lisdexamfetamine-dimesylate and Myocardial-Infarction

Stimulant medications like amphetamines have been associated with various cardiovascular complications like coronary artery spasm, coronary dissections and thrombus formation, the pathophysiology of which is theorized to be the endothelial damage induced by the medication and the inflammatory cascade that follows. We report a case of 52-year-old male on lisdexamfetamine, a newer stimulant agent used for attention deficit hyperactivity disorder (ADHD) who presented with sudden chest pain and ECG changes concerning for myocardial infarction and mildly elevated troponins. However, coronary angiogram showed no obstructive coronary artery disease and there was spontaneous resolution of his symptoms and ECG changes.

Topics: Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Humans; Lisdexamfetamine Dimesylate; Male; Middle Aged; MINOCA; Myocardial Infarction; Risk Factors