lipoxin-b4 and Influenza--Human

Vaccination has been the most effective way to prevent or reduce infectious diseases; examples include the eradication of smallpox and attenuation of tetanus and measles. However, there is a large segment of the population that responds poorly to vaccines, in part because they are immunocompromised because of disease, age, or pharmacologic therapy and are unable to generate long-term protection. Specialized proresolving mediators are endogenously produced lipids that have potent proresolving and anti-inflammatory activities. Lipoxin B

Topics: Adaptive Immunity; Adjuvants, Immunologic; Antibodies, Viral; Antibody Formation; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Humans; Immunologic Memory; Influenza Vaccines; Influenza, Human; Lipoxins; Positive Regulatory Domain I-Binding Factor 1; Up-Regulation; Vaccination; X-Box Binding Protein 1