lisinopril has been researched along with Glioma* in 1 studies
1 other study(ies) available for lisinopril and Glioma
| Article | Year |
|---|---|
The renin-angiotensin system in hybrid NG108-15 cells. Renin gene is from mouse neuroblastoma, angiotensinogen and angiotensin-converting enzyme genes are of rat glioma origin.
Angiotensin II (Ang II) increases the level of tyrosine phosphorylation of several proteins in nondifferentiated NG108-15 cells, a hybrid derived from the fusion of mouse neuroblastoma and rat glioma cells. Conversely, incubation of NG108-15 cells with an angiotensin-converting enzyme (ACE) inhibitor decreased the basal level of tyrosine phosphorylation of proteins, suggesting that locally secreted Ang II may act as an autocrine regulator. By RT-PCR, we found that nondifferentiated NG108-15 cells contained the mRNA transcript of the rat angiotensinogen, mouse renin and rat ACE genes, thus confirming that NG108-15 cells contain all the elements of a local renin-angiotensin system. Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Cell Line; DNA Primers; Glioma; Hybrid Cells; Lisinopril; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Phosphorylation; Polymerase Chain Reaction; Rats; Renin-Angiotensin System; RNA, Messenger | 1998 |