistent and asymptomatic livid erythema on trunk and flanks. These areas blanched under light pressure. Measurement of the surface temperature of the patch revealed a decrease of up to 2.5 degrees C with respect to surrounding skin. Histology showed superficial dermal capillary dilatation without other significant findings. The fixed nature of the lesions, consistent histopathology, and the finding of localized hypothermia allowed the diagnosis of nevus oligemicus.. The diagnosis is mainly clinical. Our case is the eleventh case of nevus oligemicus reported in the literature.

Topics: Aged; Antihypertensive Agents; Humans; Hypertension; Lisinopril; Male; Nevus; Prostatic Hyperplasia; Skin Neoplasms; Sulfonamides; Torsemide

Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Coronary Artery Disease; Diuretics; Exanthema; Humans; Hydrochlorothiazide; Lisinopril; Lymphoma, Large B-Cell, Diffuse; Male; Platelet Aggregation Inhibitors; Skin Neoplasms; Sotalol; Stents; Ticlopidine

Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Drug Eruptions; Herpes Zoster; Humans; Lisinopril; Opportunistic Infections; Sarcoma, Kaposi; Skin Neoplasms

Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Drug Eruptions; Humans; Lisinopril; Male; Sarcoma, Kaposi; Skin Neoplasms