lisdexamfetamine-dimesylate and Cat-Diseases

To describe the clinical course and novel biochemical changes in 3 cats with lisdexamfetamine (LDX) toxicosis.. Three cats presented with LDX exposure and initially displayed typical clinical signs of amphetamine toxicosis. However, over the course of hospitalization, hypoglycemia and markedly elevated creatine kinase levels consistent with rhabdomyolysis ensued. All cats were treated with sedatives including phenothiazines and dexmedetomidine. Two cats were hospitalized for 4 days and 1 for 5 days. All cats survived.. This is the first case series in cats that reports the novel biochemical changes of delayed hypoglycemia and elevated creatine kinase several days into hospitalization for the treatment of LDX toxicity. The development of delayed clinical signs suggests reconsideration of established hospitalization guidelines for amphetamine ingestion in cats.

Topics: Animals; Cat Diseases; Cats; Dextroamphetamine; Hypoglycemia; Lisdexamfetamine Dimesylate; Rhabdomyolysis

A 5-month-old intact female domestic shorthaired cat had mydriasis, agitation, and increased locomotion after ingestion of lisdexamfetamine, 10.3 mg/kg body weight (BW). Despite treatment with IV fluids, IV acepromazine, oral cyproheptadine and intravenous lipid emulsion the patient's clinical signs worsened. Dexmedetomidine administered at 2 μg/kg BW and continued at 0.5 μg/kg BW per hour rapidly controlled the patient's signs. An episode of vomiting and hematuria developed. Follow-up 5 days after discharge revealed that the cat appeared normal.

Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cat Diseases; Cats; Dexmedetomidine; Female; Lisdexamfetamine Dimesylate; Serotonin Syndrome