lipid-a and Leukemia--Promyelocytic--Acute

lipid-a has been researched along with Leukemia--Promyelocytic--Acute* in 1 studies

Other Studies

1 other study(ies) available for lipid-a and Leukemia--Promyelocytic--Acute

Article	Year
The effect of endotoxin lipopolysaccharide from different bacterial species on the generation of intracellular inositol trisphosphate and superoxide in a human phagocytic cell line. FEMS microbiology immunology, 1990, Volume: 2, Issue:5-6 The acute effects of endotoxins and lipid A on two intracellular responses, inositol phosphate generation and superoxide production were analysed in the DMSO differentiated premyelocytic leukaemic HL-60 cell line. Short-term incubation (1-10 min) with Escherichia coli-type LPS, Salmonella-type LPS and Lipid A caused significant increases in cellular InsP1 and InsP3, compared with control cells (P less than 0.5-P less than 0.001). The Escherichia coli-type LPS released approximately twice the quantity of InsP3 compared with Salmonella-type LPS (P less than 0.001). Lipid A-dependent stimulation of InsP3 production was also detected. The rate of superoxide production increased 1-10 min after addition of both Escherichia coli- and Salmonella-type LPS and Lipid A. Endotoxins and Lipid A caused a dose-dependent increase in intracellular oxidative activity. The superoxide response showed less species dependence and a higher response to particulate lipid A compared with the inositol phosphate response. Topics: Endotoxins; Escherichia coli; Humans; Inositol 1,4,5-Trisphosphate; Leukemia, Promyelocytic, Acute; Lipid A; Lipopolysaccharides; Phagocytes; Salmonella; Signal Transduction; Species Specificity; Superoxides; Tumor Cells, Cultured	1990

Article

Year

The effect of endotoxin lipopolysaccharide from different bacterial species on the generation of intracellular inositol trisphosphate and superoxide in a human phagocytic cell line.

FEMS microbiology immunology, 1990, Volume: 2, Issue:5-6

The acute effects of endotoxins and lipid A on two intracellular responses, inositol phosphate generation and superoxide production were analysed in the DMSO differentiated premyelocytic leukaemic HL-60 cell line. Short-term incubation (1-10 min) with Escherichia coli-type LPS, Salmonella-type LPS and Lipid A caused significant increases in cellular InsP1 and InsP3, compared with control cells (P less than 0.5-P less than 0.001). The Escherichia coli-type LPS released approximately twice the quantity of InsP3 compared with Salmonella-type LPS (P less than 0.001). Lipid A-dependent stimulation of InsP3 production was also detected. The rate of superoxide production increased 1-10 min after addition of both Escherichia coli- and Salmonella-type LPS and Lipid A. Endotoxins and Lipid A caused a dose-dependent increase in intracellular oxidative activity. The superoxide response showed less species dependence and a higher response to particulate lipid A compared with the inositol phosphate response.

Topics: Endotoxins; Escherichia coli; Humans; Inositol 1,4,5-Trisphosphate; Leukemia, Promyelocytic, Acute; Lipid A; Lipopolysaccharides; Phagocytes; Salmonella; Signal Transduction; Species Specificity; Superoxides; Tumor Cells, Cultured

1990