lipid-a and Autism-Spectrum-Disorder

The link between autism spectrum disorder (ASD) and the gut microbiome has received much attention, with special focus on gut-brain-axis immunological imbalances. Gastrointestinal problems are one of the major symptoms of ASD and are thought to be related to immune dysregulation. Therefore, in silico analysis was performed on mined data from 36 individuals with ASD and 21 control subjects, with an emphasis on lipid A endotoxin-producing bacteria and their lipopolysaccharide (LPS) metabolic pathways. Analysis of enzyme distribution among the 15 most abundant genera in both groups revealed that almost all these genera utilized five early-stage enzymes responsible for catalyzing the nine conserved lipid A synthesis steps. However,

Topics: Autism Spectrum Disorder; Brain; Case-Control Studies; Child; Computer Simulation; Female; Gastrointestinal Diseases; Gastrointestinal Microbiome; Humans; Lipid A; Lipopolysaccharides; Male; Signal Transduction