linsidomine has been researched along with Myocardial Ischemia in 11 studies
linsidomine: RN given refers to parent cpd; structure
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of myocardial ischemia (30 min) and reperfusion were measured in mice, with assays of myocardial apoptosis, superoxide production, NOx and nitrotyrosine content, and myocardial infarct size." | 3.73 | Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress. ( Christopher, TA; Coletti, C; Gao, E; Hu, A; Koch, W; Lopez, BL; Ma, XL; Tao, L; Wang, Y, 2006) |
| "We observed that N-nitro-L-arginine (NOLA), a nitric oxide biosynthesis inhibitor, exacerbated necrosis in the rabbit heart during ischemia-reperfusion while 3-morpholino-sydnonimine-hydrochloride (SIN-1) (a nitric oxide donor) reduced myocardial damage in the same model." | 3.69 | The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion. ( Fung, KP; Wu, J; Wu, TW; Zeng, LH, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, L | 2 |
| Gao, E | 2 |
| Hu, A | 1 |
| Coletti, C | 1 |
| Wang, Y | 1 |
| Christopher, TA | 1 |
| Lopez, BL | 1 |
| Koch, W | 2 |
| Ma, XL | 2 |
| Jiao, X | 1 |
| Lau, WB | 1 |
| Yuan, Y | 1 |
| Lopez, B | 1 |
| Christopher, T | 1 |
| RamachandraRao, SP | 1 |
| Williams, W | 1 |
| Southan, G | 1 |
| Sharma, K | 1 |
| Barnes, CS | 1 |
| Coker, SJ | 1 |
| Vacheron, A | 1 |
| de Vernejoul, P | 1 |
| Richard, V | 4 |
| Kaeffer, N | 3 |
| Tron, C | 2 |
| Thuillez, C | 4 |
| Fung, KP | 1 |
| Wu, TW | 1 |
| Zeng, LH | 1 |
| Wu, J | 1 |
| Kober, G | 1 |
| Bender, M | 1 |
| Vallbracht, C | 1 |
| Sievert, H | 1 |
| Klepzig, H | 1 |
| Blanc, T | 1 |
| François, A | 1 |
| Lallemand, F | 2 |
| Henry, JP | 2 |
| Czarnowska, E | 1 |
| Karwatowska-Prokopczuk, E | 1 |
| Laude, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062] | 21 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for linsidomine and Myocardial Ischemia
| Article | Year |
|---|---|
SIN-1 has no direct myocardial anti-ischemic action.
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease; Double-Blind Method; Electro | 1993 |
10 other studies available for linsidomine and Myocardial Ischemia
| Article | Year |
|---|---|
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Male; Mice; Molsidomine; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nit | 2006 |
Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis.
Topics: Amino Acid Substitution; Animals; Apoptosis; Cardiotonic Agents; Cyclic N-Oxides; Free Radical Scave | 2006 |
Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Cyclic GMP; Hemodynam | 1995 |
[Value of linsidomine (SIN 1) in the evaluation of myocardial viability by 201-Tl scintigraphy after exertion].
Topics: Adult; Aged; Aged, 80 and over; Exercise Test; Female; Heart; Humans; Injections, Intravenous; Male; | 1994 |
Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion.
Topics: Acetylcholine; Animals; Arginine; Calcimycin; Coronary Vessels; Endothelium, Vascular; Male; Molsido | 1994 |
The opposing effects of an inhibitor of nitric oxide synthesis and of a donor of nitric oxide in rabbits undergoing myocardial ischemia reperfusion.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Heart; Molsidomine; Myocardial Ischemia; My | 1994 |
Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Coronary Vessels; Disease Models, Animal; Endothel | 1995 |
Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats.
Topics: Acetylcholine; Animals; Chronic Disease; Coronary Circulation; Coronary Vessels; Endothelium, Vascul | 1996 |
Role of oxygen free radicals in cardiocyte injury in the reperfused rat heart.
Topics: Animals; Endothelium; Free Radical Scavengers; Glycocalyx; Heart; Male; Molsidomine; Myocardial Isch | 1996 |
Evidence against a role of inducible nitric oxide synthase in the endothelial protective effects of delayed preconditioning.
Topics: Acetylcholine; Amidines; Animals; Benzylamines; Coronary Vessels; Endothelium, Vascular; Enzyme Inhi | 2000 |