lipid-a and Uveitis--Anterior

Acute anterior uveitis in man is related to Gram negative bacterial infection occurring at sites distant to the eye. This could involve intraocular localization of inflammatory bacterial cell wall constituents. Modulation of the blood-aqueous barrier in rabbit and rat, by muramyl dipeptide (the monomer of peptidoglycan) and lipopolysaccharide (and its monomer lipid A) was studied. The rabbit eye was found to be highly susceptible to MDP and LPS, although without cellular infiltration. In contrast the rat eye was demonstrated to be totally refractory to MDP. The response to LPS in the rat was modest, required high dosages and ocular changes were slow to occur, but cellular infiltration was readily apparent. Since MDP is found in Gram positive (as well as Gram negative) bacterial cell walls it is hypothesized that Gram positive bacteria might also play a role in causing uveitis in man.

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Anterior Eye Segment; Aqueous Humor; Capillary Permeability; Female; Lipid A; Lipopolysaccharides; Neutrophils; Rabbits; Rats; Rats, Inbred Lew; Uveitis, Anterior