lipoxin a4 has been researched along with Disease Models, Animal in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.69) | 18.2507 |
| 2000's | 9 (14.06) | 29.6817 |
| 2010's | 46 (71.88) | 24.3611 |
| 2020's | 6 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chen, R; He, C; Liu, Y; Meng, L; Wei, L | 1 |
| Hao, H; Xu, F; Zhang, J; Zhou, X | 1 |
| Dec, K; Drozd, A; Jakubczyk, K; Maciejewska, D; Pilutin, A; Skonieczna-Żydecka, K; Skórka-Majewicz, M; Stachowska, E | 1 |
| Chen, BW; Chen, SQ; Fu, CC; Fu, XQ; He, MZ; Li, PJ; Lin, ZL; Yu, BY; Zheng, YH; Zhu, JH; Zhu, JJ | 1 |
| Bazan, HEP; Bazan, NG; Calandria, J; Do, KV; He, J; Kakazu, AH; Lam, TF; Nshimiyimana, R; Petasis, NA; Pham, TL | 1 |
| Feng, X; Koliwad, SK; Lutrin, D; Maze, M; Uchida, Y; Valdearcos, M | 1 |
| Alexander, JC; Candelario-Jalil, E; de Leon, LG; DeMars, KM; Febo, M; Frankowski, JC; Garrett, TJ; Graves, C; Hawkins, KE; McCrea, AO; Pacheco, SC; Yang, C | 1 |
| Bai, L; Kong, Y; Wang, Y; Yang, Y; Zhang, X | 1 |
| Chen, QH; Chen, QX; Dai, SJ; Huang, ZX; Lin, DC; Ng, TW; Ran, J; Wu, RF | 1 |
| Chen, H; Duan, X; Gan, L; He, M; Hu, F; Liu, X; Ming, Z; Poorun, D; Wang, X; Xu, J; Zhang, S; Zhu, K | 1 |
| Bahl, CD; Bomberger, JM; Dolben, E; Flitter, BA; Hampton, TH; Hogan, DA; Hvorecny, KL; Levy, BD; Madden, DR; Moreau-Marquis, S; Shabaneh, TB; Stanton, BA | 1 |
| Aytan, N; Benincasa, C; Carreras, I; Crabtree, L; Dedeoglu, A; Jenkins, BG; Kantarci, A; Palaska, I; Stephens, D | 1 |
| Dong, Y; Duan, Y; Liu, X; Lu, T; Shang, C; Wei, N; Wu, X; Zhou, Y | 1 |
| Bae, JS; Baek, B; Choi, MK; Han, SH; He, X; Jin, HK; Kim, SH; Lee, JY; Park, MH; Ryu, H; Schuchman, EH; Song, IS; Takuwa, Y | 1 |
| Chen, QF; Hao, H; Huang, YH; Kuang, XD; Yuan, QF; Zhang, T; Zhou, XY | 1 |
| Ellett, F; Feng, Y; Lee, JA; Levy, BD; Loynes, CA; Renshaw, SA; Robertson, AL; Steel, MJ; Whyte, MKB | 1 |
| Aronica, E; Colas, RA; Craparotta, I; Dalli, J; Foerch, P; Frigerio, F; Hansen, TV; Kaminski, RM; Leclercq, K; Marchini, S; Pasqualini, G; Perretti, M; Pistorius, K; Porcu, L; van Vliet, EA; Vandenplas, C; Vezzani, A | 1 |
| Bielenberg, DR; Gartung, A; Gilligan, MM; Huang, S; Kieran, MW; Norris, PC; Panigrahy, D; Serhan, CN; Sukhatme, VP; Sulciner, ML | 1 |
| Gao, Y; Lu, Z; Yin, ZQ; Zhang, H; Zhang, X | 1 |
| Campos-Estrada, C; Castillo, C; Escanilla, S; Faúndez, M; Henriquez, N; Kemmerling, U; López-Muñoz, RA; Maya, JD; Molina-Berríos, A; Morello, A; Torres, G | 1 |
| Du, J; Hu, X; Shao, L; Wu, G; Xia, J; Zhao, Q | 1 |
| Cebrián, C; Esquivias, P; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S | 1 |
| Huang, Y; Lin, F; Wang, N; Xiang, H; Xu, Z; Ye, D; Zhao, F | 1 |
| Hu, S; Jiang, JW; Li, Q; Liu, SB; Ma, HJ; Mao-Ying, QL; Mi, WL; Tian, Y; Wang, YQ; Wang, ZF; Wu, GC; Zhao, J | 1 |
| Freedman, SD; Gilkey, C; Hasturk, H; Kantarci, A; Martin, CR; Salguero, MV; Van Dyke, TE; Zaman, MM | 1 |
| Allen, MJ; Beckham, Y; Birukov, KG; Birukova, AA; Gardel, ML; Leff, A; Mambetsariev, I; Meliton, A; Meng, F; Tian, Y | 1 |
| Ager, RR; Baglietto-Vargas, D; Cheng, D; Cribbs, DH; Dunn, HC; Kitazawa, M; Medeiros, R | 1 |
| Haworth, O; Karra, L; Levi-Schaffer, F; Levy, BD; Priluck, R | 1 |
| Rodriguez, A; Spur, B; Walker, J; Wu, B; Yin, K | 1 |
| Catalano, RD; Norman, JE; Rinaldi, SF; Rossi, AG; Wade, J | 1 |
| Antunes, B; Candéa, AP; Caruso-Neves, C; Carvalho, L; Estato, V; Henriques, MG; Maramaldo, T; Pádua, TA; Penido, C; Pinheiro, AA; Seito, LN; Silva, L; Souza Costa, MF; Souza, MC; Tibiriçá, E; Torres, ND | 1 |
| Kakutani, S; Kaneda, Y; Kawashima, H; Morita, I; Shibata, H; Tateishi, N | 1 |
| Fu, ZJ; Liu, ZH; Luo, JG; Miao, GS; Sun, T; Wei, SX | 1 |
| Bento, AF; Berta, T; Chen, G; Forner, S; Ji, RR; Martini, AC; Rae, GA | 1 |
| Han, X; Hei, Z; Li, H; Liu, Z; Xia, Z; Yao, W; Zhang, ZJ | 1 |
| Castillo, C; Cramer, A; González-Herrera, F; Kemmerling, U; Liempi, A; Machado, FS; Maya, JD; Pimentel, P | 1 |
| Cernadas, M; Haworth, O; Levy, BD; Serhan, CN; Yang, R | 1 |
| Bruni, F; Carvalho, RR; Felisbino, SL; Hiruma-Lima, CA; Justulin, L; Lopes-Ferreira, M; Pellizzon, CH; Vilegas, W | 1 |
| Chen, QH; Chen, QX; Huang, QS; Li, T; Pu, DM; Zhou, WD | 1 |
| Dong, L; Liu, B; Wu, HJ; Wu, SH | 1 |
| Croze, R; Levy, BD; Pfeffer, MA; Planagumà, A; Rubin, G; Serhan, CN; Uddin, M | 1 |
| Chen, J; Ge, S; Liu, D; Liu, X; Xu, G; Yin, Q; Zhang, R; Zhou, G; Zhu, W | 1 |
| Guo, PP; Shang, Y; Wang, J; Wu, Y; Xu, SP; Yao, SL; Ye, XH; Yuan, SY | 1 |
| Börgeson, E; Docherty, NG; Godson, C; Goldschmeding, R; Guiry, PJ; Higgins, DF; Murphy, M; O'Sullivan, TP; Rodgers, K; Ryan, A | 1 |
| Bouchier-Hayes, D; Condron, C; Cunningham, AJ; Gang, C; Scully, M | 1 |
| Altavilla, D; Bitto, A; David, A; Irrera, N; Minutoli, L; Rinaldi, M; Squadrito, F; Venuti, FS | 1 |
| Arantes, RM; Araujo, RR; Barroso, A; Brant, F; Campos, CF; Castro, LL; Cruz, JS; Esper, L; Gomes, ER; Guatimosim, S; Lara, A; Lisanti, MP; Machado, FS; Mukherjee, S; Ramos, IP; Rocha, NN; Roman-Campos, D; Tanowitz, HB; Teixeira, MM; Vieira, LQ; Weiss, LM | 1 |
| Cai, L; Hao, H; Li, HH; Miao, S; Tang, K; Wu, L; Wu, P; Wu, Q; Xiong, J; Ye, DY; Zeng, P; Zou, LB | 1 |
| Bazan, HE; He, J; Kakazu, A; Kenchegowda, S | 1 |
| Bajaj, M; Birnbaum, Y; Castillo, AC; Ling, S; Perez-Polo, JR; Qian, J; Ye, H; Ye, Y | 2 |
| Britton, SL; Chawla, A; Feng, X; Koch, LG; Matthay, MA; Maze, M; Su, X; Terrando, N; Yan, Y | 1 |
| Chen, XP; Li, BX; Li, LL; Li, QQ; Luo, CL; Tao, LY; Zhang, XM; Zhao, ZQ | 1 |
| Asadullah, K; Bauman, J; Colgan, SP; Fierro, IM; Giesen, C; Guilford, W; Parkinson, JF; Perez, HD; Schottelius, AJ | 1 |
| Arnaout, MA; Devchand, PR; Nikolic, B; Primo, VC; Schmidt, BA; Serhan, CN; Zhang, QY | 1 |
| Bonnans, C; Fredenburgh, LE; Fukunaga, K; Kohli, P; Levy, BD | 1 |
| Arroyo, V; Clària, J; Gaya, J; González-Périz, A; López-Parra, M; Miquel, R; Planagumà, A; Rodés, J; Titos, E | 1 |
| Schwab, JM; Serhan, CN | 1 |
| Baumgart, DC; Kang, JX; Weylandt, KH; Wiedenmann, B | 1 |
| Berlin, AA; Guilford, WJ; Levy, BD; Lukacs, NW; Parkinson, JF; Schmidt, B; Serhan, CN | 1 |
| Assmann, KJ; Brady, HR; Cotran, RS; Hynes, RO; Mayadas, TN; Mendrick, DL; Papayianni, A; Tang, T; Wagner, DD | 1 |
| Maddox, JF; Serhan, CN; Takano, T | 1 |
| Chiang, N; Clish, CB; Gronert, K; Serhan, CN; Takano, T | 1 |
4 review(s) available for lipoxin a4 and Disease Models, Animal
| Article | Year |
|---|---|
Lipoxins and new lipid mediators in the resolution of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Inflammation; Lipid Metabolism; Lipoxins; Signal Transduction | 2006 |
Lipoxins and resolvins in inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Inflammatory Bowel Diseases; Lipoxins; Treatment Outcome | 2007 |
Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Sequence; Binding Sites; Disease Models, Animal; Ear; Humans; Hydroxyeicosatetraenoic Acids; Leukocytes; Lipoxins; Mice; Molecular Sequence Data; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Lipoxin; Tissue Distribution | 1999 |
Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators.
Topics: Amino Acid Sequence; Animals; Aspirin; Dermatitis; Disease Models, Animal; Endothelium; Humans; Hydroxyeicosatetraenoic Acids; Lipoxins; Molecular Sequence Data; Monocytes; Neutrophils; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Lipoxin; Sequence Homology, Amino Acid | 1999 |
60 other study(ies) available for lipoxin a4 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Lipoxin A4 inhibits ovalbumin-induced airway inflammation and airway remodeling in a mouse model of asthma.
Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Lipoxins; Mice; Mice, Inbred BALB C; Ovalbumin; Trachea | 2021 |
Lipoxin A
Topics: Animals; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Foam Cells; Heptanoic Acids; Humans; Kelch-Like ECH-Associated Protein 1; Lipoxins; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Lipoxin; Signal Transduction; THP-1 Cells | 2022 |
Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?
Topics: Animals; Biomarkers; Chromatography, Liquid; Dinoprostone; Disease Models, Animal; Disease Progression; Docosahexaenoic Acids; Eicosanoids; Eicosapentaenoic Acid; Hydroxyeicosatetraenoic Acids; Linoleic Acids; Lipoxins; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2020 |
LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Hypoxia; Hypoxia-Ischemia, Brain; I-kappa B Proteins; Inflammation; Injections, Intraventricular; Lipoxins; Male; Neurons; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
ELV-N32 and RvD6 isomer decrease pro-inflammatory cytokines, senescence programming, ACE2 and SARS-CoV-2-spike protein RBD binding in injured cornea.
Topics: Angiotensin-Converting Enzyme 2; Animals; Cells, Cultured; Cellular Senescence; Corneal Injuries; COVID-19; Cytokines; Disease Models, Animal; Docosahexaenoic Acids; Drug Discovery; Epithelial Cells; Epithelium, Corneal; Humans; Lipoxins; Male; Protein Binding; Protein Domains; Rats; Rats, Sprague-Dawley; SARS-CoV-2; Signal Transduction; Spike Glycoprotein, Coronavirus; Virus Attachment; Virus Internalization | 2021 |
Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cognitive Dysfunction; Disease Models, Animal; Fear; Hippocampus; Inflammation; Lipoxins; Male; Mice; Mice, Inbred C57BL; Microglia; Neurons; Organic Chemicals; Postoperative Complications; Receptors, CCR2; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; Tibial Fractures | 2017 |
Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Heptanoic Acids; Infarction, Middle Cerebral Artery; Inflammation; Lipoxins; Male; Microglia; Protective Factors; Rats; Rats, Sprague-Dawley; Recovery of Function; Stroke; Time | 2017 |
The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats.
Topics: Animals; Blotting, Western; Cartilage, Articular; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Iodoacetates; Joints; Lipoxins; Male; NF-kappa B; Osteoarthritis; Physical Conditioning, Animal; Polymerase Chain Reaction; Rats, Sprague-Dawley; Signal Transduction | 2017 |
Lipoxin A
Topics: Adult; Animals; Cell Movement; Disease Models, Animal; Endometriosis; Endometrium; Epithelial-Mesenchymal Transition; Estradiol; Female; Humans; Lipoxins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Middle Aged; Ovarian Diseases; Phosphorylation; Young Adult | 2018 |
Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Heptanoic Acids; HMGB1 Protein; Immunohistochemistry; Inflammation Mediators; Keratinocytes; Lipoxins; Mice; Protein Transport; Psoriasis; Signal Transduction; Toll-Like Receptor 4 | 2017 |
An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
Topics: Animals; Bacterial Proteins; Biological Transport; Bronchi; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Humans; Lipoxins; Male; Mice; Mice, Inbred C57BL; Mucociliary Clearance; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Virulence Factors | 2018 |
Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Therapy, Combination; Eicosapentaenoic Acid; Female; Hippocampus; Inflammation; Lipoxins; Mice; Mice, Transgenic | 2018 |
Lipoxin A4 protects against spinal cord injury via regulating Akt/nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromones; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase-1; Lipoxins; Male; Morpholines; Neuroprotective Agents; NF-E2-Related Factor 2; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries | 2018 |
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Topics: Acetyl Coenzyme A; Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cyclooxygenase 2; Disease Models, Animal; Humans; Lipoxins; Male; Mice; Mice, Transgenic; Microglia; Neurons; Phagocytosis; Presenilin-1; Serine; Transgenes | 2018 |
Lipoxin A
Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Cell Line, Tumor; Disease Models, Animal; Humans; Imidazoles; Leucine; Lipopolysaccharides; Lipoxins; Male; Mice; NF-kappa B; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Signal Transduction | 2018 |
PGE
Topics: Animals; Animals, Genetically Modified; Cell Movement; Dinoprostone; Disease Models, Animal; Inflammation; Lipoxins; Lipoxygenases; Macrophages; Neutrophils; Phenotype; Receptors, Prostaglandin E, EP4 Subtype; Wounds and Injuries; Zebrafish | 2018 |
n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis.
Topics: Animals; Anticonvulsants; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; CD11b Antigen; Cytokines; Dinoprostone; Disease Models, Animal; Docosahexaenoic Acids; Encephalitis; Epilepsy; Gene Expression Regulation; Hippocampus; Kainic Acid; Leukotriene B4; Lipid Metabolism; Lipoxins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2018 |
Aspirin-triggered proresolving mediators stimulate resolution in cancer.
Topics: Animals; Antineoplastic Agents; Aspirin; Chemokine CCL2; Chemokines; Cytokines; Disease Models, Animal; Docosahexaenoic Acids; Eicosanoids; Fatty Acids, Unsaturated; Female; Inflammation; Lipoxins; Macrophages; Metabolomics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neoplasm Metastasis; Neoplasms; Nerve Tissue Proteins; Phagocytosis; Plasminogen Inactivators; Prostaglandins | 2019 |
Lipoxin A4 delays the progression of retinal degeneration via the inhibition of microglial overactivation.
Topics: Animals; Apoptosis; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Behavior, Animal; Cytokines; Disease Models, Animal; Disease Progression; Electroretinography; Female; Gene Expression Regulation; Humans; Intravitreal Injections; Lipoxins; Male; Mice; Microglia; Photoreceptor Cells, Vertebrate; Protein Isoforms; Receptors, Formyl Peptide; Retina; Retinal Degeneration; Vision, Ocular | 2019 |
Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection: evidence of a 15-epi-lipoxin A₄-mediated effect.
Topics: Animals; Aspirin; Cell Line; Chagas Disease; Disease Models, Animal; Lipoxins; Male; Mice; Mice, Inbred BALB C; Trypanosoma cruzi | 2013 |
LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats.
Topics: Animals; Apoptosis; Biomarkers; Caspase 12; Cytoprotection; Disease Models, Animal; Down-Regulation; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Inflammation Mediators; Lipoxins; Male; Myocardial Reperfusion Injury; Myocardium; Neutrophil Infiltration; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2014 |
Effect of aspirin treatment on the prevention of esophageal adenocarcinoma in a rat experimental model.
Topics: Adenocarcinoma; Animals; Aspirin; Barrett Esophagus; Dinoprostone; Disease Models, Animal; Esophageal Neoplasms; Gastroesophageal Reflux; Gene Expression Regulation, Neoplastic; Humans; Lipoxins; Neoplasms, Experimental; Rats | 2014 |
Preeclampsia is associated with a deficiency of lipoxin A4, an endogenous anti-inflammatory mediator.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Arachidonate Lipoxygenases; Biomarkers; Case-Control Studies; Cell Line; Disease Models, Animal; Female; Heptanoic Acids; Humans; Inflammation Mediators; Interferon-gamma; Interleukin-6; Lipopolysaccharides; Lipoxins; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Lipoxin; RNA, Messenger; Signal Transduction; Time Factors; Trophoblasts; Tumor Necrosis Factor-alpha | 2014 |
Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Astrocytes; Constriction, Pathologic; Disease Models, Animal; Hyperalgesia; Interleukin-1beta; Interleukin-6; Janus Kinase 2; Lipoxins; Male; Neuralgia; Neuroimmunomodulation; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve; Signal Transduction; Spinal Cord; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Touch; Tumor Necrosis Factor-alpha | 2014 |
Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Docosahexaenoic Acids; Female; Hyperoxia; Lipoxins; Lung Injury; Male; Mice; Mice, Inbred C57BL; Pulmonary Alveoli | 2014 |
Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Humans; Interleukin-8; Lipopolysaccharides; Lipoxins; Lung Injury; Mice, Inbred C57BL; Pneumonia; Signal Transduction | 2015 |
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Topics: Alzheimer Disease; Animals; Brain; Cognition; Disease Models, Animal; Disease Progression; Lipoxins; Mice; Mice, Transgenic; Microglia; Phosphorylation; Recognition, Psychology; Signal Transduction | 2015 |
Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice.
Topics: Animals; Cell Degranulation; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Inflammation; Leukocytes; Lipoxins; Lung; Male; Mast Cells; Mice; Mucus; Nasal Mucosa; Respiratory Hypersensitivity | 2015 |
Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteremia; Bacterial Load; Disease Models, Animal; Leukocytes; Lipoxins; Male; Neutrophil Activation; Neutrophils; Peritoneum; Phagocytosis; Rats; Rats, Sprague-Dawley | 2015 |
15-epi-lipoxin A4 reduces the mortality of prematurely born pups in a mouse model of infection-induced preterm birth.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cyclooxygenase 2; Disease Models, Animal; Female; Fetus; Gene Expression; Humans; Hydroxyprostaglandin Dehydrogenases; Lipopolysaccharides; Lipoxins; Mice; Obstetric Labor, Premature; Placenta; Pregnancy; Pregnancy Complications, Infectious; Uterus | 2015 |
Lipoxin A4 attenuates endothelial dysfunction during experimental cerebral malaria.
Topics: Animals; Brain; Cell Line; Disease Models, Animal; Endothelial Cells; Heme Oxygenase-1; Intercellular Adhesion Molecule-1; Lipoxins; Malaria, Cerebral; Male; Membrane Proteins; Mice, Inbred C57BL; Plasmodium berghei; Tumor Necrosis Factor-alpha | 2015 |
Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model.
Topics: Animals; Arachidonic Acid; Arthritis, Experimental; Bone and Bones; Dietary Supplements; Dinoprostone; Disease Models, Animal; Gene Expression Regulation; Leukotriene B4; Lipoxins; Male; Rats, Inbred Lew; Time Factors | 2015 |
Lipoxin A4 attenuates radicular pain possibly by inhibiting spinal ERK, JNK and NF-κB/p65 and cytokine signals, but not p38, in a rat model of non-compressive lumbar disc herniation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Intervertebral Disc Degeneration; Intervertebral Disc Displacement; JNK Mitogen-Activated Protein Kinases; Lipoxins; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Transcription Factor RelA | 2015 |
Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection.
Topics: Animals; Axotomy; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Inflammation; Injections, Spinal; Lipoxins; Male; Mice; Microglia; Neuralgia; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Spinal Cord Injuries | 2016 |
Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner.
Topics: Animals; Antioxidants; Dinoprost; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fatty Acid-Binding Proteins; Intestines; Isoprostanes; Kelch-Like ECH-Associated Protein 1; Lactic Acid; Lipoxins; Male; Microscopy, Fluorescence; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Lipoxin; Reperfusion Injury; RNA Interference; RNA, Small Interfering; Superoxide Dismutase | 2016 |
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Topics: Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; E-Selectin; Endothelium; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Myocardium; Nitroimidazoles; Parasitemia; Simvastatin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vascular Cell Adhesion Molecule-1 | 2017 |
Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation.
Topics: Animals; Asthma; Disease Models, Animal; Eicosapentaenoic Acid; Inflammation; Inflammation Mediators; Interferon-gamma; Interleukin-23; Lipoxins; Lung; Mice | 2008 |
Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling.
Topics: Alveolar Bone Loss; Animals; Cell Adhesion; Cell Proliferation; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Leukocyte Rolling; Lipoxins; Male; Neovascularization, Pathologic; Periodontitis; Piroxicam; Rats; Rats, Wistar; Xanthones | 2009 |
15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascitic Fluid; Disease Models, Animal; Disease Progression; Down-Regulation; Endometriosis; Endometrium; Enzyme-Linked Immunosorbent Assay; Estrus; Female; Gene Expression Regulation, Enzymologic; Injections, Intraperitoneal; Lipoxins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
NF-kappaB is involved in inhibition of lipoxin A4 on dermal inflammation and hyperplasia induced by mezerein.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Cell Line; Cytokines; Dermis; Disease Models, Animal; Diterpenes; Female; Humans; Hyperplasia; Inflammation; Keratinocytes; Lipoxins; Mice; Mice, Inbred Strains; NF-kappa B | 2010 |
Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.
Topics: 8,11,14-Eicosatrienoic Acid; Acute Disease; Animals; Anticholesteremic Agents; Cell Line; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Inflammation; Inflammation Mediators; Lipoxins; Lovastatin; Male; Mice; Neutrophils; Pneumonia; Respiratory Mucosa | 2010 |
Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Atorvastatin; Carotid Stenosis; Carrier Proteins; Disease Models, Animal; Elastic Tissue; Enzyme-Linked Immunosorbent Assay; Gene Expression; Heptanoic Acids; Leukotriene D4; Lipids; Lipoxins; Membrane Proteins; Muscle, Smooth, Vascular; Pyrroles; Rabbits; Receptors, Leukotriene; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tunica Intima | 2010 |
Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia.
Topics: Animals; Astrocytes; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Encephalitis; Esters; Injections, Intraventricular; Lipid Peroxidation; Lipoxins; Male; Neuroprotective Agents; Neutrophils; Rats; Rats, Sprague-Dawley; Recovery of Function | 2010 |
Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Collagen; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Kidney; Kidney Diseases; Ligation; Lipoxins; Male; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2011 |
Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect.
Topics: Animals; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Iloprost; Lipoxins; Lung; Lung Injury; Male; Protective Agents; Pyrazoles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides | 2012 |
Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.
Topics: Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Catechin; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Disease Models, Animal; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Lipoxins; Lipoxygenase Inhibitors; Liver; Lung; Mice, Inbred C57BL; NF-kappa B; Peroxidase; Sepsis | 2012 |
Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease.
Topics: Acute Disease; Animals; Arachidonate 5-Lipoxygenase; Cells, Cultured; Chagas Cardiomyopathy; Cytokines; Disease Models, Animal; Heart; Lipoxins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Parasite Load; Parasitemia; Patch-Clamp Techniques; Suppressor of Cytokine Signaling Proteins; T-Lymphocyte Subsets; Trypanosoma cruzi | 2012 |
Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury.
Topics: Animals; Animals, Newborn; Arachidonate 5-Lipoxygenase; Astrocytes; Brain Edema; Brain Ischemia; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Glucose; Leukotriene B4; Leukotriene C4; Leukotrienes; Lipoxins; Male; MAP Kinase Signaling System; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger | 2012 |
Lipoxin A₄ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Corneal Stroma; Dihydropyridines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Injuries; Fibronectins; Fluorescent Antibody Technique, Indirect; Interleukin-1alpha; Lipoxins; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Wound Healing | 2012 |
Phosphodiesterase III inhibition increases cAMP levels and augments the infarct size limiting effect of a DPP-4 inhibitor in mice with type-2 diabetes mellitus.
Topics: Animals; Blood Glucose; Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glucagon-Like Peptide 1; Glycated Hemoglobin; Immunoblotting; Lipids; Lipoxins; Male; Membrane Proteins; Mice; Myocardial Infarction; Myocardium; Phosphodiesterase 3 Inhibitors; PTEN Phosphohydrolase; Tetrazoles; Triazoles | 2012 |
Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes.
Topics: Animals; Blood Glucose; Blotting, Western; Cholesterol; Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Exenatide; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Hypoglycemic Agents; Isoquinolines; Lipoxins; Male; Mice; Myocardial Infarction; Myocardium; Peptides; Phosphodiesterase 3 Inhibitors; Phosphorylation; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Receptors, Glucagon; Signal Transduction; Sulfonamides; Tetrazoles; Triglycerides; Up-Regulation; Venoms | 2013 |
Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
Topics: Animals; Anti-Inflammatory Agents; CD3 Complex; Cell Polarity; Choline; Cognition Disorders; Disease Models, Animal; Hippocampus; Inflammation; Leukotriene B4; Lipoxins; Lymphocyte Count; Macrophages; Male; Metabolic Syndrome; Physical Conditioning, Animal; Postoperative Period; Rats; Receptors, Adrenergic, beta-2; Signal Transduction; Spleen; T-Lymphocytes, Regulatory | 2013 |
Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; CD11b Antigen; Cytokines; Disease Models, Animal; Down-Regulation; Lipoxins; Male; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger | 2013 |
An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Cell Movement; Chemotaxis, Leukocyte; Croton Oil; Disease Models, Animal; Diterpenes; Female; Guinea Pigs; Humans; Hydroxyeicosatetraenoic Acids; Hypersensitivity, Delayed; Iloprost; Inflammation; Leukotriene B4; Lipoxins; Mice; Phthalic Anhydrides; Skin; Terpenes | 2002 |
A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils.
Topics: Animals; Biomimetic Materials; Bone Marrow Cells; Bone Marrow Transplantation; Cell Movement; Disease Models, Animal; Eicosanoids; Female; Graft vs Host Disease; Host vs Graft Reaction; Leukocytes; Lipoxins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils; Transplantation, Homologous | 2005 |
Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury.
Topics: Animals; Base Sequence; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; DNA, Complementary; Gene Expression; Humans; Hydrochloric Acid; Inflammation Mediators; Lipoxins; Lung; Lung Injury; Male; Membrane Proteins; Mice; Mice, Transgenic; Prostaglandin-Endoperoxide Synthases; Receptors, Formyl Peptide; Receptors, Lipoxin; Signal Transduction | 2005 |
Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Arachidonate 5-Lipoxygenase; Carbon Tetrachloride; Carrier Proteins; Cell Count; Chemical and Drug Induced Liver Injury; Chronic Disease; Disease Models, Animal; Hepatocytes; Kupffer Cells; Leukotrienes; Lipoxins; Lipoxygenase Inhibitors; Liver; Liver Diseases; Male; Matrix Metalloproteinase 2; Membrane Proteins; Quinolines; Rats; Rats, Wistar; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-2 | 2005 |
Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism.
Topics: Acetates; Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Plant; Cyclopropanes; Disease Models, Animal; Leukotriene Antagonists; Lipoxins; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Ovalbumin; Phenyl Ethers; Quinolines; Receptors, Leukotriene; Respiratory Hypersensitivity; Structure-Activity Relationship; Sulfides | 2007 |
Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice.
Topics: Acute Disease; Animals; Basement Membrane; Blood Platelets; Disease Models, Animal; Eicosanoids; Female; Glomerulonephritis; Hydroxyeicosatetraenoic Acids; Immunization, Passive; Kidney Glomerulus; Lipoxins; Lipoxygenase; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Neutrophils; P-Selectin; Proteinuria | 1996 |